Golgi pH, its regulation and roles in human disease

Annals of Medicine

Volumn 44, Issue 6, 2012, Pages 542-554

  Rivinoja, Antti ^a   Pujol, Francois M ^a   Hassinen, Antti ^a   Kellokumpu, Sakari ^a  

^a UNIVERSITY OF OULU   (Finland)

Author keywords

Disease; Glycosylation; Golgi; PH regulation

Indexed keywords

ADENOSINE TRIPHOSPHATASE; PROTON;

CELL ORGANELLE; CELL PH; CELL VACUOLE; CUTIS LAXA; CYSTIC FIBROSIS; ENZYME GLYCOSYLATION; ENZYME STRUCTURE; GOLGI COMPLEX; HAILEY HAILEY DISEASE; HUMAN; ION CONDUCTANCE; NEOPLASM; PRIORITY JOURNAL; REVIEW;

CUTIS LAXA; CYSTIC FIBROSIS; DISEASE; ENDOCYTOSIS; EUKARYOTIC CELLS; EXOCYTOSIS; GLYCOSYLATION; GOLGI APPARATUS; HUMANS; HYDROGEN-ION CONCENTRATION; NEOPLASMS; ORGANELLES; PEMPHIGUS, BENIGN FAMILIAL;

EID: 84860222212     PISSN: 07853890     EISSN: 13652060     Source Type: Journal    
DOI: 10.3109/07853890.2011.579150     Document Type: Review

References (146)

1. Demaurex N. pH Homeostasis of cellular organelles. News Physiol Sci. 2002;17:1-5.
2. Paroutis P, Touret N, Grinstein S. The pH of the secretory pathway: measurement, determinants, and regulation. Physiology (Bethesda). 2004;19:207-15. (Pubitemid 39481936)
3. Schapiro FB, Grinstein S. Determinants of the pH of the Golgi complex. J Biol Chem. 2000;275:21025-32. (Pubitemid 30481791)
4. Griffiths G, Quinn P, Warren G. Dissection of the Golgi complex. I. Monensin inhibits the transport of viral membrane proteins from medial to trans Golgi cisternae in baby hamster kidney cells infected with Semliki Forest virus. J Cell Biol. 1983;96:835-50. (Pubitemid 13131345)
5. Matlin KS. Ammonium chloride slows transport of the influenza virus hemagglutinin but does not cause missorting in a polarized epithelial cell line. J Biol Chem. 1986;261:15172-8. (Pubitemid 17218093)
6. Thorens B, Vassalli P. Chloroquine and ammonium chloride prevent terminal glycosylation of immunoglobulins in plasma cells without affecting secretion. Nature. 1986;321:618-20. (Pubitemid 16042215)
7. Caplan MJ, Stow JL, Newman AP, Madri J, Anderson HC, Farquhar MG, et al. Dependence on pH of polarized sorting of secreted proteins. Nature. 1987;329:632-5. (Pubitemid 17140113)
8. Gawlitzek M, Ryll T, Lofgren J, Sliwkowski MB. Ammonium alters N-glycan structures of recombinant TNFR-IgG: degradative versus biosynthetic mechanism. Biotechnol Bioeng. 2000;68:637-47.
9. Palokangas H, Ying M, Vaananen K, Saraste J. Retrograde transport from the pre-Golgi intermediate compartment and the Golgi complex is affected by the vacuolar H+-ATPase inhibitor bafilomycin A1. Mol Biol Cell. 1998;9:3561-78. (Pubitemid 28551048)
10. Axelsson MA, Karlsson NG, Steel DM, Ouwendijk J, Nilsson T, Hansson GC. Neutralization of pH in the Golgi apparatus causes redistribution of glycosyltransferases and changes in the O-glycosylation of mucins. Glycobiology. 2001;11:633-44. (Pubitemid 32785269)
11. Campbell BJ, Rowe GE, Leiper K, Rhodes JM. Increasing the intra-Golgi pH of cultured LS174T goblet-differentiated cells mimics the decreased mucin sulfation and increased Thomsen-Friedenreich antigen (Gal beta1-3GalNac alpha-) expression seen in colon cancer. Glycobiology. 2001;11:385-93. (Pubitemid 32691111)
12. Kellokumpu S, Sormunen R, Kellokumpu I. Abnormal glycosylation and altered Golgi structure in colorectal cancer: dependence on intra-Golgi pH. FEBS Lett. 2002;516:217-24. (Pubitemid 34311965)
13. Ellis MA, Weisz OA. In vitro assays differentially recapitulate protein export from the trans-Golgi network. Anal Biochem. 2006;354:314-6.
14. Wu MM, Llopis J, Adams S, McCaffery JM, Kulomaa MS, Machen TE, et al. Organelle pH studies using targeted avidin and fluorescein-biotin. Chem Biol. 2000;7:197-209. (Pubitemid 30147204)
15. Wu MM, Grabe M, Adams S, Tsien RY, Moore HP, Machen TE. Mechanisms of pH regulation in the regulated secretory pathway. J Biol Chem. 2001;276:33027-35.
16. +-ATPasetransfected HEK-293 cells: implications for pH regulation in the secretory pathway. Am J Physiol Cell Physiol. 2003;285:C205-14. (Pubitemid 36736352)
17. Demaurex N, Furuya W, D'Souza S, Bonifacino JS, Grinstein S. Mechanism of acidification of the trans-Golgi network (TGN). J Biol Chem. 1998;273:2044-51.
18. Kim JH, Johannes L, Goud B, Antony C, Lingwood CA, Daneman R, et al. Noninvasive measurement of the pH of the endoplasmic reticulum at rest and during calcium release. Proc Natl Acad Sci USA. 1998;95:2997-3002. (Pubitemid 28135843)
19. Llopis J, McCaffery JM, Miyawaki A, Farquhar MG, Tsien RY. Measurement of cytosolic, mitochondrial, and Golgi pH in single living cells with green fluorescent proteins. Proc Natl Acad Sci USA. 1998;95:6803-8. (Pubitemid 28278061)
20. Golgi C. Sur la structure des cellules nerveuses des ganglions spinaux. Arch Ital Biol 1898;30:278-86.
21. Farquhar MG, Palade GE. The Golgi apparatus (complex) (1954-1981)-from artifact to center stage. J Cell Biol. 1981;91(3 Pt 2):77s-103s. (Pubitemid 12177862)
22. Farquhar MG, Palade GE. The Golgi apparatus: 100 years of progress and controversy. Trends Cell Biol. 1998;8:2-10. (Pubitemid 28040839)
23. Rodriguez-Boulan E, Musch A. Protein sorting in the Golgi complex: shifting paradigms. Biochim Biophys Acta. 2005;1744:455-64. (Pubitemid 40848261)
24. Bonifacino JS, Rojas R. Retrograde transport from endosomes to the trans-Golgi network. Nat Rev Mol Cell Biol. 2006;7:568-79. (Pubitemid 44325348)
25. De Matteis MA, Luini A. Exiting the Golgi complex. Nat Rev Mol Cell Biol. 2008;9:273-84. (Pubitemid 351430855)
26. Saraste J, Kuismanen E. Pre-and post-Golgi vacuoles operate in the transport of Semliki Forest virus membrane glycoproteins to the cell surface. Cell. 1984;38:535-49. (Pubitemid 14022046)
27. Appenzeller-Herzog C, Hauri HP. The ER-Golgi intermediate compartment (ERGIC): in search of its identity and function. J Cell Sci. 2006;119(Pt 11):2173-83. (Pubitemid 43960307)
28. Tanaka K, Mitsushima A, Fukudome H, Kashima Y. Three-dimensional architecture of the Golgi complex observed by high resolution scanning electron microscopy. J Submicrosc Cytol. 1986;18:1-9. (Pubitemid 16148928)
29. Cooper MS, Cornell-Bell AH, Chernjavsky A, Dani JW, Smith SJ. Tubulovesicular processes emerge from trans-Golgi cisternae, extend along microtubules, and interlink adjacent trans-golgi elements into a reticulum. Cell. 1990;61:135-45.
30. Rambourg A, Clermont Y. Three-dimensional electron microscopy: structure of the Golgi apparatus. Eur J Cell Biol. 1990;51:189-200. (Pubitemid 20147872)
31. Weidman PJ. Anterograde transport through the Golgi complex: do Golgi tubules hold the key? Trends Cell Biol. 1995;5:302-5.
32. Mironov AA, Weidman P, Luini A. Variations on the intracellular transport theme: maturing cisternae and trafficking tubules. J Cell Biol. 1997;138:481-4. (Pubitemid 27349831)
33. Griffiths G. Gut thoughts on the Golgi complex. Traffic. 2000;1:738-45.
34. Kepes F, Rambourg A, Satiat-Jeunemaitre B. Morphodynamics of the secretory pathway. Int Rev Cytol. 2005;242:55-120. (Pubitemid 39642961)
35. Rogalski AA, Singer SJ. Associations of elements of the Golgi apparatus with microtubules. J Cell Biol. 1984;99:1092-100. (Pubitemid 14043367)
36. Rios RM, Bornens M. The Golgi apparatus at the cell centre. Curr Opin Cell Biol. 2003;15:60-6. (Pubitemid 36044716)
37. Varki A. Factors controlling the glycosylation potential of the Golgi apparatus. Trends Cell Biol. 1998;8:34-40. (Pubitemid 28040845)
38. Brockhausen I. Pathways of O-glycan biosynthesis in cancer cells. Biochim Biophys Acta. 1999;1473:67-95.
39. Wopereis S, Lefeber DJ, Morava E, Wevers RA. Mechanisms in protein O-glycan biosynthesis and clinical and molecular aspects of protein O-glycan biosynthesis defects: a review. Clin Chem. 2006;52:574-600.
40. Maccioni HJ. Glycosylation of glycolipids in the Golgi complex. J Neurochem. 2007;103(Suppl 1):81-90.
41. De Matteis MA, D'Angelo G. The role of the phosphoinositides at the Golgi complex. Biochem Soc Symp. 2007:107-16.
42. Griffiths G, Simons K. The trans Golgi network: sorting at the exit site of the Golgi complex. Science. 1986;234:438-43. (Pubitemid 17181425)
43. Jefferies KC, Cipriano DJ, Forgac M. Function, structure and regulation of the vacuolar (H+)-ATPases. Arch Biochem Biophys. 2008;476:33-42.
44. Grabe M, Oster G. Regulation of organelle acidity. J Gen Physiol. 2001;117:329-44.
45. Drory O, Nelson N. The emerging structure of vacuolar ATPases. Physiology (Bethesda). 2006;21:317-25. (Pubitemid 44511759)
46. Jansen E J R. V-ATPase-mediated granular acidification is regulated by the V-ATPase accessory subunit Ac45 in POMC-producing cells. Mol Biol Cell. 2010;21:3330-9.
47. Glickman J, Croen K, Kelly S, Al-Awqati Q. Golgi membranes contain an electrogenic H+ pump in parallel to a chloride conductance. J Cell Biol. 1983;97:1303-8. (Pubitemid 13017133)
48. Rybak SL, Lanni F, Murphy RF. Theoretical considerations on the role of membrane potential in the regulation of endosomal pH. Biophys J. 1997;73:674-87. (Pubitemid 27337604)
49. Hara-Chikuma M, Wang Y, Guggino SE, Guggino WB, Verkman AS. Impaired acidification in early endo-somes of ClC-5 deficient proximal tubule. Biochem Biophys Res Commun. 2005;329:941-6. (Pubitemid 40341368)
50. Hara-Chikuma M, Yang B, Sonawane ND, Sasaki S, Uchida S, Verkman AS. ClC-3 chloride channels facilitate endosomal acidification and chloride accumulation. J Biol Chem. 2005;280:1241-7.
51. Jentsch TJ. Chloride and the endosomal-lysosomal pathway: emerging roles of CLC chloride transporters. J Physiol. 2007;578(Pt 3):633-40. (Pubitemid 46165500)
52. Maeda Y, Ide T, Koike M, Uchiyama Y, Kinoshita T. GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus. Nat Cell Biol. 2008;10:1135-45.
53. Nordeen MH, Jones SM, Howell KE, Caldwell JH. GOLAC: an endogenous anion channel of the Golgi complex. Biophys J. 2000;78:2918-28. (Pubitemid 30396924)
54. Thompson RJ, Nordeen MH, Howell KE, Caldwell JH. A large-conductance anion channel of the Golgi complex. Biophys J. 2002;83:278-89. (Pubitemid 34694738)
55. Barasch J, Kiss B, Prince A, Saiman L, Gruenert D, Al-Awqati Q. Defective acidification of intracellular organelles in cystic fibrosis. Nature. 1991;3526:70-3. (Pubitemid 21896700)
56. Barasch J, Al-Awqati Q. Defective acidification of the biosynthetic pathway in cystic fibrosis. J Cell Sci Suppl. 1993;17:229-33. (Pubitemid 24041303)
57. Nagasawa M, Kanzaki M, Iino Y, Morishita Y, Kojima I. Identification of a novel chloride channel expressed in the endoplasmic reticulum, golgi apparatus, and nucleus. J Biol Chem. 2001;276:20413-8.
58. Schwappach B, Stobrawa S, Hechenberger M, Steinmeyer K, Jentsch TJ. Golgi localization and functionally important domains in the NH2 and COOH terminus of the yeast CLC putative chloride channel Gef1p. J Biol Chem. 1998;273:15110-8. (Pubitemid 28272808)
59. Jentsch TJ, Friedrich T, Schriever A, Yamada H. The CLC chloride channel family. Pflugers Arch. 1999;437:783-95. (Pubitemid 29210494)
60. Gentzsch M, Cui L, Mengos A, Chang XB, Chen JH, Riordan JR. The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins. J Biol Chem. 2003;278:6440-9. (Pubitemid 36800903)
61. Poschet JF, Boucher JC, Tatterson L, Skidmore J, Van Dyke RW, Deretic V. Molecular basis for defective glycosylation and Pseudomonas pathogenesis in cystic fibrosis lung. Proc Natl Acad Sci USA. 2001;98:13972-7. (Pubitemid 33116008)
62. Varki A, Cummings RD, Esko JD, Freeze HH, Stanley P, Bertozzi CR, et al, editors. Essentials of glycobiology. 2nd ed. La Jolla, California: The Consortium of Glycobiology Editors; 2007.
63. Ruetz S, Lindsey AE, Ward CL, Kopito RR. Functional activation of plasma membrane anion exchangers occurs in a pre-Golgi compartment. J Cell Biol. 1993;121:37-48. (Pubitemid 23097360)
64. Kellokumpu S, Neff L, Jamsa-Kellokumpu S, Kopito R, Baron R. A 115-kD polypeptide immunologically related to erythrocyte band 3 is present in Golgi membranes. Science. 1988;2424:1308-11. (Pubitemid 19008063)
65. Alper SL, Chernova MN, Stewart AK. Regulation of Na+ independent Cl-/HCO3-exchangers by pH. JOP. 2001;2(4 Suppl):171-5.
66. Holappa K, Suokas M, Soininen P, Kellokumpu S. Identification of the full-length AE2 (AE2a) isoform as the Golgi-associated anion exchanger in fibroblasts. J Histochem Cytochem. 2001;49:259-69. (Pubitemid 32113388)
67. Holappa K, Munoz MT, Egea G, Kellokumpu S. The AE2 anion exchanger is necessary for the structural integrity of the Golgi apparatus in mammalian cells. FEBS Lett. 2004;564:97-103. (Pubitemid 38490706)
68. Romero MF, Fulton CM, Boron WF. The SLC4 family of HCO 3-transporters. Pflugers Arch. 2004;447:495-509.
69. Alper SL. Molecular physiology of SLC4 anion exchangers. Exp Physiol. 2006;91:153-61.
70. Cherny VV, DeCoursey TE. pH-dependent inhibition of voltage-gated H (+) currents in rat alveolar epithelial cells by Zn (2+) and other divalent cations. J Gen Physiol. 1999;114:819-38.
71. Numata M, Orlowski J. Molecular cloning and characterization of a novel (Na+, K+)/H+ exchanger localized to the trans-Golgi network. J Biol Chem. 2001;276:17387-94.
72. Nakamura N, Tanaka S, Teko Y, Mitsui K, Kanazawa H. Four Na+/H+ exchanger isoforms are distributed to Golgi and post-Golgi compartments and are involved in organelle pH regulation. J Biol Chem. 2005;280:1561-72.
73. Lawrence SP, Bowers K. The sodium/proton exchanger NHE8 regulates late endosomal morphology and function. Mol Biol Cell. 2010;21:3540-51.
74. Paulson JC. Glycoproteins: what are the sugar chains for? Trends Biochem Sci. 1989;14:272-6. (Pubitemid 19187254)
75. Varki A. Biological roles of oligosaccharides: all of the theories are correct. Glycobiology. 1993;3:97-130. (Pubitemid 23132602)
76. Lowe JB, Marth JD. A genetic approach to mammalian glycan function. Ann Rev Biochem. 2003;72:643-91. (Pubitemid 36930456)
77. Marth JD, Grewal PK. Mammalian glycosylation in immunity. Nat Rev Immunol. 2008;8:874-87.
78. Freeze HH, Aebi M. Altered glycan structures: the molecular basis of congenital disorders of glycosylation. Curr Opin Struct Biol. 2005;15:490-8. (Pubitemid 41393479)
79. Freeze HH. Genetic defects in the human glycome. Nat Rev Genet. 2006;7:537-51. (Pubitemid 43943571)
80. Ungar D. Golgi linked protein glycosylation and associated diseases. Semin Cell Dev Biol. 2009;20:762-9.
81. Reis CA, Osorio H, Silva L, Gomes C, David L. Alterations in glycosylation as biomarkers for cancer detection. J Clin Pathol. 2010;63:322-9.
82. Ohtsubo K, Marth JD. Glycosylation in cellular mechanisms of health and disease. Cell. 2006;126:855-67. (Pubitemid 44310784)
83. Ohtsubo K. Targeted genetic inactivation of N- acetylglucosaminyltransferase-IVa impairs insulin secretion from pancreatic beta cells and evokes type 2 diabetes. Methods Enzymol. 2010;479:205-22.
84. Kim YJ, Varki A. Perspectives on the significance of altered glycosylation of glycoproteins in cancer. Glycoconj J. 1997;14:569-76. (Pubitemid 27353200)
85. Campbell BJ, Yu LG, Rhodes JM. Altered glycosylation in inflammatory bowel disease: a possible role in cancer development. Glycoconj J. 2001;18:851-8. (Pubitemid 36315049)
86. Ono M, Hakomori S. Glycosylation defining cancer cell motility and invasiveness. Glycoconj J. 2004;20:71-8. (Pubitemid 38392180)
87. Yu LG. The oncofetal Thomsen-Friedenreich carbohydrate antigen in cancer progression. Glycoconj J. 2007;24:411-20.
88. Zhao YY, Takahashi M, Gu JG, Miyoshi E, Matsumoto A, Kitazume S, et al. Functional roles of N-glycans in cell signaling and cell adhesion in cancer. Cancer Sci. 2008;99:1304-10. (Pubitemid 351761717)
89. Boland CR, Deshmukh GD. The carbohydrate composition of mucin in colonic cancer. Gastroenterology. 1990;98(5 Pt 1):1170-7. (Pubitemid 20143099)
90. Campbell BJ, Finnie IA, Hounsell EF, Rhodes JM. Direct demonstration of increased expression of Thomsen-Friedenreich (TF) antigen in colonic adenocarcinoma and ulcerative colitis mucin and its concealment in normal mucin. J Clin Invest. 1995;95:571-6.
91. Karlen P, Young E, Brostrom O, Lofberg R, Tribukait B, Ost K, et al. Sialyl-Tn antigen as a marker of colon cancer risk in ulcerative colitis: relation to dysplasia and DNA aneuploidy. Gastroenterology. 1998;115:1395-404. (Pubitemid 28545990)
92. Itzkowitz SH, Marshall A, Kornbluth A, Harpaz N, McHugh JB, Ahnen D, et al. Sialosyl-Tn antigen: initial report of a new marker of malignant progression in long-standing ulcerative colitis. Gastroenterology. 1995;109:490-7.
93. Kuhns W, Jain RK, Matta KL, Paulsen H, Baker MA, Geyer R, et al. Characterization of a novel mucin sulphotransferase activity synthesizing sulphated O-glycan core 1, 3-sulphate-Gal beta 1-3GalNAc alpha-R. Glycobiology. 1995;5:689-97.
94. Jass JR, Allison LM, Edgar S. Monoclonal antibody TKH2 to the cancer-associated epitope sialosyl Tn shows crossreactivity with variants of normal colorectal goblet cell mucin. Pathology. 1994;26:418-22.
95. Ogata S, Ho I, Chen A, Dubois D, Maklansky J, Singhal A, et al. Tumor-associated sialylated antigens are constitutively expressed in normal human colonic mucosa. Cancer Res. 1995;55:1869-74.
96. Parodi AJ, Blank EW, Peterson JA, Ceriani RL. Dolicholbound oligosaccharides and the transfer of distal monosaccharides in the synthesis of glycoproteins by normal and tumor mammary epithelial cells. Breast Cancer Res Treat. 1982;2:227-37. (Pubitemid 13225062)
97. Yamashita K, Totani K, Kuroki M, Matsuoka Y, Ueda I, Kobata A. Structural studies of the carbohydrate moieties of carcinoembryonic antigens. Cancer Res. 1987;47:3451.
98. Roth J. Protein N-glycosylation along the secretory pathway: relationship to organelle topography and function, protein quality control, and cell interactions. Chem Rev. 2002;102:285-303. (Pubitemid 35381634)
99. Kim YS, Yuan M, Itzkowitz SH, Sun QB, Kaizu T, Palekar A, et al. Expression of LeY and extended LeY blood grouprelated antigens in human malignant, premalignant, and nonmalignant colonic tissues. Cancer Res. 1986;46:5985-92. (Pubitemid 17178016)
100. Moriyama H, Nakano H, Igawa M, Nihira H. T antigen expression in benign hyperplasia and adenocarcinoma of the prostate. Urol Int. 1987;42:120-3. (Pubitemid 17094281)
101. Wolf MF, Ludwig A, Fritz P, Schumacher K. Increased expression of Thomsen-Friedenreich antigens during tumor progression in breast cancer patients. Tumour Biol. 1988;9:190-4.
102. Lloyd KO, Burchell J, Kudryashov V, Yin BW, Taylor-Papadimitriou J. Comparison of O-linked carbohydrate chains in MUC-1 mucin from normal breast epithelial cell lines and breast carcinoma cell lines. Demonstration of simpler and fewer glycan chains in tumor cells. J Biol Chem. 1996;271:33325-34. (Pubitemid 27010142)
103. Van Kooyk Y, Rabinovich GA. Protein-glycan interactions in the control of innate and adaptive immune responses. Nat Immunol. 2008;9:593-601. (Pubitemid 351712630)
104. Whitehouse C, Burchell J, Gschmeissner S, Brockhausen I, Lloyd KO, Taylor-Papadimitriou J. A transfected sialyltransferase that is elevated in breast cancer and localizes to the medial/trans-Golgi apparatus inhibits the development of core-2-based O-glycans. J Cell Biol. 1997;137:1229-41. (Pubitemid 27265938)
105. Burchell J, Poulsom R, Hanby A, Whitehouse C, Cooper L, Clausen H, et al. An alpha2, 3 sialyltransferase (ST3Gal I) is elevated in primary breast carcinomas. Glycobiology. 1999;9:1307-11. (Pubitemid 30011510)
106. Dalziel M, Whitehouse C, McFarlane I, Brockhausen I, Gschmeissner S, Schwientek T, et al. The relative activities of the C2GnT1 and ST3Gal-I glycosyltransferases determine O-glycan structure and expression of a tu-mor-associated epitope on MUC1. J Biol Chem. 2001;276:11007-15. (Pubitemid 38089281)
107. Yang JM, Byrd JC, Siddiki BB, Chung YS, Okuno M, Sowa M, et al. Alterations of O-glycan biosynthesis in human colon cancer tissues. Glycobiology. 1994;4:873-84.
108. Brockhausen I, Yang JM, Burchell J, Whitehouse C, Taylor-Papadimitriou J. Mechanisms underlying aberrant glycosylation of MUC1 mucin in breast cancer cells. Eur J Biochem. 1995;233:607-17.
109. Hanisch FG, Stadie TR, Deutzmann F, Peter-Katalinic J. MUC1 glycoforms in breast cancer-cell line T47D as a model for carcinoma-associated alterations of 0-glycosylation. Eur J Biochem. 1996;236:318-27. (Pubitemid 26074885)
110. Muller S, Hanisch FG. Recombinant MUC1 probe authentically reflects cell-specific O-glycosylation profiles of endogenous breast cancer mucin. High density and prevalent core 2-based glycosylation. J Biol Chem. 2002;277:26103-12. (Pubitemid 34967094)
111. Taylor-Papadimitriou J, Burchell J, Miles DW, Dalziel M. MUC1 and cancer. Biochim Biophys Acta. 1999;1455:301-13. (Pubitemid 29435996)
112. Kumamoto K, Goto Y, Sekikawa K, Takenoshita S, Ishida N, Kawakita M, et al. Increased expression of UDP-galactose transporter messenger RNA in human colon cancer tissues and its implication in synthesis of Thomsen-Friedenreich antigen and sialyl Lewis A/X determinants. Cancer Res. 2001;61:4620-7. (Pubitemid 32685798)
113. Schietinger A, Philip M, Yoshida BA, Azadi P, Liu H, Meredith SC, et al. A mutant chaperone converts a wild-type protein into a tumor-specific antigen. Science. 2006;3145:304-8. (Pubitemid 44571976)
114. Singh R, Campbell BJ, Yu LG, Fernig DG, Milton JD, Goodlad RA, et al. Cell surface-expressed Thomsen-Friedenreich antigen in colon cancer is predominantly carried on high molecular weight splice variants of CD44. Glycobiology. 2001;11:587-92. (Pubitemid 32677836)
115. Rivinoja A, Kokkonen N, Kellokumpu I, Kellokumpu S. Elevated Golgi pH in breast and colorectal cancer cells correlates with the expression of oncofetal carbohydrate T-antigen. J Cell Physiol. 2006;208:167-74. (Pubitemid 43849002)
116. Fukushima K. Carbohydrate structures of a normal counterpart of the carcinoembryonic antigen produced by colon epithelial cells of normal adults. Glycobiology. 1995;5:105.
117. Waldman BC, Rudnick G. UDP-GlcNAc transport across the Golgi membrane: electroneutral exchange for dianionic UMP. Biochemistry. 1990;29:44-52. (Pubitemid 20033705)
118. Rivinoja A, Hassinen A, Kokkonen N, Kauppila A, Kellokumpu S. Elevated Golgi pH impairs terminal N-glycosylation by inducing mislocalization of Golgi glycosyltransferases. J Cell Physiol. 2009;220:144-54.
119. Bachert C, Lee TH, Linstedt AD. Lumenal endosomal and Golgi-retrieval determinants involved in pH-sensitive targeting of an early Golgi protein. Mol Biol Cell. 2001;12:3152-60. (Pubitemid 33062969)
120. Young W W Jr. Organization of Golgi glycosyltransferases in membranes: complexity via complexes. J Membr Biol. 2004;198:1-13. (Pubitemid 38393451)
121. Simon SM. Role of organelle pH in tumor cell biology and drug resistance. Drug Discov Today. 1999;4:32-8. (Pubitemid 29332911)
122. Schindler M, Grabski S, Hoff E, Simon SM. Defective pH regulation of acidic compartments in human breast cancer cells (MCF-7) is normalized in adriamycin-resistant cells (MCF-7adr). Biochemistry. 1996;35:2811-7. (Pubitemid 26086788)
123. Altan N, Chen Y, Schindler M, Simon SM. Defective acidification in human breast tumor cells and implications for chemotherapy. J Exp Med. 1998;187:1583-98. (Pubitemid 28235100)
124. Kornak U, Reynders E, Dimopoulou A, Van Reeuwijk J, Fischer B, Rajab A, et al. Impaired glycosylation and cutis laxa caused by mutations in the vesicular H-ATPase subunit ATP6V0A2. Nat Genet. 2007;40:32-4.
125. Morava É, Guillard M, Lefeber DJ, Wevers RA. Autosomal recessive cutis laxa syndrome revisited. Eur J Hum Genet. 2009;17:1099-110.
126. Morava E, Wopereis S, Coucke P, Gillessen-Kaesbach G, Voit T, Smeitink J, et al. Defective protein glyco-sylation in patients with cutis laxa syndrome. Eur J Hum Genet. 2005;13:414-21. (Pubitemid 40520931)
127. Wopereis S, Morava É, Grünewald S, Mills PB, Winchester BG, Clayton P, et al. A combined defect in the biosynthesis of N-and O-glycans in patients with cutis laxa and neurological involvement: the biochemical characteristics. Biochim Biophys Acta. 2005;174:156-64. (Pubitemid 40825001)
128. Hurtado-Lorenzo A, Skinner M, El Annan J, Futai M, Sun-Wada G, Bourgoin S, et al. V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway. Nature Cell Biol. 2006;8:124-36.
129. Rhim AD, Stoykova L, Glick MC, Scanlin TF. Terminal glycosylation in cystic fibrosis (CF): a review emphasizing the airway epithelial cell. Glycoconj J. 2001;18:649-59. (Pubitemid 35398672)
130. Weisz OA. Organelle acidification and disease. Traffic. 2003;4:57-64. (Pubitemid 36621699)
131. Schulz BL, Sloane AJ, Robinson LJ, Prasad SS, Lindner RA, Robinson M, et al. Glycosylation of sputum mucins is altered in cystic fibrosis patients. Glycobiology. 2007;17:698-712. (Pubitemid 47050659)
132. Barasch J, Al-Awqati Q. Chloride channels, Golgi pH and cystic fibrosis. Trends Cell Biol. 1992;2:35-7.
133. Seksek O, Biwersi J, Verkman AS. Evidence against defective trans-Golgi acidification in cystic fibrosis. J Biol Chem. 1996;271:15542-8. (Pubitemid 26225328)
134. Gibson GA, Hill WG, Weisz OA. Evidence against the acidification hypothesis in cystic fibrosis. Am J Physiol Cell Physiol. 2000;279:C1088-99.
135. Biwersi J, Verkman AS. Functional CFTR in endosomal compartment of CFTR-expressing fibroblasts and T84 cells. Am J Physiol. 1994;266(1 Pt 1):C149-56.
136. + permeability in regulation of Golgi pH. JOP. 2001;2(Suppl): 229-36. (Pubitemid 38963855)
137. Chandy G, Grabe M, Moore HP, Machen TE. Proton leak and CFTR in regulation of Golgi pH in respiratory epithelial cells. Am J Physiol Cell Physiol. 2001;281:C908-21.
138. Vanoevelen J, Dode L, Raeymaekers L, Wuytack F, Missiaen L. Diseases involving the Golgi calcium pump. Subcell Biochem. 2007;45:385-404.
139. Okunade GW, Miller ML, Azhar M, Andringa A, Sanford LP, Doetschman T, et al. Loss of the Atp2c1 secretory pathway Ca (2+)-ATPase (SPCA1) in mice causes Golgi stress, apoptosis, and midgestational death in homozygous embryos and squamous cell tumors in adult heterozygotes. J Biol Chem. 2007;282:26517-27. (Pubitemid 47443792)
140. Van Baelen K, Dode L, Vanoevelen J, Callewaert G, De Smedt H, Missiaen L, et al. The Ca2+/Mn2+ pumps in the Golgi apparatus. Biochim Biophys Acta. 2004;174:103-12.
141. Missiaen L, Raeymaekers L, Dode L, Vanoevelen J, Van Baelen K, Parys JB, et al. SPCA1 pumps and Hailey-Hailey disease. Biochem Biophys Res Commun. 2004;322:1204-13. (Pubitemid 39164650)
142. Grice DM, Vetter I, Faddy HM, Kenny PA, Roberts-Thomson SJ, Monteith GR. Golgi calcium pump secretory pathway calcium ATPase 1 (SPCA1) is a key regulator of insulin-like growth factor receptor (IGF1R) processing in the basal-like breast cancer cell line MDA-MB-231. J Biol Chem. 2010;285:37458-66.
143. Kaufman RJ, Swaroop M, Murtha-Riel P. Depletion of manganese within the secretory pathway inhibits O-linked glycosylation in mammalian cells. Biochemistry. 1994;33:9813-9. (Pubitemid 24286053)
144. Yang RY, Rabinovich GA, Liu FT. Galectins: structure, function and therapeutic potential. Expert Rev Mol Med. 2008;10:e17.
145. Crocker PR, Paulson JC, Varki A. Siglecs and their roles in the immune system. Nat Rev Immunol. 2007;7:255-66. (Pubitemid 46480955)
146. Rivinoja A. Golgi pH and glycosylation [thesis]. Acta Universitatis Ouluensis. A scientiae rerum naturalium 535. Oulu: University of Oulu; 2009.