Stimulation of adenosine A 2B receptors induces interleukin-6 secretion in cardiac fibroblasts via the PKC-δ-P38 signalling pathway

British Journal of Pharmacology

Volumn 159, Issue 8, 2010, Pages 1598-1607

  Feng, Wei ^a   Song, Yao ^a   Chen, Chao ^a   Lu, Zhi Zhen ^a   Zhang, Youyi ^a  

^a PEKING UNIVERSITY THIRD HOSPITAL   (China)

Author keywords

A 2b adenosine receptors; Cardiac fibroblasts; Il 6; Pkc

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 1,4 DIHYDRO 2 METHYL 6 PHENYL 4 (2 PHENYLETHYNYL) 3,5 PYRIDINEDICARBOXYLIC ACID 5 BENZYL 3 ETHYL ESTER; 12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 5 AMINO 2 (2 FURYL) 7 (2 PHENYLETHYL)PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; 6 N (3 IODOBENZYL)ADENOSINE 5' N METHYLCARBOXAMIDE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE A2B RECEPTOR; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; INTERLEUKIN 6; KT 5720; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; N (4 CYANOPHENYL) 2 [4 (2,3,6,7 TETRAHYDRO 2,6 DIOXO 1,3 DIPROPYL 1H PURIN 8 YL)PHENOXY]ACETAMIDE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PROTEIN KINASE C DELTA; PROTEIN KINASE C INHIBITOR; STRESS ACTIVATED PROTEIN KINASE; UO 126;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROBLAST; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

ADENOSINE-5'-(N-ETHYLCARBOXAMIDE); ANIMALS; BASE SEQUENCE; CELLS, CULTURED; DNA PRIMERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBROBLASTS; IMIDAZOLES; INTERLEUKIN-6; MALE; MICE; MICE, INBRED BALB C; MICROSCOPY, FLUORESCENCE; MYOCARDIUM; NIH 3T3 CELLS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN KINASE C-DELTA; PYRIDINES; RECEPTOR, ADENOSINE A2B; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 77950203301     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00558.x     Document Type: Article

References (38)

1. Alexander SP, Mathie A, Peters JA (2008). Guide to Receptors and Channels (GRAC), 3rd edn. Br J Pharmacol 153 (Suppl. 2 S1 S209.
2. Ashton KJ, Peart JN, Morrison RR, Matherne GP, Blackburn MR, Headrick JP (2007). Genetic modulation of adenosine receptor function and adenosine handling in murine hearts: insights and issues. J Mol Cell Cardiol 42 (4 693 705.
3. Carapau D, Kruhofer M, Chatalbash A, Orengo JM, Mota MM, Rodriguez A (2007). Transcriptome profile of dendritic cells during malaria: cAMP regulation of IL-6. Cell Microbiol 9 (7 1738 1752.
4. Chen L, Hahn H, Wu G, Chen CH, Liron T, Schechtman D et al. (2001). Opposing cardioprotective actions and parallel hypertrophic effects of delta PKC and epsilon PKC. Proc Natl Acad Sci USA 98 (20 11114 11119.
5. Chio CC, Chang YH, Hsu YW, Chi KH, Lin WW (2004). PKA-dependent activation of PKC, p38 MAPK and IKK in macrophage: implication in the induction of inducible nitric oxide synthase and interleukin-6 by dibutyryl cAMP. Cell Signal 16 (5 565 575.
6. Epperson SA, Brunton LL, Ramirez-Sanchez I, Villarreal F (2009). Adenosine receptors and second messenger signaling pathways in rat cardiac fibroblasts. Am J Physiol Cell Physiol 296 (5 C1171 C1177.
7. Evans BA, Elford C, Pexa A, Francis K, Hughes AC, Deussen A et al. (2006). Human osteoblast precursors produce extracellular adenosine, which modulates their secretion of IL-6 and osteoprotegerin. J Bone Miner Res 21 (2 228 236.
8. 2B receptors. Pharmacol Rev 49 (4 381 402.
9. Feoktistov I, Goldstein AE, Biaggioni I (1999). Role of p38 mitogen-activated protein kinase and extracellular signal-regulated protein kinase kinase in adenosine A2B receptor-mediated interleukin-8 production in human mast cells. Mol Pharmacol 55 (4 726 734.
10. Fiebich BL, Biber K, Gyufko K, Berger M, Bauer J, van Calker, D (1996). Adenosine A2b receptors mediate an increase in interleukin (IL)-6 mRNA and IL-6 protein synthesis in human astroglioma cells. J Neurochem 66 (4 1426 1431.
11. 2B receptor stimulation in U373 MG cells depends on p38 mitogen activated kinase and protein kinase C. Neurochem Int 46 (6 501 512.
12. Fredholm BB, IJzerman AP, Jacobson KA, Klotz KN, Linden J (2001). International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol Rev 53 (4 527 552.
13. Funaya H, Kitakaze M, Node K, Minamino T, Komamura K, Hori M (1997). Plasma adenosine levels increase in patients with chronic heart failure. Circulation 95 (6 1363 1365.
14. He TC, Zhou S, da Costa LT, Yu J, Kinzler KW, Vogelstein B (1998). A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci USA 95 (5 2509 2514.
15. Jacobson KA, Gao ZG (2006). Adenosine receptors as therapeutic targets. Nat Rev Drug Discov 5 (3 247 264.
16. Kanda T, Takahashi T (2004). Interleukin-6 and cardiovascular diseases. Jpn Heart J 45 (2 183 193.
17. Kim YC, Ji X, Melman N, Linden J, Jacobson KA (2000). Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A(2B) adenosine receptors. J Med Chem 43 (6 1165 1172.
18. Kiriyama Y, Murayama T, Tokumitsu Y, Nomura Y (1997). Protein kinase A-dependent IL-6 production induced by calcitonin in human glioblastoma A172 cells. J Neuroimmunol 76 (1-2 139 144.
19. MacGowan GA, Mann DL, Kormos RL, Feldman AM, Murali S (1997). Circulating interleukin-6 in severe heart failure. Am J Cardiol 79 (8 1128 1131.
20. Martiny-Baron G, Kazahietz MG, Mischak H, Blumberg PM, Kochs G, Hug H et al. (1993). Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976. J Biol Chem 268 (13 9194 9197.
21. Nelson AR, Borland L, Allbritton NL, Sims CE (2007). Myristoyl-based transport of peptides into living cells. Biochemistry 46 (51 14771 14781.
22. Ohnishi A, Li P, Branch RA, Biaggioni IO, Jackson EK (1988). Adenosine in renin-dependent renovascular hypertension. Hypertension 12 (2 152 161.
23. Rees DA, Lewis BM, Lewis MD, Francis K, Scanlon MF, Ham J (2003). Adenosine-induced IL-6 expression in pituitary folliculostellate cells is mediated via A2b adenosine receptors coupled to PKC and p38 MAPK. Br J Pharmacol 140 (4 764 772.
24. Roig E, Orus J, Pare C, Azqueta M, Filella X, Perez-Villa F et al. (1998). Serum interleukin-6 in congestive heart failure secondary to idiopathic dilated cardiomyopathy. Am J Cardiol 82 (5 688 690, A8.
25. Ryzhov S, Zaynagetdinov R, Goldstein AE, Novitskiy SV, Blackburn MR, Biaggioni I et al. (2008). Effect of A2B adenosine receptor gene ablation on adenosine-dependent regulation of proinflammatory cytokines. J Pharmacol Exp Ther 324 (2 694 700.
26. Schulte G, Fredholm BB (2003). The G(s)-coupled adenosine A(2B) receptor recruits divergent pathways to regulate ERK1/2 and p38. Exp Cell Res 290 (1 168 176.
27. Schwaninger M, Neher M, Viegas E, Schneider A, Spranger M (1997). Stimulation of interleukin-6 secretion and gene transcription in primary astrocytes by adenosine. J Neurochem 69 (3 1145 1150.
28. Tsutamoto T, Hisanaga T, Wada A, Maeda K, Ohnishi M, Fukai D et al. (1998). Interleukin-6 spillover in the peripheral circulation increases with the severity of heart failure, and the high plasma level of interleukin-6 is an important prognostic predictor in patients with congestive heart failure. J Am Coll Cardiol 31 (2 391 398.
29. Vazquez JF, Clement HW, Sommer O, Schulz E, van Calker D (2008). Local stimulation of the adenosine A2B receptors induces an increased release of IL-6 in mouse striatum: an in vivo microdialysis study. J Neurochem 105 (3 904 909.
30. Wan S, DeSmet JM, Barvais L, Goldstein M, Vincent JL, LeClerc JL (1996). Myocardium is a major source of proinflammatory cytokines in patients undergoing cardiopulmonary bypass. J Thorac Cardiovasc Surg 112 (3 806 811.
31. Ward NE, O'Brian CA (1993). Inhibition of protein kinase C by N-myristoylated peptide substrate analogs. Biochemistry 32 (44 11903 11909.
32. Yamada K, Goto A, Ishii M, Yoshioka M, Matsuoka H, Sugimoto T (1992). Plasma adenosine concentrations are elevated in conscious spontaneously hypertensive rats. Clin Exp Pharmacol Physiol 19 (8 563 567.
33. Yamada K, Goto A, Ishii M, Yoshioka M, Sugimoto T (1995). Plasma adenosine concentrations are elevated in Dahl salt-sensitive rats. Experientia 51 (3 227 229.
34. Yeo EJ, Exton JH (1995). Stimulation of phospholipase D by epidermal growth factor requires protein kinase C activation in Swiss 3T3 cells. J Biol Chem 270 (8 3980 3988.
35. Yin F, Li P, Zheng M, Chen L, Xu Q, Chen K et al. (2003). Interleukin-6 family of cytokines mediates isoproterenol-induced delayed STAT3 activation in mouse heart. J Biol Chem 278 (23 21070 21075.
36. Zhao LJ, Jian H, Zhu H (2003). Specific gene inhibition by adenovirus-mediated expression of small interfering RNA. Gene 316 : 137 141.
37. Zhong H, Belardinelli L, Maa T, Feoktistov I, Biaggioni I, Zeng D (2004). A(2B) adenosine receptors increase cytokine release by bronchial smooth muscle cells. Am J Respir Cell Mol Biol 30 (1 118 125.
38. Zhong H, Belardinelli L, Maa T, Zeng D (2005). Synergy between A2B adenosine receptors and hypoxia in activating human lung fibroblasts. Am J Respir Cell Mol Biol 32 (1 2 8.