Multiple nuclear dots and rim-like/membranous IgG isotypes in primary biliary cirrhosis

Autoimmunity

Volumn 42, Issue 3, 2009, Pages 224-227

  Muratori, Paolo ^a   Granito, Alessandro ^a   Ferri, Silvia ^a   Pappas, Georgios ^a   Volta, Umberto ^a   Menichella, Rita ^a   Bianchi, Francesco ^a   Lenzi, Marco ^a   Muratori, Luigi ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Autoimmune liver disease; Immunoglobulins; Multiple nuclear dots; Primary biliary cirrhosis; Rim like membranous

Indexed keywords

IMMUNOGLOBULIN CLASS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN G4; MITOCHONDRION ANTIBODY; URSODEOXYCHOLIC ACID; ANTINUCLEAR ANTIBODY; AUTOANTIBODY; IMMUNOGLOBULIN M;

ADULT; AGED; ANAMNESIS; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; HEP 2 CELL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; MAJOR CLINICAL STUDY; PHYSICAL EXAMINATION; PRIMARY BILIARY CIRRHOSIS; PROGNOSIS; SENSITIVITY AND SPECIFICITY; SEROLOGY; WESTERN BLOTTING; BILIARY CIRRHOSIS; BLOOD; IMMUNOLOGY; MIDDLE AGED; MITOCHONDRION;

ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES, ANTINUCLEAR; AUTOANTIBODIES; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN ISOTYPES; IMMUNOGLOBULIN M; LIVER CIRRHOSIS, BILIARY; MIDDLE AGED; MITOCHONDRIA;

EID: 67649656293     PISSN: 08916934     EISSN: 1607842X     Source Type: Journal    
DOI: 10.1080/08916930802709133     Document Type: Article

References (22)

1. Kaplan, MM and Gerschwin, ME (2005) Primary biliary cirrhosis. N Engl J Med, 353, pp. 1261-1273.
2. Bogdanos, DP, Baum, H. and Vergani, D. (2003) Antimitochondrial and other autoantibodies. Clin Liver Dis, 7:4, pp. 759-777.
3. Muratori, L., Granito, A., Muratori, P., Pappas, G. and Bianchi, FB (2008) Antimitochondrial antibodies and other antibodies in primary biliary cirrhosis: Diagnostic and prognostic value. Clin Liver Dis, 12:2, pp. 261-276.
4. Meda, F., Zuin, M., Invernizzi, P., Vergani, D. and Selmi, C. (2008) Serum autoantibodies: A road map for the clinical hepatologist. Autoimmunity, pp. 27-34.
5. Szostecki, C., Guldner, HH and Will, H. (1997) Autoantibodies against "nuclear dots" in primary biliary cirrhosis. Semin Liver Dis, 17, pp. 71-78.
6. Nickowitz, RE, Wozniak, RW Schaffner, F. et al. (1994) Autoantibodies against integral membrane proteins of the nuclear envelope in patients with primary biliary cirrhosis. Gastroenterology, 106, pp. 193-199.
7. Muratori, P., Muratori, L., Ferrari, R., Cassani, F., Bianchi, G., Lenzi, M., Rodrigo, L., Linares, A., Fuentes, D. and Bianchi, FB (2003) Characterization and clinical impact of antinuclear antibodies in primary biliary cirrhosis. Am J Gastroenterol, 98:2, pp. 431-437.
8. Szostecki, C., Krippner, H. Penner, E. et al. (1987) Autoimmune sera recognize a 100 kD nuclear protein antigen (sp-100). Clin Exp Immunol, 68, pp. 108-116.
9. Sternsdorf, T., Guldner, HH Szostecki, C. et al. (1995) Two nuclear dot-associated proteins, PML and Sp100, are often co-autoimmunogenic in patients with primary biliary cirrhosis. Scand J Immunol, 42, pp. 257-268.
10. Lassoued, K., Brenard, R. Degos, F. et al. (1990) Antinuclear antibodies directed to a 200-kilodalton polypeptide of the nuclear envelope in primary biliary cirrhosis. A clinical and immunological study of a series of 150 patients with primary biliary cirrhosis. Gastroenterology, 99, pp. 181-186.
11. Courvalin, JC, Lassoued, K. Bartnik, E. et al. (1990) The 210-kD nuclear envelope polipeptide recognized by human autoantibodies in primary biliary cirrhosis is the major glycoprotein of the nuclear pore. J Clin Invest, 86, pp. 279-285.
12. Courvalin, JC, Lassoued, K. Worman, HJ et al. (1990) Identification and characterization of autoantibodies against the nuclear envelope lamin B receptor from patients with primary biliary cirrhosis. J Exp Med, 172, pp. 961-967.
13. Lozano, F., Pares, A. Borche, L. et al. (1988) Autoantibodies against nuclear envelope-associated proteins in primary biliary cirrhosis. Hepatology, 8, pp. 930-938.
14. Bandin, O., Courvalin, JC Poupon, R. et al. (1996) Specificity and sensitivity of gp210 autoantibodies detected using an enzyme-linked immunosorbent assay and a synthetic polypeptide in the diagnosis of primary biliary cirrhosis. Hepatology, 23, pp. 1020-1024.
15. Invernizzi, P., Podda, M., Battezzati, PM, Crosignani, A., Zuin, M., Hitchman, E., Maggioni, M., Meroni, PL, Penner, E. and Wesierska-Gadek, J. (2001) Autoantibodies against nuclear pore complexes are associated with more active and severe liver disease in primary biliary cirrhosis. J Hepatol, 34:3, pp. 366-372.
16. Rigopoulou, EI, Davies, ET, Pares, A., Zachou, K., Liaskos, C., Bogdanos, DP, Rodes, J., Dalekos, GN and Vergani, D. (2005) Prevalence and clinical significance of isotype specific antinuclear antibodies in primary biliary cirrhosis. Gut, 54:4, pp. 528-532.
17. Powell, F., Schroeter, AL and Dickson, ER (1984) Antinuclear antibodies in primary biliary cirrhosis. Lancet, 1, pp. 288-289.
18. Muratori, P., Muratori, L., Cassani, F., Terlizzi, P., Lenzi, M., Rodrigo, L. and Bianchi, FB (2002) Anti-multiple nuclear dots (anti-MND) and anti-SP100 antibodies in hepatic and rheumatological disorders. Clin Exp Immunol, 127:1, pp. 172-175.
19. Heathcote, EJ (2000) Management of primary biliary cirrhosis. The American Association for the Study of Liver Diseases practice guidelines. Hepatology, 31, pp. 1005-1013.
20. Michieletti, P., Wanless, IR Katz, A. et al. (1994) Antimitochondrial antibody negative primary biliary cirrhosis: A distinct syndrome of autoimmune cholangitis. Gut, 35, pp. 260-265.
21. Bogdanos, DP, Vergani, D., Muratori, P., Muratori, L. and Bianchi, FB (2004) Specificity of anti-sp100 antibody for primary biliary cirrhosis. Scand J Gastroenterol, 39, pp. 405-406.
22. Granito, A., Muratori, P., Muratori, L., Pappas, G., Cassani, F., Worthington, J., Guidi, M., Ferri, S., DE Molo, C., Lenzi, M., Chapman, RW and Bianchi, FB (2006) Antinuclear antibodies giving the 'multiple nuclear dots' or the 'rim-like/membranous' patterns: Diagnostic accuracy for primary biliary cirrhosis. Aliment Pharmacol Ther, 24, pp. 1575-1583.