N,N-diethyldithiocarbamate promotes oxidative stress prior to myelin structural changes and increases myelin copper content

Toxicology and Applied Pharmacology

Volumn 239, Issue 1, 2009, Pages 71-79

  Viquez, Olga M ^a   Lai, Barry ^b   Ahn, Jae Hee ^a   Does, Mark D ^c,d   Valentine, Holly L ^a   Valentine, William M ^a  

^a Center for Molecular Neuroscience   (United States)

^b ARGONNE NATIONAL LABORATORY   (United States)

^c VANDERBILT UNIVERSITY   (United States)

^d VANDERBILT UNIVERSITY   (United States)

Author keywords

Copper; Glutathione transferase; Heme oxygenase; Multiexponential transverse relaxation; Myelinopathy; N,N diethyldithiocarbamate; Superoxide dismutase; Synchrotron X ray fluorescence microscopy

Indexed keywords

COPPER; COPPER ZINC SUPEROXIDE DISMUTASE; DIETHYLDITHIOCARBAMIC ACID; GLUTATHIONE TRANSFERASE ALPHA; HEME OXYGENASE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; COPPER METABOLISM; DEMYELINATION; LIPID PEROXIDATION; MALE; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; SCIATIC NERVE;

ANIMALS; BLOTTING, WESTERN; BRAIN; COPPER; DITIOCARB; GLUTATHIONE TRANSFERASE; HEME OXYGENASE (DECYCLIZING); ISOENZYMES; LIPID PEROXIDATION; MALE; MICROSCOPY, FLUORESCENCE; MYELIN SHEATH; OXIDATIVE STRESS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN CARBONYLATION; RATS; RATS, SPRAGUE-DAWLEY; SCIATIC NERVE; SPINAL CORD; SUPEROXIDE DISMUTASE;

ANIMALIA; RATTUS;

EID: 67651039353     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.05.017     Document Type: Article

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