Lumpectomy plus tamoxifen with or without irradiation in women 70 years of age or older with early breast cancer

New England Journal of Medicine

Volumn 351, Issue 10, 2004, Pages 971-977

  Hughes, Kevin S ^a   Schnaper, Lauren A ^b   Berry, Donald ^c   Cirrincione, Constance ^c   McCormick, Beryl ^d   Shank, Brenda ^e   Wheeler, Judith ^c   Champion, Lorraine A ^f   Smith, Thomas J ^g   Smith, Barbara L ^a   Shapiro, Charles ^h   Muss, Hyman B ⁱ   Winer, Eric ^j   Hudis, Clifford ^d   Wood, William ^k   Sugarbaker, David ^j   Henderson, I Craig ^l   Norton, Larry ^d  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Greater Baltimore Medical Center   (Canada)

^c Cancer and Leukemia Group B Statistical Center   (United States)

^d MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^e MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^f SUTTER HEALTH   (United States)

^g MORRISTOWN MEMORIAL HOSPITAL   (United States)

^h OHIO STATE UNIVERSITY   (United States)

ⁱ UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^j DANA FARBER CANCER INSTITUTE   (United States)

^k EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^l UNIVERSITY OF CALIFORNIA   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN RECEPTOR; TAMOXIFEN; ANTINEOPLASTIC HORMONE AGONISTS AND ANTAGONISTS;

AGED; AGING; ARM EDEMA; ARTICLE; BREAST CANCER; CANCER ADJUVANT THERAPY; CANCER HORMONE THERAPY; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER STAGING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; EARLY CANCER; EDEMA; ESTHETICS; FEMALE; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MASTALGIA; METASTASIS; PARTIAL MASTECTOMY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SHOULDER PAIN; SKIN COLOR; SKIN FIBROSIS; SURVIVAL RATE; THORAX PAIN; BREAST TUMOR; FOLLOW UP; MULTICENTER STUDY; MULTIMODALITY CANCER THERAPY; NEOPLASM; PROGNOSIS; RADIOTHERAPY; SEGMENTAL MASTECTOMY; SURVIVAL; TUMOR RECURRENCE;

AGED; ANTINEOPLASTIC AGENTS, HORMONAL; BREAST NEOPLASMS; COMBINED MODALITY THERAPY; FEMALE; FOLLOW-UP STUDIES; HUMANS; LYMPHATIC METASTASIS; MASTECTOMY, SEGMENTAL; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; NEOPLASMS, HORMONE-DEPENDENT; PROGNOSIS; RADIOTHERAPY; SURVIVAL ANALYSIS; TAMOXIFEN;

EID: 4344628403     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJMoa040587     Document Type: Article

References (22)

1. Stablien DM. Final report of a reanalysis of NSABP protocol B06. Bethesda, Md.: National Cancer Institute, April 1994. (Accessed August 9, 2004, at http://bitmed.med.uchile.cl/pub/CancerNet/english/400027.)
2. Early Breast Cancer Trialists' Collaborative Group. Favourable and unfavourable effects on long-term survival of radiotherapy for early breast cancer: an overview of the randomised trials. Lancet 2000;355:1757-70.
3. Fisher B, Anderson S. Conservative surgery for the management of invasive and noninvasive carcinoma of the breast: NSAPB trials. World J Surg 1994;18:63-9.
4. Wolmark N, Dignam J, Margolese R, Wickerham DL, Fisher B. The role of radiotherapy and tamoxifen in the management of node negative invasive breast cancer -1.0 cm treated with lumpectomy: preliminary results of NSABP protocol B-21. Prog Proc Am Soc Clin Oncol 2000;19:70a. abstract.
5. Lichter AS, Lippman ME, Danforth DN Jr, et al. Mastectomy versus breast-conserving therapy in the treatment of stage I and II carcinoma of the breast: a randomized trial at the National Cancer Institute. J Clin Oncol 1992;10:976-83.
6. Whelan TJ, Levine M, Julian J, Kirkbride P, Skingley P. The effects of radiation therapy on quality of life of women with breast carcinoma: results of a randomized trial. Cancer 2000;88:2260-6.
7. Graydon JE. Women with breast cancer: their quality of life following a course of radiation therapy. J Adv Nurs 1994;19:617-22.
8. Nemoto T, Patel JK, Rosner D, Dao TL, Schuh M, Penetrante R. Factors affecting recurrence in lumpectomy without irradiation for breast cancer. Cancer 1991;67:2079-82.
9. Fisher B, Dignam J, Bryant J, et al. Five versus more than five years of tamoxifen therapy for breast cancer patients with negative lymph nodes and estrogen receptor-positive tumors. J Natl Cancer Inst 1996;88:1529-42.
10. Stewart HJ, Forrest AP, Everington D, et al. Randomised comparison of 5 years of adjuvant tamoxifen with continuous therapy for operable breast cancer. Br J Cancer 1996;74:297-9.
11. Fisher B, Redmond C, Fisher ER, et al. Ten-year results of a randomized clinical trial comparing radical mastectomy and total mastectomy with or without radiation. N Engl J Med 1985;312:674-81.
12. O'Brien PC, Fleming TR. A multiple testing procedure for clinical trials. Biometrics 1979;35:549-56.
13. Lan KKG, DeMets DL. Discrete sequential boundaries for clinical trials. Biometrika 1983;70:659-63.
14. Knuth DE. The art of computer programming. Vol. 2. Seminumerical algorithms. 3rd ed. Reading, Mass.: Addison-Wesley, 1997:32.
15. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958;53:457-81.
16. Peto R, Pike MC, Armitage P, et al. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples. Br J Cancer 1977;35:1-39.
17. Bureau of the Census. Americans with disabilities: 1994-95. Current population reports. Series P-70. No. 61. Washington, D.C.: Government Printing Office, August 1997.
18. Anderson RN. United States life tables, 1997. National vital statistics report. Vol. 47. No. 28. Hyattsville, Md.: National Center for Health Statistics, December 1999. (DHHS publication no. (PHS) 2000-1120 9-0749.) (Accessed August 9, 2004, at http: //www.cdc.gov/nchs/data/nvsr/nvsr47/ nvs47_28.pdf.)
19. McCready DR, Fish EB, Hiraki GY, Ross TM, Wall JL, Lickley HL. Total mastectomy is not always mandatory for the treatment of recurrent breast cancer after lumpectomy alone. Can J Surg 1992;35:485-8. [Erratum, Can J Surg 1992;35:641.]
20. McCready DR, Fish EB, Hiraki GY, Ross TM, Wall JL, Lickley HL. Total mastectomy is not always mandatory for the treatment of recurrent breast cancer after lumpectomy alone. Can J Surg 1992;35:485-8. [Erratum, Can J Surg 1992;35:641.]
21. Wazer DE, DiPetrillo T, Schmidt-Ullrich R, et al. Factors influencing cosmetic outcome and complication risk after conservative surgery and radiotherapy for early-stage breast carcinoma. J Clin Oncol 1992;10:356-63.
22. Rose MA, Olivotto I, Cady B, et al. Conservative surgery and radiation therapy for early breast cancer: long-term cosmetic results. Arch Surg 1989;124:153-7.