Ethanolic extract of vitis thunbergii exhibits lipid lowering properties via modulation of the AMPK-ACC pathway in hypercholesterolemic rabbits

Evidence-based Complementary and Alternative Medicine

Volumn 2012, Issue , 2012, Pages

  Pan, Chun Hsu ^a   Tsai, Chia Hua ^a   Lin, Wen Hsin ^a   Chen, Guo Yan ^b   Wu, Chieh Hsi ^a  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b Medigreen Biotechnology Corp   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ANTILIPEMIC AGENT; CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LIPID; LOW DENSITY LIPOPROTEIN; PLANT EXTRACT; UNCLASSIFIED DRUG; VITIS THUNBERGII EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROGENESIS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; HYPERCHOLESTEROLEMIA; LIPID BLOOD LEVEL; LIPID STORAGE; LIVER; MALE; MEDICINAL PLANT; NONHUMAN; PRIORITY JOURNAL; RABBIT; TREATMENT DURATION; VITIS THUNBERGII;

EID: 84859779932     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2012/436786     Document Type: Article

References (57)

1. Baer A. N., Wortmann R. L., Myotoxicity associated with lipid-lowering drugs Current Opinion in Rheumatology 2007 19 1 67 73 (Pubitemid 44885730)
2. Adams J., Chen Z. P., Van Denderen B. J. W., Morton C. J., Parker M. W., Witters L. A., Stapleton D., Kemp B. E., Intrasteric control of AMPK via the 1 subunit AMP allosteric regulatory site Protein Science 2004 13 1 155 165 (Pubitemid 38021150)
3. Lee J. M., Seo W. Y., Song K. H., Chanda D., Kim Y. D., Kim D. K., Lee M. W., Ryu D., Kim Y. H., Noh J. R., Lee C. H., Chiang J. Y. L., Koo S. H., Choi H. S., AMPK-dependent repression of hepatic gluconeogenesis via disruption of CREB CRTC2 complex by orphan nuclear receptor small heterodimer partner Journal of Biological Chemistry 2010 285 42 32182 32191
4. Hardie D. G., The AMP-activated protein kinase pathwaynew players upstream and downstream Journal of Cell Science 2004 117 23 5479 5487 (Pubitemid 40012195)
5. Ojuka E. O., Role of calcium and AMP kinase in the regulation of mitochondrial biogenesis and GLUT4 levels in muscle Proceedings of the Nutrition Society 2004 63 2 275 278 (Pubitemid 38787478)
6. Hardie D. G., Pan D. A., Regulation of fatty acid synthesis and oxidation by the AMP-activated protein kinase Biochemical Society Transactions 2002 30 6 1064 1070 (Pubitemid 36002407)
7. Clarke P. R., Hardie D. G., Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver EMBO Journal 1990 9 8 2439 2446
8. An Z., Wang H., Song P., Zhang M., Geng X., Zou M. H., Nicotine-induced activation of AMP-activated protein kinase inhibits fatty acid synthase in 3T3L1 adipocytes: a role for oxidant stress Journal of Biological Chemistry 2007 282 37 26793 26801 (Pubitemid 47501967)
9. Huang Y. L., Loke S. H., Hsu C. C., Chiou W. F., (+)-Vitisin A inhibits influenza A virus-induced RANTES production in A549 alveolar epithelial cells through interference with Akt and STAT1 phosphorylation Planta Medica 2008 74 2 156 162
10. Ku K. T., Huang Y. L., Huang Y. J., Chiou W. F., Miyabenol A inhibits LPS-induced NO production via IKK/I B inactivation in RAW 264.7 macrophages: possible involvement of the p38 and PI3K pathways Journal of Agricultural and Food Chemistry 2008 56 19 8911 8918
11. Huang Y. L., Tsai W. J., Shen C. C., Chen C. C., Resveratrol derivatives from the roots of Vitis thunbergii Journal of Natural Products 2005 68 2 217 220
12. Lin L. L., Lien C. Y., Cheng Y. C., Ku K. L., An effective sample preparation approach for screening the anticancer compound piceatannol using HPLC coupled with UV and fluorescence detection Journal of Chromatography B 2007 853 1-2 175 182
13. Peng S. C., Cheng C. Y., Sheu F., Su C. H., The antimicrobial activity of heyneanol A extracted from the root of taiwanese wild grape Journal of Applied Microbiology 2008 105 2 485 491 (Pubitemid 351989444)
14. Chung I.-M., Yeo M.-A., Kim S.-J., Moon H.-I., Neuroprotective effects of resveratrol derivatives from the roots of Vitis thunbergii var. sinuate against glutamate-induced neurotoxicity in primary cultured rat cortical cells Human and Experimental Toxicology 2011 30 9 1404 1408
15. Wang C. K., Chen L. G., Wen C. L., Hou W. C., Hung L. F., Yen S. J., Shen Y. J., Lin S. Y., Liang Y. C., Neuroprotective activity of vitis thunbergii var. taiwaniana extracts in vitro and in vivo Journal of Medicinal Food 2010 13 1 170 178
16. Chiou W. F., Shen C. C., Chen C. C., Lin C. H., Huang Y. L., Oligostilbenes from the roots of Vitis thunbergii Planta Medica 2009 75 8 856 859
17. Yang S. C., Studies on the Chemical Constituents of the Stems of Vitis thunbergii Sieb. et Zucc, M.S. thesis 2005 Taichung, Taiwan China Medical University
18. Wu J. M., Wang Z. R., Hsieh T. C., Bruder J. L., Zou J. G., Huang Y. Z., Mechanism of cardioprotection by resveratrol, a phenolic antioxidant present in red wine (Review) International journal of molecular medicine 2001 8 1 3 17
19. Berrougui H., Grenier G., Loued S., Drouin G., Khalil A., A new insight into resveratrol as an atheroprotective compound: inhibition of lipid peroxidation and enhancement of cholesterol efflux Atherosclerosis 2009 207 2 420 427
20. Ramprasath V. R., Jones P. J. H., Anti-atherogenic effects of resveratrol European Journal of Clinical Nutrition 2010 64 7 660 668
21. Das S., Cordis G. A., Maulik N., Das D. K., Pharmacological preconditioning with resveratrol: Role of CREB-dependent Bcl-2 signaling via adenosine A3 receptor activation American Journal of Physiology 2005 288 1 H328 H335
22. Das S., Das D. K., Resveratrol: a therapeutic promise for cardiovascular diseases Recent Patents on Cardiovascular Drug Discovery 2007 2 2 133 138 (Pubitemid 46957321)
23. Kirk R. I., Deitch J. A., Wu J. M., Lerea K. M., Resveratrol decreases early signaling events in washed platelets but has little effect on platelet aggregation in whole blood Blood Cells, Molecules, and Diseases 2000 26 2 144 150 (Pubitemid 30604894)
24. Pendurthi U. R., Williams J. T., Rao L. V. M., Resveratrol, a polyphenolic compound found in wine, inhibits tissue factor expression in vascular cells: a possible mechanism for the cardiovascular benefits associated with moderate consumption of wine Arteriosclerosis, Thrombosis, and Vascular Biology 1999 19 2 419 426 (Pubitemid 29072759)
25. Zini R., Morin C., Bertelli A., Bertelli A. A. E., Tillement J. P., Effects of resveratrol on the rat brain respiratory chain Drugs under Experimental and Clinical Research 1999 25 2-3 87 97 (Pubitemid 29257599)
26. Jang M., Pezzuto J. M., Cancer chemopreventive activity of resveratrol Drugs under Experimental and Clinical Research 1999 25 2-3 65 77 (Pubitemid 29257597)
27. Ray P. S., Maulik G., Cordis G. A., Bertelli A. A. E., Bertelli A., Das D. K., The red wine antioxidant resveratrol protects isolated rat hearts from ischemia reperfusion injury Free Radical Biology and Medicine 1999 27 1-2 160 169 (Pubitemid 29353096)
28. Manna S. K., Mukhopadhyay A., Aggarwal B. B., Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF- B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation Journal of Immunology 2000 164 12 6509 6519 (Pubitemid 30408836)
29. Kimura Y., Okuda H., Kubo M., Effects of stilbenes isolated from medicinal plants on arachidonate metabolism and degranulation in human polymorphonuclear leukocytes Journal of Ethnopharmacology 1995 45 2 131 139
30. Das S., Das D. K., Anti-inflammatory responses of resveratrol Inflammation and AllergyDrug Targets 2007 6 3 168 173 (Pubitemid 47455785)
31. Ignatowicz E., Baer-Dubowska W., Resveratrol, a natural chemopreventive agent against degenerative diseases Polish Journal of Pharmacology 2001 53 6 557 569
32. Penumathsa S. V., Thirunavukkarasu M., Koneru S., Juhasz B., Zhan L., Pant R., Menon V. P., Otani H., Maulik N., Statin and resveratrol in combination induces cardioprotection against myocardial infarction in hypercholesterolemic rat Journal of Molecular and Cellular Cardiology 2007 42 3 508 516 (Pubitemid 46349117)
33. Rocha K. K. R., Souza G. A., Ebaid G. X., Seiva F. R. F., Cataneo A. C., Novelli E. L. B., Resveratrol toxicity: effects on risk factors for atherosclerosis and hepatic oxidative stress in standard and high-fat diets Food and Chemical Toxicology 2009 47 6 1362 1367
34. Miura D., Miura Y., Yagasaki K., Hypolipidemic action of dietary resveratrol, a phytoalexin in grapes and red wine, in hepatoma-bearing rats Life Sciences 2003 73 11 1393 1400 (Pubitemid 36798126)
35. Rivera L., Morn R., Zarzuelo A., Galisteo M., Long-term resveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats Biochemical Pharmacology 2009 77 6 1053 1063
36. Ahn J., Cho I., Kim S., Kwon D., Ha T., Dietary resveratrol alters lipid metabolism-related gene expression of mice on an atherogenic diet Journal of Hepatology 2008 49 6 1019 1028
37. Cho I. J., Ahn J. Y., Kim S., Choi M. S., Ha T. Y., Resveratrol attenuates the expression of HMG-CoA reductase mRNA in hamsters Biochemical and Biophysical Research Communications 2008 367 1 190 194
38. Do G. M., Kwon E. Y., Kim H. J., Jeon S. M., Ha T. Y., Park T., Choi M. S., Long-term effects of resveratrol supplementation on suppression of atherogenic lesion formation and cholesterol synthesis in apo E-deficient mice Biochemical and Biophysical Research Communications 2008 374 1 55 59
39. Gnoni G. V., Paglialonga G., Resveratrol inhibits fatty acid and triacylglycerol synthesis in rat hepatocytes European Journal of Clinical Investigation 2009 39 3 211 218
40. Goldberg D. M., Hahn S. E., Parkes J. G., Beyond alcohol: beverage consumption and cardiovascular mortality Clinica Chimica Acta 1995 237 1-2 155 187
41. Barter P. J., Caulfield M., Eriksson M., Grundy S. M., Kastelein J. J. P., Komajda M., Lopez-Sendon J., Mosca L., Tardif J. C., Waters D. D., Shear C. L., Revkin J. H., Buhr K. A., Fisher M. R., Tall A. R., Brewer B., Effects of torcetrapib in patients at high risk for coronary events New England Journal of Medicine 2007 357 21 2109 2122 (Pubitemid 350146106)
42. Gomaraschi M., Baldassarre D., Amato M., Eligini S., Conca P., Sirtori C. R., Franceschini G., Calabresi L., Normal vascular function despite low levels of high-density lipoprotein cholesterol in carriers of the apolipoprotein A-IMilano mutant Circulation 2007 116 19 2165 2172 (Pubitemid 350060354)
43. Trigatti B. L., Krieger M., Rigotti A., Influence of the HDL receptor SR-BI on lipoprotein metabolism and atherosclerosis Arteriosclerosis, Thrombosis, and Vascular Biology 2003 23 10 1732 1738 (Pubitemid 37254855)
44. César T. B., Oliveira M. R. M., Mesquita C. H., Maranho R. C., High cholesterol intake modifies chylomicron metabolism in normolipidemic young men Journal of Nutrition 2006 136 4 971 976
45. Clarke R., Frost C., Collins R., Appleby P., Peto R., Dietary lipids and blood cholesterol: quantitative meta-analysis of metabolic ward studies British Medical Journal 1997 314 7074 112 117 (Pubitemid 27022952)
46. You M., Rogers C. Q., Adiponectin: a key adipokine in alcoholic fatty liver Experimental Biology and Medicine 2009 234 8 850 859
47. Kusakabe T., Tanioka H., Ebihara K., Hirata M., Miyamoto L., Miyanaga F., Hige H., Aotani D., Fujisawa T., Masuzaki H., Hosoda K., Nakao K., Beneficial effects of leptin on glycaemic and lipid control in a mouse model of type 2 diabetes with increased adiposity induced by streptozotocin and a high-fat diet Diabetologia 2009 52 4 675 683
48. Lin C. L., Huang H. C., Lin J. K., Theaflavins attenuate hepatic lipid accumulation through activating AMPK in human HepG2 cells Journal of Lipid Research 2007 48 11 2334 2343
49. Liu J.-F., Ma Y., Wang Y., Du Z.-Y., Shen J.-K., Peng H.-L., Reduction of lipid accumulation in HepG2 Cells by luteolin is associated with activation of AMPK and Mitigation of oxidative stress Phytotherapy Research 2011 25 4 588 596
50. Zang M., Zuccollo A., Hou X., Nagata D., Walsh K., Herscovitz H., Brecher P., Ruderman N. B., Cohen R. A., AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells Journal of Biological Chemistry 2004 279 46 47898 47905 (Pubitemid 39540941)
51. Zhou G., Myers R., Li Y., Chen Y., Shen X., Fenyk-Melody J., Wu M., Ventre J., Doebber T., Fujii N., Musi N., Hirshman M. F., Goodyear L. J., Moller D. E., Role of AMP-activated protein kinase in mechanism of metformin action Journal of Clinical Investigation 2001 108 8 1167 1174 (Pubitemid 32995375)
52. Shang J., Chen L. L., Xiao F. X., Resveratrol improves high-fat induced nonalcoholic fatty liver in rats Zhonghua Gan Zang Bing Za Zhi 2008 16 8 616 619
53. Ajmo J. M., Liang X., Rogers C. Q., Pennock B., You M., Resveratrol alleviates alcoholic fatty liver in mice American Journal of Physiology 2008 295 4 G833 G842
54. Shang J., Chen L. L., Xiao F. X., Sun H., Ding H. C., Xiao H., Resveratrol improves non-alcoholic fatty liver disease by activating AMP-activated protein kinase Acta Pharmacologica Sinica 2008 29 6 698 706 (Pubitemid 351799479)
55. Goldstein J. L., Brown M. S., Atherosclerosis: the low-density lipoprotein receptor hypothesis Metabolism 1977 26 11 1257 1275 (Pubitemid 8210421)
56. Brown M. S., Goldstein J. L., Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth Journal of Lipid Research 1980 21 5 505 517 (Pubitemid 11194847)
57. Rudney H., Sexton R. C., Regulation of cholesterol biosynthesis Annual Review of Nutrition 1986 6 245 272