Antiobesity effect of baicalin involves the modulations of proadipogenic and antiadipogenic regulators of the adipogenesis pathway

Phytotherapy Research

Volumn 23, Issue 11, 2009, Pages 1615-1623

  Lee, Haeyong ^a   Kang, Ryunhwa ^a   Hahn, Yoonsoo ^a   Yang, Young ^b   Sung, Su Kim ^a   Soo, Hyun Cho ^a   Chung, Sang In ^a   Yoon, Yoosik ^a  

^a Chung Ang University   (South Korea)

^b Sookmyung Women's University   (South Korea)

Author keywords

3T3 L1; Adipogenesis; Baicalin; Mechanism; Obesity

Indexed keywords

BAICALIN; CCAAT ENHANCER BINDING PROTEIN ALPHA; CCAAT ENHANCER BINDING PROTEIN BETA; CCAAT ENHANCER BINDING PROTEIN DELTA; CHOLESTEROL; FAT DROPLET; FATTY ACID BINDING PROTEIN 4; KRUPPEL LIKE FACTOR; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; ROSIGLITAZONE; TRIACYLGLYCEROL;

ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; FOCAL ADHESION; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; OBESITY; PROADIPOCYTE; PROTEIN EXPRESSION; UPREGULATION;

3T3-L1 CELLS; ADIPOGENESIS; ANIMALS; ANTI-OBESITY AGENTS; CCAAT-ENHANCER-BINDING PROTEINS; DNA-BINDING PROTEINS; FATTY ACID-BINDING PROTEINS; FLAVONOIDS; GENE EXPRESSION REGULATION; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MICE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PPAR GAMMA; TRANSCRIPTION FACTORS; TRIGLYCERIDES;

EID: 70350437658     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2937     Document Type: Article

References (20)

1. Banerjee SS, Feinberg MW, Watanabe M et al. 2003. The Kruppel-like factor KLF2 inhibits peroxisome proliferator-activated receptor-gamma expression and adipogenesis. J Biol Chem 278: 2581-2584. (Pubitemid 36801336)
2. Chan FL, Choi HL, Chen ZY et al. 2000. Induction of apoptosis in prostate cancer cell lines by a flavonoid, baicalin. Cancer Lett 160: 219-228. (Pubitemid 30798060)
3. Chen Z, Torrens JI, Anand A et al. 2005. Krox20 stimulates adipogenesis via C/EBPbeta-dependent and -independent mechanisms. Cell Metab 1: 93-106. (Pubitemid 43960592)
4. Darlington GJ, Ross SE, MacDougald OA. 1998. The role of C/EBP genes in adipocyte differentiation. J Biol Chem 273: 30057-30060.
5. Freshney RI. 1994. Culture of Animal Cells: A Manual of Basic Technique, 3rd edn. Wiley-Liss Inc: New York.
6. Gustafson B, Smith U. 2006. Cytokines promote Wnt signaling and inflammation and impair the normal differentiation and lipid accumulation in 3T3-L1 preadipocytes. J Biol Chem 281: 9507-9516. (Pubitemid 43864668)
7. Kasturi R, Joshi VC. 1982. Hormonal regulation of stearoyl coenzyme A desaturase activity and lipogenesis during adipose conversion of 3T3-L1 cells. J Biol Chem 257: 12224-12230. (Pubitemid 13180121)
8. Krakauer T, Li BQ, Young HA. 2001. The flavonoid baicalin inhibits superantigen-induced inflammatory cytokines and chemokines. FEBS Lett 500: 52-55. (Pubitemid 32575317)
9. Li BQ, Fu T, Dongyan Y et al. 2000. Flavonoid baicalin inhibits HIV-1 infection at the level of viral entry. Biochem Biophys Res Commun 276: 534-538. (Pubitemid 30750950)
10. Li-Weber M. 2009. New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents wogonin, baicalein and baicalin. Cancer Treat Rev 35: 57-68.
11. Livak KJ, Schmittgen TD. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25: 402-408. (Pubitemid 34164012)
12. Mori T, Sakaue H, Iguchi H et al. 2005. Role of Kruppel-like factor 15 (KLF15) in transcriptional regulation of adipogenesis. J Biol Chem 280: 12867-12875. (Pubitemid 40491108)
13. Oishi Y, Manabe I, Tobe K et al. 2005. Kruppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation. Cell Metab 1: 27-39. (Pubitemid 43960584)
14. Rosen ED, Hsu CH, Wang X et al. 2002. C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway. Genes Dev 16: 22-26. (Pubitemid 34049634)
15. Rosen ED, MacDougald OA. 2006. Adipocyte differentiation from the inside out. Nat Rev Mol Cell Biol 7: 885-896.
16. Rosen ED, Walkey CJ, Puigserver P et al. 2000. Transcriptional regulation of adipogenesis. Genes Dev 14: 1293-1307.
17. Spiegelman BM, Choy L, Hotamisligil GS et al. 1993. Regulation of adipocyte gene expression in differentiation and syndromes of obesity/diabetes. J Biol Chem 268: 6823-6826. (Pubitemid 23105553)
18. Tontonoz P, Hu E, Spiegelman BM. 1994. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell 79: 1147-1156.
19. Yeh WC, Cao Z, Classon M et al. 1995. Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins. Genes Dev 9: 168-181.
20. Zhao Y, Li H, Gao Z et al. 2005. Effects of dietary baicalin supplementation on iron overload-induced mouse liver oxidative injury. Eur J Pharmacol 509: 195-200. (Pubitemid 40279078)