Prion protein interconversions

Philosophical Transactions of the Royal Society B: Biological Sciences

Volumn 356, Issue 1406, 2001, Pages 197-202

  Caughey, Byron ^a   Chesebro, Bruce ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Bovine spongiform encephalopathy; Conversion; Creutzfeldt Jakob disease; Prion; Structure; Transmissible spongiform encephalopathies

Indexed keywords

ANIMALIA; BOS TAURUS; BOVINAE;

EID: 0035961323     PISSN: 09628436     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (41)

1. Distinct PrP properties suggest the molecular basis of strain variation in transmissible mink encephalopathy
2. Nongenetic propagation of strain-specific phenotypes of scrapie prion protein
3. In situ formation of protease-resistant prion protein in transmissible spongiform encephalopathy-infected brain slices
4. Scrapie and cellular prion proteins differ in the kinetics of synthesis and topology in cultured cells
5. Evidence for synthesis of scrapie prion protein in the endocytic pathway
6. Scrapie susceptibility-linked polymorphisms modulate the in vitro conversion of sheep prion protein to protease-resistant forms
7. The scrapie-associated form of PrP is made from a cell surface precursor that is both protease- and phospholipase-sensitive
8. N-terminal truncation of the scrapie-associated form of PrP by lysosomal protease(s): Implications regarding the site of conversion of PrP to the protease-resistant state
9. Aggregates of scrapie associated prion protein induce the cell-free conversion of protease-sensitive prion protein to the protease-resistant state
10. Scrapie infectivity correlates with converting activity, protease resistance, and aggregation of scrapie-associated prion protein in guanidine denaturation studies
11. Strain-dependent differences in beta-sheet conformations of abnormal prion protein
12. Inhibition of protease-resistant prion protein formation by porphyrins and phthalocyanines
13. Specific inhibition of in vitro formation of protease-resistant prion protein by synthetic peptides
14. Species-independent inhibition of abnormal prion protein (PrP) formation by a peptide containing a conserved PrP sequence
15. Prion protein and the transmissible spongiform encephalopathy diseases
16. Chaperone-supervised conversion of prion protein to its protease-resistant form
17. Inhibition of formation of protease-resistant prion protein by trypan blue, sirius red and other Congo red analogs
18. Lysosomotropic agents and cysteine protease inhibitors inhibit accumulation of scrapie-associated prion protein
19. Structure of the recombinant full-length hamster prion protein PrP (29-231): The N terminus is highly flexible
20. Cellular biology of prion diseases
21. The importance of the disulfide bond in prion protein conversion
22. Prion protein interconversions and the transmissible spongiform encephalopathies
23. Specific binding of normal prion protein to the scrapie form via a localized domain initiates its conversion to the protease-resistant state
24. Interactions between heterologous forms of prion protein: Binding, inhibition of conversion, and species barriers
25. Cell-free formation of protease-resistant prion protein
26. Species specificity in the cell-free conversion of prion protein to protease-resistant forms: A model for the scrapie species barrier
27. Partial unfolding and refolding of scrapie-associated prion protein: Evidence for a critical 16-kDa C-terminal domain
28. Typing prion strains
29. A single hamster amino acid blocks conversion to protease-resistant PrP in scrapie-infected mouse neuroblastoma cells
30. Heterologous PrP molecules interfere with accumulation of protease-resistant PrP in scrapie-infected murine neuroblastoma cells
31. Novel therapeutic uses for porphyrins and phthalocyanines in the transmissible spongiform encephalopathies
32. Porphyrin and phthalocyanine anti-scrapie compounds
33. Evidence of a molecular barrier limiting susceptibility of humans, cattle and sheep to chronic wasting disease
34. Molecular assessment of the transmissibilities of BSE and scrapie to humans
35. NMR characterization of the full-length recombinant murine prion protein, mPrP(23-21)
36. Detection and discrimination of PrPSc by multi-spectral ultraviolet fluorescence
37. Eight prion strains have PrP(Sc) molecules with different conformation
38. Chimeric prion protein expression in cultured cells and transgenic mice
39. Biochemical typing of scrapie strains
40. Molecular genetics of transmissible spongiform encephalopathies
41. Transmissible spongiform encephalopathies