Synthesis of some 5-phenylisoxazole-3-carboxylic acid derivatives as potent xanthine oxidase inhibitors

European Journal of Medicinal Chemistry

Volumn 45, Issue 6, 2010, Pages 2663-2670

  Wang, Shaojie ^a   Yan, Jufang ^b   Wang, Jian ^a   Chen, Jiarun ^a   Zhang, Tingjian ^a   Zhao, Yong ^a   Xue, Mingxing ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b Drug Screening Center   (China)

Author keywords

5 Phenylisoxazole 3 carboxylic acid; Synthesis; Xanthine oxidase inhibitor

Indexed keywords

1 (4 BENZYLOXY 3 IODOPHENYL)ETHANONE; 1 (4 BENZYLOXY 3 NITROPHENYL)ETHANONE; 1 (4 HYDROXY 3 IODOPHENYL)ETHANONE; 1 (4 ISOBUTOXY 3 IODOPHENYL)ETHANONE; 1 (4 ISOBUTYLOXY 3 NITROPHENYL)ETHANONE; 1 [3 IODO 4 (4 METHYLBENZYLOXY) PHENYL]ETHANONE; 1 [4 (4 CHLOROBENZYLOXY) 3 IODOPHENYL]ETHANONE; 1 [4 (4 CHLOROBENZYLOXY) 3 NITROPHENYL]ETHANONE; 1 [4 (4 METHYLBENZYLOXY) 3 NITROPHENYL]ETHANONE; 1 [4 (4 TERT BUTYLBENZYLOXY) 3 IODOPHENYL]ETHANONE; 1 [4 (4 TERT BUTYLBENZYLOXY) 3 NITROPHENYL]ETHANONE; 5 (4 BENZYLOXY 3 NITROPHENYL)ISOXAZOLE 3 CARBOXYLIC ACID; 5 (4 ISOBUTOXY 3 NITROPHENYL)ISOXAZOLE 3 CARBOXYLIC ACID; 5 [4 (4 CHLOROBENZYLOXY) 3 NITROPHENYL]ISOXAZOLE 3 CARBOXYLICYLIC ACID; 5 [4 (4 METHYLBENZYLOXY) 3 NITROPHENYL]ISOXAZOLE 3 CARBOXYLIC ACID; 5 [4 (4 TERT BUTYLBENZYLOXY) 3 NITROPHENYL]ISOXAZOLE 3 CARBOXYLIC ACID; CARBOXYLIC ACID DERIVATIVE; ETHYL 2 HYDROXY 4 (4 ISOBUTOXY 3 NITROPHENYL) 4 OXOBUT 2 ENOATE; ETHYL 2 HYDROXY 4 [4 (4 METHYLBENZYLOXY) 3 NITROPHENYL] 4 OXOBUT 2 ENOATE; ETHYL 4 (4 BENZYLOXY 3 NITROPHENYL) 2 HYDROXY 4 OXOBUT 2 ENOATE; ETHYL 4 [4 (4 CHLOROBENZYLOXY) 3 NITROPHENYL] 2 HYDROXY 4 OXOBUT 2 ENOATE; ETHYL 4 [4 (4 TERT BUTYLBENZYLOXY) 3 NITROPHENYL] 2 HYDROXY 4 OXOBUT 2 ENOATE; ETHYL 5 (4 BENZYLOXY 3 NITROPHENYL)ISOXAZOLE 3 CARBOXYLATE; ETHYL 5 (4 ISOBUTOXY 3 NITROPHENYL)ISOXAZOLE 3 CARBOXYLATE; ETHYL 5 [4 (4 CHLOROBENZYLOXY) 3 NITROPHENYL]ISOXAZOLE 3 CARBOXYLATE; ETHYL 5 [4 (4 METHYLBENZYLOXY) 3 NITROPHENYL]ISOXAZOLE 3 CARBOXYLATE; ETHYL 5 [4 (4 TERT BUTYLBENZYLOXY) 3 NITROPHENYL)]ISOXAZOLE 3 CARBOXYLATE; FEBUXOSTAT; UNCLASSIFIED DRUG; UNINDEXED DRUG; XANTHINE OXIDASE INHIBITOR;

ARTICLE; CONTROLLED STUDY; DRUG BINDING; DRUG DESIGN; DRUG SYNTHESIS; ENZYME BINDING; ENZYME INHIBITION; MOLECULAR MODEL;

ANIMALS; CARBOXYLIC ACIDS; CATTLE; ENZYME INHIBITORS; HUMANS; ISOXAZOLES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; XANTHINE OXIDASE;

EID: 77950863641     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.02.013     Document Type: Article

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