Synthesis, biological evaluation, and molecular docking studies of benzyl, alkyl and glycosyl [2-(arylamino)-4,4-dimethyl-6-oxo-cyclohex-1-ene] carbodithioates, as potential immunomodulatory and immunosuppressive agents

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 9, 2012, Pages 3000-3008

  El Ashry, El Sayed H ^a,b   Amer, Mohammad R ^a   Abdalla, Omer M ^a   Aly, Aly A ^c   Soomro, Samreen ^a   Jabeen, Almas ^a   Halim, Sobia Ahsan ^a   Ahmed Mesaik, M ^a   Ul Haq, Zaheer ^a  

^a UNIVERSITY OF KARACHI   (Pakistan)

^b Alexandria University Faculty Of Science   (Egypt)

^c BENHA UNIVERSITY   (Egypt)

Author keywords

Carbodithioate; Dimedone; Docking; Enamine; Glycosyl; Immunomodulatory; Immunosuppressive; Indazolethione

Indexed keywords

(2',3',4',6' TETRA O ACETYL BETA DEXTRO GALACTOPYRANOSYL) [2 (2,4 DICHLOROPHENYLAMINO) 4,4 DIMETHYL 6 OXOCYCLOHEX 1 ENE]CARBODITHIOIC ACID; (2',3',4',6' TETRA O ACETYL BETA DEXTRO GLUCOPYRANOSYL) [2 (2 CHLOROPHENYLAMINO) 4,4 DIMETHYL 6 OXOCYCLOHEX 1 ENE]CARBODITHIOIC ACID; (2',3',4',6' TETRA O ACETYL BETA DEXTRO GLUCOPYRANOSYL) [2 (2,4 DICHLOROPHENYLAMINO) 4,4 DIMETHYL 6 OXOCYCLOHEX 1 ENE]CARBODITHIOIC ACID; (2',3',4',6' TETRA O ACETYL BETA DEXTRO GLUCOPYRANOSYL) [2 (4 BROMOPHENYLAMINO) 4,4 DIMETHYL 6 OXOCYCLOHEX 1 ENE]CARBODITHIOIC ACID; 2 HYDROXYETHYL [2 (2,4 DICHLOROPHENYLAMINO) 4,4 DIMETHYL 6 OXOCYCLOHEX 1 ENE]CARBODITHIOIC ACID; 2 HYDROXYETHYL [2 (4 BROMOPHENYLAMINO) 4,4 DIMETHYL 6 OXOCYCLOHEX 1 ENE]CARBODITHIOIC ACID; 2 HYDROXYETHYL [2 (4 CHLOROPHENYLAMINO) 4,4 DIMETHYL 6 OXOCYCLOHEX 1 ENE]CARBODITHIOIC ACID; 6,6 DIMETHYL 4 [2 (PROPAN 2 YLIDENE)HYDRAZINYL] 6,7 DIHYDRO 2H INDAZOLE 3(5H) THIONE; 6,6 DIMETHYL 4 [2 (PROPAN 2 YLIDENE)HYDRAZINYL] 6,7 DIHYDRO 2H INDAZOLE 3(5H) THIONE DERIVATIVE; [2 (ARYLAMINO) 4,4 DIMETHYL 6 OXOCYCLOHEX 1 ENE]CARBODITHIOIC ACID DERIVATIVE; BENZYL [2 (2,4 DICHLOROPHENYLAMINO) 4,4 DIMETHYL 6 OXOCYCLOHEX 1 ENE]CARBODITHIOIC ACID; BENZYL [2 (4 BROMOPHENYLAMINO) 4,4 DIMETHYL 6 OXOCYCLOHEX 1 ENE]CARBODITHIOIC ACID; BENZYL [2 (4 CHLOROPHENYLAMINO) 4,4 DIMETHYL 6 OXOCYCLOHEX 1 ENE]CARBODITHIOIC ACID; IMMUNOMODULATING AGENT; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 1BETA; INTERLEUKIN 2; N BUTYL [2 (2,4 DICHLOROPHENYLAMINO) 4,4 DIMETHYL 6 OXOCYCLOHEX 1 ENE]CARBODITHIOIC ACID; N BUTYL [2 (4 BROMOPHENYLAMINO) 4,4 DIMETHYL 6 OXOCYCLOHEX 1 ENE]CARBODITHIOIC ACID; N BUTYL [2 (4 CHLOROPHENYLAMINO) 4,4 DIMETHYL 6 OXOCYCLOHEX 1 ENE]CARBODITHIOIC ACID; N UNDECANYL [2 (2,4 DICHLOROPHENYLAMINO) 4,4 DIMETHYL 6 OXOCYCLOHEX 1 ENE]CARBODITHIOIC ACID; N UNDECANYL [2 (4 BROMOPHENYLAMINO) 4,4 DIMETHYL 6 OXOCYCLOHEX 1 ENE]CARBODITHIOIC ACID; N UNDECANYL [2 (4 CHLOROPHENYLAMINO) 4,4 DIMETHYL 6 OXOCYCLOHEX 1 ENE]CARBODITHIOIC ACID; PHYTOHEMAGGLUTININ; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL PROLIFERATION; CELL STIMULATION; COMPUTER PROGRAM; CONCENTRATION RESPONSE; CYTOKINE PRODUCTION; DRUG CYTOTOXICITY; DRUG INHIBITION; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FIBROBLAST; HUMAN; HUMAN CELL; HYDROPHILICITY; HYDROPHOBICITY; IC 50; IMMUNOMODULATION; LIGAND BINDING; MACROPHAGE; MOLECULAR DOCKING; MOUSE; NONHUMAN; PHAGOCYTE; RAT; RESPIRATORY BURST; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING SITES; BIPHENYL COMPOUNDS; CELL LINE; CELL PROLIFERATION; COMPUTER SIMULATION; CYCLOHEXENES; HEPATOCYTES; HUMANS; IMIDAZOLES; IMMUNOLOGIC FACTORS; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-1BETA; INTERLEUKIN-2; LEUKOCYTES, MONONUCLEAR; MACROPHAGES; MICE; NIH 3T3 CELLS; PROTEIN STRUCTURE, TERTIARY; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; THIOCARBAMATES; THIONES; TUMOR NECROSIS FACTOR-ALPHA;

RATTUS;

EID: 84859894306     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.03.003     Document Type: Article

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