A mechanism-based approach to predict the relative biological effectiveness of protons and carbon ions in radiation therapy

International Journal of Radiation Oncology Biology Physics

Volumn 83, Issue 1, 2012, Pages 442-450

  Frese, Malte C ^a,b   Yu, Victor K ^a   Stewart, Robert D ^c   Carlson, David J ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Carbon ions; Cell survival; Protons; RBE; Repair misrepair fixation (RMF) model

Indexed keywords

BIOLOGICAL EFFECTS; BIOLOGICAL PARAMETER; BRAGG PEAKS; CARBON IONS; CELL SURVIVAL; COLD SPOTS; DAMAGE SIMULATION; DOSE RANGE; DOUBLE-STRAND BREAKS; ION KINETIC ENERGY; MONTE CARLO; MONTE CARLO MODEL; PARTICLE DISTRIBUTIONS; PARTICLE ENERGY; RADIATION QUALITY; RBE; RELATIVE BIOLOGICAL EFFECTIVENESS; TRACK STRUCTURE;

BIOLOGICAL RADIATION EFFECTS; COMPUTER SOFTWARE; FORECASTING; IONS; MONTE CARLO METHODS; PROTONS; RADIOTHERAPY; TISSUE;

CARBON;

ARTICLE; COMPUTER PROGRAM; DNA STRAND BREAKAGE; MATHEMATICAL MODEL; MONTE CARLO METHOD; PARTICLE RADIATION; PRIORITY JOURNAL; PROTON RADIATION; RELATIVE BIOLOGIC EFFECTIVENESS; SIMULATION;

ALGORITHMS; CARBON; CELL SURVIVAL; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; HUMANS; LINEAR ENERGY TRANSFER; LINEAR MODELS; MONTE CARLO METHOD; PROTONS; RADIATION TOLERANCE; RELATIVE BIOLOGICAL EFFECTIVENESS; SOFTWARE;

EID: 84859875201     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2011.06.1983     Document Type: Article

References (24)

1. H. Paganetti, A. Niemierko, and M. Ancukiewicz Relative biological effectiveness (RBE) values for proton beam therapy Int J Radiat Oncol Biol Phys 53 2002 407 421
2. ICRU. Prescribing, recording, and reporting proton-beam therapy. ICRU Report 78; International Commission on Radiation Units & Measurements (ICRU), Bethesda, MD 2007.
3. M.C. Frese, J.J. Wilkens, and P.E. Huber Application of constant vs. variable relative biological effectiveness in treatment planning of intensity-modulated proton therapy Int J Radiat Oncol Biol Phys 79 2011 80 88
4. M. Kramer, and M. Scholz Treatment planning for heavy-ion radiotherapy: Calculation and optimization of biologically effective dose Phys Med Biol 45 2000 3319 3330
5. D.J. Carlson, R.D. Stewart, and V.A. Semenenko Combined use of Monte Carlo DNA damage simulations and deterministic repair models to examine putative mechanisms of cell killing Radiat Res 169 2008 447 459
6. V.A. Semenenko, and R.D. Stewart Fast Monte Carlo simulation of DNA damage formed by electrons and light ions Phys Med Biol 51 2006 1693 1706
7. V.A. Semenenko, and R.D. Stewart A fast Monte Carlo algorithm to simulate the spectrum of DNA damages formed by ionizing radiation Radiat Res 161 2004 451 457
8. R.R. Wilson Radiological use of fast protons Radiology 47 1946 487 491
9. T. Bortfeld An analytical approximation of the Bragg curve for therapeutic proton beams Med Phys 24 1997 2024 2033
10. J.J. Wilkens, and U. Oelfke Three-dimensional LET calculations for treatment planning of proton therapy Z Med Phys 14 2004 41 46
11. H. Bethe Zur Theorie des Durchgangs schneller Korpuskularstrahlen durch Materie [On the theory of the passage of fast corpuscular beams through matter] Annalen der Physik 397 1930 325 400
12. M. Zaider, and H.H. Rossi The synergistic effects of different radiations Radiat Res 83 1980 732 739
13. J.J. Wilkens, and U. Oelfke Fast multifield optimization of the biological effect in ion therapy Phys Med Biol 51 2006 3127 3140
14. Y. Furusawa, K. Fukutsu, and M. Aoki Inactivation of aerobic and hypoxic cells from three different cell lines by accelerated (3)He-, (12)C- and (20)Ne- ion beams Radiat Res 154 2000 485 496
15. D.J. Carlson, R.D. Stewart, and X.A. Li Comparison of in vitro and in vivo alpha/beta ratios for prostate cancer Phys Med Biol 49 2004 4477 4491
16. T. Girinsky, R. Lubin, and J.P. Pignon Predictive value of in vitro radiosensitivity parameters in head and neck cancers and cervical carcinomas: Preliminary correlations with local control and overall survival Int J Radiat Oncol Biol Phys 25 1993 3 7
17. M. Stuschke, and H.D. Thames Fractionation sensitivities and dose-control relations of head and neck carcinomas: Analysis of the randomized hyperfractionation trials Radiother Oncol 51 1999 113 121
18. Y. Hsiao, and R.D. Stewart Monte Carlo simulation of DNA damage induction by x-rays and selected radioisotopes Phys Med Biol 53 2008 233 244
19. U. Weber, and G. Kraft Design and construction of a ripple filter for a smoothed depth dose distribution in conformal particle therapy Phys Med Biol 44 1999 2765 2775
20. C. Grassberger, A. Trofimov, and A. Lomax Variations in linear energy transfer within clinical proton therapy fields and the potential for biological treatment planning Int J Radiat Oncol Biol Phys 80 2011 1559 1566
21. A. Carabe-Fernandez, R.G. Dale, and J.W. Hopewell Fractionation effects in particle radiotherapy: Implications for hypo-fractionation regimes Phys Med Biol 55 2010 5685 5700
22. M. Scholz, and G. Kraft Track structure and the calculation of biological effects of heavy charged particles Adv Space Res 18 1996 5 14
23. J.J. Wilkens, and U. Oelfke Direct comparison of biologically optimized spread-out Bragg peaks for protons and carbon ions Int J Radiat Oncol Biol Phys 70 2008 262 266
24. T. Inaniwa, T. Furukawa, and Y. Kase Treatment planning for a scanned carbon beam with a modified microdosimetric kinetic model Phys Med Biol 55 2010 6721 6737