Identification of novel isocytosine derivatives as xanthine oxidase inhibitors from a set of virtual screening hits

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 9, 2012, Pages 2930-2939

  B Rao, Chandrika ^a   Kulkarni Almeida, Asha ^a   Katkar, Kamlesh V ^a   Khanna, Smriti ^a   Ghosh, Usha ^a   Keche, Ashish ^a   Shah, Pranay ^a   Srivastava, Ankita ^a   Korde, Vaidehi ^a   Nemmani, Kumar V S ^a   Deshmukh, Nitin J ^a   Dixit, Amol ^a   Brahma, Manoja K ^a   Bahirat, Umakant ^a   Doshi, Lalit ^a   Sharma, Rajiv ^a   Sivaramakrishnan, H ^a  

^a Piramal Enterprises Limited   (India)

Author keywords

Docking; Hit identification; Isocytosine; Virtual screening; Xanthine oxidase inhibitors

Indexed keywords

2 AMINO 6 (3,4 DIMETHOXYPHENYL)PYRIMIDIN 4 OL; 2 AMINO 6 (3,4 DIMETHOXYPHENYL)PYRIMIDINE 4 THIOL; 2 AMINO 6 (4 METHOXYPHENYL)PYRIMIDIN 4 OL; 2,4 DICHLORO 6 (4 METHOXYPHENYL)PYRIMIDINE; 4 CHLORO 6 (4 METHOXYPHENYL) 2 PYRIMIDINAMINE; 4 METHOXY 6 (4 METHOXYPHENYL)2 PYRIMIDINAMINE; 6 (4 METHOXYPHENYL) 2,4 PYRIMIDINEDIAMINE; 6 (4 METHOXYPHENYL) 2,4 PYRIMIDINEDIOL; ALLOPURINOL; CYTOSINE DERIVATIVE; FEBUXOSTAT; ISOCYTOSINE DERIVATIVE; MOLECULAR SCAFFOLD; N [2 AMINO 6 (4 METHOXYPHENYL) 4 PYRIMIDIN YL]METHANESULFONAMIDE; UNCLASSIFIED DRUG; URIC ACID; XANTHINE OXIDASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING; DRUG EFFECT; DRUG MECHANISM; DRUG SCREENING; ENZYME INHIBITION; HIGH THROUGHPUT SCREENING; HYDROGEN BOND; HYPERURICEMIA; IC 50; IN VITRO STUDY; IN VIVO STUDY; MALE; MOLECULAR DOCKING; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; URIC ACID BLOOD LEVEL; VIRTUAL REALITY;

ANIMALS; COMPUTER SIMULATION; CYTOSINE; ENZYME ACTIVATION; ENZYME INHIBITORS; HYPERURICEMIA; MALE; OXONIC ACID; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; XANTHINE OXIDASE;

EID: 84859914042     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.03.019     Document Type: Article

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