메뉴 건너뛰기




Volumn 168, Issue 3, 2012, Pages 261-267

Epitope-specific anti-nuclear antibodies are expressed in a mouse model of primary biliary cirrhosis and are cytokine-dependent

Author keywords

AMA; ANA; Autoantibodies; Cytokines; Gp210

Indexed keywords

ANTINUCLEAR ANTIBODY; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12P35; INTERLEUKIN 12P40; INTERLEUKIN 17; INTERLEUKIN 23P19; INTERLEUKIN 6; MITOCHONDRION ANTIBODY; NUCLEAR PROTEIN; PROTEIN GP210; PROTEIN SP100; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84859939127     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2012.04577.x     Document Type: Article
Times cited : (20)

References (55)
  • 1
  • 3
    • 0038387867 scopus 로고    scopus 로고
    • Antinuclear antibodies specific for primary biliary cirrhosis
    • Worman HJ, Courvalin JC. Antinuclear antibodies specific for primary biliary cirrhosis. Autoimmun Rev 2003; 2:211-17.
    • (2003) Autoimmun Rev , vol.2 , pp. 211-217
    • Worman, H.J.1    Courvalin, J.C.2
  • 4
    • 0025315528 scopus 로고
    • Antinuclear antibodies directed to a 200-kilodalton polypeptide of the nuclear envelope in primary biliary cirrhosis. A clinical and immunological study of a series of 150 patients with primary biliary cirrhosis
    • Lassoued K, Brenard R, Degos F etal. Antinuclear antibodies directed to a 200-kilodalton polypeptide of the nuclear envelope in primary biliary cirrhosis. A clinical and immunological study of a series of 150 patients with primary biliary cirrhosis. Gastroenterology 1990; 99:181-6.
    • (1990) Gastroenterology , vol.99 , pp. 181-186
    • Lassoued, K.1    Brenard, R.2    Degos, F.3
  • 5
    • 0023749359 scopus 로고
    • Autoantibodies against nuclear envelope-associated proteins in primary biliary cirrhosis
    • Lozano F, Pares A, Borche L etal. Autoantibodies against nuclear envelope-associated proteins in primary biliary cirrhosis. Hepatology 1988; 8:930-8.
    • (1988) Hepatology , vol.8 , pp. 930-938
    • Lozano, F.1    Pares, A.2    Borche, L.3
  • 6
    • 0023790694 scopus 로고
    • Autoantibodies to 200kD polypeptide(s) of the nuclear envelope: a new serologic marker of primary biliary cirrhosis
    • Lassoued K, Guilly MN, Andre C etal. Autoantibodies to 200kD polypeptide(s) of the nuclear envelope: a new serologic marker of primary biliary cirrhosis. Clin Exp Immunol 1988; 74:283-8.
    • (1988) Clin Exp Immunol , vol.74 , pp. 283-288
    • Lassoued, K.1    Guilly, M.N.2    Andre, C.3
  • 7
    • 0022186238 scopus 로고
    • Nuclear membrane-staining antinuclear antibody in patients with primary biliary cirrhosis
    • Ruffatti A, Arslan P, Floreani A etal. Nuclear membrane-staining antinuclear antibody in patients with primary biliary cirrhosis. J Clin Immunol 1985; 5:357-61.
    • (1985) J Clin Immunol , vol.5 , pp. 357-361
    • Ruffatti, A.1    Arslan, P.2    Floreani, A.3
  • 8
    • 0025286071 scopus 로고
    • The 210-kD nuclear envelope polypeptide recognized by human autoantibodies in primary biliary cirrhosis is the major glycoprotein of the nuclear pore
    • Courvalin JC, Lassoued K, Bartnik E, Blobel G, Wozniak RW. The 210-kD nuclear envelope polypeptide recognized by human autoantibodies in primary biliary cirrhosis is the major glycoprotein of the nuclear pore. J Clin Invest 1990; 86:279-85.
    • (1990) J Clin Invest , vol.86 , pp. 279-285
    • Courvalin, J.C.1    Lassoued, K.2    Bartnik, E.3    Blobel, G.4    Wozniak, R.W.5
  • 9
    • 0027362748 scopus 로고
    • Autoantibodies from patients with primary biliary cirrhosis recognize a restricted region within the cytoplasmic tail of nuclear pore membrane glycoprotein Gp210
    • Nickowitz RE, Worman HJ. Autoantibodies from patients with primary biliary cirrhosis recognize a restricted region within the cytoplasmic tail of nuclear pore membrane glycoprotein Gp210. J Exp Med 1993; 178:2237-42.
    • (1993) J Exp Med , vol.178 , pp. 2237-2242
    • Nickowitz, R.E.1    Worman, H.J.2
  • 10
    • 0023142958 scopus 로고
    • Autoimmune sera recognize a 100kD nuclear protein antigen (sp-100)
    • Szostecki C, Krippner H, Penner E, Bautz FA. Autoimmune sera recognize a 100kD nuclear protein antigen (sp-100). Clin Exp Immunol 1987; 68:108-16.
    • (1987) Clin Exp Immunol , vol.68 , pp. 108-116
    • Szostecki, C.1    Krippner, H.2    Penner, E.3    Bautz, F.A.4
  • 11
    • 0025633966 scopus 로고
    • Isolation and characterization of cDNA encoding a human nuclear antigen predominantly recognized by autoantibodies from patients with primary biliary cirrhosis
    • Szostecki C, Guldner HH, Netter HJ, Will H. Isolation and characterization of cDNA encoding a human nuclear antigen predominantly recognized by autoantibodies from patients with primary biliary cirrhosis. J Immunol 1990; 145:4338-47.
    • (1990) J Immunol , vol.145 , pp. 4338-4347
    • Szostecki, C.1    Guldner, H.H.2    Netter, H.J.3    Will, H.4
  • 12
    • 78651064512 scopus 로고    scopus 로고
    • The autoimmunity of primary biliary cirrhosis and the clonal selection theory
    • Selmi C, Mackay IR, Gershwin ME. The autoimmunity of primary biliary cirrhosis and the clonal selection theory. Immunol Cell Biol 2011; 89:70-80.
    • (2011) Immunol Cell Biol , vol.89 , pp. 70-80
    • Selmi, C.1    Mackay, I.R.2    Gershwin, M.E.3
  • 13
    • 0344958748 scopus 로고    scopus 로고
    • Identification of major linear epitopes on the sp100 nuclear PBC autoantigen by the gene-fragment phage-display technology
    • Blüthner M, Schäfer C, Schneider C, Bautz FA. Identification of major linear epitopes on the sp100 nuclear PBC autoantigen by the gene-fragment phage-display technology. Autoimmunity 1999; 29:33-42.
    • (1999) Autoimmunity , vol.29 , pp. 33-42
    • Blüthner, M.1    Schäfer, C.2    Schneider, C.3    Bautz, F.A.4
  • 14
    • 80053538903 scopus 로고    scopus 로고
    • Primary biliary cirrhosis-related autoantibodies in a large cohort of Italian patients with systemic sclerosis
    • Cavazzana I, Ceribelli A, Taraborelli M etal. Primary biliary cirrhosis-related autoantibodies in a large cohort of Italian patients with systemic sclerosis. J Rheumatol 2011; 38:2180-5.
    • (2011) J Rheumatol , vol.38 , pp. 2180-2185
    • Cavazzana, I.1    Ceribelli, A.2    Taraborelli, M.3
  • 15
    • 77958150189 scopus 로고    scopus 로고
    • PBC screen: an IgG/IgA dual isotype ELISA detecting multiple mitochondrial and nuclear autoantibodies specific for primary biliary cirrhosis
    • Liu H, Norman GL, Shums Z etal. PBC screen: an IgG/IgA dual isotype ELISA detecting multiple mitochondrial and nuclear autoantibodies specific for primary biliary cirrhosis. J Autoimmun 2010; 35:436-42.
    • (2010) J Autoimmun , vol.35 , pp. 436-442
    • Liu, H.1    Norman, G.L.2    Shums, Z.3
  • 16
    • 0027976228 scopus 로고
    • Autoantibodies against integral membrane proteins of the nuclear envelope in patients with primary biliary cirrhosis
    • Nickowitz RE, Wozniak RW, Schaffner F, Worman HJ. Autoantibodies against integral membrane proteins of the nuclear envelope in patients with primary biliary cirrhosis. Gastroenterology 1994; 106:193-9.
    • (1994) Gastroenterology , vol.106 , pp. 193-199
    • Nickowitz, R.E.1    Wozniak, R.W.2    Schaffner, F.3    Worman, H.J.4
  • 17
    • 33846449067 scopus 로고    scopus 로고
    • Anti-gp210 and anti-centromere antibodies are different risk factors for the progression of primary biliary cirrhosis
    • Nakamura M, Kondo H, Mori T etal. Anti-gp210 and anti-centromere antibodies are different risk factors for the progression of primary biliary cirrhosis. Hepatology 2007; 45:118-27.
    • (2007) Hepatology , vol.45 , pp. 118-127
    • Nakamura, M.1    Kondo, H.2    Mori, T.3
  • 18
    • 33646571925 scopus 로고    scopus 로고
    • Correlation of initial autoantibody profile and clinical outcome in primary biliary cirrhosis
    • Wesierska-Gadek J, Penner E, Battezzati PM etal. Correlation of initial autoantibody profile and clinical outcome in primary biliary cirrhosis. Hepatology 2006; 43:1135-44.
    • (2006) Hepatology , vol.43 , pp. 1135-1144
    • Wesierska-Gadek, J.1    Penner, E.2    Battezzati, P.M.3
  • 19
    • 0031946553 scopus 로고    scopus 로고
    • Autoantibodies against a 210kDa glycoprotein of the nuclear pore complex as a prognostic marker in patients with primary biliary cirrhosis
    • Itoh S, Ichida T, Yoshida T etal. Autoantibodies against a 210kDa glycoprotein of the nuclear pore complex as a prognostic marker in patients with primary biliary cirrhosis. J Gastro Hepatol 1998; 13:257-65.
    • (1998) J Gastro Hepatol , vol.13 , pp. 257-265
    • Itoh, S.1    Ichida, T.2    Yoshida, T.3
  • 20
    • 0037283230 scopus 로고    scopus 로고
    • Characterization and clinical impact of antinuclear antibodies in primary biliary cirrhosis
    • Muratori P, Muratori L, Ferrari R etal. Characterization and clinical impact of antinuclear antibodies in primary biliary cirrhosis. Am J Gastroenterol 2003; 98:431-7.
    • (2003) Am J Gastroenterol , vol.98 , pp. 431-437
    • Muratori, P.1    Muratori, L.2    Ferrari, R.3
  • 21
    • 0035073026 scopus 로고    scopus 로고
    • Autoantibodies against nuclear pore complexes are associated with more active and severe liver disease in primary biliary cirrhosis
    • Invernizzi P, Podda M, Battezzati PM etal. Autoantibodies against nuclear pore complexes are associated with more active and severe liver disease in primary biliary cirrhosis. J Hepatol 2001; 34:366-72.
    • (2001) J Hepatol , vol.34 , pp. 366-372
    • Invernizzi, P.1    Podda, M.2    Battezzati, P.M.3
  • 23
    • 0034131557 scopus 로고    scopus 로고
    • Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease
    • Gorelik L, Flavell RA. Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease. Immunity 2000; 12:171-81.
    • (2000) Immunity , vol.12 , pp. 171-181
    • Gorelik, L.1    Flavell, R.A.2
  • 24
    • 33746210257 scopus 로고    scopus 로고
    • Anti-mitochondrial antibodies and primary biliary cirrhosis in TGF-beta receptor II dominant-negative mice
    • Oertelt S, Lian Z-X, Cheng C-M etal. Anti-mitochondrial antibodies and primary biliary cirrhosis in TGF-beta receptor II dominant-negative mice. J Immunol 2006; 177:1655-60.
    • (2006) J Immunol , vol.177 , pp. 1655-1660
    • Oertelt, S.1    Lian, Z.-X.2    Cheng, C.-M.3
  • 25
    • 1342324752 scopus 로고    scopus 로고
    • Compromised humoral and delayed-type hypersensitivity responses in IL-23-deficient mice
    • Ghilardi N, Kljavin N, Chen Q, Lucas S. Compromised humoral and delayed-type hypersensitivity responses in IL-23-deficient mice. J Immunol 2004; 172:2827-33.
    • (2004) J Immunol , vol.172 , pp. 2827-2833
    • Ghilardi, N.1    Kljavin, N.2    Chen, Q.3    Lucas, S.4
  • 26
    • 0030670875 scopus 로고    scopus 로고
    • Prevalence, kinetics, and therapeutic modulation of autoantibodies against Sp100 and promyelocytic leukemia protein in a large cohort of patients with primary biliary cirrhosis
    • Züchner D, Sternsdorf T, Szostecki C, Heathcote EJ, Cauch-Dudek K, Will H. Prevalence, kinetics, and therapeutic modulation of autoantibodies against Sp100 and promyelocytic leukemia protein in a large cohort of patients with primary biliary cirrhosis. Hepatology 1997; 26:1123-30.
    • (1997) Hepatology , vol.26 , pp. 1123-1130
    • Züchner, D.1    Sternsdorf, T.2    Szostecki, C.3    Heathcote, E.J.4    Cauch-Dudek, K.5    Will, H.6
  • 27
    • 0029942408 scopus 로고    scopus 로고
    • Specificity and sensitivity of gp210 autoantibodies detected using an enzyme-linked immunosorbent assay and a synthetic polypeptide in the diagnosis of primary biliary cirrhosis
    • Bandin O, Courvalin JC, Poupon R, Dubel L, Homberg JC, Johanet C. Specificity and sensitivity of gp210 autoantibodies detected using an enzyme-linked immunosorbent assay and a synthetic polypeptide in the diagnosis of primary biliary cirrhosis. Hepatology 1996; 23:1020-4.
    • (1996) Hepatology , vol.23 , pp. 1020-1024
    • Bandin, O.1    Courvalin, J.C.2    Poupon, R.3    Dubel, L.4    Homberg, J.C.5    Johanet, C.6
  • 28
    • 0028987045 scopus 로고
    • Detection of Gp210 autoantibodies in primary biliary cirrhosis using a recombinant protein containing the predominant autoepitope
    • Tartakovsky F. Detection of Gp210 autoantibodies in primary biliary cirrhosis using a recombinant protein containing the predominant autoepitope. Hepatology 1995; 21:495-500.
    • (1995) Hepatology , vol.21 , pp. 495-500
    • Tartakovsky, F.1
  • 29
    • 34848888965 scopus 로고    scopus 로고
    • Comparison of two ELISA assays for anti-Sp100 determination
    • Manuel Lucena J, Montes Cano M, Luis Caro J etal. Comparison of two ELISA assays for anti-Sp100 determination. Ann NY Acad Sci 2007; 1109:203-11.
    • (2007) Ann NY Acad Sci , vol.1109 , pp. 203-211
    • Manuel Lucena, J.1    Montes Cano, M.2    Luis Caro, J.3
  • 30
    • 0026713520 scopus 로고
    • Autoantibodies to the nuclear Sp100 protein in primary biliary cirrhosis and associated diseases: epitope specificity and immunoglobulin class distribution
    • Szostecki C, Will H, Netter HJ, Guldner HH. Autoantibodies to the nuclear Sp100 protein in primary biliary cirrhosis and associated diseases: epitope specificity and immunoglobulin class distribution. Scand J Immunol 1992; 36:555-64.
    • (1992) Scand J Immunol , vol.36 , pp. 555-564
    • Szostecki, C.1    Will, H.2    Netter, H.J.3    Guldner, H.H.4
  • 31
    • 72949093141 scopus 로고    scopus 로고
    • Deletion of interleukin-12p40 suppresses autoimmune cholangitis in dominant negative transforming growth factor beta receptor type II mice
    • Yoshida K, Yang G-X, Zhang W etal. Deletion of interleukin-12p40 suppresses autoimmune cholangitis in dominant negative transforming growth factor beta receptor type II mice. Hepatology 2009; 50:1494-500.
    • (2009) Hepatology , vol.50 , pp. 1494-1500
    • Yoshida, K.1    Yang, G.-X.2    Zhang, W.3
  • 32
  • 33
    • 21844444831 scopus 로고    scopus 로고
    • New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions
    • Hunter CA. New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions. Nat Rev Immunol 2005; 5:521-31.
    • (2005) Nat Rev Immunol , vol.5 , pp. 521-531
    • Hunter, C.A.1
  • 34
    • 0344389016 scopus 로고    scopus 로고
    • Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis
    • Matusevicius D, Kivisäkk P, He B etal. Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis. Mult Scler 1999; 5:101-4.
    • (1999) Mult Scler , vol.5 , pp. 101-104
    • Matusevicius, D.1    Kivisäkk, P.2    He, B.3
  • 35
    • 0033083111 scopus 로고    scopus 로고
    • IL-17 is produced by some proinflammatory Th1/Th0 cells but not by Th2 cells
    • Aarvak T, Chabaud M, Miossec P. IL-17 is produced by some proinflammatory Th1/Th0 cells but not by Th2 cells. J Immunol 1999; 162:1246-51.
    • (1999) J Immunol , vol.162 , pp. 1246-1251
    • Aarvak, T.1    Chabaud, M.2    Miossec, P.3
  • 36
    • 33750282677 scopus 로고    scopus 로고
    • The IL-23/Th(17) axis: therapeutic targets for autoimmune inflammation
    • Kikly K, Liu L, Na S, Sedgwick JD. The IL-23/Th(17) axis: therapeutic targets for autoimmune inflammation. Curr Opin Immunol 2006; 18:670-5.
    • (2006) Curr Opin Immunol , vol.18 , pp. 670-675
    • Kikly, K.1    Liu, L.2    Na, S.3    Sedgwick, J.D.4
  • 37
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli E, Carrier Y, Gao W etal. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006; 441:235-8.
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3
  • 38
    • 71649095850 scopus 로고    scopus 로고
    • Serum inflammatory cytokines, complement components, and soluble interleukin 2 receptor in primary biliary cirrhosis
    • Barak V, Selmi C, Schlesinger M etal. Serum inflammatory cytokines, complement components, and soluble interleukin 2 receptor in primary biliary cirrhosis. J Autoimmun 2009; 33:178-82.
    • (2009) J Autoimmun , vol.33 , pp. 178-182
    • Barak, V.1    Selmi, C.2    Schlesinger, M.3
  • 39
    • 0033452028 scopus 로고    scopus 로고
    • Cytokine profile in the liver of primary biliary cirrhosis
    • Nagano T, Yamamoto K, Matsumoto S etal. Cytokine profile in the liver of primary biliary cirrhosis. J Clin Immunol 1999; 19:422-7.
    • (1999) J Clin Immunol , vol.19 , pp. 422-427
    • Nagano, T.1    Yamamoto, K.2    Matsumoto, S.3
  • 40
    • 0033054811 scopus 로고    scopus 로고
    • The tumor necrosis factor-alpha promoter correlates with progression of primary biliary cirrhosis
    • Tanaka A, Quaranta S, Mattalia A etal. The tumor necrosis factor-alpha promoter correlates with progression of primary biliary cirrhosis. J Hepatol 1999; 30:826-9.
    • (1999) J Hepatol , vol.30 , pp. 826-829
    • Tanaka, A.1    Quaranta, S.2    Mattalia, A.3
  • 41
    • 77954227129 scopus 로고    scopus 로고
    • Deletion of interleukin-6 in mice with the dominant negative form of transforming growth factor beta receptor II improves colitis but exacerbates autoimmune cholangitis
    • Zhang W, Tsuda M, Yang G-X etal. Deletion of interleukin-6 in mice with the dominant negative form of transforming growth factor beta receptor II improves colitis but exacerbates autoimmune cholangitis. Hepatology 2010; 52:215-22.
    • (2010) Hepatology , vol.52 , pp. 215-222
    • Zhang, W.1    Tsuda, M.2    Yang, G.-X.3
  • 42
    • 0023851809 scopus 로고
    • The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells
    • Muraguchi A, Hirano T, Tang B etal. The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells. J Exp Med 1988; 167:332-44.
    • (1988) J Exp Med , vol.167 , pp. 332-344
    • Muraguchi, A.1    Hirano, T.2    Tang, B.3
  • 43
    • 0022499547 scopus 로고
    • Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin
    • Hirano T, Yasukawa K, Harada H etal. Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature 1986; 324:73-6.
    • (1986) Nature , vol.324 , pp. 73-76
    • Hirano, T.1    Yasukawa, K.2    Harada, H.3
  • 44
    • 60449119927 scopus 로고    scopus 로고
    • B cells suppress the inflammatory response in a mouse model of primary biliary cirrhosis
    • Moritoki Y, Zhang W, Tsuneyama K etal. B cells suppress the inflammatory response in a mouse model of primary biliary cirrhosis. Gastroenterology 2009; 136:1037-47.
    • (2009) Gastroenterology , vol.136 , pp. 1037-1047
    • Moritoki, Y.1    Zhang, W.2    Tsuneyama, K.3
  • 45
    • 34249886050 scopus 로고    scopus 로고
    • Interpreting serological tests in diagnosing autoimmune liver diseases
    • Invernizzi P, Lleo A, Podda M. Interpreting serological tests in diagnosing autoimmune liver diseases. Semin Liver Dis 2007; 27:161-72.
    • (2007) Semin Liver Dis , vol.27 , pp. 161-172
    • Invernizzi, P.1    Lleo, A.2    Podda, M.3
  • 46
    • 33845474743 scopus 로고    scopus 로고
    • Antinuclear antibodies giving the 'multiple nuclear dots' or the 'rim-like/membranous' patterns: diagnostic accuracy for primary biliary cirrhosis
    • Granito A, Muratori P, Muratori L etal. Antinuclear antibodies giving the 'multiple nuclear dots' or the 'rim-like/membranous' patterns: diagnostic accuracy for primary biliary cirrhosis. Aliment Pharmacol Ther 2006; 24:1575-83.
    • (2006) Aliment Pharmacol Ther , vol.24 , pp. 1575-1583
    • Granito, A.1    Muratori, P.2    Muratori, L.3
  • 48
    • 0037282886 scopus 로고    scopus 로고
    • Positive markers in AMA-negative PBC
    • Bogdanos D. Positive markers in AMA-negative PBC. Am J Gastroenterol 2003; 98:241-3.
    • (2003) Am J Gastroenterol , vol.98 , pp. 241-243
    • Bogdanos, D.1
  • 49
    • 67649656293 scopus 로고    scopus 로고
    • Multiple nuclear dots and rim-like/membranous IgG isotypes in primary biliary cirrhosis
    • Muratori P, Granito A, Ferri S etal. Multiple nuclear dots and rim-like/membranous IgG isotypes in primary biliary cirrhosis. Autoimmunity 2009; 42:224-7.
    • (2009) Autoimmunity , vol.42 , pp. 224-227
    • Muratori, P.1    Granito, A.2    Ferri, S.3
  • 50
    • 43049165565 scopus 로고    scopus 로고
    • Antimitochondrial antibodies and other antibodies in primary biliary cirrhosis: diagnostic and prognostic value
    • Muratori L, Granito A, Muratori P, Pappas G, Bianchi FB. Antimitochondrial antibodies and other antibodies in primary biliary cirrhosis: diagnostic and prognostic value. Clin Liver Dis 2008; 12:261-76, vii.
    • (2008) Clin Liver Dis , vol.12 , Issue.7 , pp. 261-276
    • Muratori, L.1    Granito, A.2    Muratori, P.3    Pappas, G.4    Bianchi, F.B.5
  • 51
    • 15444366750 scopus 로고    scopus 로고
    • Prevalence and clinical significance of isotype specific antinuclear antibodies in primary biliary cirrhosis
    • Rigopoulou EI, Davies ET, Pares A etal. Prevalence and clinical significance of isotype specific antinuclear antibodies in primary biliary cirrhosis. Gut 2005; 54:528-32.
    • (2005) Gut , vol.54 , pp. 528-532
    • Rigopoulou, E.I.1    Davies, E.T.2    Pares, A.3
  • 52
    • 0036179108 scopus 로고    scopus 로고
    • Anti-multiple nuclear dots (anti-MND) and anti-SP100 antibodies in hepatic and rheumatological disorders
    • Muratori P, Muratori L, Cassani F etal. Anti-multiple nuclear dots (anti-MND) and anti-SP100 antibodies in hepatic and rheumatological disorders. Clin Exp Immunol 2002; 127:172-5.
    • (2002) Clin Exp Immunol , vol.127 , pp. 172-175
    • Muratori, P.1    Muratori, L.2    Cassani, F.3
  • 53
  • 54
    • 77954423957 scopus 로고    scopus 로고
    • Autoantibodies as prognostic markers in autoimmune liver disease
    • Czaja AJ. Autoantibodies as prognostic markers in autoimmune liver disease. Dig Dis Sci 2010; 55:2144-61.
    • (2010) Dig Dis Sci , vol.55 , pp. 2144-2161
    • Czaja, A.J.1
  • 55
    • 31344445698 scopus 로고    scopus 로고
    • Increased expression of nuclear envelope gp210 antigen in small bile ducts in primary biliary cirrhosis
    • Nakamura M, Takii Y, Ito M etal. Increased expression of nuclear envelope gp210 antigen in small bile ducts in primary biliary cirrhosis. J Autoimmun 2006; 26:138-45.
    • (2006) J Autoimmun , vol.26 , pp. 138-145
    • Nakamura, M.1    Takii, Y.2    Ito, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.