Basic peptide-morpholino oligomer conjugate that is very effective in killing bacteria by gene-specific and nonspecific modes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 40, 2011, Pages 16582-16587

  Wesolowski, Donna ^a   Tae, Hyun Seop ^a   Gandotra, Neeru ^a   Llopis, Paula ^a,b   Shen, Ning ^a,c   Altman, Sidney ^a  

^a YALE UNIVERSITY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Gene expression; Pathogenic bacteria

Indexed keywords

BACTERICIDE; CHLORAMPHENICOL; DNA TOPOISOMERASE (ATP HYDROLYSING) A; PENICILLIN G; POLYPEPTIDE ANTIBIOTIC AGENT; RIBONUCLEASE P; TYROSYLALANYLVALYLARGINYLARGINYLARGINYLGLYCYLPROLYLARGINYLGLYCYLTYROSYLALANYLARGINYLVALYLARGINYLARGINYLARGINYLGLYCYLPROLYLARGINYLARGININE PHOSPHORODIAMIDATE MORPHOLINO OLIGONUCLEOTIDE CONJUGATE; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL CELL; BACTERIAL VIABILITY; BACTERICIDAL ACTIVITY; CELL VIABILITY; CONTROLLED STUDY; DRUG BINDING; DRUG CONJUGATION; DRUG EFFICACY; DRUG SYNTHESIS; ENZYME ACTIVITY; GEL ELECTROPHORESIS; GENE EXPRESSION; GENE TARGETING; NONHUMAN; NUCLEOTIDE SEQUENCE; PENICILLIN RESISTANCE; PHENOTYPE; PRIORITY JOURNAL;

CELL-PENETRATING PEPTIDES; ESCHERICHIA COLI; FLUORESCEIN; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; MORPHOLINOS; MULTIPROTEIN COMPLEXES; T-LYMPHOCYTES;

MAMMALIA;

EID: 80053623455     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1112561108     Document Type: Article

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