Selective neuronal vulnerability during experimental scrapie infection: Insights from an ultrastructural investigation

Brain Research

Volumn 874, Issue 2, 2000, Pages 210-215

  Bouzamondo, Essia ^a,b   Milroy, Antonia M ^a   Ralston III, Henry J ^a   Prusiner, Stanley B ^b   DeArmond, Stephen J ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c HSW 430   (United States)

Author keywords

Electron microscopy; GABA; Neuronal degeneration; Shrunken dark neuron; Syrian hamster

Indexed keywords

4 AMINOBUTYRIC ACID;

ANIMAL; ARTICLE; ELECTRON MICROSCOPY; HAMSTER; IMMUNOHISTOCHEMISTRY; MALE; METABOLISM; NERVE CELL; NERVE DEGENERATION; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SCRAPIE; SYRIAN HAMSTER; ULTRASTRUCTURE;

ANIMALS; CRICETINAE; GAMMA-AMINOBUTYRIC ACID; IMMUNOHISTOCHEMISTRY; MALE; MESOCRICETUS; MICROSCOPY, ELECTRON; NERVE DEGENERATION; NEURONS; SCRAPIE;

EID: 0034714012     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)02498-7     Document Type: Article

References (31)

1. R.N. Auer, H. Kalimo, Y. Olsson, B.K. Siesjö, The temporal evolution of hypoglycemic brain damages. I. Light- and electron-microscopic findings in the rat cerebral cortex, Acta Neuropathol. 67 (1-2) (1985) 13-24.
2. A.W. Brown, J.B. Brierley, The nature, distribution and earliest stages of anoxic-ischaemic nerve cell damage in the rat brain as defined by the optical microscope, Br. J. Exp. Pathol. 49 (1968) 87-106.
3. J. Cammermeyer, The importance of avoiding 'dark' neurons in experimental neuropathology, Acta Neuropathol. 1 (1961) 245-270.
4. S.J De Armond, J.W. Ironside, Neuropathology of prion diseases, in: S.B. Prusiner (Ed.), Prion Biology and Diseases, Cold Spring Harbor Laboratory Press, pp. 585-652.
5. S.J. De Armond, S.B. Prusiner, Etiology and pathogenesis of prion diseases, Am. J. Path. 146 (1995) 785-811.
6. S.J. De Armond, S.B. Prusiner, Prion diseases, in: D.I. Graham, P.L. Lantos (Eds.), Greenfield's Neuropathology, 6th Edition, Arnold (Oxford University Press), London, pp. 235-280.
7. C.I. De Zeeuw, J.C. Holstege, F. Calkoen, T.J.H. Ruigrok, J. Voogd, A new combination of WGA-HRP anterograde tracing and GABA immunohistochemistry applied to afferents of the cat inferior olive at the ultrastructural level, Brain Res. 447 (1988) 369-375.
8. J.W. Finnie, J.D. O'Shea, Pathological and pathogenic changes in the central nervous system of guinea pigs given tunicamycin, Acta Neuropath. 75 (1988) 411-421.
9. F. Gallyas, G. Zoltay, Z. Horvah, K. David, L. Kelenyi, An immediate morphopathologic response of neurons to electroshock; a reliable model for producing 'dark' neurons in experimental neuropathology, Neurobiology 1 (1993) 133-146.
10. F. Gray, F. Chretien, H. Adle-Biassette, A. Dorandeu, T. Ereau, M.B. Delisle, N. Kopp, W. Ironside, C. Vital, Neuronal apoptosis in Creutzfeldt-Jakob Disease, J. Neuropath. Exp. Neurol. 58 (1999) 321-328.
11. M. Guentchev, M.H. Groshup, R. Kordek, P. Liberski, H. Budka, Severe early and selective loss of a subpopulation of GABAergic inhibitory neurons in experimental transmissible spongiform encephalopathies, Brain Pathol. 8 (1998) 615-623.
12. M. Guentchev, J. Wanschitz, T. Voigtlander, H. Flicker, H. Budka, Selective neuronal vulnerability in human prion diseases: fatal familial insomnia differs from others types of prion diseases, Am. J. Pathol. 155 (5) (1999) 1453-1457.
13. L. Heimer, R. Kalil, Rapid transneuronal degeneration and death of cortical neurons following removal of the olfactory bulb, J. Comp. Neurol. 178 (1978) 559-610.
14. N. Islam, A. Moriawaki, Y. Hattori, Y. Hori, Appearance of dark neurons following anodal polarization in the rat brain, Acta Med. Okayama 48 (1994) 123-130.
15. K. Jendroska, F. P Heinzel, M. Torchia, L. Stowring, H.A. Kretzschmar, A. Kon, A. Stern, S.B. Prusiner, S.J. DeArmond, Proteinase-resistant prion protein accumulation in scrapie hamster brain correlates with regional pathology and scrapie infectivity, Neurology 41 (1991) 1482-1490.
16. E.G. Jones, GABAergic neurons and their role in cortical plasticity in primates, Cerebral Cortex 3 (1993) 361-372.
17. H.A. Kretzschmar, S.B. Prusiner, L.E. Stowring, S.J. DeArmond, Scrapie prion proteins are synthesized in neurons, Am. J. Pathol. 122 (1986) 1-5.
18. E.M. Loberg, A. Torvik, Distinction between artefactually shrunken and truly degenerated 'dark' neurons by in situ fixation with microwave irradiation, Neuropathol. Appl. Neurobiol. 19 (1993) 359-363.
19. P. Lu, J.A. Sturman, D.C. Bolton, Altered GABA distribution in hamster brain is an early molecular consequence of infection by scrapie prions, Brain Res. 681 (1995) 235-241.
20. T. Majewska, I. Krolikowska-Prasal, B. Budzynska, Histologic examination of some hippocampus fields after experimental ischemia, Ann. Univ. Mariae Curie Sklodowska [Med] 52 (1997) 39-43.
21. C.L. Masters, E.P.J. Richardson, Subacute spongiform encephalopathy Creutzfeldt-Jakob disease - the nature and progression of spongiform change, Brain 101 (1978) 333-344.
22. A.M. Milroy, D.D. Ralston, Electron microscopic imaging of multiple markers in glutaraldehyde fixed CNS tissue of Macaco fascicularis: maximizing information from a single experimental animal, J. Neurosci. Meth. 56 (1995) 145-154.
23. T. Murakami, T. Murakami, N. Mahmut, S. Hitomi, A. Ohtsuka, Dark and light neurons in the human brain, with special reference to their reactions to Golgi's silver nitrate, luxol fast blue MBS and azocarmine, Arch. Histol. Cytol. 60 (1997) 265-274.
24. A. Ohtsuka, T. Murakami, Dark neurons in the mouse brain: an investigation into the possible significance of their variable appearance within a day and their relation to negatively charged cell coats, Arch. Histol. Cytol. 59 (1996) 79-85.
25. J.W. Olney, Glutamate-induced neuronal necrosis in the infant mouse hypothalamus: an electron microscopic study, J. Neuropathol. Exp. Neurol. 30 (1971) 75-90.
26. S.B. Prusiner, The prion diseases, Brain Pathol. 8 (1998) 499-513.
27. S.B. Prusiner, Novel proteinaceous infectious particles cause scrapie, Science 216 (1982) 136-144.
28. T.S. Salahuddin, H. Kalimo, B.B. Johansson, Y. Olsson, Observations on exudation of fibronectin, fibrinogen and albumin in the brain after carotid infusion of hyperosmolar solutions, Acta Neuropathol. 76 (1988) 1-10.
29. R.S. Sloviter, 'Epileptic' brain damage in rats induced by sustained electrical stimulation of the perforant path. I. Acute electrophysiological and light microscopic studies, Brain Res. Bull. 10 (1983) 675-697.
30. R.P. Simon, T. Griffiths, M.C. Evans, J.H. Swan, B.S. Meldrum, Calcium overload in selectively vulnerable neurons of the hippocampus during and after ischemia: an electron microscopy study in the rat, J. Cerebr. Blood Flow Metab. 4 (1984) 350-361.
31. R.P. Simon, J.H. Swan, T. Griffiths, B.S. Meldrum, Blockade of N-methyl-D-aspartate receptors may protect against ischemic damage in the brain, Science 226 (1984) 850-852.