Expression of the G protein-coupled estrogen receptor (GPER) in endometriosis: a tissue microarray study

Reproductive Biology and Endocrinology

Volumn 10, Issue , 2012, Pages

  Samartzis, Nicolas ^a   Samartzis, Eleftherios P ^a   Noske, Aurelia ^b   Fedier, André ^a   Dedes, Konstantin J ^a   Caduff, Rosmarie ^b   Fink, Daniel ^a   Imesch, Patrick ^a  

^a UNIVERSITÄTSSPITAL ZÜRICH   (Switzerland)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Endometriosis; GPER; GPR30; Immunohistochemistry; Tissue microarray

Indexed keywords

ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; G PROTEIN COUPLED RECEPTOR 30; PROGESTERONE RECEPTOR;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; ENDOMETRIOSIS; EPITHELIUM CELL; FEMALE; HUMAN; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; MICROARRAY ANALYSIS; PROTEIN EXPRESSION; STROMA;

ADULT; ENDOMETRIOSIS; ENDOMETRIUM; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FEMALE; HUMANS; MIDDLE AGED; RECEPTORS, ESTROGEN; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, PROGESTERONE; RETROSPECTIVE STUDIES; TISSUE ARRAY ANALYSIS;

EID: 84859910799     PISSN: None     EISSN: 14777827     Source Type: Journal    
DOI: 10.1186/1477-7827-10-30     Document Type: Article

References (28)

1. Giudice LC, Kao LC. Endometriosis. Lancet 2004, 364:1789-1799. 10.1016/S0140-6736(04)17403-5, 15541453.
2. Bulun SE. Endometriosis. N Engl J Med 2009, 360:268-279. 10.1056/NEJMra0804690, 19144942.
3. Eskenazi B, Warner ML. Epidemiology of endometriosis. Obstet Gynecol Clin North Am 1997, 24:235-258. 10.1016/S0889-8545(05)70302-8, 9163765.
4. Giudice LC. Clinical practice. Endometriosis. N Engl J Med 2010, 362:2389-2398. 10.1056/NEJMcp1000274, 3108065, 20573927.
5. Prossnitz ER, Maggiolini M. Mechanisms of estrogen signaling and gene expression via GPR30. Mol Cell Endocrinol 2009, 308:32-38. 10.1016/j.mce.2009.03.026, 2847286, 19464786.
6. Maggiolini M, Picard D. The unfolding stories of GPR30, a new membrane-bound estrogen receptor. J Endocrinol 2010, 204:105-114. 10.1677/JOE-09-0242, 19767412.
7. Lin BC, Suzawa M, Blind RD, Tobias SC, Bulun SE, Scanlan TS, Ingraham HA. Stimulating the GPR30 estrogen receptor with a novel tamoxifen analogue activates SF-1 and promotes endometrial cell proliferation. Cancer Res 2009, 69:5415-5423. 10.1158/0008-5472.CAN-08-1622, 2756996, 19549922.
8. Revankar CM, Cimino DF, Sklar LA, Arterburn JB, Prossnitz ER. A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science 2005, 307:1625-1630. 10.1126/science.1106943, 15705806.
9. Prossnitz ER, Oprea TI, Sklar LA, Arterburn JB. The ins and outs of GPR30: a transmembrane estrogen receptor. J Steroid Biochem Mol Biol 2008, 109:350-353. 10.1016/j.jsbmb.2008.03.006, 2481563, 18406603.
10. He YY, Cai B, Yang YX, Liu XL, Wan XP. Estrogenic G protein-coupled receptor 30 signaling is involved in regulation of endometrial carcinoma by promoting proliferation, invasion potential, and interleukin-6 secretion via the MEK/ERK mitogen-activated protein kinase pathway. Cancer Sci 2009, 100:1051-1061. 10.1111/j.1349-7006.2009.01148.x, 19432902.
11. Bulun SE, Cheng YH, Pavone ME, Xue Q, Attar E, Trukhacheva E, Tokunaga H, Utsunomiya H, Yin P, Luo X, et al. Estrogen receptor-beta, estrogen receptor-alpha, and progesterone resistance in endometriosis. Semin Reprod Med 2010, 28:36-43. 10.1055/s-0029-1242991, 3073375, 20104427.
12. Kononen J, Bubendorf L, Kallioniemi A, Barlund M, Schraml P, Leighton S, Torhorst J, Mihatsch MJ, Sauter G, Kallioniemi OP. Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat Med 1998, 4:844-847. 10.1038/nm0798-844, 9662379.
13. Samartzis EP, Samartzis N, Noske A, Fedier A, Caduff R, Dedes KJ, Fink D, Imesch P. Loss of ARID1A/BAF250a-expression in endometriosis: a biomarker for risk of carcinogenic transformation?. Mod Pathol 2012, [Epub ahead of print]..
14. Remmele W, Stegner HE. Recommendation for uniform definition of an immunoreactive score (IRS) for immunohistochemical estrogen receptor detection (ER-ICA) in breast cancer tissue. Pathologe 1987, 8:138-140.
15. Ignatov T, Eggemann H, Semczuk A, Smith B, Bischoff J, Roessner A, Costa SD, Kalinski T, Ignatov A. Role of GPR30 in endometrial pathology after tamoxifen for breast cancer. Am J Obstet Gynecol 2010, 203:595-e599-516.
16. ASRM Revised American Society for Reproductive Medicine classification of endometriosis: 1996. Fertil Steril 1997, 67:817-821. 10.1016/S0015-0282(97)81391-X, 9130884, ASRM.
17. Bulun SE, Cheng YH, Pavone ME, Yin P, Imir G, Utsunomiya H, Thung S, Xue Q, Marsh EE, Tokunaga H, et al. 17Beta-hydroxysteroid dehydrogenase-2 deficiency and progesterone resistance in endometriosis. Semin Reprod Med 2010, 28:44-50. 10.1055/s-0029-1242992, 20108182.
18. Prossnitz ER, Arterburn JB, Sklar LA. GPR30: A G protein-coupled receptor for estrogen. Mol Cell Endocrinol 2007, 265-266:138-142.
19. Filardo E, Quinn J, Pang Y, Graeber C, Shaw S, Dong J, Thomas P. Activation of the novel estrogen receptor G protein-coupled receptor 30 (GPR30) at the plasma membrane. Endocrinology 2007, 148:3236-3245. 10.1210/en.2006-1605, 17379646.
20. Sakamoto H, Matsuda K, Hosokawa K, Nishi M, Morris JF, Prossnitz ER, Kawata M. Expression of G protein-coupled receptor-30, a G protein-coupled membrane estrogen receptor, in oxytocin neurons of the rat paraventricular and supraoptic nuclei. Endocrinology 2007, 148:5842-5850. 10.1210/en.2007-0436, 17872373.
21. Funakoshi T, Yanai A, Shinoda K, Kawano MM, Mizukami Y. G protein-coupled receptor 30 is an estrogen receptor in the plasma membrane. Biochem Biophys Res Commun 2006, 346:904-910. 10.1016/j.bbrc.2006.05.191, 16780796.
22. Kolkova Z, Noskova V, Ehinger A, Hansson S, Casslen B. G protein-coupled estrogen receptor 1 (GPER, GPR 30) in normal human endometrium and early pregnancy decidua. Mol Hum Reprod 2010, 16:743-751. 10.1093/molehr/gaq043, 20508064.
23. Madeo A, Maggiolini M. Nuclear alternate estrogen receptor GPR30 mediates 17beta-estradiol-induced gene expression and migration in breast cancer-associated fibroblasts. Cancer Res 2010, 70:6036-6046. 10.1158/0008-5472.CAN-10-0408, 20551055.
24. Cheng SB, Graeber CT, Quinn JA, Filardo EJ. Retrograde transport of the transmembrane estrogen receptor, G-protein-coupled-receptor-30 (GPR30/GPER) from the plasma membrane towards the nucleus. Steroids 2011, 76:892-896.
25. Wang A, Ji L, Shang W, Li M, Chen L, White RE, Han G. Expression of GPR30, ERalpha and ERbeta in endometrium during window of implantation in patients with polycystic ovary syndrome: a pilot study. Gynecol Endocrinol 2011, 27:251-255. 10.3109/09513590.2010.487584, 21269226.
26. Dennis MK, Burai R, Ramesh C, Petrie WK, Alcon SN, Nayak TK, Bologa CG, Leitao A, Brailoiu E, Deliu E, et al. In vivo effects of a GPR30 antagonist. Nat Chem Biol 2009, 5:421-427. 10.1038/nchembio.168, 2864230, 19430488.
27. Prossnitz ER, Arterburn JB, Smith HO, Oprea TI, Sklar LA, Hathaway HJ. Estrogen signaling through the transmembrane G protein-coupled receptor GPR30. Annu Rev Physiol 2008, 70:165-190. 10.1146/annurev.physiol.70.113006.100518, 18271749.
28. Filardo EJ, Quinn JA, Sabo E. Association of the membrane estrogen receptor, GPR30, with breast tumor metastasis and transactivation of the epidermal growth factor receptor. Steroids 2008, 73:870-873. 10.1016/j.steroids.2007.12.025, 18289622.