Cellular host responses to gliomas

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Najbauer, Joseph ^a   Huszthy, Peter C ^b   Barish, Michael E ^a   Garcia, Elizabeth ^a   Metz, Marianne Z ^a   Myers, Sarah M ^a   Gutova, Margarita ^a   Frank, Richard T ^a   Miletic, Hrvoje ^b   Kendall, Stephen E ^a   Glackin, Carlotta A ^a   Bjerkvig, Rolf ^b,c   Aboody, Karen S ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF BERGEN   (Norway)

^c LUXEMBOURG INSTITUTE OF HEALTH   (Luxembourg)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; NESTIN; SMOOTH MUSCLE ACTIN; STROMAL CELL DERIVED FACTOR 1; CXCR4 PROTEIN, RAT; INTERMEDIATE FILAMENT PROTEIN; NERVE PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CANCER INVASION; CELL MIGRATION; CELL POPULATION; CELL STRUCTURE; FEMALE; GLIOBLASTOMA; GLIOMA; GLIOMA CELL; HOST CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; MICROVASCULATURE; MOUSE; NONHUMAN; PERICYTE; PROTEIN EXPRESSION; RAT; SUBVENTRICULAR ZONE; TUMOR BIOPSY; TUMOR MICROENVIRONMENT; TUMOR VASCULARIZATION; TUMOR XENOGRAFT; ANIMAL; BRAIN TUMOR; CELL COMMUNICATION; DISEASE MODEL; IMMUNOHISTOCHEMISTRY; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; PHENOTYPE; TUMOR CELL LINE; XENOGRAFT;

ANIMALS; BRAIN NEOPLASMS; CELL COMMUNICATION; CELL LINE, TUMOR; CHEMOKINE CXCL12; DISEASE MODELS, ANIMAL; FEMALE; GLIOMA; HUMANS; IMMUNOHISTOCHEMISTRY; INTERMEDIATE FILAMENT PROTEINS; MICE; NEOPLASM INVASIVENESS; NEOVASCULARIZATION, PATHOLOGIC; NERVE TISSUE PROTEINS; PHENOTYPE; RATS; RECEPTORS, CXCR4; TRANSPLANTATION, HETEROLOGOUS; TUMOR MICROENVIRONMENT;

EID: 84860009369     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0035150     Document Type: Article

References (74)

1. Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, et al. (2005) Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 352: 987-996.
2. Stupp R, Hegi ME, Mason WP, van den Bent MJ, Taphoorn MJ, et al. (2009) Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol 10: 459-466.
3. Wen PY, Kesari S, (2008) Malignant gliomas in adults. N Engl J Med 359: 492-507.
4. Westphal M, Lamszus K, (2011) The neurobiology of gliomas: from cell biology to the development of therapeutic approaches. Nat Rev Neurosci 12: 495-508.
5. Kriegstein A, Alvarez-Buylla A, (2009) The glial nature of embryonic and adult neural stem cells. Annu Rev Neurosci 32: 149-184.
6. Sofroniew MV, Vinters HV, (2010) Astrocytes: biology and pathology. Acta Neuropathol 119: 7-35.
7. Zhao C, Deng W, Gage FH, (2008) Mechanisms and functional implications of adult neurogenesis. Cell 132: 645-660.
8. Curtis MA, Faull RL, Eriksson PS, (2007) The effect of neurodegenerative diseases on the subventricular zone. Nat Rev Neurosci 8: 712-723.
9. Luskin MB, (1993) Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone. Neuron 11: 173-189.
10. Imayoshi I, Sakamoto M, Ohtsuka T, Takao K, Miyakawa T, et al. (2008) Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain. Nat Neurosci 11: 1153-1161.
11. Aboody KS, Najbauer J, Danks MK, (2008) Stem and progenitor cell-mediated tumor selective gene therapy. Gene Ther 15: 739-752.
12. Najbauer J, Danks MK, Schmidt NO, Kim SU, Aboody KS, (2007) Neural stem cell-mediated therapy of primary and metastatic solid tumors. In: Bertolotti R, Ozawa K, editors. Progress in Gene Therapy, Autologous and Cancer Stem Cell Gene Therapy Singapore World Scientific pp. 335-372.
13. Aboody KS, Brown A, Rainov NG, Bower KA, Liu S, et al. (2000) Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas. Proc Natl Acad Sci U S A 97: 12846-12851.
14. Lindvall O, Kokaia Z, (2010) Stem cells in human neurodegenerative disorders-time for clinical translation? J Clin Invest 120: 29-40.
15. Aboody K, Capela A, Niazi N, Stern JH, Temple S, (2011) Translating stem cell studies to the clinic for CNS repair: current state of the art and the need for a rosetta stone. Neuron 70: 597-613.
16. Benedetti S, Pirola B, Pollo B, Magrassi L, Bruzzone MG, et al. (2000) Gene therapy of experimental brain tumors using neural progenitor cells. Nat Med 6: 447-450.
17. Glass R, Synowitz M, Kronenberg G, Walzlein JH, Markovic DS, et al. (2005) Glioblastoma-induced attraction of endogenous neural precursor cells is associated with improved survival. J Neurosci 25: 2637-2646.
18. Walzlein JH, Synowitz M, Engels B, Markovic DS, Gabrusiewicz K, et al. (2008) The antitumorigenic response of neural precursors depends on subventricular proliferation and age. Stem Cells 26: 2945-2954.
19. Wiese C, Rolletschek A, Kania G, Blyszczuk P, Tarasov KV, et al. (2004) Nestin expression-a property of multi-lineage progenitor cells? Cell Mol Life Sci 61: 2510-2522.
20. Gilyarov AV, (2008) Nestin in central nervous system cells. Neurosci Behav Physiol 38: 165-169.
21. Candolfi M, Curtin JF, Nichols WS, Muhammad AG, King GD, et al. (2007) Intracranial glioblastoma models in preclinical neuro-oncology: neuropathological characterization and tumor progression. J Neurooncol 85: 133-148.
22. Bello L, Giussani C, Carrabba G, Pluderi M, Lucini V, et al. (2002) Suppression of malignant glioma recurrence in a newly developed animal model by endogenous inhibitors. Clin Cancer Res 8: 3539-3548.
23. Engebraaten O, Hjortland GO, Hirschberg H, Fodstad O, (1999) Growth of precultured human glioma specimens in nude rat brain. J Neurosurg 90: 125-132.
24. Sakariassen PO, Prestegarden L, Wang J, Skaftnesmo KO, Mahesparan R, et al. (2006) Angiogenesis-independent tumor growth mediated by stem-like cancer cells. Proc Natl Acad Sci U S A 103: 16466-16471.
25. Wang J, Miletic H, Sakariassen PO, Huszthy PC, Jacobsen H, et al. (2009) A reproducible brain tumour model established from human glioblastoma biopsies. BMC Cancer 9: 465.
26. Bjerkvig R, Tonnesen A, Laerum OD, Backlund EO, (1990) Multicellular tumor spheroids from human gliomas maintained in organ culture. J Neurosurg 72: 463-475.
27. Christensen K, Aaberg-Jessen C, Andersen C, Goplen D, Bjerkvig R, et al. (2010) Immunohistochemical expression of stem cell, endothelial cell, and chemosensitivity markers in primary glioma spheroids cultured in serum-containing and serum-free medium. Neurosurgery 66: 933-947.
28. De Witt Hamer PC, Van Tilborg AA, Eijk PP, Sminia P, Troost D, et al. (2008) The genomic profile of human malignant glioma is altered early in primary cell culture and preserved in spheroids. Oncogene 27: 2091-2096.
29. Goings GE, Sahni V, Szele FG, (2004) Migration patterns of subventricular zone cells in adult mice change after cerebral cortex injury. Brain Res 996: 213-226.
30. Amoh Y, Yang M, Li L, Reynoso J, Bouvet M, et al. (2005) Nestin-linked green fluorescent protein transgenic nude mouse for imaging human tumor angiogenesis. Cancer Res 65: 5352-5357.
31. Wesseling P, Ruiter DJ, Burger PC, (1997) Angiogenesis in brain tumors; pathobiological and clinical aspects. J Neurooncol 32: 253-265.
32. Gilbertson RJ, Rich JN, (2007) Making a tumour's bed: glioblastoma stem cells and the vascular niche. Nat Rev Cancer 7: 733-736.
33. Lee S, Jilani SM, Nikolova GV, Carpizo D, Iruela-Arispe ML, (2005) Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors. J Cell Biol 169: 681-691.
34. VanMeter TE, Rooprai HK, Kibble MM, Fillmore HL, Broaddus WC, et al. (2001) The role of matrix metalloproteinase genes in glioma invasion: co-dependent and interactive proteolysis. J Neurooncol 53: 213-235.
35. Santarelli JG, Udani V, Yung YC, Cheshier S, Wagers A, et al. (2006) Incorporation of bone marrow-derived Flk-1-expressing CD34+ cells in the endothelium of tumor vessels in the mouse brain. Neurosurgery 59: 374-382; discussion 374-382.
36. Bababeygy SR, Cheshier SH, Hou LC, Higgins DM, Weissman IL, et al. (2008) Hematopoietic stem cell-derived pericytic cells in brain tumor angio-architecture. Stem Cells Dev 17: 11-18.
37. Du R, Lu KV, Petritsch C, Liu P, Ganss R, et al. (2008) HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell 13: 206-220.
38. Aghi M, Cohen KS, Klein RJ, Scadden DT, Chiocca EA, (2006) Tumor stromal-derived factor-1 recruits vascular progenitors to mitotic neovasculature, where microenvironment influences their differentiated phenotypes. Cancer Res 66: 9054-9064.
39. Armulik A, Abramsson A, Betsholtz C, (2005) Endothelial/pericyte interactions. Circ Res 97: 512-523.
40. Kalluri R, (2003) Basement membranes: structure, assembly and role in tumour angiogenesis. Nat Rev Cancer 3: 422-433.
41. Morikawa S, Baluk P, Kaidoh T, Haskell A, Jain RK, et al. (2002) Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors. Am J Pathol 160: 985-1000.
42. Sica G, Lama G, Anile C, Geloso MC, La Torre G, et al. (2011) Assessment of angiogenesis by CD105 and nestin expression in peritumor tissue of glioblastoma. Int J Oncol 38: 41-49.
43. Cabioglu N, Sahin AA, Morandi P, Meric-Bernstam F, Islam R, et al. (2009) Chemokine receptors in advanced breast cancer: differential expression in metastatic disease sites with diagnostic and therapeutic implications. Ann Oncol 20: 1013-1019.
44. Grunewald M, Avraham I, Dor Y, Bachar-Lustig E, Itin A, et al. (2006) VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells. Cell 124: 175-189.
45. Rubin JB, Kung AL, Klein RS, Chan JA, Sun Y, et al. (2003) A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors. Proc Natl Acad Sci U S A 100: 13513-13518.
46. Schulte A, Gunther HS, Phillips HS, Kemming D, Martens T, et al. (2011) A distinct subset of glioma cell lines with stem cell-like properties reflects the transcriptional phenotype of glioblastomas and overexpresses CXCR4 as therapeutic target. Glia 59: 590-602.
47. Kioi M, Vogel H, Schultz G, Hoffman RM, Harsh GR, et al. (2010) Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice. J Clin Invest 120: 694-705.
48. Magnon C, Lucas D, Frenette PS, (2011) Trafficking of stem cells. Methods Mol Biol 750: 3-24.
49. Rempel SA, Dudas S, Ge S, Gutierrez JA, (2000) Identification and localization of the cytokine SDF1 and its receptor, CXC chemokine receptor 4, to regions of necrosis and angiogenesis in human glioblastoma. Clin Cancer Res 6: 102-111.
50. Zhao D, Najbauer J, Garcia E, Metz MZ, Gutova M, et al. (2008) Neural stem cell tropism to glioma: critical role of tumor hypoxia. Mol Cancer Res 6: 1819-1829.
51. Tran PB, Banisadr G, Ren D, Chenn A, Miller RJ, (2007) Chemokine receptor expression by neural progenitor cells in neurogenic regions of mouse brain. J Comp Neurol 500: 1007-1033.
52. Robin AM, Zhang ZG, Wang L, Zhang RL, Katakowski M, et al. (2006) Stromal cell-derived factor 1alpha mediates neural progenitor cell motility after focal cerebral ischemia. J Cereb Blood Flow Metab 26: 125-134.
53. Tran PB, Miller RJ, (2003) Chemokine receptors: signposts to brain development and disease. Nat Rev Neurosci 4: 444-455.
54. Tran PB, Ren D, Veldhouse TJ, Miller RJ, (2004) Chemokine receptors are expressed widely by embryonic and adult neural progenitor cells. J Neurosci Res 76: 20-34.
55. Dziembowska M, Tham TN, Lau P, Vitry S, Lazarini F, et al. (2005) A role for CXCR4 signaling in survival and migration of neural and oligodendrocyte precursors. Glia 50: 258-269.
56. Kucia M, Reca R, Miekus K, Wanzeck J, Wojakowski W, et al. (2005) Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: pivotal role of the SDF-1-CXCR4 axis. Stem Cells 23: 879-894.
57. Imitola J, Raddassi K, Park KI, Mueller FJ, Nieto M, et al. (2004) Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway. Proc Natl Acad Sci U S A 101: 18117-18122.
58. Brat DJ, Castellano-Sanchez AA, Hunter SB, Pecot M, Cohen C, et al. (2004) Pseudopalisades in glioblastoma are hypoxic, express extracellular matrix proteases, and are formed by an actively migrating cell population. Cancer Res 64: 920-927.
59. Rong Y, Durden DL, Van Meir EG, Brat DJ, (2006) 'Pseudopalisading' necrosis in glioblastoma: a familiar morphologic feature that links vascular pathology, hypoxia, and angiogenesis. J Neuropathol Exp Neurol 65: 529-539.
60. Zagzag D, Lukyanov Y, Lan L, Ali MA, Esencay M, et al. (2006) Hypoxia-inducible factor 1 and VEGF upregulate CXCR4 in glioblastoma: implications for angiogenesis and glioma cell invasion. Lab Invest 86: 1221-1232.
61. Sontheimer H, (2003) Malignant gliomas: perverting glutamate and ion homeostasis for selective advantage. Trends Neurosci 26: 543-549.
62. Ubiali F, Nava S, Nessi V, Frigerio S, Parati E, et al. (2007) Allorecognition of human neural stem cells by peripheral blood lymphocytes despite low expression of MHC molecules: role of TGF-beta in modulating proliferation. Int Immunol 19: 1063-1074.
63. Uccelli A, Moretta L, Pistoia V, (2008) Mesenchymal stem cells in health and disease. Nat Rev Immunol 8: 726-736.
64. Bjerkvig R, Tysnes BB, Aboody KS, Najbauer J, Terzis AJ, (2005) Opinion: the origin of the cancer stem cell: current controversies and new insights. Nat Rev Cancer 5: 899-904.
65. Niclou SP, Danzeisen C, Eikesdal HP, Wiig H, Brons NH, et al. (2008) A novel eGFP-expressing immunodeficient mouse model to study tumor-host interactions. Faseb J 22: 3120-3128.
66. Skog J, Wurdinger T, van Rijn S, Meijer DH, Gainche L, et al. (2008) Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol 10: 1470-1476.
67. Ricci-Vitiani L, Pallini R, Biffoni M, Todaro M, Invernici G, et al. (2010) Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells. Nature 468: 824-828.
68. Wang R, Chadalavada K, Wilshire J, Kowalik U, Hovinga KE, et al. (2010) Glioblastoma stem-like cells give rise to tumour endothelium. Nature 468: 829-833.
69. Charles NA, Holland EC, Gilbertson R, Glass R, Kettenmann H, (2011) The brain tumor microenvironment. Glia 59: 1169-1180.
70. Polajeva J, Sjosten AM, Lager N, Kastemar M, Waern I, et al. (2011) Mast cell accumulation in glioblastoma with a potential role for stem cell factor and chemokine CXCL12. PLoS One 6: e25222.
71. Pollard JW, (2009) Trophic macrophages in development and disease. Nat Rev Immunol 9: 259-270.
72. Lin D, Najbauer J, Salvaterra PM, Mamelak AN, Barish ME, et al. (2007) Novel method for visualizing and modeling the spatial distribution of neural stem cells within intracranial glioma. Neuroimage 37 (Suppl 1): S18-26.
73. Huszthy PC, Svendsen A, Wilson JM, Kotin RM, Lonning PE, et al. (2005) Widespread dispersion of adeno-associated virus serotype 1 and adeno-associated virus serotype 6 vectors in the rat central nervous system and in human glioblastoma multiforme xenografts. Hum Gene Ther 16: 381-392.
74. Aboody KS, Bush RA, Garcia E, Metz MZ, Najbauer J, et al. (2006) Development of a tumor-selective approach to treat metastatic cancer. PLoS ONE 1: e23.