Treatment planning for a scanned carbon beam with a modified microdosimetric kinetic model

Physics in Medicine and Biology

Volumn 55, Issue 22, 2010, Pages 6721-6737

  Inaniwa, Taku ^a   Furukawa, Takuji ^a   Kase, Yuki ^a   Matsufuji, Naruhiro ^a   Toshito, Toshiyuki ^a   Matsumoto, Yoshitaka ^a   Furusawa, Yoshiya ^a   Noda, Koji ^a  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL EFFECTS; CARBON BEAMS; CELL LINES; CURRENT CELLS; FULLY INTEGRATED; HEAVY ION MEDICAL ACCELERATOR IN CHIBA; ION IRRADIATION; KINETIC MODELS; MEASURED DEPTHS; MIXED RADIATION; RELATIVE BIOLOGICAL EFFECTIVENESS; SALIVARY GLAND TUMOR; SURVIVAL CURVES; TREATMENT PLANNING; TREATMENT PLANNING SYSTEMS;

CELL CULTURE; IONS; IRRADIATION; KINETIC THEORY;

CURVE FITTING;

CARBON;

ARTICLE; BIOLOGICAL MODEL; CELL SURVIVAL; COMPUTER ASSISTED RADIOTHERAPY; HUMAN; KINETICS; METHODOLOGY; RADIATION EXPOSURE; RADIOMETRY; RELATIVE BIOLOGIC EFFECTIVENESS; REPRODUCIBILITY; TUMOR CELL LINE;

CARBON; CELL LINE, TUMOR; CELL SURVIVAL; HUMANS; KINETICS; MODELS, BIOLOGICAL; RADIOMETRY; RADIOTHERAPY PLANNING, COMPUTER-ASSISTED; RELATIVE BIOLOGICAL EFFECTIVENESS; REPRODUCIBILITY OF RESULTS;

EID: 78650016388     PISSN: 00319155     EISSN: 13616560     Source Type: Journal    
DOI: 10.1088/0031-9155/55/22/008     Document Type: Article

References (29)

1. Agostinelli S et al 2003 Geant4 - a simulation toolkit Nucl. Instrum. Methods. Phys. Res. A 506 250-303
2. Aso T et al 2007 GEANT4 based simulation framework for particle therapy system Nucl. Sci. Symp. IEEE Conf. Rec. 4 2564-7
3. Chatterjee A and Schaefer H J 1976 Microdosimetric structure of heavy ion tracks in tissue Radiat. Environm. Biophys. 13 215-27
4. Elsässer T and ScholzM2006 Improvement of the local effect model (LEM) - implications of clustered DNA damage Radiat. Prot. Dosimetry 122 475-7
5. Elsässer T and Scholz M 2007 Cluster effects within the local effect model Radiat. Res. 167 319-29
6. Furukawa T et al 2010 Performance of NIRS fast scanning system for heavy-ion radiotherapy Med. Phys. in press
7. Furusawa Y, Fukutsu K, Aoki M, Itsukaichi H, Eguchi-Kasai K, Ohara H, Yatagai F, Kanai T and Ando K 2000 Inactivation of aerobic and hypoxic cells from three different cell lines by accelerated He-, C- and Ne-ion beams Radiat. Res. 154 485-96
8. Gemmel A, Hasch B, Ellerbrock M,WeyratherWK and Krämer M 2008 Biological dose optimization with multiple ion fields Phys. Med. Biol. 53 6991-7012
9. Hawkins R B 1994 A statistical theory of cell killing by radiation of varying linear energy transfer Radiat. Res. 140 366-47
10. Hawkins R B 2003 A microdosimetric-kinetic model for the effect of non-Poisson distribution of lethal lesions on the variation of RBE with LET Radiat. Res. 160 61-9
11. Hirao Y et al 1992 Heavy ion synchrotron for medical use - HIMAC project at NIRS-JAPAN Nucl. Phys. A 538 541c - 50c
12. Inaniwa T, Furukawa T, Nagano A, Sato S, Saotome N, Noda K and Kanai T 2009 Field-size effect of physical doses in carbon-ion scanning using range shifter plates Med. Phys. 36 2889-97
13. Inaniwa T, Furukawa T, Sato S, Tomitani T, Kobayashi M, Minohara S, Noda K and Kanai T 2008 Development of treatment planning for scanning irradiation at HIMAC Nucl. Instrum. Methods. Phys. Res. B 266 2194-8
14. Inaniwa T, Furukawa T, Tomitani T, Sato S, Noda K and Kanai T 2007 Optimization for fast-scanning irradiation in particle therapy Med. Phys. 34 3302-11
15. Kanai T et al 1999 Biophysical characteristics of HIMAC clinical irradiation system for heavy-ion radiation therapy Int. J. Radiat. Oncol. Biol. Phys. 44 201-10
16. Kanai T, Matsufuji N, Miyamoto T, Mizoe J, Kamada T, Tsuji H, Kato H, Baba M and Tsujii H 2006 Examination of GyE system for HIMAC carbon therapy Int. J. Radiat. Oncol. Biol. Phys. 64 650-56
17. Kase Y, Kanai T, Matsufuji N, Furusawa Y, Elsässer T and Scholz M 2008 Biophysical calculation of cell survival probabilities using amorphous track structure models for heavy-ion irradiation Phys. Med. Biol. 53 37-59
18. Kase Y, Kanai T,Matsumoto Y, Furusawa Y, Okamoto H, Asaba T, SakamaMand Shinoda H 2006 Microdosimetric measurements and estimation of human cell survival for heavy-ion beams Radiat. Res. 166 629-38
19. Kellerer M and Rossi H H 1978 A generalized formation of dual radiation action Radiat. Res. 75 471-88
20. Kiefer J and Straaten H 1986 A model of ion track structure based on classical collision dynamics Phys. Med. Biol. 31 1201-9
21. Kraft G 2000 Tumor therapy with ion beams Nucl. Instrum. Methods A 454 1-10
22. Kraft G, Scholz M and Bechthold U 1999 Tumor therapy and track structure Radiat. Environ. Biophys. 38 229-37
23. Krämer M and Scholz M 2000 Treatment planning for heavy-ion radiotherapy: calculation and optimization of biologically effective dose Phys. Med. Biol. 45 3319-30
24. KrämerMand ScholzM2006 Rapid calculation of biological effects in ion radiotherapy Phys.Med. Biol. 51 1959-70
25. Nose H, Kase Y, Matsufuji N and Kanai T 2009 Field size effect of radiation quality in carbon therapy using passive method Med. Phys. 36 870-5
26. Sato T, Kase Y, Watanabe R, Niita K and Sihver H 2009 Biological dose estimation for charged-particle therapy using an improved PHITS code coupled with a microdosimetric kinetic model Radiat. Res. 171 107-17
27. Scholz M, Kellerer A M, Kraft-Weyrather W and Kraft G 1997 Computation of cell survival in heavy ion beams for therapy Radiat. Environ. Biophys. 36 59-66
28. Scholz M and Kraft G 1996 Track structure and the calculation of biological effects of heavy charged particles Adv. Space Res. 18 5-14
29. Toshito T, Inaniwa T, Furukawa T, Takeshita E, Himukai T, Sato S, Noda K, Kanematsu N and Kase Y 2010 Introduction of Monte Carlo method to treatment planning for scanning carbon beam therapy Proc. 99th Scientific Meeting of JSMP pp 125-6