Biological, clinical, and psychosocial correlates at the interface of cancer and aging research

Journal of the National Cancer Institute

Volumn 104, Issue 8, 2012, Pages 581-589

  Dale, William ^a   Mohile, Supriya G ^c   Eldadah, Basil A ^d   Trimble, Edward L ^e   Schilsky, Richard L ^b   Cohen, Harvey J ^g   Muss, Hyman B ^h   Schmader, Kenneth E ^g,i   Ferrell, Betty ^j   Extermann, Martine ^l   Nayfield, Susan G ^f   Hurria, Arti ^k  

^a Department of Medicine   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^d NATIONAL INSTITUTE ON AGING   (United States)

^e NATIONAL CANCER INSTITUTE   (United States)

^f UNIVERSITY OF FLORIDA   (United States)

^g DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

ⁱ DURHAM VA MEDICAL CENTER   (United States)

^j Division of Nursing Research and Education   (United States)

^k Department of Medical Oncology and Therapeutics Research ^*  (United States)

^l H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CAPECITABINE; CARBOPLATIN; CYTARABINE; DAUNORUBICIN; DOCETAXEL; FLUOROURACIL; FOLINIC ACID; MITOXANTRONE; NAVELBINE; OXALIPLATIN; PACLITAXEL; TAMOXIFEN; TIPIFARNIB;

ACUTE GRANULOCYTIC LEUKEMIA; AGED; AGING; ANTIANDROGEN THERAPY; BREAST CANCER; CANCER ADJUVANT THERAPY; CANCER CENTER; CANCER HORMONE THERAPY; CANCER PATIENT; CANCER RESEARCH; CASTRATION RESISTANT PROSTATE CANCER; CLINICAL TRIAL (TOPIC); COLORECTAL CANCER; CORRELATION ANALYSIS; GERIATRIC ASSESSMENT; GERIATRIC PATIENT; HUMAN; LUNG CANCER; METHODOLOGY; OVARY CANCER; PARTIAL MASTECTOMY; PRIORITY JOURNAL; REVIEW; SOCIAL PSYCHOLOGY; STANDARDIZATION;

ADVISORY COMMITTEES; AGE FACTORS; AGED; AGING; BIOMEDICAL RESEARCH; CLINICAL TRIALS AS TOPIC; FRAIL ELDERLY; GERIATRIC ASSESSMENT; HEALTH SERVICES FOR THE AGED; HUMANS; MIDDLE AGED; NEOPLASMS; RESEARCH DESIGN; UNITED STATES;

EID: 84860136326     PISSN: 00278874     EISSN: 14602105     Source Type: Journal    
DOI: 10.1093/jnci/djs145     Document Type: Review

References (58)

1. Smith BD, Smith GL, Hurria A, Hortobagyi GN, Buchholz TA. Future of cancer incidence in the United States: burdens upon an aging, changing nation. J Clin Oncol. 2009;27(17):2758-2765.
2. Murthy VH, Krumholz HM, Gross CP. Participation in cancer clinical trials: race-, sex-, and age-based disparities. JAMA. 2004;291(22):2720-2726. (Pubitemid 38725421)
3. Hurria A, Balducci L, Naeim A, et al. Mentoring junior faculty in geriatric oncology: report from the Cancer and Aging Research Group. J Clin Oncol. 2008;26(19):3125-3127.
4. Hughes KS, Schnaper LA, Berry D, et al. Lumpectomy plus tamoxifen with or without irradiation in women 70 years of age or older with early breast cancer. N Engl J Med. 2004;351(10):971-977. (Pubitemid 39166260)
5. Muss HB, Berry DA, Cirrincione CT, et al. Adjuvant chemotherapy in older women with early-stage breast cancer. N Engl J Med. 2009;360(20):2055-2065.
6. Hensing TA, Peterman AH, Schell MJ, Lee JH, Socinski MA. The impact of age on toxicity, response rate, quality of life, and survival in patients with advanced, stage IIIB or IV nonsmall cell lung carcinoma treated with carboplatin and paclitaxel. Cancer. 2003;98(4):779-788. (Pubitemid 36959275)
7. Hesketh PJ, Lilenbaum RC, Chansky K, et al. Chemotherapy in patients or = 80 with advanced non-small cell lung cancer: combined results from SWOG 0027 and LUN 6. J Thorac Oncol. 2007;2(6):494-498. (Pubitemid 47171802)
8. D'Andre S, Sargent DJ, Cha SS, et al. 5-Fluorouracil-based chemotherapy for advanced colorectal cancer in elderly patients: a north central cancer treatment group study. Clin Colorectal Cancer. 2005;4(5):325-331. (Pubitemid 40309379)
9. Goldberg RM, Tabah-Fisch I, Bleiberg H, et al. Pooled analysis of safety and efficacy of oxaliplatin plus fluorouracil/leucovorin administered bimonthly in elderly patients with colorectal cancer. J Clin Oncol. 2006;24(25):4085-4091. (Pubitemid 46622283)
10. Mayer RJ, Davis RB, Schiffer CA, et al. Intensive postremission chemotherapy in adults with acute myeloid leukemia. Cancer and Leukemia Group B. N Engl J Med. 1994;331(14):896-903. (Pubitemid 24299870)
11. Harousseau JL, Martinelli G, Jedrzejczak WW, et al. A randomized phase 3 study of tipifarnib compared with best supportive care, including hydroxyurea, in the treatment of newly diagnosed acute myeloid leukemia in patients 70 years or older. Blood. 2009;114(6):1166-1173.
12. Italiano A, Ortholan C, Oudard S, et al. Docetaxel-based chemotherapy in elderly patients (age 75 and older) with castration-resistant prostate cancer. Eur Urol. 2009;55(6):1368-1375.
13. Berthold DR, Pond GR, Soban F, de Wit R, Eisenberger M, Tannock IF. Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer: updated survival in the TAX 327 study. J Clin Oncol. 2008;26(2):242-245.
14. D'Amico AV, Chen MH, Renshaw AA, Loffredo M, Kantoff PW. Androgen suppression and radiation vs radiation alone for prostate cancer: a randomized trial. JAMA. 2008;299(3):289-295. (Pubitemid 351159365)
15. McLean KA, Shah CA, Thompson SA, Gray HJ, Swensen RE, Goff BA. Ovarian cancer in the elderly: outcomes with neoadjuvant chemotherapy or primary cytoreduction. Gynecol Oncol. 2010;118(1):43-46.
16. Inouye SK, Peduzzi PN, Robison JT, Hughes JS, Horwitz RI, Concato J. Importance of functional measures in predicting mortality among older hospitalized patients. JAMA. 1998;279(15):1187-1193.
17. Extermann M, Overcash J, Lyman GH, Parr J, Balducci L. Comorbidity and functional status are independent in older cancer patients. J Clin Oncol. 1998;16(4):1582-1587. (Pubitemid 28175784)
18. Hwang SS, Scott CB, Chang VT, Cogswell J, Srinivas S, Kasimis B. Prediction of survival for advanced cancer patients by recursive partitioning analysis: role of Karnofsky performance status, quality of life, and symptom distress. Cancer Invest. 2004;22(5):678-687. (Pubitemid 40064727)
19. Mohile SG, Xian Y, Dale W, et al. Association of a cancer diagnosis with vulnerability and frailty in older Medicare beneficiaries. J Natl Cancer Inst. 2009;101(17):1206-1215.
20. Rochon PA, Katz JN, Morrow LA, et al. Comorbid illness is associated with survival and length of hospital stay in patients with chronic disability. A prospective comparison of three comorbidity indices. Med Care. 1996;34(11):1093-1101. (Pubitemid 126433208)
21. Gross CP, McAvay GJ, Guo Z, Tinetti ME. The impact of chronic illnesses on the use and effectiveness of adjuvant chemotherapy for colon cancer. Cancer. 2007;109(12):2410-2419. (Pubitemid 46906459)
22. Satariano WA, Ragland DR. The effect of comorbidity on 3-year survival of women with primary breast cancer. Ann Intern Med. 1994;120(2):104-110. (Pubitemid 24027550)
23. Hajjar ER, Hanlon JT, Artz MB, et al. Adverse drug reaction risk factors in older outpatients. Am J Geriatr Pharmacother. 2003;1(2):82-89. (Pubitemid 40410978)
24. Maggiore RJ, Gross CP, Hurria A. Polypharmacy in older adults with cancer. Oncologist. 2010;15(5):507-522.
25. Plassman BL, Langa KM, Fisher GG, et al. Prevalence of cognitive impairment without dementia in the United States. Ann Intern Med. 2008;148(6):427-434. (Pubitemid 351665442)
26. Gupta SK, Lamont EB. Patterns of presentation, diagnosis, and treatment in older patients with colon cancer and comorbid dementia. J Am Geriatr Soc. 2004;52(10):1681-1687. (Pubitemid 41709922)
27. Inouye SK. Delirium in older persons. N Engl J Med. 2006;354(11):1157- 1165.
28. Mitsiades N, Correa D, Gross CP, Hurria A, Slovin SF. Cognitive effects of hormonal therapy in older adults. Semin Oncol. 2008;35(6):569-581.
29. Lyness JM. Treatment of depressive conditions in later life: real-world light for dark (or dim) tunnels. JAMA. 2004;291(13):1626-1628. (Pubitemid 38552436)
30. Rao A, Cohen HJ. Symptom management in the elderly cancer patient: fatigue, pain, and depression. J Natl Cancer Inst Monogr. 2004;(32):150-157.
31. Dale W, Hemmerich J, Bylow K, Mohile S, Mullaney M, Stadler WM. Patient anxiety about prostate cancer independently predicts early initiation of androgen deprivation therapy for biochemical cancer recurrence in older men: a prospective cohort study. J Clin Oncol. 2009;27(10):1557-1563.
32. Rothman MD, Leo-Summers L, Gill TM. Prognostic significance of potential frailty criteria. J Am Geriatr Soc. 2008;56(12):2211-116.
33. Liv Wergeland S. Cancer in home care: unintended weight loss and ethical challenges. A cross-sectional study of older people at 11 sites in Europe. Arch Gerontol Geriatr. 2011;53(1):64-69.
34. Steinbach U. Social networks, institutionalization, and mortality among elderly people in the United States. J Gerontol. 1992;47(4):S183-S190.
35. Basche M, Baron AE, Eckhardt SG, et al. Barriers to enrollment of elderly adults in early-phase cancer clinical trials. J Oncol Pract. 2008;4(4):162-168.
36. Brunello A, Sandri R, Extermann M. Multidimensional geriatric evaluation for older cancer patients as a clinical and research tool. Cancer Treat Rev. 2009;35(6):487-492.
37. Koroukian SM, Murray P, Madigan E. Comorbidity, disability, and geriatric syndromes in elderly cancer patients receiving home health care. J Clin Oncol. 2006;24(15):2304-2310. (Pubitemid 46630661)
38. Repetto L, Fratino L, Audisio RA, et al. Comprehensive geriatric assessment adds information to Eastern Cooperative Oncology Group performance status in elderly cancer patients: an Italian Group for Geriatric Oncology Study. J Clin Oncol. 2002;20(2):494-502. (Pubitemid 34072534)
39. Extermann M, Hurria A. Comprehensive geriatric assessment for older patients with cancer. J Clin Oncol. 2007;25(14):1824-1831. (Pubitemid 46860271)
40. Hurria A, Togawa K, Mohile SG, et al. Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study. J Clin Oncol. 2011;29(25):3457-3465.
41. Extermann M, Boler I, Reich R, et al. The Chemotherapy Risk Assessment Scale for High-Age patients (CRASH) score: design and validation. J Clin Oncol. 2010;28(15s)(suppl). Abstract 9000.
42. Hurria A, Cirrincione CT, Muss HB, et al. Implementing a geriatric assessment in Cooperative Group Clinical Cancer Trials: CALGB 360401. J Clin Oncol. 2011;29(10):1290-1296.
43. Alley DE, Koster A, Mackey D, et al. Hospitalization and change in body composition and strength in a population-based cohort of older persons. J Am Geriatr Soc. 2010;58(11):2085-2091.
44. Ferrucci L, Corsi A, Lauretani F, et al. The origins of age-related proinflammatory state. Blood. 2005;105(6):2294-2299. (Pubitemid 40387022)
45. Ferrucci L, Harris TB, Guralnik JM, et al. Serum IL-6 level and the development of disability in older persons. J Am Geriatr Soc. 1999;47(6):639-646. (Pubitemid 29266628)
46. DePinho RA. The age of cancer. Nature. 2000;408(6809):248-254.
47. Campisi J. Cellular senescence and apoptosis: how cellular responses might influence aging phenotypes. Exp Gerontol. 2003;38(1-2):5-11. (Pubitemid 36110494)
48. Davalos AR, Coppe JP, Campisi J, Desprez PY. Senescent cells as a source of inflammatory factors for tumor progression. Cancer Metastasis Rev. 2010;29(2):273-283.
49. Campisi J, Kim SH, Lim CS, Rubio M. Cellular senescence, cancer and aging: the telomere connection. Exp Gerontol. 2001;36(10):1619-1637. (Pubitemid 32982869)
50. Kim WY, Sharpless NE. The regulation of INK4/ARF in cancer and aging. Cell. 2006;127(2):265-275. (Pubitemid 44572384)
51. Giannelli SV, Patel KV, Windham BG, Pizzarelli F, Ferrucci L, Guralnik JM. Magnitude of underascertainment of impaired kidney function in older adults with normal serum creatinine. J Am Geriatr Soc. 2007;55(6):816-823. (Pubitemid 47011053)
52. Lichtman SM, Hollis D, Miller AA, et al. Prospective evaluation of the relationship of patient age and paclitaxel clinical pharmacology: Cancer and Leukemia Group B (CALGB 9762). J Clin Oncol. 2006;24(12):1846-1851. (Pubitemid 46638982)
53. Klepin HD, Balducci L. Acute myelogenous leukemia in older adults. Oncologist. 2009;14(3):222-232.
54. Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56(3):M146-M157.
55. Simon MS, Du W, Flaherty L, et al. Factors associated with breast cancer clinical trials participation and enrollment at a large academic medical center. J Clin Oncol. 2004;22(11):2046-2052. (Pubitemid 41095136)
56. Kemeny MM, Peterson BL, Kornblith AB, et al. Barriers to clinical trial participation by older women with breast cancer. J Clin Oncol. 2003;21(12):2268-2275. (Pubitemid 46621862)
57. Basche M, Barón AE, Eckhardt SG, et al. Barriers to enrollment of elderly adults in early-phase cancer clinical trials. J Oncol Pract. 2008;4(4):162-168.
58. Given B, Given CW. Cancer treatment in older adults: implications for psychosocial research. J Am Geriatr Soc. 2009;57(suppl 2):s283-s285.