Assessment of the genotoxicity of atenolol in human peripheral blood lymphocytes: Correlation between chromosomal fragility and content of micronuclei

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 695, Issue 1-2, 2010, Pages 46-54

  Télez, Mercedes ^a   Ortiz Lastra, Eduardo ^a   Gonzalez, Adolfo J ^a   Flores, Piedad ^a   Huerta, Iratxe ^a   Ramírez, Juan M ^a   Barasoain, Maitane ^a   Criado, Begoña ^b   Arrieta, Isabel ^a  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^b INSTITUTO DE INVESTIGAÇÃO E FORMAÇÃO AVANÇADA EM CIÊNCIAS E TECNOLOGIAS DA SAÚDE   (Portugal)

Author keywords

Antihypertensives; Content of micronuclei; Fragile sites; Genotoxicity

Indexed keywords

ATENOLOL;

ADULT; AGED; ARTICLE; CHROMOSOME 17; CHROMOSOME ABERRATION; CHROMOSOME FRAGILE SITE; CHROMOSOME FRAGILITY; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATIONAL STUDY; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENOTOXICITY; HUMAN; HYPERTENSION; MALE; MICRONUCLEUS; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL;

EID: 84859857094     PISSN: 13835718     EISSN: 18793592     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2009.02.015     Document Type: Article

References (69)

1. Mancia G., De Backer G., Dominiczak A., Cifkova R., Fagard R., Germano G., Grassi G., Heagerty A.V., Kjeldsen S.E., Laurent S., Narkiewicz K., Ruilope L., Rynkiewicz A., Schmieder R.E., Struijker Boudier H.A.J., Zanchetti A. Guía de 2007 para el manejo de la hipertensión arterial. J. Hypertens. 2007, 25:1105-1187.
2. Brambilla G., Martelli A. Genotoxicity and carcinogenicity studies of antihypertensive agents. Mutat. Res. 2006, 612:115-149.
3. Robbiano L., Martelli A., Allavena A., Mazzei M., Gazzaniga G.M., Brambilla G. Formation of the N-nitroso derivatives of six beta-adrenergic-blocking agents and their genotoxic effects in rat and human hepatocytes. Cancer Res. 1991, 51:2273-2279.
4. Télez M., Martínez B., Criado B., Lostao C.M., Peñagarikano O., Ortega B., Flores P., Ortiz-Lastra E., Alonso R.M., Jiménez R.M., Arrieta I. In vitro and in vivo evaluation of the antihypertensive drug atenolol in cultured human lymphocytes: effects of long-term therapy. Mutagenesis 2000, 15:195-202.
5. Bender M.A., Preston R.J., Leonard R.C., Pyatt B.E., Gooch P.C. On the distributions of spontaneous chromosomal aberrations in human peripheral blood lymphocytes in culture. Mutat. Res. 1990, 244:215-220.
6. Tucker J.D., Senft J.R. Analysis of naturally occurring and radiation-induced breakpoint locations in human chromosomes 1, 2 and 4. Radiat. Res. 1994, 140:31-36.
7. Brown T., Fox D.P., Robertson F.W., Bullock I. Non-random chromosome loss in PHA-stimulated lymphocytes from normal individuals. Mutat. Res. 1983, 122:403-406.
8. Richard F., Aurias A., Couturier J., Dutrillaux A.M., Flury-Herard A., Gerbault-Seureau M., Hoffschir F., Lamoliatte E., Lefrancois D., Lombard M., Muleris M., Prieur M., Ricoul M., Sabatier L., Viegas-Pequignot E., Volobouev V., Dutrillaux B. Aneuploidy in human lymphocytes: an extensive study of eight individuals of various ages. Mutat. Res. 1993, 295:71-80.
9. Fauth E., Scherthan H., Zankl H. Frequencies of occurrence of all human chromosomes in micronuclei from normal and 5-azacytidine-treated lymphocytes as revealed by chromosome painting. Mutagenesis 1998, 13:235-241.
10. Catalán J., Falck G.C.M., Norppa H. The X chromosome frequently lags behind in female lymphocyte anaphase. Am. J. Hum. Genet. 2000, 66:687-691.
11. Carere A., Antoccia A., Cimini D., Crebelli R., Degrassi F., Leopardi P., Marcon F., Sgura A., Tanzarella C., Zijno A. Analysis of chromosome loss and non-disjunction in cytokinesis-blocked lymphocytes of 24 male subjects. Mutagenesis 1999, 14:491-496.
12. Migliore L., Martelli L., Scarpato R. Detection of chromosome loss and gain induce by griseofulvin, estramustine and vanadate in binucleated lymphocytes using FISH analysis. Environ. Mol. Mutagen. 1999, 34:64-68.
13. Peace B.E., Livingston G., Silberstein E.B., Loper J.C. A case of elevated spontaneous micronucleus frequency derived from chromosome 2. Mutat. Res. 1999, 430:109-119.
14. Fauth E., Scherthan H., Zankl H. Chromosome painting reveals specific patterns of chromosome occurrence in mitomycin C- and diethylstilboestrol-induced micronuclei. Mutagenesis 2000, 15:459-467.
15. Shi Y., Zou M., Farid N.R., Paterson M.C. Association of FHIT (fragile histidine triad), a candidate tumour suppressor gene, with the ubiquitin-conjugating enzyme hUBC9. Biochem. J. 2000, 352:443-448.
16. Norppa H., Falck G.C.M. What do human micronuclei contain?. Mutagenesis 2003, 18:221-233.
17. Dekaban A. Persisting clone of cells with an abnormal chromosome in a woman previously irradiated. J. Nucl. Med. 1965, 6:740-746.
18. Lejeune J., Dutrillaux B., Lafourcade J., Berger R., Abonyi D., Rethore M.O. Endoréduplication sélective du bras long du chromosome 2 chez une femme et sa fille. C. R. Acad. Sci. Paris 1968, 266:24-26.
19. Margulis R.E., Hecht F., Lovrien E.W. Heritable fragile sites on chromosome 16 probable localization of Haptoglobin locus in man. Science 1970, 170:85-87.
20. Hecht F., Ramesh K.H., Lockwood D.H. A guide to fragile sites on human chromosomes. Cancer Genet. Cytogenet. 1990, 44:37-45.
21. Sutherland G.R. Fragile sites on human chromosomes. Fragile Sites: New Discoveries and Changing Perspectives 2007, 3-17. Nova Science Publishers, Inc., New York. I. Arrieta, O. Peñagarikano, M. Télez (Eds.).
22. Morelli C., Tognon M., Barbanti-Brodano G. Role of DNA packaging and rare fragile site expression. Fragile Sites: New Discoveries and Changing Perspectives 2007, 119-146. Nova Science Publishers, Inc., New York. I. Arrieta, O. Peñagarikano, M. Télez (Eds.).
23. Shucker M., Zlotorynski E., Kerem B. The molecular basis for the expression of common and rare fragile sites in the human genome. Fragile Sites: New Discoveries and Changing Perspectives 2007, 21-43. Nova Science Publishers, Inc., New York. I. Arrieta, O. Peñagarikano, M. Télez (Eds.).
24. Guler G., Iliopoulos D., Han S.Y., Druck T., McCorkell K.A., Huebner K. Fragile genes at common chromosomal fragile sites: roles in carcinogenesis. Fragile Sites: New Discoveries and Changing Perspectives 2007, 223-239. Nova Science Publishers, Inc., New York. I. Arrieta, O. Peñagarikano, M. Télez (Eds.).
25. Casper A.M., Arlt M.F., Glover T.W. Common fragile sites: cytogenetics and cell cycle checkpoints. Fragile Sites: New Discoveries and Changing Perspectives 2007, 47-66. Nova Science Publishers, Inc., New York. I. Arrieta, O. Peñagarikano, M. Télez (Eds.).
26. Peace B.E., Succop P. Spontaneous micronucleus frequency and age: what are normal values?. Mutat. Res. 1999, 425:225-230.
27. Countryman P.I., Heddle J.A. The production of micronuclei from chromosome aberrations in irradiated cultures of human lymphocytes. Mutat. Res. 1976, 41:321-332.
28. Bonassi S., Ugolini D., Kirsch-Volders M., Stromberg U., Vermeulen R., Tucker J.D. Human population studies with cytogenetic biomarkers: review of the literature and future prospectives. Environ. Mol. Mutagen. 2005, 45:258-270.
29. Bonassi S., Znaor A., Ceppi M., Lando C., Chang W.P.N., Holland, Kirsch-Volders M., Zeiger E., Ban S., Barale R., Bigatti M.P., Bolognesi C., Cebulska-Wasilewska A., Fabianova E., Fucic A., Hagmar L., Joksic G., Martelli A., Migliore L., Mirkova E., Scarfi M.R., Zijno A., Norppa H., Fenech M. An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans. Carcinogenesis 2007, 28:625-631.
30. Demsia G., Vlastos D., Goumenou M., Matthopoulos D.P. Assessment of the genotoxicity of imidacloprid and metalaxyl in cultured human lymphocytes and rat bone-marrow. Mutat. Res. 2007, 634:32-39.
31. Kocaman A.Y., Rencuzogullari E., Ila H.B., Topaktas M. The genotoxic effects of potassium metabisulfite using chromosome aberration, sister chromatid exchange, micronucleus tests in human lymphocytes and chromosome aberration test in bone marrow cells of rats. Environ. Mol. Mutagen. 2008, 49:276-282.
32. Lindberg H.K., Falck G.C., Järventaus H., Norppa H. Characterization of chromosomes and chromosomal fragments in human lymphocytes micronuclei by telomeric and centromeric FISH. Mutagenesis 2008, 23:371-376.
33. Surrallés J., Carbonell E., Marcos R., Degrassi F., Antoccia A., Tanzarella C. A collaborative study on the improvement of the micronucleus test in cultured human lymphocytes. Mutagenesis 1992, 6:407-410.
34. ISCN An International System for Human Cytogenetic Nomenclature 1995, S. Karger, Basel/USA, (Published in collaboration with Cytogenet. Cell. Genet.). F. Mitelman (Ed.).
35. Mariani T. Fragile sites and statistics. Hum. Genet. 1989, 81:319-322.
36. Arrieta I., Peñagarikano O., Télez M., Ortega B., Flores P., Criado B., Veiga I., Peixoto A.L., Lostao C.M. The FMR1 CGG repeat and linked microsatellite markers in two Basque valleys. Heredity 2003, 90:206-211.
37. Arrieta I., Peñagarikano O., Télez M., Ortega B., Criado B., Lostao C.M. Chromosomal fragility and autism. Focus on Autism Research 2004, 398-416. Nova Science Publishers, Inc., New York. O.T. Ryaskin (Ed.).
38. Fenech M. The cytokinesis-block micronucleus technique: a detailed description of the method and its application to genotoxicity studies in human populations. Mutat. Res. 1993, 285:35-44.
39. Eastmond D.A., Tucker J.D. Identification of aneuploidy-inducing agents using cytokinesis-blocked human lymphocytes and an antikinetochore antibody. Environ. Mol. Mutagen. 1989, 13:34-43.
40. Tusell L., Alvarez R., Genescà A., Caballín M.R., Miró R., Egozcue J. Analysis of radiation-induced micronuclei in two-cell human-hamster embryos using telomeric and centromeric FISH probes. Cytogenet. Cell. Genet. 1996, 74:102-106.
41. Migliore L., Cocchi L., Scarpato R. Detection of centromere in micronuclei by fluorescence in situ hybridization: its application to the human lymphocyte micronucleus assay after treatment with four suspected aneugens. Mutagenesis 1996, 11:285-290.
42. Kocaman A.Y., Topaktas M. In vitro evaluation of the genotoxicity of acetamiprid in human peripheral blood lymphocytes. Environ. Mol. Mutagen. 2007, 48:483-490.
43. Bayram S., Topaktas M. Confirmation of the chromosome damaging effects of lamivudine in in vitro human peripheral blood lymphocytes. Environ. Mol. Mutagen. 2008, 49:328-333.
44. Muehlbauer P.A., Spellman R.A., Gunther W.C., Sanok K.E., Wiersch C.J., O'Lone S.D., Dobo K.L., Schuler M.J. Improving dose selection and identification of aneugens in the in vitro chromosome aberration test by integration of flow cytometry-based methods. Environ. Mol. Mutagen. 2008, 49:318-327.
45. Migliore L., Guidotti P., Favre C., Nardi M., Sessa M.R., Brunori E. Micronuclei in lymphocytes of young patients under antileukemic therapy. Mutat. Res. 1991, 263:243-248.
46. Grummt T., Grummt H.J., Schott G. Chromosomal aberrations in peripheral lymphocytes of nurses and physicians handling antineoplastic drugs. Mutat. Res. 1993, 302:19-24.
47. Bakopoulou A., Mourelatos D., Tsiftsoglou A.S., Mioglou E., Garefis P. Sister-chromatid exchange, chromosomal aberrations and delays in cell-cycle kinetics in human lymphocytes induced by dental composite resin eluates. Mutat Res. 2008, 649:79-90.
48. Mishmar D., Rahat A., Scherer S.W., Nyakatura G., Hinzmann B., Kohwi Y., Mandel-Gutfroind Y., Lee J.R., Drescher B., Sas D.E., Margalit H., Platzer M., Weiss A., Tsui L.C., Rosenthal A., Kerem B. Molecular characterization of a common fragile site (FRA7H) on human chromosome 7 by the cloning of a simian virus 40 integration site. Proc. Natl. Acad. Sci. U.S.A. 1998, 95:8141-8146.
49. Arlt M.F., Miller D.E., Beer D.G., Glover T.W. Molecular characterization of FRAXB and comparative common fragile site instability in cancer cells. Genes Chromosomes Cancer 2002, 33:82-92.
50. Hellman A., Rahat A., Scherer S.W., Darvasi A., Tsui L.C., Kerem B. Replication delay along FRA7H, a common fragile site on human chromosome 7, leads to chromosomal instability. Mol. Cell. Biol. 2000, 20:4420-4427.
51. Durkin S.G., Glover T.W. Chromosome fragile sites. Annu. Rev. Genet. 2007, 41:169-192.
52. Smith D.I., McAvoy S., Wang F. Common fragile site genes. Fragile Sites: New Discoveries and Changing Perspectives 2007, 193-222. Nova Science Publishers, Inc., New York. I. Arrieta, O. Peñagarikano, M. Télez (Eds.).
53. Lange M., Spector T.D., Andrew T. Genome-wide scan for blood pressure suggests linkage to chromosome 11, and replication of loci on 16,17, and 22. Hypertension 2004, 44:872-877.
54. Collaku A., Rankinen T., Rice T., Leon A.S., Rao D.C., Skinner J.S., Wilmore J.H., Bouchard C. A genome-wide linkage scan for dietary energy and nutrient intakes: the Health, Risk Factors, Exercise Training, and Genetics (HERITAGE) Family Study. Am. J. Clin. Nutr. 2004, 79:881-886.
55. Moran V., Obrador G.T., Thadhani R. Fabry kidney disease. Saudi J. Kidney Dis. Transpl. 2003, 14:367-377.
56. Baima J., Nicolaou M., Schwartz F., DeStefano A.L., Manolis A., Gavras I., Laffer C., Elijovich F., Farrer L., Baldwin C.T., Gavras H. Evidence for linkage between essential hypertension and a putative locus on human chromosome 17. Hypertension 1999, 34:4-7.
57. Jeunemaitre X., Gimenez-Roqueplo A.P. Genetics and arterial hypertension: 3 approaches to decode a complex disease. Bull. Acad. Natl. Med. 2002, 186:1595-1609.
58. Gu F., Ge D., Huang J., Chen J., Yang W., Gu D. Genetic susceptibility loci for essential hypertension and blood pressure on chromosome 17 in 147 Chinese pedigrees. J. Hypertens. 2004, 22:1511-1518.
59. Levy D., DeStefano A.L., Larson M.G., O'Donnell C.J., Lifton R.P., Gavras H., Cupples L.A., Myers R.H. Evidence for a gene influencing blood pressure on chromosome 17. Genome scan linkage results for longitudinal blood pressure phenotypes in subjects from the Framingham heart study. Hypertension 2000, 36:477-483.
60. Gilibert S., Kwitek A.E., Hubner N., Tschannen M., Jacob H.J., Sassard J., Bataillard A. Effects of chromosome 17 on features of the metabolic syndrome in the Lyon hypertensive rat. Physiol. Genomics. 2008, 33:212-217.
61. Richard F., Muleris M., Dutrillaux B. The frequency of micronuclei with the X chromosome increases with age in human females. Mutat. Res. 1994, 316:1-7.
62. Guttenbach M., Schakowski R., Schmid M. Aneuploidy and ageing: sex chromosome exclusion into micronuclei. Hum. Genet. 1994, 94:295-298.
63. Falck G.C., Catalán J., Norppa H. Nature of anaphase laggards and micronuclei in female cytokinesis-blocked lymphocytes. Mutagenesis 2002, 17:111-117.
64. Wojda A., Zietkiewicz E., Witt M. Effects of age and gender on micronucleus and chromosome non-disjunction frequencies in centenarians and younger subjects. Mutagenesis 2007, 22:195-200.
65. Surrallés J., Hande M.P., Marcos R., Lansdorp P.M. Accelerated telomere shortening in the human inactive X chromosome. Am. J. Hum. Genet. 1999, 65:1617-1622.
66. Tucker J.D., Nath J., Hando J.C. Activation status of the X chromosome in human micronucleated lymphocytes. Hum. Genet. 1996, 97:471-475.
67. Guttenbach M., Schakowski R., Schmid M. Incidence of chromosome 3, 7, 10, 11, 17 and X disomy in mature human sperm nuclei as determined by nonradioactive in situ hybridization. Hum. Genet. 1994, 93:7-12.
68. Obe G., Pfeiffer P., Savage J.R.K., Johannes C., Goedecke W., Jeppesen P., Natarajan A.T., Martínez-López W., Folle G.A., Drets M.E. Chromosomal aberrations: formation, identification and distribution. Mutat. Res. 2002, 504:17-36.
69. Strachan T., Read A.P. Human Molecular Genetics 3 2004, Garland Science, New York. 3rd edition.