메뉴 건너뛰기




Volumn 80, Issue 5, 2011, Pages 1559-1566

Variations in linear energy transfer within clinical proton therapy fields and the potential for biological treatment planning

Author keywords

IMPT; Linear energy transfer (LET); Monte Carlo; Protons; Relative biological effectiveness (RBE)

Indexed keywords

ACTIVE SCANNING; ANALYTICAL TECHNIQUES; BIOLOGICAL EFFECTS; BIOLOGICAL TREATMENT; BRAINSTEM; CLINICAL PROTONS; CRITICAL STRUCTURES; DELIVERY TECHNIQUES; EDGE TRACKING; IMPT; LET DISTRIBUTION; LINEAR ENERGY TRANSFER; MONTE CARLO; MONTE CARLO STUDY; NORMAL TISSUE; ORGANS AT RISKS; PROTON THERAPY; RELATIVE BIOLOGICAL EFFECTIVENESS; SECONDARY PARTICLES; TREATMENT PLANS;

EID: 79960103519     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2010.10.027     Document Type: Article
Times cited : (162)

References (26)
  • 2
    • 0017696995 scopus 로고
    • In vivo determinations of RBE in a high energy modulated proton beam using normal tissue reactions and fractionated dose schedules
    • J. Tepper, L. Verhey, and M. Goitein In vivo determinations of RBE in a high energy modulated proton beam using normal tissue reactions and fractionated dose schedules Int J Radiat Oncol Biol Phys 2 1977 1115 1122 (Pubitemid 8247876)
    • (1977) International Journal of Radiation Oncology Biology Physics , vol.2 , Issue.11-12 , pp. 1115-1122
    • Tepper, J.1    Verhey, L.2    Goitein, M.3
  • 3
    • 0029785770 scopus 로고    scopus 로고
    • Measurements of relative biological effectiveness of the 70 MeV proton beam at TRIUMF using Chinese hamster V79 cells and the high-precision cell sorter assay
    • B.G. Wouters, G.K.Y. Lam, and U. Oelfke RBE measurement on the 70 MeV proton beam at TRIUMF using V79 cells and the high precision cell sorter assay Rad Res 146 1996 159 170 (Pubitemid 26262043)
    • (1996) Radiation Research , vol.146 , Issue.2 , pp. 159-170
    • Wouters, B.G.1    Lam, G.K.Y.2    Oelfke, U.3    Gardey, K.4    Durand, R.E.5    Skarsgard, L.D.6
  • 4
    • 0032945625 scopus 로고    scopus 로고
    • Relative biological effectiveness of proton beams in clinical therapy
    • DOI 10.1016/S0167-8140(98)00092-9, PII S0167814098000929
    • L. Gerweck, and S.V. Kozin relative biological effectiveness of proton beams in clinical therapy Radiother Oncol 50 1999 135 142 (Pubitemid 29155537)
    • (1999) Radiotherapy and Oncology , vol.50 , Issue.2 , pp. 135-142
    • Gerweck, L.E.1    Kozin, S.V.2
  • 5
    • 0034821824 scopus 로고    scopus 로고
    • Biophysical modelling of proton radiation effects based on amorphous track models
    • DOI 10.1080/09553000110066059
    • H. Paganetti, and M. Goitein Biophysical modeling of proton radiation effects based on amorphous track models Int J Radiat Biol 77 2001 911 928 (Pubitemid 32889410)
    • (2001) International Journal of Radiation Biology , vol.77 , Issue.9 , pp. 911-928
    • Paganetti, H.1    Goitein, M.2
  • 6
    • 3442895110 scopus 로고    scopus 로고
    • A phenomenological model for the relative biological effectiveness in therapeutic proton beams
    • DOI 10.1088/0031-9155/49/13/004, PII S0031915504749842
    • J.J. Wilkens, and U. Oelfke A phenomenological model for the relative biological effectiveness in therapeutic proton beams Phys Med Biol 49 2004 2811 2825 (Pubitemid 39004134)
    • (2004) Physics in Medicine and Biology , vol.49 , Issue.13 , pp. 2811-2825
    • Wilkens, J.J.1    Oelfke, U.2
  • 8
    • 1842564091 scopus 로고    scopus 로고
    • Three-dimensional LET calculations for treatment planning of proton therapy
    • J.J. Wilkens, and U. Oelfke Three-dimensional LET calculations for treatment planning of proton therapy Z Med Phys 14 2004 41 46 (Pubitemid 38435680)
    • (2004) Zeitschrift fur Medizinische Physik , vol.14 , Issue.1 , pp. 41-46
    • Wilkens, J.J.1    Oelfke, U.2
  • 10
    • 78650016931 scopus 로고    scopus 로고
    • Application of constant vs. variable relative biological effectiveness in treatment planning of intensity-modulated proton therapy
    • M.C. Frese, J.J. Wilkens, and P.E. Huber Application of constant vs. variable relative biological effectiveness in treatment planning of intensity-modulated proton therapy Int J Radiat Oncol Biol Phys 79 2011 80 88
    • (2011) Int J Radiat Oncol Biol Phys , vol.79 , pp. 80-88
    • Frese, M.C.1    Wilkens, J.J.2    Huber, P.E.3
  • 11
    • 0016833839 scopus 로고
    • Radiobiological studies of a high-energy modulated proton beam utilizing cultured mammalian cells
    • J.B. Robertson, J.R. Williams, and R.A. Schmidt Radiobiological studies of a high-energy modulated proton beam utilizing cultured mammalian cells Cancer 35 1975 1664 1677
    • (1975) Cancer , vol.35 , pp. 1664-1677
    • Robertson, J.B.1    Williams, J.R.2    Schmidt, R.A.3
  • 12
    • 33845959379 scopus 로고    scopus 로고
    • Depth absorbed dose and LET distributions of therapeutic 1H, 4He, 7Li, and 12C beams
    • J. Kempe, I. Gudowska, and A. Brahme Depth absorbed dose and LET distributions of therapeutic 1H, 4He, 7Li, and 12C beams Med Phys 34 2007 183 192
    • (2007) Med Phys , vol.34 , pp. 183-192
    • Kempe, J.1    Gudowska, I.2    Brahme, A.3
  • 13
    • 34047274408 scopus 로고    scopus 로고
    • Influence of dose engine accuracy on the optimum dose distribution in intensity-modulated proton therapy treatment plans
    • DOI 10.1088/0031-9155/52/3/014, PII S0031915507292012, 014
    • M. Soukup, and M. Alber Influence of dose engine accuracy on the optimum dose distribution in intensity-modulated proton therapy treatment plans Phys Med Biol 52 2007 725 740 (Pubitemid 46646443)
    • (2007) Physics in Medicine and Biology , vol.52 , Issue.3 , pp. 725-740
    • Soukup, M.1    Alber, M.2
  • 15
    • 45849111096 scopus 로고    scopus 로고
    • Physics settings for using the Geant4 toolkit in proton therapy
    • C. Zacharatou-Jarlskog, and H. Paganetti Physics settings for using the Geant4 toolkit in proton therapy IEEE Trans Nucl Sci 55 2008 1018 1025
    • (2008) IEEE Trans Nucl Sci , vol.55 , pp. 1018-1025
    • Zacharatou-Jarlskog, C.1    Paganetti, H.2
  • 16
    • 3142702743 scopus 로고    scopus 로고
    • Accurate Monte Carlo simulations for nozzle design, commissioning and quality assurance for a proton radiation therapy facility
    • DOI 10.1118/1.1762792
    • H. Paganetti, H. Jiang, and S.-Y. Lee Accurate Monte Carlo for nozzle design, commissioning, and quality assurance in proton therapy Med Phys 31 2004 2107 2118 (Pubitemid 38924832)
    • (2004) Medical Physics , vol.31 , Issue.7 , pp. 2107-2118
    • Paganetti, H.1    Jiang, H.2    Lee, S.-Y.3    Kooy, H.M.4
  • 17
    • 4744360413 scopus 로고    scopus 로고
    • Adaptation of GEANT4 to Monte Carlo dose calculations based on CT data
    • DOI 10.1118/1.1796952
    • H. Jiang, and H. Paganetti Adaptation of GEANT4 to Monte Carlo dose calculations based on CT data Med Phys 31 2004 2811 2818 (Pubitemid 39431008)
    • (2004) Medical Physics , vol.31 , Issue.10 , pp. 2811-2818
    • Jiang, H.1    Paganetti, H.2
  • 18
    • 51849122521 scopus 로고    scopus 로고
    • Clinical implementation of full Monte Carlo dose calculation in proton beam therapy
    • H. Paganetti, H. Jiang, and K. Parodi Clinical implementation of full Monte Carlo dose calculation in proton beam therapy Phys Med Biol 53 2008 4825 4853
    • (2008) Phys Med Biol , vol.53 , pp. 4825-4853
    • Paganetti, H.1    Jiang, H.2    Parodi, K.3
  • 19
    • 77950430637 scopus 로고    scopus 로고
    • Development and application of a multimodality inverse treatment planning system
    • S. Nill Development and application of a multimodality inverse treatment planning system Med Phys 29 2002 258
    • (2002) Med Phys , vol.29 , pp. 258
    • Nill, S.1
  • 20
    • 0037573249 scopus 로고    scopus 로고
    • Analytical linear energy transfer calculations for proton therapy
    • DOI 10.1118/1.1567852
    • J.J. Wilkens, and U. Oelfke Analytical linear energy transfer calculations for proton therapy Med Phys 30 2003 806 815 (Pubitemid 36578683)
    • (2003) Medical Physics , vol.30 , Issue.5 , pp. 806-815
    • Wilkens, J.J.1    Oelfke, U.2
  • 21
    • 23944524788 scopus 로고    scopus 로고
    • Interpretation of proton relative biological effectiveness using lesion induction, lesion repair, and cellular dose distribution
    • DOI 10.1118/1.1949807
    • H. Paganetti Interpretation of proton relative biological effectiveness using lesion induction, lesion repair and cellular dose distribution Med Phys 32 2005 2548 2556 (Pubitemid 41197192)
    • (2005) Medical Physics , vol.32 , Issue.8 , pp. 2548-2556
    • Paganetti, H.1
  • 22
    • 0032949514 scopus 로고    scopus 로고
    • Intensity modulation methods for proton therapy
    • A.J. Lomax Intensity modulation methods for proton therapy Phys Med Biol 44 1999 185 205
    • (1999) Phys Med Biol , vol.44 , pp. 185-205
    • Lomax, A.J.1
  • 23
    • 39049164210 scopus 로고    scopus 로고
    • Intensity modulated proton therapy and its sensitivity to treatment uncertainties 1: The potential effects of calculational uncertainties
    • DOI 10.1088/0031-9155/53/4/014, PII S0031915508549608
    • A.J. Lomax Intensity modulated proton therapy and its sensitivity to treatment uncertainties 1: The potential effects of calculational uncertainties Phys Med Biol 53 2008 1027 1042 (Pubitemid 351238121)
    • (2008) Physics in Medicine and Biology , vol.53 , Issue.4 , pp. 1027-1042
    • Lomax, A.J.1
  • 24
    • 39049126842 scopus 로고    scopus 로고
    • Intensity modulated proton therapy and its sensitivity to treatment uncertainties 2: The potential effects of inter-fraction and inter-field motions
    • DOI 10.1088/0031-9155/53/4/015, PII S0031915508549589
    • A.J. Lomax Intensity modulated proton therapy and its sensitivity to treatment uncertainties 2: The potential effects of inter-fraction and inter-field motions Phys Med Biol 53 2008 1043 1056 (Pubitemid 351238122)
    • (2008) Physics in Medicine and Biology , vol.53 , Issue.4 , pp. 1043-1056
    • Lomax, A.J.1
  • 26
    • 0034042404 scopus 로고    scopus 로고
    • Radiobiological significance of beamline dependent proton energy distributions in a spread-out Bragg peak
    • DOI 10.1118/1.598977
    • H. Paganetti, and M. Goitein Radiobiological significance of beam line dependent proton energy distributions in a spread-out Bragg peak Med Phys 27 2000 1119 1126 (Pubitemid 30350024)
    • (2000) Medical Physics , vol.27 , Issue.5 , pp. 1119-1126
    • Paganetti, H.1    Goitein, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.