Entropy-driven binding of opioid peptides induces a large domain motion in human dipeptidyl peptidase III

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 17, 2012, Pages 6525-6530

  Bezerra, Gustavo A ^a   Dobrovetsky, Elena ^b   Viertlmayr, Roland ^a   Dong, Aiping ^b   Binter, Alexandra ^c   Abramić, Marija ^d   Macheroux, Peter ^c   Dhe Paganon, Sirano ^b,e   Gruber, Karl ^a  

^a UNIVERSITY OF GRAZ   (Austria)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d GRAZ UNIVERSITY OF TECHNOLOGY   (Austria)

^e RUDER BO KOVI INSTITUTE   (Croatia)

Author keywords

Isothermal titration calorimetry; Metallopeptidase; Peptide binding; X ray crystallography

Indexed keywords

DIPEPTIDYL PEPTIDASE; DIPEPTIDYL PEPTIDASE III; OPIATE PEPTIDE; TYNORPHIN; UNCLASSIFIED DRUG; WATER;

ARTICLE; COMPLEX FORMATION; ENTROPY; ENZYME STRUCTURE; ENZYME SUBSTRATE; FORCE; HUMAN; LIGAND BINDING; MICROCALORIMETRY; MOTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; THERMODYNAMICS; X RAY;

CALORIMETRY; CRYSTALLOGRAPHY, X-RAY; DIPEPTIDYL-PEPTIDASES AND TRIPEPTIDYL-PEPTIDASES; ENTROPY; HUMANS; LIGANDS; MODELS, MOLECULAR; OLIGOPEPTIDES; OPIOID PEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 84860183170     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1118005109     Document Type: Article

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