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Volumn 13, Issue 1, 2006, Pages 12-19

Challenge and promise: Roles for clusterin in pathogenesis, progression and therapy of cancer

Author keywords

Apoptosis; Clusterin; DNA repair; Human tumours; nCLU; sCLU

Indexed keywords

ADVEXIN; ANTINEOPLASTIC AGENT; ANTISENSE OLIGONUCLEOTIDE; BXL 628; CALCITRIOL; CALCITRIOL DERIVATIVE; CISPLATIN; CLUSTERIN; CLUSTERIN ANTISENSE OLIGONUCLEOTIDE; CYTOTOXIC AGENT; DOUBLE STRANDED RNA; NUCLEAR CLUSTERIN; OGX 011; PACLITAXEL; PROTEIN BCL 2 ANTISENSE OLIGONUCLEOTIDE; SECRETORY CLUSTERIN; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TRASTUZUMAB; UNCLASSIFIED DRUG; CLU PROTEIN, HUMAN; ISOPROTEIN; TUMOR MARKER;

EID: 33644996125     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/sj.cdd.4401779     Document Type: Review
Times cited : (293)

References (52)
  • 1
    • 0036829661 scopus 로고    scopus 로고
    • Clusterin/apolipoprotein J in human ageing and cancer
    • Trougakos IP and Gonos ES (2002) Clusterin/apolipoprotein J in human ageing and cancer. Int. J. Biochem. Cell Biol. 34: 1430-1448
    • (2002) Int. J. Biochem. Cell Biol. , vol.34 , pp. 1430-1448
    • Trougakos, I.P.1    Gonos, E.S.2
  • 2
    • 1642282641 scopus 로고    scopus 로고
    • Silencing expression of the clusterin/apolipoprotein J gene in human cancer cells using small interfering RNA induces spontaneous apoptosis, reduced growth ability, and cell sensitization to genotoxic and oxidative stress
    • Trougakso IP, So A, Jansen B, Gleave ME and Gonos ES (2004) Silencing expression of the clusterin/apolipoprotein J gene in human cancer cells using small interfering RNA induces spontaneous apoptosis, reduced growth ability, and cell sensitization to genotoxic and oxidative stress. Cancer Res. 64: 1834-1842
    • (2004) Cancer Res. , vol.64 , pp. 1834-1842
    • Trougakso, I.P.1    So, A.2    Jansen, B.3    Gleave, M.E.4    Gonos, E.S.5
  • 3
    • 1842589298 scopus 로고    scopus 로고
    • Modulation of different clusterin isoforms in human colon tumorigenesis
    • Pucci S, Bonanno E, Pichiorri F, Angeloni C and Spagnoli LG (2004) Modulation of different clusterin isoforms in human colon tumorigenesis. Oncogene 23: 2298-2304
    • (2004) Oncogene , vol.23 , pp. 2298-2304
    • Pucci, S.1    Bonanno, E.2    Pichiorri, F.3    Angeloni, C.4    Spagnoli, L.G.5
  • 4
    • 15944390264 scopus 로고    scopus 로고
    • Use of antisense oligonucleotides targeting the cytoprotective gene, clusterin, to enhance androgen- and chemo-sensitivity in prostate cancer
    • Gleave M and Miyake H (2005) Use of antisense oligonucleotides targeting the cytoprotective gene, clusterin, to enhance androgen- and chemo-sensitivity in prostate cancer. World J. Urol. 23: 38-46
    • (2005) World J. Urol. , vol.23 , pp. 38-46
    • Gleave, M.1    Miyake, H.2
  • 6
    • 0035675829 scopus 로고    scopus 로고
    • Synergistic chemosensitization and inhibition of tumor growth and metastasis by the antisense oligodeoxynucleotide targeting clusterin gene in a human bladder cancer model
    • Miyake H, Hara I, Kamidono S and Gleave ME (2001) Synergistic chemosensitization and inhibition of tumor growth and metastasis by the antisense oligodeoxynucleotide targeting clusterin gene in a human bladder cancer model. Clin. Cancer Res. 7: 4245-4252
    • (2001) Clin. Cancer Res. , vol.7 , pp. 4245-4252
    • Miyake, H.1    Hara, I.2    Kamidono, S.3    Gleave, M.E.4
  • 7
    • 0035213607 scopus 로고    scopus 로고
    • Introduction of clusterin gene into human renal cell carcinoma cells enhances their resistance to cytotoxic chemotherapy through inhibition of apoptosis both in vitro and in vivo
    • Hara I, Miyake H, Gleave ME and Kamidono S (2001) Introduction of clusterin gene into human renal cell carcinoma cells enhances their resistance to cytotoxic chemotherapy through inhibition of apoptosis both in vitro and in vivo. Jpn. J. Cancer Res. 92: 1220-1224
    • (2001) Jpn. J. Cancer Res. , vol.92 , pp. 1220-1224
    • Hara, I.1    Miyake, H.2    Gleave, M.E.3    Kamidono, S.4
  • 8
    • 9444288705 scopus 로고    scopus 로고
    • Protection of androgen-dependent human prostate cancer cells from oxidative stress-induced DNA damage by overexpression of clusterin and its modulation by androgen
    • Miyake H, Hara I, Gleave ME and Eto H (2004) Protection of androgen-dependent human prostate cancer cells from oxidative stress-induced DNA damage by overexpression of clusterin and its modulation by androgen. Prostate 61: 318-323
    • (2004) Prostate , vol.61 , pp. 318-323
    • Miyake, H.1    Hara, I.2    Gleave, M.E.3    Eto, H.4
  • 9
    • 0033978525 scopus 로고    scopus 로고
    • Testosterone-repressed prostate message-2 is an antiapoptotic gene involved in progression to androgen independence in prostate cancer
    • Miyake H, Nelson C, Rennie PS and Gleave ME (2000) Testosterone-repressed prostate message-2 is an antiapoptotic gene involved in progression to androgen independence in prostate cancer. Cancer Res. 60: 170-176
    • (2000) Cancer Res. , vol.60 , pp. 170-176
    • Miyake, H.1    Nelson, C.2    Rennie, P.S.3    Gleave, M.E.4
  • 10
    • 0036796026 scopus 로고    scopus 로고
    • Enhanced radiosensitivity in prostate cancer by inhibition of the cell survival protein clusterin
    • Zellweger T, Chi K, Miyake H, Adomat H, Kiyama S, Skov K and Gleave ME (2002) Enhanced radiosensitivity in prostate cancer by inhibition of the cell survival protein clusterin. Clin. Cancer Res. 8: 3276-3284
    • (2002) Clin. Cancer Res. , vol.8 , pp. 3276-3284
    • Zellweger, T.1    Chi, K.2    Miyake, H.3    Adomat, H.4    Kiyama, S.5    Skov, K.6    Gleave, M.E.7
  • 11
    • 0037142616 scopus 로고    scopus 로고
    • Clusterin (SGP-2) transient overexpression decreases proliferation rate of SV40-immortalized human prostate epithelial cells by slowing down cell cycle progression
    • Bettuzzi S, Scorcioni F, Astancolle S, Davalli P, Scaltriti M and Corti A (2002) Clusterin (SGP-2) transient overexpression decreases proliferation rate of SV40-immortalized human prostate epithelial cells by slowing down cell cycle progression. Oncogene 21: 4328-4334
    • (2002) Oncogene , vol.21 , pp. 4328-4334
    • Bettuzzi, S.1    Scorcioni, F.2    Astancolle, S.3    Davalli, P.4    Scaltriti, M.5    Corti, A.6
  • 12
    • 0010958949 scopus 로고    scopus 로고
    • Apoptotic regression of MCF-7 xenografts in nude mice treated with the vitamin D3 analogue, EB1089
    • van Weelden K, Flanagan L, Binderup L, Tenniswood M and Welsh JE (1998) Apoptotic regression of MCF-7 xenografts in nude mice treated with the vitamin D3 analogue, EB1089. Endocrinology 139: 2102-2110
    • (1998) Endocrinology , vol.139 , pp. 2102-2110
    • van Weelden, K.1    Flanagan, L.2    Binderup, L.3    Tenniswood, M.4    Welsh, J.E.5
  • 13
    • 0037837729 scopus 로고    scopus 로고
    • Synthesis and functional analyses of nuclear clusterin, a cell death protein
    • Leskov KS, Klokov DY, Li J, Kinsella TJ and Boothman DA (2003) Synthesis and functional analyses of nuclear clusterin, a cell death protein. J. Biol. Chem. 278: 11590-11600
    • (2003) J. Biol. Chem. , vol.278 , pp. 11590-11600
    • Leskov, K.S.1    Klokov, D.Y.2    Li, J.3    Kinsella, T.J.4    Boothman, D.A.5
  • 14
    • 4444222462 scopus 로고    scopus 로고
    • Nucleotide-based therapies targeting clusterin chemosensitized human lung adenocarcinoma cells both in vitro and in vivo
    • July LV, Beraldi E, So A, Fazil L, Evans K, English JC and Gleave ME (2004) Nucleotide-based therapies targeting clusterin chemosensitized human lung adenocarcinoma cells both in vitro and in vivo. Mol. Cancer Ther. 3: 223-232
    • (2004) Mol. Cancer Ther. , vol.3 , pp. 223-232
    • July, L.V.1    Beraldi, E.2    So, A.3    Fazil, L.4    Evans, K.5    English, J.C.6    Gleave, M.E.7
  • 15
    • 0033565594 scopus 로고    scopus 로고
    • Transforming growth factor beta regulates clusterin gene expression via modulation of transcription factor c-Fos
    • Jin G and Howe PH (1999) Transforming growth factor beta regulates clusterin gene expression via modulation of transcription factor c-Fos. Eur. J. Biochem. 263: 534-542
    • (1999) Eur. J. Biochem. , vol.263 , pp. 534-542
    • Jin, G.1    Howe, P.H.2
  • 17
    • 2342566706 scopus 로고    scopus 로고
    • Repression of IR-inducible clusterin expression by the p53 tumour suppressor protein
    • Criswell T, Klokov D, Beman M, Lavik JP and Boothman DA (2003) Repression of IR-inducible clusterin expression by the p53 tumour suppressor protein. Cancer Biol. Ther. 2: 372-380
    • (2003) Cancer Biol. Ther. , vol.2 , pp. 372-380
    • Criswell, T.1    Klokov, D.2    Beman, M.3    Lavik, J.P.4    Boothman, D.A.5
  • 18
    • 0042912014 scopus 로고    scopus 로고
    • Overexpression of the cytoprotective protein clusterin decreases radiosensitivity in the human LNCaP prostate tumour model
    • Zellweger T, Kiyama S, Chi K, Miyake H, Adomat H, Skov K and Gleave ME (2003) Overexpression of the cytoprotective protein clusterin decreases radiosensitivity in the human LNCaP prostate tumour model. BJU Int. 92: 463-469
    • (2003) BJU Int. , vol.92 , pp. 463-469
    • Zellweger, T.1    Kiyama, S.2    Chi, K.3    Miyake, H.4    Adomat, H.5    Skov, K.6    Gleave, M.E.7
  • 19
    • 0037810710 scopus 로고    scopus 로고
    • Resistance to cytotoxc chemotherapy induced apoptosis in human prostate cancer cells is associated with intracellular clusterin expression
    • Miyake H, Hara I, Kamidono S, Gleave ME and Eto H (2003) Resistance to cytotoxc chemotherapy induced apoptosis in human prostate cancer cells is associated with intracellular clusterin expression. Oncol. Rep. 10: 469-4673
    • (2003) Oncol. Rep. , vol.10 , pp. 469-4673
    • Miyake, H.1    Hara, I.2    Kamidono, S.3    Gleave, M.E.4    Eto, H.5
  • 20
    • 0036380878 scopus 로고    scopus 로고
    • Vitamin D and systemic cancer: Is this relevant to malignant melanoma?
    • Osborne JE and Hutchinson PE (2002) Vitamin D and systemic cancer: Is this relevant to malignant melanoma? Br. J. Dermatol. 147: 197-213
    • (2002) Br. J. Dermatol. , vol.147 , pp. 197-213
    • Osborne, J.E.1    Hutchinson, P.E.2
  • 22
    • 0141643351 scopus 로고    scopus 로고
    • Essential requirements of apolipoprotein J (clusterin) signalling for IκB expression and regulation of NF-κB activity
    • Sankilli G, Aronow BJ and Sala A (2003) Essential requirements of apolipoprotein J (clusterin) signalling for IκB expression and regulation of NF-κB activity. J. Biol. Chem. 278: 38214-38219
    • (2003) J. Biol. Chem. , vol.278 , pp. 38214-38219
    • Sankilli, G.1    Aronow, B.J.2    Sala, A.3
  • 23
    • 0032955802 scopus 로고    scopus 로고
    • Clusterin (SGP-2) gene expression is cell cycle dependent in normal human dermal fibroblasts
    • Bettuzzi S, Astancolle S, Guidentti G, Moretti M, Tiozzo R and Corti A (1999) Clusterin (SGP-2) gene expression is cell cycle dependent in normal human dermal fibroblasts. FEBS Lett. 448: 297-300
    • (1999) FEBS Lett. , vol.448 , pp. 297-300
    • Bettuzzi, S.1    Astancolle, S.2    Guidentti, G.3    Moretti, M.4    Tiozzo, R.5    Corti, A.6
  • 26
    • 0037386258 scopus 로고    scopus 로고
    • Cytoprotective membrane-permeable peptides designed from the Bax-binding domain of Ku70
    • Sawada M, Hayes P and Matsuyama S (2003) Cytoprotective membrane-permeable peptides designed from the Bax-binding domain of Ku70. Nat. Cell Biol. 5: 352-357
    • (2003) Nat. Cell Biol. , vol.5 , pp. 352-357
    • Sawada, M.1    Hayes, P.2    Matsuyama, S.3
  • 27
    • 0141815661 scopus 로고    scopus 로고
    • Clusterin: An abundant serum factor, is a possible negative regulator of MT6-MMP/MMP-25 produced by neutrophils
    • Matuda A, Itoh Y, Koshikawa N, Akizawa T, Yana I and Sieki M (2003) Clusterin: An abundant serum factor, is a possible negative regulator of MT6-MMP/MMP-25 produced by neutrophils. J. Biol. Chem. 278: 36350-36357
    • (2003) J. Biol. Chem. , vol.278 , pp. 36350-36357
    • Matuda, A.1    Itoh, Y.2    Koshikawa, N.3    Akizawa, T.4    Yana, I.5    Sieki, M.6
  • 28
    • 0028937368 scopus 로고
    • Clusterin expression within skin correlates with hair growth
    • Seiberg M and Marthinuss J (1995) Clusterin expression within skin correlates with hair growth. Dev. Dyn. 202: 294-01
    • (1995) Dev. Dyn. , vol.202 , pp. 294-301
    • Seiberg, M.1    Marthinuss, J.2
  • 29
    • 0028321386 scopus 로고
    • Clusterin expression in differentiating smooth muscle cells
    • Thomas-Salgar S and Millis AJ (1994) Clusterin expression in differentiating smooth muscle cells. J. Biol. Chem. 269: 17879-17885
    • (1994) J. Biol. Chem. , vol.269 , pp. 17879-17885
    • Thomas-Salgar, S.1    Millis, A.J.2
  • 32
    • 85047676031 scopus 로고    scopus 로고
    • Characterization of vitamin D3-resistant MCF-7 cell line
    • Narvaez CJ, Vanweelden K, Byrne I and Welsh J (1996) Characterization of vitamin D3-resistant MCF-7 cell line. Endocrinology 137: 400-409
    • (1996) Endocrinology , vol.137 , pp. 400-409
    • Narvaez, C.J.1    Vanweelden, K.2    Byrne, I.3    Welsh, J.4
  • 34
    • 0033136252 scopus 로고    scopus 로고
    • Nerve growth factor and epidermal growth factor stimulate clusterin gene expression in PC12 cells
    • Gutacker C, Klock G, Diel P and Kock-Brabdt C (1999) Nerve growth factor and epidermal growth factor stimulate clusterin gene expression in PC12 cells. Biochem. J. 339: 759-766
    • (1999) Biochem. J. , vol.339 , pp. 759-766
    • Gutacker, C.1    Klock, G.2    Diel, P.3    Kock-Brabdt, C.4
  • 35
    • 0033558784 scopus 로고    scopus 로고
    • Transforming growth factor beta-1 up-regulates clusterin synthesis in thyroid epithelial cells
    • Wegrowski Y, Perreau C, Martiny L, Haye B, Maquart FX and Bellon C (1999) Transforming growth factor beta-1 up-regulates clusterin synthesis in thyroid epithelial cells. Exp. Cell Res. 247: 475-483
    • (1999) Exp. Cell Res. , vol.247 , pp. 475-483
    • Wegrowski, Y.1    Perreau, C.2    Martiny, L.3    Haye, B.4    Maquart, F.X.5    Bellon, C.6
  • 41
    • 0037963140 scopus 로고    scopus 로고
    • Loss of clusterin both in serum and tissue correlates with the tumorigenesis of oesophageal squamous cell carcinoma via proteomic approaches
    • Zhang LY, Ying WT, Mao YS, He HZ, Liu Y, Wang HX, Liu F, Wang K and Zha XH (2003) Loss of clusterin both in serum and tissue correlates with the tumorigenesis of oesophageal squamous cell carcinoma via proteomic approaches. World J Gastroenterol 9: 650-654
    • (2003) World J Gastroenterol , vol.9 , pp. 650-654
    • Zhang, L.Y.1    Ying, W.T.2    Mao, Y.S.3    He, H.Z.4    Liu, Y.5    Wang, H.X.6    Liu, F.7    Wang, K.8    Zha, X.H.9
  • 44
    • 0037083472 scopus 로고    scopus 로고
    • Clusterin expression is significantly enhanced in prostate cancer cells following androgen withdrawal therapy
    • July LV, Akbari M, Zellweger T, Jones EC, Goldenberry SL and Gleave ME (2002) Clusterin expression is significantly enhanced in prostate cancer cells following androgen withdrawal therapy. Prostate 50: 179-188
    • (2002) Prostate , vol.50 , pp. 179-188
    • July, L.V.1    Akbari, M.2    Zellweger, T.3    Jones, E.C.4    Goldenberry, S.L.5    Gleave, M.E.6
  • 45
    • 20344402686 scopus 로고    scopus 로고
    • Antisense clusterin oligonucleotides increase the response of HER-2 gene amplified breast cancer cells to Trastuzumab
    • Biroccio A, D'angel C, Jansen B, Gleave ME and Zupi G (2005) Antisense clusterin oligonucleotides increase the response of HER-2 gene amplified breast cancer cells to Trastuzumab. J. Cell. Physiol. 204: 463-469
    • (2005) J. Cell. Physiol. , vol.204 , pp. 463-469
    • Biroccio, A.1    D'angel, C.2    Jansen, B.3    Gleave, M.E.4    Zupi, G.5
  • 46
    • 20344371233 scopus 로고    scopus 로고
    • Antisense therapy for cancer
    • Gleave ME and Monia BP (2005) Antisense therapy for cancer. Nat. Rev. Cancer. 5: 468-479
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 468-479
    • Gleave, M.E.1    Monia, B.P.2
  • 47
    • 14844293486 scopus 로고    scopus 로고
    • Synergistic antitumor effect of combined use of adenoviral-mediated p53 gene transfer and antisense oligodeoxynucleotide targeting clusterin gene in an androgen-independent human prostate cancer model
    • Yamanaka K, Gleave ME, Hara I, Muramaki M and Miyake H (2005) Synergistic antitumor effect of combined use of adenoviral-mediated p53 gene transfer and antisense oligodeoxynucleotide targeting clusterin gene in an androgen-independent human prostate cancer model. Mol. Cancer Ther. 4: 187-195
    • (2005) Mol. Cancer Ther. , vol.4 , pp. 187-195
    • Yamanaka, K.1    Gleave, M.E.2    Hara, I.3    Muramaki, M.4    Miyake, H.5
  • 48
    • 0034870685 scopus 로고    scopus 로고
    • Chemosensitization of human renal cell cancer using antisense oligonucleotides targeting the antiapoptotic gene clusterin
    • Zellweger T, Miyake H, July LV, Akbari M, Kiyama S and Gleave ME (2001) Chemosensitization of human renal cell cancer using antisense oligonucleotides targeting the antiapoptotic gene clusterin. Neoplasia 3: 360-367
    • (2001) Neoplasia , vol.3 , pp. 360-367
    • Zellweger, T.1    Miyake, H.2    July, L.V.3    Akbari, M.4    Kiyama, S.5    Gleave, M.E.6
  • 49
    • 1342268524 scopus 로고    scopus 로고
    • Clusterin and IGFBPs as antisense targets in prostate cancer
    • Gleave M and Jansen B (2003) Clusterin and IGFBPs as antisense targets in prostate cancer. Ann. NY Acad. Sci. 1002: 95-104
    • (2003) Ann. NY Acad. Sci. , vol.1002 , pp. 95-104
    • Gleave, M.1    Jansen, B.2
  • 50
    • 17144414465 scopus 로고    scopus 로고
    • Delayed activation of insulin-like growth factor-1 receptor/Src/MAPK/Egr-1 signaling regulates clusterin expression, a pro-survival factor
    • Criswell T, Beman M, Araki S, Leskov K, Cataldo E, Mayp LD and Boothman DA (2005) Delayed activation of insulin-like growth factor-1 receptor/ Src/MAPK/Egr-1 signaling regulates clusterin expression, a pro-survival factor. J. Biol. Chem. 280: 14212-14221
    • (2005) J. Biol. Chem. , vol.280 , pp. 14212-14221
    • Criswell, T.1    Beman, M.2    Araki, S.3    Leskov, K.4    Cataldo, E.5    Mayp, L.D.6    Boothman, D.A.7
  • 51
    • 0034883854 scopus 로고    scopus 로고
    • Antitumor activity of antisense clusterin oligonucleotides is improved in vitro and in vivo by incorporation of 2′-O(2-methoxy) ethyl chemistry
    • Zellweger T, Miyake H, Cooper S, Chi K, Conklin BS, Monia BP and Gleave ME (2001) Antitumor activity of antisense clusterin oligonucleotides is improved in vitro and in vivo by incorporation of 2′-O(2-methoxy) ethyl chemistry. J. Pharmacol. Exp. Ther. 298: 934-940
    • (2001) J. Pharmacol. Exp. Ther. , vol.298 , pp. 934-940
    • Zellweger, T.1    Miyake, H.2    Cooper, S.3    Chi, K.4    Conklin, B.S.5    Monia, B.P.6    Gleave, M.E.7
  • 52
    • 0346724931 scopus 로고    scopus 로고
    • Enhanced chemosensitivity of baldder cancer cells to cisplatin by suppression of clusterin in vitro
    • Chung J, Kwak C, Jin RJ, Lee CH, Lee KH and Lee SE (2004) Enhanced chemosensitivity of baldder cancer cells to cisplatin by suppression of clusterin in vitro. Cancer Lett. 203: 155-161
    • (2004) Cancer Lett. , vol.203 , pp. 155-161
    • Chung, J.1    Kwak, C.2    Jin, R.J.3    Lee, C.H.4    Lee, K.H.5    Lee, S.E.6


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