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Volumn 7, Issue 4, 2012, Pages

Differential regulation of cutaneous oncoprotein HPVE6 by wtp53, mutant p53R248W and ΔNp63α is HPV type dependent

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CYCLIN D1; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR 2A; DELTANP63ALPHA PROTEIN; MUTANT PROTEIN; PROTEASOME; PROTEIN C JUN; PROTEIN HPV20E6; PROTEIN HPVE6; PROTEIN P53; PROTEIN P63; PROTEIN WTP53; RETINOBLASTOMA PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

EID: 84859970127     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0035540     Document Type: Article
Times cited : (4)

References (64)
  • 1
    • 0031899349 scopus 로고    scopus 로고
    • Human papillomaviruses are commonly found in normal skin of immunocompetent hosts
    • Astori G, Lavergne D, Benton C, Höckmayr B, Egawa K, et al. (1998) Human papillomaviruses are commonly found in normal skin of immunocompetent hosts. J Invest Dermatol 110: 752-755.
    • (1998) J Invest Dermatol , vol.110 , pp. 752-755
    • Astori, G.1    Lavergne, D.2    Benton, C.3    Höckmayr, B.4    Egawa, K.5
  • 2
    • 0034466769 scopus 로고    scopus 로고
    • The ubiquity and impressive genomic diversity of human skin papillomaviruses suggest a comensalic nature of these viruses
    • Antonsson A, Forslund O, Ekberg H, Stemer G, Hansson BG, (2000) The ubiquity and impressive genomic diversity of human skin papillomaviruses suggest a comensalic nature of these viruses. J Virol 74: 11636-11641.
    • (2000) J Virol , vol.74 , pp. 11636-11641
    • Antonsson, A.1    Forslund, O.2    Ekberg, H.3    Stemer, G.4    Hansson, B.G.5
  • 3
    • 34548515934 scopus 로고    scopus 로고
    • Cutaneous human papillomaviruses found in sun-exposed skin: Beta-papillomavirus species 2 predominates in squamous cell carcinoma
    • Forslund O, Iftner T, Andersson K, Lindelöf B, Hradil E, et al. (2007) Cutaneous human papillomaviruses found in sun-exposed skin: Beta-papillomavirus species 2 predominates in squamous cell carcinoma. J Infect Dis 196: 876-883.
    • (2007) J Infect Dis , vol.196 , pp. 876-883
    • Forslund, O.1    Iftner, T.2    Andersson, K.3    Lindelöf, B.4    Hradil, E.5
  • 4
    • 43749125071 scopus 로고    scopus 로고
    • Detection of human papillomavirus DNA in cutaneous squamous cell carcinoma among immunocompetent individuals
    • Asgari M, Kiviat NB, Critchlow CW, Stern JE, Argenyi Z, et al. (2008) Detection of human papillomavirus DNA in cutaneous squamous cell carcinoma among immunocompetent individuals. J Invest Dermatol 128: 1409-1417.
    • (2008) J Invest Dermatol , vol.128 , pp. 1409-1417
    • Asgari, M.1    Kiviat, N.B.2    Critchlow, C.W.3    Stern, J.E.4    Argenyi, Z.5
  • 5
    • 56349127837 scopus 로고    scopus 로고
    • Human papillomavirus type spectrum in normal skin of individuals with or without a history of frequent sun exposure
    • Chen AC, McMillan NA, Antonsson A, (2008) Human papillomavirus type spectrum in normal skin of individuals with or without a history of frequent sun exposure. J Gen Virol 89: 2891-2897.
    • (2008) J Gen Virol , vol.89 , pp. 2891-2897
    • Chen, A.C.1    McMillan, N.A.2    Antonsson, A.3
  • 6
    • 67849117162 scopus 로고    scopus 로고
    • Prevalence and associated factors of betapapillomavirus infections in individuals without cutaneous squamous cell carcinoma
    • de Koning MN, Weissenborn SJ, Abeni D, Bouwes Bavinck JN, Euvrard S, et al. (2009) Prevalence and associated factors of betapapillomavirus infections in individuals without cutaneous squamous cell carcinoma. J Gen Virol 90: 1611-1621.
    • (2009) J Gen Virol , vol.90 , pp. 1611-1621
    • de Koning, M.N.1    Weissenborn, S.J.2    Abeni, D.3    Bouwes Bavinck, J.N.4    Euvrard, S.5
  • 7
    • 77951219218 scopus 로고    scopus 로고
    • Betapapillomavirus infection profiles in tissue sets from cutaneous squamous cell-carcinoma patients
    • Plasmeijer EI, Neale RE, Buettner PG, de Koning MN, Ter Schegget J, et al. (2010) Betapapillomavirus infection profiles in tissue sets from cutaneous squamous cell-carcinoma patients. Int J Cancer 126: 2614-2621.
    • (2010) Int J Cancer , vol.126 , pp. 2614-2621
    • Plasmeijer, E.I.1    Neale, R.E.2    Buettner, P.G.3    de Koning, M.N.4    Ter Schegget, J.5
  • 8
    • 80053339671 scopus 로고    scopus 로고
    • High throughput sequencing reveals diversity of human papillomaviruses in cutaneous lesions
    • Ekström J, Bzhalava D, Svenback D, Forslund O, Dillner J, (2011) High throughput sequencing reveals diversity of human papillomaviruses in cutaneous lesions. Int J Cancer 129: 2643-2650.
    • (2011) Int J Cancer , vol.129 , pp. 2643-2650
    • Ekström, J.1    Bzhalava, D.2    Svenback, D.3    Forslund, O.4    Dillner, J.5
  • 9
    • 0035956215 scopus 로고    scopus 로고
    • The human papillomavirus E6 protein and its contribution to malignant progression
    • Mantovani F, Banks L, (2001) The human papillomavirus E6 protein and its contribution to malignant progression. Oncogene 20: 7874-7887.
    • (2001) Oncogene , vol.20 , pp. 7874-7887
    • Mantovani, F.1    Banks, L.2
  • 10
    • 0036559896 scopus 로고    scopus 로고
    • Papillomaviruses and cancer: from basic studies to clinical application
    • zur Hausen H, (2002) Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer 2: 342-350.
    • (2002) Nat Rev Cancer , vol.2 , pp. 342-350
    • zur Hausen, H.1
  • 11
    • 0037153381 scopus 로고    scopus 로고
    • Chimaeric HPV E6 proteins allow dissection of the proteolytic pathways regulating different E6 cellular target proteins
    • Pim D, Thomas M, Banks L, (2002) Chimaeric HPV E6 proteins allow dissection of the proteolytic pathways regulating different E6 cellular target proteins. Oncogene 21: 8140-8148.
    • (2002) Oncogene , vol.21 , pp. 8140-8148
    • Pim, D.1    Thomas, M.2    Banks, L.3
  • 13
    • 43949131787 scopus 로고    scopus 로고
    • Degradation of HPV20E6 by p53: ΔNp63α and mutant p53R248W protect the wild type p53 mediated caspase-degradation
    • Fei JW, de Villiers EM, (2008) Degradation of HPV20E6 by p53: ΔNp63α and mutant p53R248W protect the wild type p53 mediated caspase-degradation. Int J Cancer 123: 108-116.
    • (2008) Int J Cancer , vol.123 , pp. 108-116
    • Fei, J.W.1    de Villiers, E.M.2
  • 14
    • 77149149956 scopus 로고    scopus 로고
    • The biological properties of E6 and E7 oncoproteins from human papillomaviruses
    • Ghittoni R, Accardi R, Hasan U, Gheit T, Sylla B, et al. (2010) The biological properties of E6 and E7 oncoproteins from human papillomaviruses. Virus Genes 40: 1-13.
    • (2010) Virus Genes , vol.40 , pp. 1-13
    • Ghittoni, R.1    Accardi, R.2    Hasan, U.3    Gheit, T.4    Sylla, B.5
  • 16
    • 77950938389 scopus 로고    scopus 로고
    • Classification of papillomaviruses (PVs) based on 189 PV types and proposal of taxonomic amendments
    • Bernard HU, Burk RD, Chen Z, van Doorslaer K, Hausen H, et al. (2010) Classification of papillomaviruses (PVs) based on 189 PV types and proposal of taxonomic amendments. Virology 401: 70-79.
    • (2010) Virology , vol.401 , pp. 70-79
    • Bernard, H.U.1    Burk, R.D.2    Chen, Z.3    van Doorslaer, K.4    Hausen, H.5
  • 17
    • 41949139392 scopus 로고    scopus 로고
    • The E6 oncoproteins from human betapapillomaviruses differentially activate telomerase through an E6AP-dependent mechanism and prolong the lifespan of primary keratinocytes
    • Bedard KM, Underbrink MP, Howie HL, Galloway DA, (2008) The E6 oncoproteins from human betapapillomaviruses differentially activate telomerase through an E6AP-dependent mechanism and prolong the lifespan of primary keratinocytes. J Virol 82: 3894-3902.
    • (2008) J Virol , vol.82 , pp. 3894-3902
    • Bedard, K.M.1    Underbrink, M.P.2    Howie, H.L.3    Galloway, D.A.4
  • 18
    • 38949092837 scopus 로고    scopus 로고
    • Impairment of the telomere/telomerase system and genomic instability are associated with keratinocyte immortalization induced by the skin human papillomavirus type 38
    • Gabet A-S, Accardi R, Bellopede A, Popp S, Boukamp P, et al. (2008) Impairment of the telomere/telomerase system and genomic instability are associated with keratinocyte immortalization induced by the skin human papillomavirus type 38. FASEB J 22: 622-632.
    • (2008) FASEB J , vol.22 , pp. 622-632
    • Gabet, A.-S.1    Accardi, R.2    Bellopede, A.3    Popp, S.4    Boukamp, P.5
  • 19
    • 0026578703 scopus 로고
    • Differences in transforming activity and coded amino acid sequence among E6 genes of several papillomaviruses associated with epidermodysplasia verruciformis
    • Kiyono T, Hiraiwa A, Ishibashi M, (1992) Differences in transforming activity and coded amino acid sequence among E6 genes of several papillomaviruses associated with epidermodysplasia verruciformis. Virology 186: 628-639.
    • (1992) Virology , vol.186 , pp. 628-639
    • Kiyono, T.1    Hiraiwa, A.2    Ishibashi, M.3
  • 20
    • 38649105474 scopus 로고    scopus 로고
    • Comparative transforming potential of different human papillomaviruses associated with non-melanoma skin cancer
    • Massimi P, Thomas M, Bouvard V, Ruberto I, Campo MS, et al. (2008) Comparative transforming potential of different human papillomaviruses associated with non-melanoma skin cancer. Virology 371: 374-379.
    • (2008) Virology , vol.371 , pp. 374-379
    • Massimi, P.1    Thomas, M.2    Bouvard, V.3    Ruberto, I.4    Campo, M.S.5
  • 22
    • 0025719491 scopus 로고
    • A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma
    • Brash DE, Rudolf JA, Simon JA, Kin A, McKenna GJ, et al. (1991) A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Proc Natl Acad Sci USA 88: 10124-10128.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 10124-10128
    • Brash, D.E.1    Rudolf, J.A.2    Simon, J.A.3    Kin, A.4    McKenna, G.J.5
  • 23
    • 0036258111 scopus 로고    scopus 로고
    • The IARC p53 Database: new online mutation analysis and recommendations to users
    • Oliver M, Eeles R, Hollstein M, Khan MA, Harris CC, et al. (2002) The IARC p53 Database: new online mutation analysis and recommendations to users. Hum Mutat 19: 607-614.
    • (2002) Hum Mutat , vol.19 , pp. 607-614
    • Oliver, M.1    Eeles, R.2    Hollstein, M.3    Khan, M.A.4    Harris, C.C.5
  • 24
    • 79956139237 scopus 로고    scopus 로고
    • ChIP-on-chip analysis of in vivo mutant p53 binding to selected gene promoters
    • Dell'Orso S, Fontemaggi G, Stambolsky P, Goeman F, Voellenkle C, et al. (2011) ChIP-on-chip analysis of in vivo mutant p53 binding to selected gene promoters. OMICS 15: 305-312.
    • (2011) OMICS , vol.15 , pp. 305-312
    • Dell'Orso, S.1    Fontemaggi, G.2    Stambolsky, P.3    Goeman, F.4    Voellenkle, C.5
  • 26
    • 79955054710 scopus 로고    scopus 로고
    • Gain of function of mutant p53 by coaggregation with multiple tumor suppressors
    • Xu J, Couceiro JR, De Smet F, Gallrado R, Rudyak S, et al. (2011) Gain of function of mutant p53 by coaggregation with multiple tumor suppressors. Nat Chem Biol 7: 285-295.
    • (2011) Nat Chem Biol , vol.7 , pp. 285-295
    • Xu, J.1    Couceiro, J.R.2    De Smet, F.3    Gallrado, R.4    Rudyak, S.5
  • 27
    • 80051789515 scopus 로고    scopus 로고
    • p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53
    • Melino G, (2011) p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53. Cel Death Diff 18: 1487-1499.
    • (2011) Cel Death Diff , vol.18 , pp. 1487-1499
    • Melino, G.1
  • 28
    • 67650461955 scopus 로고    scopus 로고
    • Rescue of key features of the p63-null epithelial phenotype by inactivation of Ink4a and Arf
    • Su X, Cho MS, Gi Y-J, Ayanga BA, Sherr CJ, et al. (2009) Rescue of key features of the p63-null epithelial phenotype by inactivation of Ink4a and Arf. EMBO J 28: 1904-1915.
    • (2009) EMBO J , vol.28 , pp. 1904-1915
    • Su, X.1    Cho, M.S.2    Gi, Y.-J.3    Ayanga, B.A.4    Sherr, C.J.5
  • 29
    • 33847048245 scopus 로고    scopus 로고
    • The roles of p63 in cancer
    • Flores ER, (2007) The roles of p63 in cancer. Cell Cycle 6: 300-304.
    • (2007) Cell Cycle , vol.6 , pp. 300-304
    • Flores, E.R.1
  • 30
    • 40549104468 scopus 로고    scopus 로고
    • Properties of the six isoforms of p63: p53-like regulation in response to genotoxic stress and cross talk with ΔNp73
    • Petitjean A, Ruptier C, Tribollet V, Hautefeauille A, Chardon F, et al. (2008) Properties of the six isoforms of p63: p53-like regulation in response to genotoxic stress and cross talk with ΔNp73. Carcinogenesis 29: 273-281.
    • (2008) Carcinogenesis , vol.29 , pp. 273-281
    • Petitjean, A.1    Ruptier, C.2    Tribollet, V.3    Hautefeauille, A.4    Chardon, F.5
  • 32
    • 48549102989 scopus 로고    scopus 로고
    • The p53 homologue ΔNp63α interacts with the nuclear factor-κB pathway to modulate epithelial cell growth
    • King KE, Ponnamperuma RM, Allen C, Lu H, Duggal P, et al. (2008) The p53 homologue ΔNp63α interacts with the nuclear factor-κB pathway to modulate epithelial cell growth. Cancer Res 68: 5122-5131.
    • (2008) Cancer Res , vol.68 , pp. 5122-5131
    • King, K.E.1    Ponnamperuma, R.M.2    Allen, C.3    Lu, H.4    Duggal, P.5
  • 34
    • 0033637306 scopus 로고    scopus 로고
    • Role of Bak in UV-induced apoptosis in skin cancer and abrogation by HPV E6 proteins
    • Jackson S, Harwood C, Thomas M, Banks L, Storey A, (2000) Role of Bak in UV-induced apoptosis in skin cancer and abrogation by HPV E6 proteins. Genes & Develop 14: 3065-3073.
    • (2000) Genes & Develop , vol.14 , pp. 3065-3073
    • Jackson, S.1    Harwood, C.2    Thomas, M.3    Banks, L.4    Storey, A.5
  • 35
    • 52649180182 scopus 로고    scopus 로고
    • Specific betapapillomaviruses associated with squamous cell carcinoma of the skin inhibit UVB-unduced apoptosis of primary keratinocytes
    • Struijk L, van der Meijden E, Kazem S, ter Schegget J, de Gruijl FR, et al. (2008) Specific betapapillomaviruses associated with squamous cell carcinoma of the skin inhibit UVB-unduced apoptosis of primary keratinocytes. J Gen Virol 89: 2303-2314.
    • (2008) J Gen Virol , vol.89 , pp. 2303-2314
    • Struijk, L.1    van der Meijden, E.2    Kazem, S.3    ter Schegget, J.4    de Gruijl, F.R.5
  • 36
    • 53749083668 scopus 로고    scopus 로고
    • Differences in transcriptional activity of cutaneous human papillomaviruses
    • Vasiljevic N, Nielsen L, Doherty G, Dillner J, Forslund O, et al. (2008) Differences in transcriptional activity of cutaneous human papillomaviruses. Virus Res 137: 213-219.
    • (2008) Virus Res , vol.137 , pp. 213-219
    • Vasiljevic, N.1    Nielsen, L.2    Doherty, G.3    Dillner, J.4    Forslund, O.5
  • 37
    • 55249122277 scopus 로고    scopus 로고
    • E6 proteins from multiple human betapapillomavirus types degrade Bak and protect keratinocytes from apoptosis after UVB irradiation
    • Underbrink MP, Howie HL, Bedard KM, Koop JI, Galloway DA, (2008) E6 proteins from multiple human betapapillomavirus types degrade Bak and protect keratinocytes from apoptosis after UVB irradiation. J Virol 82: 10408-10417.
    • (2008) J Virol , vol.82 , pp. 10408-10417
    • Underbrink, M.P.1    Howie, H.L.2    Bedard, K.M.3    Koop, J.I.4    Galloway, D.A.5
  • 38
    • 33847262957 scopus 로고    scopus 로고
    • Role of HPV E6 proteins in preventing UVB-induced release of pro-apoptotic factors from the mitochondria
    • Leverrier S, Bergamaschi D, Ghali L, Ola A, Warnes G, et al. (2007) Role of HPV E6 proteins in preventing UVB-induced release of pro-apoptotic factors from the mitochondria. Apoptosis 12: 549-560.
    • (2007) Apoptosis , vol.12 , pp. 549-560
    • Leverrier, S.1    Bergamaschi, D.2    Ghali, L.3    Ola, A.4    Warnes, G.5
  • 39
    • 0033504609 scopus 로고    scopus 로고
    • Human papillomavirus infections in nonmelanoma skin cancer
    • de Villiers E-M, Ruhland A, Sekaric P, (1999) Human papillomavirus infections in nonmelanoma skin cancer. Sem Cancer Biol 9: 413-422.
    • (1999) Sem Cancer Biol , vol.9 , pp. 413-422
    • de Villiers, E.-M.1    Ruhland, A.2    Sekaric, P.3
  • 40
    • 21244480501 scopus 로고    scopus 로고
    • Differential enhancement of a cutaneous HPV promoter by p63, Jun and mutant p53
    • Fei J-W, Wei Q-X, Angel P, de Villiers E-M, (2005) Differential enhancement of a cutaneous HPV promoter by p63, Jun and mutant p53. Cell Cycle 4: 689-696.
    • (2005) Cell Cycle , vol.4 , pp. 689-696
    • Fei, J.-W.1    Wei, Q.-X.2    Angel, P.3    de Villiers, E.-M.4
  • 41
    • 63149124929 scopus 로고    scopus 로고
    • E7 oncoprotein of novel human papillomavirus type 108 lacking the E6 gene induces dysplasia in organotypic keratinocyte cultures
    • Nobre RJ, Herráez-Hernández E, Fei JW, Langbein L, Kaden S, et al. (2009) E7 oncoprotein of novel human papillomavirus type 108 lacking the E6 gene induces dysplasia in organotypic keratinocyte cultures. J Virol 83: 2907-2916.
    • (2009) J Virol , vol.83 , pp. 2907-2916
    • Nobre, R.J.1    Herráez-Hernández, E.2    Fei, J.W.3    Langbein, L.4    Kaden, S.5
  • 42
    • 33644837882 scopus 로고    scopus 로고
    • Using an immortalized cell line to study the HPV life cycle in organotypic "raft" cultures
    • Lambert PF, Ozbun MA, Collins A, Holmgren S, Lee D, et al. (2005) Using an immortalized cell line to study the HPV life cycle in organotypic "raft" cultures. Methods Mol Med 119: 141-155.
    • (2005) Methods Mol Med , vol.119 , pp. 141-155
    • Lambert, P.F.1    Ozbun, M.A.2    Collins, A.3    Holmgren, S.4    Lee, D.5
  • 43
    • 33645354063 scopus 로고    scopus 로고
    • Induction of centrosome amplification in p53 siRNA-treated human fibroblast cells by radiation exposure
    • Kawamura K, Morita N, Domiki C, Fujikawa-Yamamoto K, Hashimoto M, et al. (2006) Induction of centrosome amplification in p53 siRNA-treated human fibroblast cells by radiation exposure. Cancer Sci 97: 252-258.
    • (2006) Cancer Sci , vol.97 , pp. 252-258
    • Kawamura, K.1    Morita, N.2    Domiki, C.3    Fujikawa-Yamamoto, K.4    Hashimoto, M.5
  • 44
    • 77950796583 scopus 로고    scopus 로고
    • Downregulation of Cdc2/CDK1 kinase activity induces the synthesis of noninfectious human papillomavirus type 31b virions in organotypic tissues exposed to benzo[a]pyrene
    • Alam S, Bowser BS, Conway MJ, Israr M, Ryndock EJ, et al. (2010) Downregulation of Cdc2/CDK1 kinase activity induces the synthesis of noninfectious human papillomavirus type 31b virions in organotypic tissues exposed to benzo[a]pyrene. J Virol 84: 4630-4645.
    • (2010) J Virol , vol.84 , pp. 4630-4645
    • Alam, S.1    Bowser, B.S.2    Conway, M.J.3    Israr, M.4    Ryndock, E.J.5
  • 45
    • 18344363072 scopus 로고    scopus 로고
    • Constitutively active K-cyclin/cdk6 kinase in Kaposi sarcoma-associated herpesvirus-infected cells
    • Van Dross R, Yao S, Asad S, Westlake G, Mays DJ, et al. (2005) Constitutively active K-cyclin/cdk6 kinase in Kaposi sarcoma-associated herpesvirus-infected cells. J Natl Cancer Inst 97: 656-666.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 656-666
    • Van Dross, R.1    Yao, S.2    Asad, S.3    Westlake, G.4    Mays, D.J.5
  • 46
    • 4143063626 scopus 로고    scopus 로고
    • Methylation of p16 CpG islands associated with malignant transformation of gastric dysplasia in a population-based study
    • Sun Y, Deng D, You WC, Bai H, Zhang L, et al. (2004) Methylation of p16 CpG islands associated with malignant transformation of gastric dysplasia in a population-based study. Clin Cancer Res 10: 5087-5093.
    • (2004) Clin Cancer Res , vol.10 , pp. 5087-5093
    • Sun, Y.1    Deng, D.2    You, W.C.3    Bai, H.4    Zhang, L.5
  • 47
    • 33846911949 scopus 로고    scopus 로고
    • BLIMP1 regulates cell growth through repression of p53 transcription
    • Yan J, Jiang J, Lim CA, Wu Q, Ng HH, et al. (2007) BLIMP1 regulates cell growth through repression of p53 transcription. Proc Natl Acad Sci USA 104: 1841-1846.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 1841-1846
    • Yan, J.1    Jiang, J.2    Lim, C.A.3    Wu, Q.4    Ng, H.H.5
  • 48
    • 84255210700 scopus 로고    scopus 로고
    • Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012
    • Galluzzi L, Vitale I, Abrams JM, Alnemri ES, Baehrecke EH, et al. (2012) Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Diff 19: 107-120.
    • (2012) Cell Death Diff , vol.19 , pp. 107-120
    • Galluzzi, L.1    Vitale, I.2    Abrams, J.M.3    Alnemri, E.S.4    Baehrecke, E.H.5
  • 49
    • 0345731420 scopus 로고    scopus 로고
    • Chemical-induced apoptosis: formation of the Apaf-1 apoptosome
    • Cain K, (2003) Chemical-induced apoptosis: formation of the Apaf-1 apoptosome. Drug Metab Rev 35: 337-63.
    • (2003) Drug Metab Rev , vol.35 , pp. 337-363
    • Cain, K.1
  • 50
    • 67549118622 scopus 로고    scopus 로고
    • Ordering of caspases in cells undergoing apoptosis by the intrinsic pathway
    • Inoue S, Browne G, Melino G, Cohen GM, (2009) Ordering of caspases in cells undergoing apoptosis by the intrinsic pathway. Cell Death Diff 16: 1053-1061.
    • (2009) Cell Death Diff , vol.16 , pp. 1053-1061
    • Inoue, S.1    Browne, G.2    Melino, G.3    Cohen, G.M.4
  • 51
    • 67549142261 scopus 로고    scopus 로고
    • Life and death partners: apoptosis, autophagy and the cross-talk between them
    • Eisenberg-Lerner A, Bialik S, Simon H-U, Kimchi A, (2009) Life and death partners: apoptosis, autophagy and the cross-talk between them. Cell Death Diff 16: 966-975.
    • (2009) Cell Death Diff , vol.16 , pp. 966-975
    • Eisenberg-Lerner, A.1    Bialik, S.2    Simon, H.-U.3    Kimchi, A.4
  • 52
    • 0037075887 scopus 로고    scopus 로고
    • Cyclin D-dependent kinases, INK4 inhibitors and cancer
    • Ortega S, Malumbres M, Barbacid M, (2002) Cyclin D-dependent kinases, INK4 inhibitors and cancer. Biochim Biophys Acta 1602: 73-78.
    • (2002) Biochim Biophys Acta , vol.1602 , pp. 73-78
    • Ortega, S.1    Malumbres, M.2    Barbacid, M.3
  • 53
    • 43049099609 scopus 로고    scopus 로고
    • SV40 small T antigen and PP2A phosphatase in cell transformation
    • Sablina AA, Hahn WC, (2008) SV40 small T antigen and PP2A phosphatase in cell transformation. Cancer Metastasis Rev 27: 137-146.
    • (2008) Cancer Metastasis Rev , vol.27 , pp. 137-146
    • Sablina, A.A.1    Hahn, W.C.2
  • 54
    • 41549090369 scopus 로고    scopus 로고
    • Multiple pathways regulated by the tumor suppressor PP2A in transformation
    • Westermarck J, Hahn WC, (2008) Multiple pathways regulated by the tumor suppressor PP2A in transformation. Trends Mol Med 14: 152-160.
    • (2008) Trends Mol Med , vol.14 , pp. 152-160
    • Westermarck, J.1    Hahn, W.C.2
  • 55
    • 34147096292 scopus 로고    scopus 로고
    • Functions of cyclin D1 as an oncogene and regulation of cyclin D1 expression
    • Tashiro E, Tsuchiya A, Imoto M, (2007) Functions of cyclin D1 as an oncogene and regulation of cyclin D1 expression. Cancer Sci 98: 629-635.
    • (2007) Cancer Sci , vol.98 , pp. 629-635
    • Tashiro, E.1    Tsuchiya, A.2    Imoto, M.3
  • 56
    • 82755186408 scopus 로고    scopus 로고
    • Oncogene- and tumor suppressor gene-mediated suppression of cellular senescence
    • Larsson L-G, (2011) Oncogene- and tumor suppressor gene-mediated suppression of cellular senescence. Sem Cancer Biol 21: 367-376.
    • (2011) Sem Cancer Biol , vol.21 , pp. 367-376
    • Larsson, L.-G.1
  • 57
    • 79960297210 scopus 로고    scopus 로고
    • Transcriptome sequencing demonstrates that human papillomavirus is not active in cutaneous squamous cell carcinoma
    • Arron ST, Ruby JG, Dybbro E, Ganem D, Derisi JL, (2011) Transcriptome sequencing demonstrates that human papillomavirus is not active in cutaneous squamous cell carcinoma. J Invest Dermatol 131: 1745-1753.
    • (2011) J Invest Dermatol , vol.131 , pp. 1745-1753
    • Arron, S.T.1    Ruby, J.G.2    Dybbro, E.3    Ganem, D.4    Derisi, J.L.5
  • 58
    • 33750714110 scopus 로고    scopus 로고
    • E6/E7 expression of HPV20 and HPV27 influences proliferation and differentiation of the skin in UV-irradiated SKH-hr1 transgenic mice
    • Michel A, Kopp-Schneider A, Zentgraf H, Gruber AD, de Villiers E-M, (2006) E6/E7 expression of HPV20 and HPV27 influences proliferation and differentiation of the skin in UV-irradiated SKH-hr1 transgenic mice. J Virol 80: 11153-11164.
    • (2006) J Virol , vol.80 , pp. 11153-11164
    • Michel, A.1    Kopp-Schneider, A.2    Zentgraf, H.3    Gruber, A.D.4    de Villiers, E.-M.5
  • 59
    • 33745590420 scopus 로고    scopus 로고
    • TAp63α indirectly regulates a cutaneous HPV promoter through complex formation with Jun family members
    • Fei J-W, Angel P, Wei Q-X, de Villiers E-M, (2006) TAp63α indirectly regulates a cutaneous HPV promoter through complex formation with Jun family members. Oncogene 25: 3914-3924.
    • (2006) Oncogene , vol.25 , pp. 3914-3924
    • Fei, J.-W.1    Angel, P.2    Wei, Q.-X.3    de Villiers, E.-M.4
  • 60
    • 78649914108 scopus 로고    scopus 로고
    • Cyclin D1 and cyclin D-dependent kinases enhance oral keratinocyte proliferation but do not block keratinocyte differentiation
    • Woods M, Pant R, Mallya SM, (2010) Cyclin D1 and cyclin D-dependent kinases enhance oral keratinocyte proliferation but do not block keratinocyte differentiation. Int J Oncol 37: 1471-1475.
    • (2010) Int J Oncol , vol.37 , pp. 1471-1475
    • Woods, M.1    Pant, R.2    Mallya, S.M.3
  • 61
    • 79251475581 scopus 로고    scopus 로고
    • Unexpected reduction of skin tumorigenesis on expression of cyclin-dependent kinase 6 in mouse epidermis
    • Wang X, Sistrunk C, Rodriguez-Puebla ML, (2011) Unexpected reduction of skin tumorigenesis on expression of cyclin-dependent kinase 6 in mouse epidermis. Am J Pathol 178: 345-354.
    • (2011) Am J Pathol , vol.178 , pp. 345-354
    • Wang, X.1    Sistrunk, C.2    Rodriguez-Puebla, M.L.3
  • 62
    • 34248157632 scopus 로고    scopus 로고
    • Irreversibility of cellular senescence: dual role of p16INK4a/Rb-pathway in cell cycle control
    • Takahashi A, Ohtani N, Hara E, (2007) Irreversibility of cellular senescence: dual role of p16INK4a/Rb-pathway in cell cycle control. Cell Div 2: 10.
    • (2007) Cell Div , vol.2 , pp. 10
    • Takahashi, A.1    Ohtani, N.2    Hara, E.3
  • 63
    • 28344447599 scopus 로고    scopus 로고
    • Activation of the protein kinase B pathway by the HPV-16 E7 oncoprotein occurs through a mechanism involving interaction with PP2A
    • Pim D, Massimi P, Dilworth SM, Banks L, (2005) Activation of the protein kinase B pathway by the HPV-16 E7 oncoprotein occurs through a mechanism involving interaction with PP2A. Oncogene 24: 7830-7838.
    • (2005) Oncogene , vol.24 , pp. 7830-7838
    • Pim, D.1    Massimi, P.2    Dilworth, S.M.3    Banks, L.4
  • 64
    • 78650308849 scopus 로고    scopus 로고
    • Understanding wild-type and mutant p53 activities in human cancer: new landmarks on the way to targeted therapies
    • Goldstein I, Marcel V, Olivier M, Oren M, Rotter V, et al. (2011) Understanding wild-type and mutant p53 activities in human cancer: new landmarks on the way to targeted therapies. Cancer Gene Ther 18: 2-11.
    • (2011) Cancer Gene Ther , vol.18 , pp. 2-11
    • Goldstein, I.1    Marcel, V.2    Olivier, M.3    Oren, M.4    Rotter, V.5


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