Demethylation of a nonpromoter cytosine-phosphate-guanine island in the aromatase gene may cause the aberrant up-regulation in endometriotic tissues

Fertility and Sterility

Volumn 95, Issue 1, 2011, Pages 33-39

  Izawa, Masao ^a   Taniguchi, Fuminori ^a   Uegaki, Takashi ^a   Takai, Eri ^a   Iwabe, Tomio ^a   Terakawa, Naoki ^a   Harada, Tasuku ^a  

^a TOTTORI UNIVERSITY   (Japan)

Author keywords

aromatase gene; DNA methylation; Endometriosis; epigenetics; up regulation

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; BINDING PROTEIN; BISULFITE; GENOMIC DNA; MESSENGER RNA;

ARTICLE; CLINICAL ARTICLE; CPG ISLAND; DEMETHYLATION; ENDOMETRIOSIS; EPIGENETICS; FEMALE; GENE SEQUENCE; HUMAN; HUMAN CELL; HUMAN TISSUE; LAPAROSCOPY; LAPAROTOMY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; STROMA CELL; UPREGULATION; UTERUS;

AROMATASE; CPG ISLANDS; DNA METHYLATION; ENDOMETRIOSIS; EPIGENESIS, GENETIC; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; PROMOTER REGIONS, GENETIC; RNA, MESSENGER; STROMAL CELLS; UP-REGULATION; UTERUS;

EID: 78650415868     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2010.06.024     Document Type: Article

References (25)

1. D.L. Olive, and E.A. Pritts Treatment of endometriosis N Engl J Med 345 2001 266 275
2. S.E. Bulun, Z. Lin, G. Imir, S. Amin, M. Demura, and B. Yilmag Regulation of aromatase expression in estrogen-responsive breast and uterine disease: from bench to treatment Pharmacol Rev 57 2005 359 383
3. M. Izawa, T. Harada, Y. Ohama, Y. Takenaka, F. Taniguchi, and N. Terakawa An epigenetic disorder may cause aberrant expression of aromatase gene in endometriotic stromal cells Fertil Steril 89 2008 1390 1396
4. H.S. Taylor, C. Bagot, A. Kardana, D. Olive, and A. Arici HOX gene expression is altered in the endometrium of women with endometriosis Hum Reprod 14 1999 1328 1331
5. Y. Gui, J. Zhang, L. Yuan, and B.A. Lessey Regulation of HOXA-10 is and its expression in normal and abnormal endometrium Mol Hum Reprod 5 1999 866 873
6. Y. Wu, G. Halverson, Z. Basir, E. Strawn, P. Yan, and S.W. Guo Aberrant methylation at HOXA10 may be responsible for its aberrant expression in the endometrium of patients with endometriosis Am J Obstet Gynecol 193 2005 371 380
7. A.S. Hutchins, A.C. Mullen, H.W. Lee, K.J. Sykes, S.A. High, and B.D. Hendrich Gene silencing quantitatively controls the function of a developmental trans-activator Mol Cell 10 2002 81 91
8. R.J. Klose, and A.P. Bird Genomic DNA methylation: the mark and its mediators Trends Biochem Sci 31 2006 89 97
9. T. Iwabe, T. Harada, T. Tsudo, M. Tanikawa, Y. Oonahara, and N. Terakawa Pathogenetic significance of increased levels of interleukin-8 in the peritoneal fluid of patients with endometriosis Fertil Steril 69 1998 924 930
10. T. Iwabe, T. Harada, T. Tsudo, Y. Nagano, S. Yoshida, and M. Tanikawa Tumor necrosis factor-α promotes proliferation of endometriotic stromal cells by inducing interleukin-8 gene and protein expression J Clin Endocrinol Metab 85 2000 824 829
11. M. Izawa, T. Harada, I. Deura, F. Taniguchi, T. Iwabe, and N. Terakawa Drug-induced apoptosis was markedly attenuated in endometriotic stromal cells Hum Reprod 21 2006 600 604
12. Y. Sakamoto, T. Harada, S. Horie, Y. Iba, F. Taniguchi, and S. Yoshida Tumor necrosis factor-a-induced interleukin-8 (IL-8) expression in endometriotic stromal cells, probably through nuclear factor-kB activation: gonadotropin-releasing hormone agonist treatment reduced IL-8 expression J Clin Endocrinol Metab 88 2003 730 735
13. Y. Yamada, H. Watanabe, F. Miura, H. Soejima, M. Uchiyama, and T. Iwasaka A comprehensive analysis of allelic methylation status of CpG Islands on human chromosome 21q Genome Res 14 2004 247 266
14. L.S. Noble, E.R. Simpson, A. Johns, and S.E. Bulun Aromatase expression in endometriosis J Clin Endocrinol Metab 81 1996 174 179
15. J. Kitawaki, T. Noguchi, T. Amatsu, K. Maeda, K. Tsukamoto, and T. Yamamoto Expression of aromatase cytochrome P450 protein and messenger ribonucleic acid in human endometriotic and adenomyotic tissues but not in normal endometrium Biol Reprod 57 1997 514 519
16. S.E. Bulun, K. Zeitoun, K. Takayama, L. Noble, D. Michael, and E. Simpson Estrogen production in endometriosis and use of aromatase inhibitors to treat endometriosis Endocrinol Relat Cancer 6 1999 293 301
17. X. Nan, H.H. Ng, C.A. Johnson, C.D. Laherty, B.M. Turner, and R.N. Eisenman Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histon deacetylase complex Nature 393 1998 386 389
18. B. Hendrich, and A.P. Bird Identification and characterization of a family of mammalian methyl-CpG binding proteins Mol Cell Biol 18 1998 6538 6547
19. Q. Xue, Z. Lin, P. Yin, M.P. Milad, Y.H. Cheng, and E. Confino Transcriptional activation of steroidogenic factor-1 by hypomethylation of the CpG island in endometriosis J Clin Endocrinol Metab 92 2007 3261 3267
20. E.R. Simpson, M.O. Michael, V.R. Agarwal, M.M. Hinshelwood, S.E. Bulun, and Y. Zhao Expression of the CYP19 (aromatase) gene: an unusual case of alternative promoter usage FASEB J 11 1997 29 36
21. D. Boerboom, A. Kerban, and J. Sirois Dual regulation of promoter II- and promoter 1f-derived cytochrome P450 aromatase transcripts in equine granulosa cells during human chorionic gonadotropin-induced ovulation: a novel model for the study of aromatase promoter switching Endocrinology 140 1999 4133 4141
22. H. Dassen, C. Punyadeera, R. Kamps, B. Delvoux, A. Van Langendonckt, and J. Donnez Estrogen metabolizing enzymes in endometrium and endometriosis Hum Reprod 22 2007 3148 3158
23. C.M. Kyama, L. Overbergh, A. Mihalyi, C. Meuleman, J.M. Muvenda, and C. Mathien Endometrial and peritoneal expression of aromatase, cytokines, and adhesion factors in women with endometriosis Fertil Steril 89 2008 301 310
24. Y. Ohata, T. Harada, H. Miyakoda, F. Taniguchi, T. Iwabe, and N. Terakawa Serum interleukin-8 levels are elevated in patients with ovarian endometrioma Fertil Steril 90 2008 994 999
25. J. Lermann, A. Mueller, F. Körber, P. Oppelt, M.W. Beckmann, and R. Dittrich Evaluation of high-sensitivity C-reactive protein in comparison with C-reactive protein as biochemical serum markers in women with endometriosis Fertil Steril 93 2010 2125 2129