A brain aggregate model gives new insights into the pathobiology and treatment of prion diseases

Journal of Neuropathology and Experimental Neurology

Volumn 71, Issue 5, 2012, Pages 449-466

  Bajsarowicz, Krystyna ^a   Ahn, Misol ^a   Ackerman, Larry ^a   Dearmond, Bernadette N ^a   Carlson, George ^b   Dearmond, Stephen J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MCLAUGHLIN RESEARCH INSTITUTE   (United States)

Author keywords

Autophagosomes; Brain aggregates; Exocytosis; Prion disease; Quinacrine; Rapamycin; Scrapie

Indexed keywords

CATHEPSIN D; MEPACRINE; N2 [2 (3,5 DIFLUOROPHENYL) 2 HYDROXYACETYL] N1 (6,7 DIHYDRO 5 METHYL 6 OXO 5H DIBENZ[B,D]AZEPIN 7 YL)ALANINAMIDE; PRION PROTEIN; R 5000; RAPAMYCIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOPHAGOSOME; BRAIN NERVE CELL; CELL AGGREGATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DENDRITE; DRUG EFFECT; DRUG POTENTIATION; EMBRYO; ENDOCYTOSIS; GLIA CELL; INTRACELLULAR TRANSPORT; LIGHT CHAIN; LYSOSOME; MOUSE; NERVE CELL DEGENERATION; NEUROPATHOLOGY; NONHUMAN; PHAGOCYTOSIS; PRION DISEASE; PRIORITY JOURNAL; PROTEIN TRANSPORT; SCRAPIE AGENT; VIRUS STRAIN; WESTERN BLOTTING;

ALANINE; ANIMALS; AZEPINES; BRAIN; CATHEPSIN D; DENDRITES; DISEASE MODELS, ANIMAL; EMBRYO, MAMMALIAN; ENZYME INHIBITORS; FEMALE; GENE EXPRESSION REGULATION; IMMUNOSUPPRESSIVE AGENTS; LYSOSOMES; MALE; MICE; MICE, KNOCKOUT; MICROGLIA; MICROSCOPY, CONFOCAL; MICROTUBULE-ASSOCIATED PROTEINS; NERVE DEGENERATION; NERVE TISSUE PROTEINS; PREGNANCY; PRION DISEASES; PRIONS; PROTEIN TRANSPORT; PRPSC PROTEINS; QUINACRINE; SIROLIMUS; SUBCELLULAR FRACTIONS; TIME FACTORS;

EID: 84860223562     PISSN: 00223069     EISSN: 15546578     Source Type: Journal    
DOI: 10.1097/NEN.0b013e3182544680     Document Type: Article

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