Valproic acid and progestin inhibit lesion growth and reduce hyperalgesia in experimentally induced endometriosis in rats

Reproductive Sciences

Volumn 19, Issue 4, 2012, Pages 360-373

  Mmed, Maohua Liu ^a   Liu, Xishi ^a   Zhang, Yuqiu ^b   Guo, Sun Wei ^a  

^a FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

endometriosis; histone deacetylase inhibitor; hot plate test; hyperalgesia; inflammation; progestin; tail flick test

Indexed keywords

PROGESTERONE; TUMOR NECROSIS FACTOR ALPHA; VALPROIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DRUG EFFECT; DRUG MEGADOSE; ENDOMETRIOSIS; FEMALE; HOT PLATE TEST; HYPERALGESIA; IN VIVO STUDY; LOW DRUG DOSE; NONHUMAN; PRIORITY JOURNAL; RAT; TAIL FLICK TEST; THERMAL STIMULATION; TREATMENT RESPONSE; WEIGHT GAIN;

ANIMALS; BODY WEIGHT; DISEASE MODELS, ANIMAL; ENDOMETRIOSIS; FEMALE; HISTONE DEACETYLASE INHIBITORS; HYPERALGESIA; PAIN MEASUREMENT; PROGESTERONE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; STATISTICS, NONPARAMETRIC; TUMOR NECROSIS FACTOR-ALPHA; VALPROIC ACID;

EID: 84859884753     PISSN: 19337191     EISSN: 19337205     Source Type: Journal    
DOI: 10.1177/1933719111424453     Document Type: Article

References (57)

1. Giudice LC, Kao LC. Endometriosis. Lancet. 2004;364(9447):1789-1799. (Pubitemid 39488065)
2. Olive DL, Lindheim SR, Pritts EA. New medical treatments for endometriosis. Best Pract Res Clin Obstet Gynaecol. 2004;18(2):319-328. (Pubitemid 38786635)
3. Olive DL, Pritts EA. Treatment of endometriosis. N Engl J Med. 2001;345(4):266-275. (Pubitemid 32695068)
4. Nothnick WB, D'Hooghe TM. Medical management of endometriosis: novel targets and approaches towards the development of future treatment regimes. Gynecol Obstet Invest. 2003;55(4):189-198. (Pubitemid 36980730)
5. Wu Y, Halverson G, Basir Z, Strawn E, Yan P, Guo SW. Aberrant methylation at HOXA10 may be responsible for its aberrant expression in the endometrium of patients with endometriosis. Am J Obstet Gynecol. 2005;193(2):371-380.
6. Wu Y, Starzinski-Powitz A, Guo SW. Prolonged stimulation with tumor necrosis factor-alpha induced partial methylation at PR-B promoter in immortalized epithelial-like endometriotic cells. Fertil Steril. 2008;90(1):234-237. (Pubitemid 351885197)
7. Wu Y, Strawn E, Basir Z, Halverson G, Guo SW. Aberrant expression of deoxyribonucleic acid methyltransferases DNMT1, DNMT3A, and DNMT3B in women with endometriosis. Fertil Steril. 2007;87(1):24-32. (Pubitemid 46013877)
8. Ailawadi RK, Jobanputra S, Kataria M, Gurates B, Bulun SE. Treatment of endometriosis and chronic pelvic pain with letrozole and norethindrone acetate: a pilot study. Fertil Steril. 2004;81(2):290-296. (Pubitemid 38223905)
9. Xue Q, Lin Z, Cheng YH, Huang CC, et al. Promoter methylation regulates estrogen receptor 2 in human endometrium and endometriosis. Biol Reprod. 2007;77(4):681-687. (Pubitemid 47494383)
10. Xue Q, Lin Z, Yin P, et al. Transcriptional activation of steroidogenic factor-1 by hypomethylation of the 5′ CpG island in endometriosis. J Clin Endocrinol Metab. 2007;92(8):3261-3267. (Pubitemid 47236401)
11. Kim JJ, Taylor HS, Lu Z, et al. Altered expression of HOXA10 in endometriosis: potential role in decidualization. Mol Hum Reprod. 2007;13(5):323-332. (Pubitemid 47061643)
12. Lee B, Du H, Taylor HS. Experimental murine endometriosis induces DNA methylation and altered gene expression in eutopic endometrium. Biol Reprod. 2009;80(1):79-85.
13. Szczepanska M, Wirstlein P, Luczak M, Jagodzinski PP, Skrzypczak J. Reduced expression of HOXA10 in the midluteal endometrium from infertile women with minimal endometriosis. Biomed Pharmacother. 2010;64(10):697-705.
14. Izawa M, Taniguchi F, Uegaki T, et al. Demethylation of a non-promoter cytosine-phosphate-guanine island in the aromatase gene may cause the aberrant up-regulation in endometriotic tissues. Fertil Steril. 2010;95(1):33-39.
15. Borghese B, Barbaux S, Mondon F, et al. Research resource: genome-wide profiling of methylated promoters in endometriosis reveals a subtelomeric location of hypermethylation. Mol Endocrinol. 2010;24(9):1872-1885.
16. Guo SW. Epigenetics of endometriosis. Mol Hum Reprod. 2009;15(10):587-607.
17. Guo SW. Emerging drugs for endometriosis. Expert Opin Emerg Drugs. 2008;13(4):547-571.
18. Nie J, Liu XS, Guo SW. Promoter hypermethylation of progesterone receptor isoform B (PR-B) in Adenomyosis and its rectification by a histone deacetylase inhibitor and a demethylation agent. Reprod Sci. 2010;17(11):995-1005.
19. Wu Y, Guo SW. Inhibition of proliferation of endometrial stromal cells by trichostatin A, RU486, CDB-2914, N-acetylcysteine, and ICI 182780. Gynecol Obstet Invest. 2006, 62(4):193-.205.
20. Wu Y, Guo SW. Histone deacetylase inhibitors trichostatin A and valproic acid induce cell cycle arrest and p21 expression in immortalized human endometrial stromal cells. Eur J Obstet Gynecol Reprod Biol. 2008, 137(2):198-203. (Pubitemid 351423449)
21. Wu Y, Starzinski-Powitz A, Guo SW. Trichostatin A, a histone deacetylase inhibitor, attenuates invasiveness and reactivates E-cadherin expression in immortalized endometriotic cells. Reprod Sci. 2007;14(4):374-382. (Pubitemid 351168805)
22. WuY, Starzinski-Powitz A,GuoSW.Constitutive and tumor necrosis factor-alpha-stimulated activation of nuclear factor-kappaB in immortalized endometriotic cells and their suppression by trichostatin A. Gynecol Obstet Invest. 2010;70(1):23-33.
23. Lu Y, Nie J, Liu X, Zheng Y, Guo SW. Trichostatin A, a histone deacetylase inhibitor, reduces lesion growth and hyperalgesia in experimentally induced endometriosis in mice. Hum Reprod. 2010;25(4):1014-1025.
24. Richter ON, Dorn C, Rosing B, Flaskamp C, Ulrich U. Tumor necrosis factor alpha secretion by peritoneal macrophages in patients with endometriosis. Arch Gynecol Obstet. 2005;271(2):143-147. (Pubitemid 40476246)
25. Cunha FQ, Poole S, Lorenzetti BB, Ferreira SH. The pivotal role of tumour necrosis factor alpha in the development of inflammatory hyperalgesia. Br J Pharmacol. 1992;107(3):660-664.
26. Fang Z, Yang S, Gurates B, et al. Genetic or enzymatic disruption of aromatase inhibits the growth of ectopic uterine tissue. J Clin Endocrinol Metab. 2002;87(7):3460-3466. (Pubitemid 34816404)
27. Berkley KJ, Cason A, Jacobs H, Bradshaw H, Wood E. Vaginal hyperalgesia in a rat model of endometriosis. Neurosci Lett. 2001;306(3):185-188. (Pubitemid 32530830)
28. Le Bars D, Gozariu M, Cadden SW. Animal models of nociception. Pharmacol Rev. 2001;53(4):597-652. (Pubitemid 33136239)
29. Bannon AW, Malmberg AB. Models of nociception: hot-plate, tail-flick, and formalin tests in rodents. Curr Protoc Neurosci. 2007;Chapter 8: Unit 8 9.
30. Inhaka R, Gentleman RR. R: a language for data analysis and graphics. J comput Graph Statist. 1996;5(3):1923-1927.
31. He W, Liu XS, Zhang YQ, Guo SW. Generalized hyperalgesia in women with endometriosis and its resolution following a successful surgery. Reprod Sci. 2010;17(12):1099-1111.
32. Berkley KJ, McAllister SL, Accius BE, Winnard KP. Endometriosis-induced vaginal hyperalgesia in the rat: effect of estropause, ovariectomy, and estradiol replacement. Pain. 2007;132(suppl 1):S150-S159. (Pubitemid 350030867)
33. Zhao T, Liu X, Zhen X, Guo SW. Levo-Tetrahydropalmatine (l-THP) retards the growth of ectopic endometrial implants and alleviates generalized hyperalgesia in experimentally induced endometriosis in rats. Reprod Sci. 2010;18(1):28-45.
34. Vierck CJ Animal models of pain. In: McMahon S, Koltzenburg M, (eds.) Wall and Melzack's Textbook of Pain. 5th ed. Philadelphia, PA: Elsevier, 2006, 175-185.
35. Wu MY, Ho HN. The role of cytokines in endometriosis. Am J Reprod Immunol. 2003;49(5):285-296.
36. Ji RR, Kohno T, Moore KA, Woolf CJ. Central sensitization and LTP: do pain and memory share similar mechanisms? Trends Neurosci. 2003;26(12):696-705. (Pubitemid 37415022)
37. McAllister SL, McGinty KA, Resuehr D, Berkley KJ. Endometriosis-induced vaginal hyperalgesia in the rat: role of the ectopic growths and their innervation. Pain. 2009;147(1-3):255-264.
38. Latremoliere A, Woolf CJ. Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J Pain. 2009;10(9):895-926.
39. Matsuzaki S, Canis M, Pouly JL, Rabischong B, Botchorishvili R, MageG. Relationship between delay of surgical diagnosis and severity of disease in patients with symptomatic deep infiltrating endometriosis. Fertil Steril. 2006;86(5):1314-1316; discussion 1317.
40. Harada T, Iwabe T, Terakawa N. Role of cytokines in endometriosis. Fertil Steril. 2001;76(1):1-10. (Pubitemid 32600952)
41. Shirley SW, Stewart BH, Mirelman S. Dimethyl sulfoxide in treatment of inflammatory genitourinary disorders. Urology. 1978;11(3):215-220. (Pubitemid 8286153)
42. Swanson BN. Medical use of dimethyl sulfoxide (DMSO). Rev Clin Basic Pharm. 1985;5(1-2):1-33. (Pubitemid 16024487)
43. Bedaiwy MA, Falcone T, Sharma RK, et al. Prediction of endometriosis with serum and peritoneal fluid markers: a prospective controlled trial. Hum Reprod. 2002;17(2):426-431. (Pubitemid 34168452)
44. May KE, Conduit-Hulbert SA, Villar J, Kirtley S, Kennedy SH, Becker CM. Peripheral biomarkers of endometriosis: a systematic review. Hum Reprod Update. 2010;16(6):651-674.
45. Malick A, Jakubowski M, Elmquist JK, Saper CB, Burstein R. A neurohistochemical blueprint for pain-induced loss of appetite. Proc Natl Acad Sci U S A. 2001;98(17):9930-9935. (Pubitemid 32769406)
46. Stevenson GW, Bilsky EJ, Negus SS. Targeting pain-suppressed behaviors in preclinical assays of pain and analgesia: effects of morphine on acetic acid-suppressed feeding in C57BL/6 J mice. J Pain. 2006;7(6):408-416. (Pubitemid 43794888)
47. Spannhoff A, Kim YK, Raynal NJ, et al. Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees. EMBO Rep. 2011;12(3):238-243.
48. Kucharski R, Maleszka J, Foret S, Maleszka R. Nutritional control of reproductive status in honeybees via DNA methylation. Science. 2008;319(5871):1827-1830. (Pubitemid 351451590)
49. Kim HJ, Bae SC. Histone deacetylase inhibitors: molecular mechanisms of action and clinical trials as anti-cancer drugs. Am J Transl Res. 2011;3(2):166-179.
50. Giudice LC. Clinical practice. Endometriosis. N Engl J Med. 2010;362(25):2389-2398.
51. Vercellini P, Cortesi I, Crosignani PG. Progestins for symptomatic endometriosis: a critical analysis of the evidence. Fertil Steril. 1997;68(3):393-401. (Pubitemid 27412901)
52. Attia GR, Zeitoun K, Edwards D, Johns A, Carr BR, Bulun SE. Progesterone receptor isoform A but not B is expressed in endometriosis. J Clin EndocrinolMetab. 2000;85(8):2897-2902. (Pubitemid 32269170)
53. Wu Y, Strawn E, Basir Z, Halverson G, Guo SW. Promoter hypermethylation of progesterone receptor isoform B (PR-B) in endometriosis. Epigenetics. 2006;1(2):106-111.
54. Wu Y, Guo SW. Suppression of IL-1beta-induced COX-2 expression by trichostatin A (TSA) in human endometrial stromal cells. Eur J Obstet Gynecol Reprod Biol. 2007;135(1): 88-93. (Pubitemid 350026147)
55. Tsai SJ, Wu MH, Lin CC, Sun HS, Chen HM. Regulation of steroidogenic acute regulatory protein expression and progesterone production in endometriotic stromal cells. J Clin Endocrinol Metab. 2001;86(12):5765-5773. (Pubitemid 33152622)
56. Attar E, Tokunaga H, Imir G, et al. Prostaglandin E2 via steroidogenic factor-1 coordinately regulates transcription of steroidogenic genes necessary for estrogen synthesis in endometriosis. J Clin Endocrinol Metab. 2009;94(2):623-631.
57. Xishi L, Lei Y, Guo SW. Valproic acid as a therapy for adenomyosis: a comparative case series. Reprod Sci. 2010;17(10):904-912.