Serotonin 2C receptors in the nucleus accumbens are involved in enhanced alcohol-drinking behavior

European Journal of Neuroscience

Volumn 35, Issue 8, 2012, Pages 1368-1380

  Yoshimoto, Kanji ^a   Watanabe, Yoshihisa ^a   Tanaka, Masaki ^a   Kimura, Minoru ^a,b  

^a Department of Forensic Medicine ^*  (Japan)

^b TAMAGAWA UNIVERSITY   (Japan)

Author keywords

Alcohol; Mesoaccumbens reward pathway; Microdialysis; Nucleus accumbens shell; Serotonin 2C receptor

Indexed keywords

DOPAMINE; MESSENGER RNA; SEROTONIN; SEROTONIN 2C RECEPTOR; 3,N DIMETHYL N [1 METHYL 3 (4 METHYL 1 PIPERIDINYL)PROPYL]BENZENESULFONAMIDE; 6 CHLORO 5 METHYL 1 ((2 (2 METHYLPYRID 3 YLOXY)PYRID 5 YL)CARBAMOYL)INDOLINE; 6-CHLORO-5-METHYL-1-((2-(2-METHYLPYRID-3-YLOXY)PYRID-5-YL)CARBAMOYL)INDOLINE; ALCOHOL; AMINOPYRIDINE DERIVATIVE; BIOGENIC AMINE; CENTRAL DEPRESSANT AGENT; DOPAMINE RECEPTOR; INDOLE DERIVATIVE; PIPERIDINE DERIVATIVE; SEROTONIN RECEPTOR AFFECTING AGENT; SULFONAMIDE;

ALCOHOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CAUDATE NUCLEUS; CONTROLLED STUDY; DOPAMINE RELEASE; DORSAL RAPHE NUCLEUS; DRINKING BEHAVIOR; GENE EXPRESSION; HIPPOCAMPUS; LATERAL HYPOTHALAMUS; MALE; MOUSE; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PUTAMEN; SEROTONINERGIC SYSTEM; ANALYSIS OF VARIANCE; ANIMAL; C57BL MOUSE; DISEASE MODEL; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; METHODOLOGY; MICRODIALYSIS; MICROINJECTION; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RAPHE NUCLEUS;

ALCOHOL DRINKING; AMINOPYRIDINES; ANALYSIS OF VARIANCE; ANIMALS; BIOGENIC MONOAMINES; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DISEASE MODELS, ANIMAL; ETHANOL; GENE EXPRESSION REGULATION; INDOLES; MALE; MICE; MICE, INBRED C57BL; MICRODIALYSIS; MICROINJECTIONS; NUCLEUS ACCUMBENS; PIPERIDINES; RAPHE NUCLEI; RECEPTOR, SEROTONIN, 5-HT2C; RECEPTORS, DOPAMINE; RNA, MESSENGER; SEROTONIN AGENTS; SULFONAMIDES;

EID: 84860008696     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2012.08037.x     Document Type: Article

References (50)

1. Barnes, N.M. & Sharp, T. (1999) A review of central 5-HT receptors and their function. Neuropharmacology, 38, 1083-1152.
2. Becker, H.C. (2000) Animal models of alcohol withdrawal. Alcohol Res. Health, 24, 105-113.
3. Bonaventure, P., Nepomuceno, D., Kwok, A., Chai, W., Langlois, X., Hen, R., Stark, K., Carruthers, N. & Lovenberg, T.W. (2002) Reconsideration of 5-hydroxytryptamine (5-HT)(7) receptor distribution using [(3)H]5-carboxamidotryptamine and [(3)H]8-hydroxy-2-(di-n-propylamino)tetraline: analysis in brain of 5-HT(1A) knockout and 5-HT(1A/1B) double-knockout mice. J. Pharmacol. Exp. Ther., 302, 240-248.
4. Boyce-Rustay, J.M., Wiedholz, L.M., Millstein, R.A., Carroll, J., Murphy, D.L., Daws, L.C. & Holmes, A. (2006) Ethanol-related behaviors in serotonin transporter knockout mice. Alcohol. Clin. Exp. Res., 30, 1957-1965.
5. Bubar, M.J., Seitz, P.K., Thomas, M.L. & Cunningham, K.A. (2005) Validation of a selective serotonin 5-HT(2C) receptor antibody for utilization in fluorescence immunohistochemistry studies. Brain Res., 1063, 105-113.
6. Burbassi, S. & Cervo, L. (2008) Stimulation of serotonin2C receptors influences cocaine-seeking behavior in response to drug-associated stimuli in rats. Psychopharmacology, 196, 15-27.
7. Clapp, P., Bhave, S.V. & Hoffman, P.L. (2008) How adaptation of the brain to alcohol leads to dependence. A pharmacological perspective. Alcohol Res. and Health, 31, 310-339.
8. 2C receptors potentiates consequences of serotonin reuptake blockade. Neuropsychopharmacol., 29, 1782-1789.
9. Daws, L.C., Montanez, S., Munn, J.L., Owens, W.A., Baganz, N.L., Boyce-Rustay, J.M., Millstein, R.A., Wiedholz, L.M., Murphy, D.L. & Holmes, A. (2006) Ethanol inhibits clearance of brain serotonin by a serotonin transporter-independent mechanism. J. Neurosci., 26, 6431-6438.
10. De Deurwaerdere, P., Navailles, S., Berg, K.A., Clarke, W.P. & Spampinato, U. (2004) Constitutive activity of the serotonin2C receptor inhibits in vivo dopamine release in the rat striatum and nucleus accumbens. J. Neurosci., 24, 3235-3241.
11. Engleman, E.A., Ding, Z.M., Oster, S.M., Toalston, J.E., Bell, R.L., Murphy, J.M., McBride, W.J. & Rodd, Z.A. (2009) Ethanol is self-administered into the nucleus accumbens shell, but not the core: evidence of genetic sensitivity. Alcohol. Clin. Exp. Res., 33, 2162-2171.
12. Ferraz, I.C. & Boerngen-Lacerda, R. (2008) Serotonin 5-HT2 receptor antagonist does not reverse established ethanol-induced sensitization but blocks its development and expression. Pharmacol. Biochem. Behav., 88, 456-464.
13. Fletcher, P.J., Chintoh, A.F., Sinyard, J. & Higgins, G.A. (2004) Injection of the 5-HT2C receptor agonist Ro60-0175 into the ventral tegmental area reduces cocaine-induced locomotor activity and cocaine self-administration. Neuropsychopharmacol., 29, 308-318.
14. Franklin, K.B. & Paxinos, G. (1997) The Mouse Brain in Stereotaxic Coordinates. Academic Press, Tokyo.
15. Gatto, G.J., McBride, W.J., Murphy, J.M., Lumeng, L. & Li, T.K. (1994) Ethanol self-infusion into the ventral tegmental area by alcohol-preferring rats. Alcohol, 11, 557-564.
16. Griffin, W.C., III, Lopez, M.F. & Becker, H.C. (2009) Intensity and duration of chronic ethanol exposure is critical for subsequent escalation of voluntary ethanol drinking in mice. Alcohol Cli. Exp. Res., 33, 1893-1900.
17. Hannon, J. & Hoyer, D. (2008) Molecular biology of 5-HT receptors. Behav. Brain Res., 195, 198-213.
18. Hayes, D.J. & Greenshaw, A.J. (2011) 5-HT receptors and reward-related behaviour: a review. Neurosci. Biobehav. Rev., 35, 1419-1449.
19. Higgins, G.A. & Fletcher, P.J. (2003) Serotonin and drug reward: focus on 5-HT2C receptors. Eur. J. Pharmacol., 480, 151-162.
20. Hoyer, D., Hannon, J.P. & Martin, G.R. (2002) Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacol. Biochem. Behav., 71, 533-554.
21. Hwa, L.S., Chu, A., Levinson, S.A., Kayyali, T.M., DeBodd, J.F. & Miczek, K.A. (2011) Persistent escalation of alcohol drinking in C57BL/6J mice with intermittent access to 20% ethanol. Alcohol. Clin. Exp. Res., 35, 1-10.
22. Kirby, L.G., Zeeb, F.D. & Winstanley, C.A. (2011) Contributions of serotonin in addiction vulnerability. Neuropharmacol., 61, 421-432.
23. Koob, G.F. & Le Moal, M. (2001) Drug addiction, dysregulation of reward, and allostasis. Neuropsychopharmacol., 24, 97-129.
24. Koob, G.F. & Volkow, N.D. (2010) Neurocircuitry of addiction. Neuropsychopharmacol., 35, 217-238.
25. Lesch, K.P. (2005) Alcohol dependence and gene x environment interaction in emotion regulation: is serotonin the link? Eur. J. Pharmacol., 526, 113-124.
26. McBride, W.J., Murphy, J.M., Gatto, G.J., Levy, A.D., Yoshimoto, K., Lumeng, L. & Li, T.K. (1993) CNS mechanisms of alcohol self-administration. Alcohol Alcohol. Suppl., 2, 463-467.
27. Mnie-Filali, O., Lambas-Senas, L., Zimmer, L. & Haddjeri, N. (2007) 5-HT7 receptor antagonists as a new class of antidepressants. Drug News Perspect., 20, 613-618.
28. Muller, C.P. & Huston, J.P. (2006) Determining the region-specific contributions of 5-HT receptors to the psychostimulant effects of cocaine. Trends Pharmacol. Sci., 27, 105-112.
29. Nakajima, M., Inui, A., Teranishi, A., Miura, M., Hirosue, Y., Okita, M., Himori, N., Baba, S. & Kasuga, M. (1994) Effects of pancreatic polypeptide family peptides on feeding and learning behavior in mice. J. Pharmacol. Exp. Ther., 268, 1010-1014.
30. Nestler, E.J. & Aghajanian, G.K. (1997) Molecular and cellular basis of addiction. Science, 278, 58-63.
31. O'Dell, L.E., Roberts, A.J., Smith, R.T. & Koob, G.F. (2004) Enhanced alcohol self-administration after intermittent versus continuous alcohol vapor exposure. Alcohol. Clin. Exp. Res., 28, 1676-1682.
32. Pandey, S.C., Lumeng, L. & Li, T.K. (1996) Serotonin2C receptors and serotonin2C receptor-mediated phosphoinositide hydrolysis in the brain of alcohol-preferring and alcohol-nonpreferring rats. Alcohol. Clin. Exp. Res., 20, 1038-1042.
33. Pasinetti, G.M., Osterburg, H.H., Kelly, A.B., Kohama, S., Morgan, D.G., Reinhard, J.F., Jr, Stellwagen, R.H. & Finch, C.E. (1992) Slow changes of tyrosine hydroxylase gene expression in dopaminergic brain neurons after neurotoxin lesioning: a model for neuron aging. Brain Res. Mol. Brain Res., 13, 63-73.
34. Qu, Y., Villacreses, N., Murphy, D.L. & Rapoport, S.I. (2005) 5-HT2A/2C receptor signaling via phospholipase A2 and arachidonic acid is attenuated in mice lacking the serotonin reuptake transporter. Psychopharmacology, 180, 12-20.
35. Sarkisyan, G., Roberts, A.J. & Hedlund, P.B. (2010) The 5-HT(7) receptor as a mediator and modulator of antidepressant-like behavior. Behav. Brain Res., 209, 99-108.
36. Schenk, S. (2000) Effects of the serotonin 5-HT(2) antagonist, ritanserin, and the serotonin 5-HT(1A) antagonist, WAY 100635, on cocaine-seeking in rats. Pharmacol. Biochem. Behav., 67, 363-369.
37. Silvestre, J.S., Palacios, J.M., Fernandez, A.G. & O'Neill, M.F. (1998) Comparison of effects of a range of 5-HT receptor modulators on consumption and preference for a sweetened ethanol solution in rats. J. Psychopharmacol., 12, 168-176.
38. Strother, W.N., Lumeng, L., Li, T.K. & McBride, W.J. (2005) Dopamine and serotonin content in select brain regions of weanling and adult alcohol drinking rat lines. Pharmacol. Biochem. Behav., 80, 229-237.
39. Sudhof, T.C. (2004) The synaptic vesicle cycle. Annu. Rev. Neurosci., 27, 509-547.
40. Tanaka, M., Iijima, N., Miyamoto, Y., Fukusumi, S., Itoh, Y., Ozawa, H. & Ibata, Y. (2005) Neurons expressing relaxin 3/INSL 7 in the nucleus incertus respond to stress. Eur. J. Neurosci., 21, 1659-1670.
41. Tanaka, M., Watanabe, Y. & Yoshimoto, K. (2009) Regulation of relaxin 3 gene expression via cAMP-PKA in a neuroblastoma cell line. J. Neurosci. Res., 87, 820-829.
42. Theile, J.W., Morikawa, H., Gonzales, R.A. & Morrisett, R.A. (2009) Role of 5-hydroxytryptamine2C receptors in Ca2+-dependent ethanol potentiation of GABA release onto ventral tegmental area dopamine neurons. J. Pharmacol. Exp. Ther., 329, 625-633.
43. Tomkins, D.M., Joharchi, N., Tampakeras, M., Martin, J.R., Wichmann, J. & Higgins, G.A. (2002) An investigation of the role of 5-HT(2C) receptors in modifying ethanol self-administration behaviour. Pharmacol. Biochem. Behav., 71, 735-744.
44. Ueda, S., Aikawa, M., Ishizuya-Oka, A., Koibuchi, N., Yamaoka, S. & Yoshimoto, K. (1998) Age-related degeneration of the serotoninergic fibers in the zitter rat brain. Synapse, 30, 62-70.
45. Walker, B.M. & Koob, G.F. (2007) The gamma-aminobutyric acid-B receptor agonist baclofen attenuates responding for ethanol in ethanol-dependent rats. Alcohol. Clin. Exp. Res., 31, 11-18.
46. Watanabe, Y., Ikegawa, M., Naruse, Y. & Tanaka, M. (2009) A novel splicing variant form suppresses the activity of full-length signal transducer and activator of transcription 5A. FEBS J., 276, 6312-6323.
47. Yoshimoto, K. & Komura, S. (1993) Monitoring of ethanol levels in the rat nucleus accumbens by brain microdialysis. Alcohol Alcohol., 28, 171-174.
48. Yoshimoto, K. & McBride, W.J. (1992) Regulation of nucleus accumbens dopamine release by the dorsal raphe nucleus in the rat. Neurochem. Res., 17, 401-407.
49. Yoshimoto, K., Ueda, S., Nishi, M., Yang, Y., Matsushita, H., Takeuchi, Y., Kato, B., Kawai, Y., Noritake, K., Kaneda, S., Sorimachi, Y. & Yasuhara, M. (2000) Changes in dopamine transporter and c-Fos expression in the nucleus accumbens of alcohol-tolerant rats. Alcohol. Clin. Exp. Res., 24, 361-365.
50. Zhou, F.C., Bledsoe, S., Lumeng, L. & Li, T.K. (1994) Reduced serotonergic immunoreactive fibers in the forebrain of alcohol-preferring rats. Alcohol. Clin. Exp. Res., 18, 571-579.