Ablation of junctin or triadin is associated with increased cardiac injury following ischaemia/reperfusion

Cardiovascular Research

Volumn 94, Issue 2, 2012, Pages 333-341

  Cai, Wen Feng ^a   Pritchard, Tracy ^a   Florea, Stela ^a   Lam, Chi Kueng ^a   Han, Peidong ^b   Zhou, Xiaoyang ^c   Yuan, Qunying ^d   Lehnart, Stephan E ^e   Allen, Paul D ^f   Kranias, Evangelia G ^a,g  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b PEKING UNIVERSITY   (China)

^c RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^d IXpressGenes Inc   (United States)

^e UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^f BRIGHAM AND WOMEN S HOSPITAL   (United States)

^g Academy of Athens Biomedical Research Foundation   (Greece)

Author keywords

Calpain; ER stress; Ischaemia reperfusion; Junctin; Triadin

Indexed keywords

[1 [(1 FORMYL 2 PHENYLETHYL)CARBAMOYL] 2 METHYLPROPYL]CARBAMIC ACID BENZYL ESTER; CALCIUM ION; CASPASE 12; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; JUNCTIN; PEPTIDES AND PROTEINS; TRIADIN; TROPONIN I; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; GENE SILENCING; HEART INJURY; HEART MUSCLE CONTRACTILITY; HEART MUSCLE INJURY; HEART MUSCLE ISCHEMIA; MOUSE; MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REPERFUSION INJURY;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CALCIUM; CALCIUM SIGNALING; CALCIUM-BINDING PROTEINS; CALPAIN; CALSEQUESTRIN; CARRIER PROTEINS; CYSTEINE PROTEINASE INHIBITORS; DIPEPTIDES; HUMANS; MEMBRANE PROTEINS; MICE; MIXED FUNCTION OXYGENASES; MUSCLE PROTEINS; MYOCARDIAL CONTRACTION; MYOCARDIAL INFARCTION; REPERFUSION INJURY;

EID: 84860158875     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvs119     Document Type: Article

References (33)

1. Lowenstein CJ. Myocardial reperfusion injury. N Engl J Med 2007;357:2409-2410.
2. Ruiz-Meana M, Fernandez-Sanz C, Garcia-Dorado D. The SR-mitochondria interaction: a new player in cardiac pathophysiology. Cardiovasc Res 2010;88:30-39.
3. Tang WH, Kravtsov GM, Sauert M, Tong XY, Hou XY, Wong TM et al. Polyol pathway impairs the function of SERCA and RyR in ischemic-reperfused rat hearts by increasing oxidative modifications of these proteins. J Mol Cell Cardiol 2010;49: 58-69.
4. Talukder MA, Kalyanasundaram A, Zhao X, Zuo L, Bhupathy P, Babu GJ et al. Expression of SERCA isoform with faster Ca2+ transport properties improves postischemic cardiac function and Ca2+ handling and decreases myocardial infarction. Am J Physiol Heart Circ Physiol 2007;293:H2418-2428. (Pubitemid 47605889)
5. Nicolaou P, Rodriguez P, Ren X, Zhou X, Qian J, Sadayappan S et al. Inducible expression of active protein phosphatase-1 inhibitor-1 enhances basal cardiac function and protects against ischemia/reperfusion injury. Circ Res 2009;104:1012-1020.
6. Yuan Q, Fan GC, Dong M, Altschafl B, Diwan A, Ren X et al. Sarcoplasmic reticulum Ca2+ overloading in junctin deficiency enhances cardiac contractility but increases ventricular automaticity. Circulation 2007;115:300-309. (Pubitemid 46148506)
7. Gergs U, Berndt T, Buskase J, Jones LR, Kirchhefer U, Muller FU et al. On the role of junctin in cardiac Ca2+ handling, contractility, and heart failure. Am J Physiol Heart Circ Physiol 2007;293:H728-734. (Pubitemid 47105135)
8. Chopra N, Yang T, Asghari P, Moore ED, Huke S, Akin B et al. Ablation of triadin causes loss of cardiac Ca2+ release units, impaired excitation- contraction coupling, and cardiac arrhythmias. Proc Natl Acad Sci USA 2009;106:7636-7641.
9. Toldo S, Severino A, Abbate A, Baldi A. The role of PDI as a survival factor in cardiomyocyte ischemia. Methods Enzymol 2011;489:47-65.
10. Sammels E, Parys JB, Missiaen L, De Smedt H, Bultynck G. Intracellular Ca2+ storage in health and disease: a dynamic equilibrium. Cell Calcium 2010;47:297-314.
11. Ruiz A, Matute C, Alberdi E. Intracellular Ca2+ release through ryanodine receptors contributes to AMPA receptor-mediated mitochondrial dysfunction and ER stress in oligodendrocytes. Cell Death Dis 2010;1:e54.
12. Qian J, Ren X, Wang X, Zhang P, Jones WK, Molkentin JD et al. Blockade of Hsp20 phosphorylation exacerbates cardiac ischemia/reperfusion injury by suppressed autophagy and increased cell death. Circ Res 2009;105:1223-1231.
13. Hernando V, Inserte J, Sartorio CL, Parra VM, Poncelas-Nozal M, Garcia-Dorado D. Calpain translocation and activation as pharmacological targets during myocardial ischemia/reperfusion. J Mol Cell Cardiol 2010;49:271-279.
14. Zhou X, Fan GC, Ren X,Waggoner JR, Gregory KN, Chen G et al. Overexpression of histidine-rich Ca2+-binding protein protects against ischemia reperfusion-induced cardiac injury. Cardiovasc Res 2007;75:487-497. (Pubitemid 47080963)
15. Li F, Suqishita K, Su Z, Ueda I, Barry WH. Activation of connexin-43 hemichannels can elevate [Ca2+]i and [Na+]i in rabbit ventricular myocytes during metabolic inhibition. J Mol Cell Cardiol 2001;33:2145-2155. (Pubitemid 34073057)
16. Boston DR, Koyama T, Rodriguez-Larrain J, Zou A, Su Z, Barry WH. Effects of Antiotensin II on intracellular calcium and contracture in metabolically inhibited cardiomyocytes. J Pharmacol Exp Ther 1998;285:716-723. (Pubitemid 28237453)
17. Tsuchiya M, Tye CE, Sharma R, Smith CE, Bartlett JD. XBP1 may determine the size of the ameloblast endoplasmic reticulum. J Dent Res 2008;87:1058-1062.
18. Wang X, Eno CO, Altman BJ, Zhu Y, Zhao G, Olberding KE et al. ER stress modulates cellular metabolism. Biochem J 2011;435:285-296.
19. Tabas I, Ron D. Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat Cell Biol 2011;13:184-190.
20. Xu C, Bailly-Maitre B, Reed JC. Endoplasmic reticulum stress: cell life and death decisions. J Clin Invest 2005;115:2656-2664. (Pubitemid 41434389)
21. Hoyer-Hansen M, Jaattela M. Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium. Cell Death Differ 2007;14:1576-1582. (Pubitemid 47278843)
22. Martinez JA, Zhang Z, Svetlov SI, Hayes RL, Wang KK, Larner SF. Calpain and caspase processing of caspase-12 contribute to the ER stress-induced cell death pathway in differentiated PC12 cells. Apoptosis 2010;15:1480-1493.
23. Fan GC, Ren X, Qian J, Yuan Q, Nicolaou P, Wang Y et al. Novel cardioprotective role of a small heat-shock protein, Hsp20, against ischemia/reperfusion injury. Circulation 2005;111:1792-1799. (Pubitemid 40525144)
24. Whelan RS, Kaplinskiy V, Kitsis RN. Cell death in the pathogenesis of heart disease: mechanisms and significance. Annu Rev Physiol 2010;72:19-44.
25. Valverde CA, Kornyeyev D, Ferreiro M, Petrosky AD, Mattiazzi A, Escorbar AL. Transient Ca2+ depletion of the sarcoplasmic reticulum at the onset of reperfusion. Cardiovasc Res 2010;85:671-680.
26. Wei GZ, Zhou JJ, Wang B, Wu F, Bi H, Wang YM et al. Diastolic Ca2+ overload caused by Na +Ca2+ exchanger during the first minutes of reperfusion results in continued myocardial stunning. Eur J Pharmacol 2007;572:1-11. (Pubitemid 47374677)
27. Ali MM, Bagratuni T, Davenport EL, Nowak PR, Silva-Santisteban MC, Hardcastle A et al. Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response. Embo J 2011;30:894-905.
28. Chiribau CB, Gaccioli F, Huang CC, Yuan CL, Hatzoglou M. Molecular symbiosis of CHOP and C/EBP beta isoform LIP contributes to endoplasmic reticulum stress-induced apoptosis. Mol Cell Biol 2010;30:3722-3731.
29. Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA et al. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 2000;403:98-103. (Pubitemid 30038529)
30. Pedrozo Z, Sanchez G, Torrealba N, Valenzuela R, Fernandez C, Hidalgo C et al. Calpains and proteasomes mediate degradation of ryanodine receptors in a model of cardiac ischemic reperfusion. Biochim Biophys Acta 2010;1802:356-362.
31. Portbury AL, Willis MS, Patterson C. Tearin' up my heart: proteolysis in the cardiac sarcomere. J Biol Chem 2011;286:9929-9934.
32. McDonough JL, Arrell DK, Van Eyk JE. Troponin I degradation and covalent complex formation accompanies myocardial ischemia/reperfusion injury. Circ Res 1999;84: 9-20. (Pubitemid 29074876)
33. Maekawa A, Lee JK, Nagaya T, Kamiya K, Yasui K, Horiba M et al. Overexpression of calpastatin by gene transfer prevents troponin I degradation and ameliorates contractile dysfunction in rat hearts subjected to ischemia/reperfusion. J Mol Cell Cardiol 2003; 35:1277-1284. (Pubitemid 37163534)