Radiosensitization by Inhibiting STAT1 in Renal Cell Carcinoma

International Journal of Radiation Oncology Biology Physics

Volumn 73, Issue 1, 2009, Pages 288-295

  Hui, Zhouguang ^a,b   Tretiakova, Maria ^c   Zhang, Zhongfa ^d   Li, Yan ^d   Wang, Xiaozhen ^a,b   Zhu, Julie Xiaohong ^a   Gao, Yuanhong ^a,e   Mai, Weiyuan ^a   Furge, Kyle ^d   Qian, Chao Nan ^d,e   Amato, Robert ^f   Butler, E Brian ^f   Teh, Bin Tean ^d   Teh, Bin S ^a,f,g  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b CANCER HOSPITAL   (China)

^c UNIVERSITY OF CHICAGO   (United States)

^d VAN ANDEL RESEARCH INSTITUTE   (United States)

^e SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^f HOUSTON METHODIST HOSPITAL   (United States)

^g MICHAEL E DEBAKEY VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Gene expression; Radiosensitization; Renal cell carcinoma; Signal transducer and activator of transcription 1; siRNA; STAT1

Indexed keywords

ANIMAL CELL CULTURE; CELL CULTURE; CELL DEATH; CELLS; CYTOLOGY; GENE EXPRESSION; RADIATION EFFECTS; TRANSCRIPTION; TRANSCRIPTION FACTORS; TRANSDUCERS;

RADIOSENSITIZATION; RENAL CELL CARCINOMA; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1; SIRNA; STAT1;

CONCRETE DAMS;

FLUDARABINE; SMALL INTERFERING RNA; STAT1 PROTEIN; STAT3 PROTEIN;

ARTICLE; CANCER CELL CULTURE; CELL DEATH; CLEAR CELL CARCINOMA; CLONOGENIC ASSAY; CONTROLLED STUDY; FIBROBLAST; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY CARCINOMA; KIDNEY PARENCHYMA; MICROARRAY ANALYSIS; NEPHROBLASTOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RADIOSENSITIVITY; RADIOSENSITIZATION; SIGNAL TRANSDUCTION; TREATMENT OUTCOME; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; CARCINOMA, RENAL CELL; CELL LINE, TUMOR; CELL SURVIVAL; HUMANS; KIDNEY NEOPLASMS; RADIATION-SENSITIZING AGENTS; STAT1 TRANSCRIPTION FACTOR; VIDARABINE;

EID: 57649089545     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2008.08.043     Document Type: Article

References (31)

1. Michael B., and Kastan J.B. Cell-cycle checkpoints and cancer. Nature 432 (2004) 316-323
2. Valerie K., and Povirk L. Regulation and mechanisms of mammalian double-strand break repair. Oncogene 22 (2003) 5792-5812
3. Takahashi M., Yang X.J., Sugimura J., et al. Molecular subclassification of kidney tumors and the discovery of new diagnostic markers. Oncogene 22 (2003) 6810-6918
4. Khodarev N.N., Beckett M., Labay E., et al. STAT1 is overexpressed in tumors selected for radioresistance and confer protection from radiation in transduced sensitive cells. PNAS 101 (2004) 1714-1719
5. Yang X.J., Sugimura J., Schafernak K.T., et al. Classification of renal neoplasms based on molecular signatures. J Urol 175 (2006) 2302-2306
6. Arany I., Chen S.H., Megyesi J.K., et al. Differentiation-dependent expression of signal transducers and activators of transcription (STATs) might modify responses to growth factors in the cancers of the head and neck. Cancer Lett 199 (2003) 83-89
7. Laimer K., Spizzo G., Obrist P., et al. STAT1 activation in squamous cell cancer of the oral cavity: A potential predictive marker of response to adjuvant chemotherapy. Cancer Lett 110 (2007) 326-333
8. Harris A.L. Hypoxia-A key regulatory factor in tumour growth. Nat Rev Cancer 2 (2002) 38-47
9. Hall E.J., and Giaccia A.J. Radiobiology for the radiobiologist. 6th ed. (2005), Lippincott Williams & Wilkins, Philadelphia
10. Amundson S.A., Bittner M., and Fornace A.J. Functional genomics as a window on radiation stress signaling. Oncogene 22 (2003) 5828-5833
11. Ahmed M.M., Alcock R.A., Chendil D., et al. Restoration of transforming growth factor-beta signaling enhances radiosensitivity by altering the Bcl-2/Bax ratio in the p53 mutant pancreatic cancer cell line MIA PaCa-2. J Biol Chem 277 (2002) 2234-2246
12. Wahl G.M., and Carr A.M. The evolution of diverse biological responses to DNA damage: Insights from yeast and p53. Nat Cell Biol 3 (2001) E277-E286
13. Haas-Kogan D.A., Kogan S.S., Yount G., et al. p53 function influences the effect of fractionated radiotherapy on glioblastoma tumors. Int J Radiat Oncol Biol Phys 43 (1999) 399-403
14. Duda D.G., Jain R.K., and Willett C.G. Antiangiogenics: The potential role of integrating this novel treatment modality with chemoradiation for solid cancers. J Clin Oncol 25 (2007) 4033-4042
15. Shewach D.S., and Lawrence T.S. Antimetabolite radiosensitizers. J Clin Oncol 25 (2007) 4043-4050
16. Amorino G.P., Hamilton V.M., Valerie K., et al. Epidermal growth factor receptor dependence of radiation-induced transcription factor activation in human breast carcinoma cells. Mol Biol Cell 13 (2002) 2233-2244
17. Costa-Pereira A.P., Tininini S., Strobl B., et al. Mutational switch of an IL-6 response to an interferon-r-like response. Proc Natl Acad Sci 99 (2002) 8043-8047
18. Messina J.L., Yu H., Riker A.I., et al. Activated Stat-3 in melanoma. Cancer Control 15 (2008) 196-201
19. Frank D.A., Mahajan S., and Ritz J. Fludarabine-induced immunosuppression is associated with inhibition of STAT1 signaling. Nat Med 5 (1999) 444-447
20. Darnell J.E. STATs and gene regulation. Science 277 (1997) 1630-1635
21. Martinez-Lostao L., Briones J., Forné I., et al. Role of the STAT1 pathway in apoptosis induced by fludarabine and JAK kinase inhibitors in B-cell chronic lymphocytic leukemia. Leukemia Lymphoma 46 (2005) 435-442
22. Terui K., Haga S., Enosawa S., et al. Hypoxia/re-oxygenation-induced, redox-dependent activation of STAT1 (signal transducer and activator of transcription 1) confers resistance to apoptotic cell death via hsp70 induction. Biochem J 380 (2004) 203-209
23. Fagard R., Mouas H., Dusanter-Fourt I., et al. Resistance to fludarabine-induced apoptosis in Epstein-Barr virus infected B cells. Oncogene 21 (2002) 4473-4480
24. Nishioka C., IkezoT T.K., et al. Fludarabine induces growth arrest and apoptosis of cytokine- or alloantigen-stimulated peripheral blood mononuclear cells, and decreases production of Th1 cytokines via inhibition of nuclear factor kB. Bone Marrow Transplant 41 (2008) 303-309
25. Tsai M.H., Cook J.A., Chandramouli G.V., et al. Gene expression profiling of breast, prostate, and glioma cells following single versus fractionated doses of radiation. Cancer Res 67 (2007) 3845-3852
26. Buettner R., Mora L.B., and Jove R. Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention. Clin Cancer Res 8 (2002) 945-954
27. Battle T.E., and Frank D.A. The role of STATs in apoptosis. Curr Mol Med 2 (2002) 381-392
28. El-Hashemite N., Zhang H., Walker V., et al. Perturbed IFN-gamma-Jak-signal transducers and activators of transcription signaling in tuberous sclerosis mouse models: Synergistic effects of rapamycin-IFN-gamma treatment. Cancer Res 64 (2004) 3436-3443
29. Cochet O., Frelin C., Peyron J.F., et al. Constitutive activation of STAT proteins in the HDLM-2 and L540 Hodgkin lymphoma-derived cell lines supports cell survival. Cell Signal 18 (2006) 449-455
30. Legrand A., Vadrot N., Lardeux B., et al. Study of the effects of interferon α on several human hepatoma cell lines: Analysis of the signalling pathway of the cytokine and of its effects on apoptosis and cell proliferation. Liver Int 24 (2004) 149-160
31. Townsend P.A., McComick J., Barry S., et al. STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage. J Cell Sci 118 (2005) 1629-1639