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Volumn 37, Issue 1, 2012, Pages 73-84

Cytotoxic effects of the novel isoflavone, phenoxodiol, on prostate cancer cell lines

Author keywords

Apoptosis; isoflavone; phenoxodiol; prostate

Indexed keywords

CASPASE 3; IDRONOXIL; ISOFLAVONE;

EID: 84859776394     PISSN: 02505991     EISSN: 09737138     Source Type: Journal    
DOI: 10.1007/s12038-011-9170-6     Document Type: Article
Times cited : (16)

References (35)
  • 1
    • 17144381683 scopus 로고    scopus 로고
    • WAF1/CIP1
    • Aguero MF, Facchinetti MM, Sheleg Z and Senderowicz AM 2005 Phenoxodiol, a novel isoflavone, induces G1 arrest by specific loss in cyclin-dependent kinase 2 activity by p53-independent induction of p21WAF1/CIP1. Cancer Res. 65 3364-3373 (Pubitemid 40524621)
    • (2005) Cancer Research , vol.65 , Issue.8 , pp. 3364-3373
    • Aguero, M.F.1    Facchinetti, M.M.2    Sheleg, Z.3    Senderowicz, A.M.4
  • 2
    • 0032864723 scopus 로고    scopus 로고
    • Genistein-induced cell cycle arrest and apoptosis in a head and neck squamous cell carcinoma cell line
    • Alhasan SA, Pietrasczkiwicz H, Alonso MD, Ensley J and Sarkar FH 1999 Genistein-induced cell cycle arrest and apoptosis in a head and neck squamous cell carcinoma cell line. Nutr. Cancer 34 12-19 (Pubitemid 29382910)
    • (1999) Nutrition and Cancer , vol.34 , Issue.1 , pp. 12-19
    • Alhasan, S.A.1    Pietrasczkiwicz, H.2    Alonso, M.D.3    Ensley, J.4    Sarkar, F.H.5
  • 3
    • 31544466555 scopus 로고    scopus 로고
    • Molecular mechanism of phenoxodiol-induced apoptosis in ovarian carcinoma cells
    • DOI 10.1002/cncr.21633
    • Alvero AB, O'Malley D, Brown D, Kelly G, Garg M, Chen W, Rutherford T and Mor G 2006 Molecular mechanism of phenoxodiol-induced apoptosis in ovarian carcinoma cells. Cancer 106 599-608 (Pubitemid 43157623)
    • (2006) Cancer , vol.106 , Issue.3 , pp. 599-608
    • Alvero, A.B.1    O'Malley, D.2    Brown, D.3    Kelly, G.4    Garg, M.5    Chen, W.6    Rutherford, T.7    Mor, G.8
  • 4
    • 19544381048 scopus 로고    scopus 로고
    • Growth of LNCaP cells in monoculture and coculture with osteoblasts and response to tNOX inhibitors
    • DOI 10.1016/j.canlet.2004.11.017, PII S0304383504008778
    • Axanova L, Morre DJ and Morre DM 2005 Growth of LNCaP cells in monoculture and coculture with osteoblasts and response to tNOX inhibitors. Cancer Lett. 225 35-40 (Pubitemid 40732766)
    • (2005) Cancer Letters , vol.225 , Issue.1 , pp. 35-40
    • Axanova, L.1    Morre, D.J.2    Morre, D.M.3
  • 5
    • 0141863402 scopus 로고    scopus 로고
    • Overview of dietary flavonoids: Nomenclature, occurrence and intake
    • Beecher GR 2003 Overview of dietary flavonoids: nomenclature, occurrence and intake. J. Nutr. 133 3248S-3254S (Pubitemid 37222252)
    • (2003) Journal of Nutrition , vol.133 , Issue.10
    • Beecher, G.R.1
  • 6
    • 14644407525 scopus 로고    scopus 로고
    • The role of apoptosis in cancer development and treatment response
    • DOI 10.1038/nrc1570
    • Brown JM and Attardi LD 2005 The role of apoptosis in cancer development and treatment response. Nat. Rev. Cancer 5 231-237 (Pubitemid 40314954)
    • (2005) Nature Reviews Cancer , vol.5 , Issue.3 , pp. 231-237
    • Brown, J.M.1    Attardi, L.D.2
  • 7
    • 1542472979 scopus 로고    scopus 로고
    • Apoptosis genes and resistance to cancer therapy: What does the experimental and clinical data tell us?
    • Brown JM and Wilson G 2003 Apoptosis genes and resistance to cancer therapy: what does the experimental and clinical data tell us? Cancer Biol. Ther. 2 477-490
    • (2003) Cancer Biol. Ther. , vol.2 , pp. 477-490
    • Brown, J.M.1    Wilson, G.2
  • 8
    • 0033118475 scopus 로고    scopus 로고
    • Apoptosis, p53, and tumor cell sensitivity to anticancer agents
    • Brown JM and Wouters BG 1999 Apoptosis, p53, and tumor cell sensitivity to anticancer agents. Cancer Res. 59 1391-1399 (Pubitemid 29160097)
    • (1999) Cancer Research , vol.59 , Issue.7 , pp. 1391-1399
    • Brown, J.M.1    Wouters, B.G.2
  • 9
    • 24644523642 scopus 로고    scopus 로고
    • Flavonoid compounds in maintenance of prostate health and prevention and treatment of cancer
    • DOI 10.1385/MB:30:3:253
    • Brown DM, Kelly GE and Husband AJ 2005 Flavonoid compounds in maintenance of prostate health and prevention and treatment of cancer. Mol. Biotechnol. 30 253-270 (Pubitemid 41272813)
    • (2005) Molecular Biotechnology , vol.30 , Issue.3 , pp. 253-270
    • Brown, D.M.1    Kelly, G.E.2    Husband, A.J.3
  • 10
    • 0034786019 scopus 로고    scopus 로고
    • L sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis
    • DOI 10.1016/S1097-2765(01)00320-3
    • Cheng EH, Wei MC, Weiler S, Flavell RA, Mak TW, Lindsten T and Korsmeyer SJ 2001 BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol. Cell 8 705-711 (Pubitemid 32946946)
    • (2001) Molecular Cell , vol.8 , Issue.3 , pp. 705-711
    • Cheng, E.H.-Y.1    Wei, M.C.2    Weiler, S.3    Flavell, R.A.4    Mak, T.W.5    Lindsten, T.6    Korsmeyer, S.J.7
  • 11
    • 0037403574 scopus 로고    scopus 로고
    • Phenoxodiol, a novel isoflavone derivative, inhibits dimethylbenz[a] anthracene (DMBA)-induced mammary carcinogenesis in female Sprague-Dawley rats
    • DOI 10.1016/S0959-8049(03)00124-2
    • Constantinou AI, Mehta R and Husband A 2003 Phenoxodiol, a novel isoflavone derivative, inhibits dimethylbenz[a]anthracene (DMBA)-induced mammary carcinogenesis in female Sprague- Dawley rats. Eur. J. Cancer 39 1012-1018 (Pubitemid 36428635)
    • (2003) European Journal of Cancer , vol.39 , Issue.7 , pp. 1012-1018
    • Constantinou, A.I.1    Mehta, R.2    Husband, A.3
  • 12
    • 0036716281 scopus 로고    scopus 로고
    • The BCL2 family: Regulators of the cellular life-or-death switch
    • DOI 10.1038/nrc883
    • Cory S and Adams JM 2002 The Bcl2 family: regulators of the cellular life-or-death switch. Nat. Rev. Cancer 2 647-656 (Pubitemid 37328916)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.9 , pp. 647-656
    • Cory, S.1    Adams, J.M.2
  • 13
    • 33746068256 scopus 로고    scopus 로고
    • NAD+/NADH and/or CoQ/CoQH2 ratios from plasma membrane electron transport may determine ceramide and sphingosine-1-phosphate levels accompanying G1 arrest and apoptosis
    • De Luca T, Morre DM, Zhao H and Morre DJ 2005 NAD+/NADH and/or CoQ/CoQH2 ratios from plasma membrane electron transport may determine ceramide and sphingosine-1-phosphate levels accompanying G1 arrest and apoptosis. Biofactors 25 43-60
    • (2005) Biofactors , vol.25 , pp. 43-60
    • De Luca, T.1    Morre, D.M.2    Zhao, H.3    Morre, D.J.4
  • 14
    • 0027952041 scopus 로고
    • Apoptosis during functional corpus luteum regression: Evidence of a role for chorionic gonadotropin in promoting luteal cell survival
    • Dharmarajan AM, Goodman SB, Tilly KI and Tilly JL 1994 Apoptosis during functional corpus luteum regression: evidence of a role for chorionic gonadotropin in promoting luteal cell survival. Endocrine J. 2 295-303 (Pubitemid 2065935)
    • (1994) Endocrine , vol.2 , Issue.4 , pp. 295-303
    • Dharmarajan, A.M.1    Goodman, S.B.2    Tilly, K.I.3    Tilly, J.L.4
  • 15
    • 0035496220 scopus 로고    scopus 로고
    • The development of androgen-independent prostate cancer
    • Feldman BJ and Feldman D 2001 The development of androgen-independent prostate cancer. Nat. Rev. Cancer 1 34-45 (Pubitemid 33741879)
    • (2001) Nature Reviews Cancer , vol.1 , Issue.1 , pp. 34-45
    • Feldman, B.J.1    Feldman, D.2
  • 16
    • 0344393732 scopus 로고    scopus 로고
    • Strategies for reversing drug resistance
    • DOI 10.1038/sj.onc.1206951, Drug Resistance
    • Fojo T and Bates S 2003 Strategies for reversing drug resistance. Oncogene 22 7512-7523 (Pubitemid 37487173)
    • (2003) Oncogene , vol.22 , Issue.47 REV. ISS. 6 , pp. 7512-7523
    • Fojo, T.1    Bates, S.2
  • 17
    • 33646426132 scopus 로고    scopus 로고
    • Phenoxodiol, an experimental anticancer drug, shows potent antiangiogenic properties in addition to its antitumour effects
    • Gamble JR, Xia P, Hahn CN, Drew JJ, Drogemuller CJ, Brown D and Vadas MA 2005 Phenoxodiol, an experimental anticancer drug, shows potent antiangiogenic properties in addition to its antitumour effects. Int. J. Cancer 118 2412-2420
    • (2005) Int. J. Cancer , vol.118 , pp. 2412-2420
    • Gamble, J.R.1    Xia, P.2    Hahn, C.N.3    Drew, J.J.4    Drogemuller, C.J.5    Brown, D.6    Vadas, M.A.7
  • 19
    • 28744441818 scopus 로고    scopus 로고
    • Beyond simple castration: Targeting the molecular basis of treatment resistance in advanced prostate cancer
    • Gleave M, Miyake H and Chi K 2005 Beyond simple castration: targeting the molecular basis of treatment resistance in advanced prostate cancer. Cancer Chemother. Pharmacol. 56 47-57
    • (2005) Cancer Chemother. Pharmacol. , vol.56 , pp. 47-57
    • Gleave, M.1    Miyake, H.2    Chi, K.3
  • 20
    • 2142694340 scopus 로고    scopus 로고
    • Nuclear and mitochondrial conversations in cell death: PARP-1 and AIF signaling
    • DOI 10.1016/j.tips.2004.03.005, PII S0165614704000690
    • Hong SJ, Dawson TM and Dawson VL 2004 Nuclear and mitochondrial conversations in cell death: PARP-1 and AIF signaling. Trends Pharmacol. Sci. 25 259-264 (Pubitemid 38553828)
    • (2004) Trends in Pharmacological Sciences , vol.25 , Issue.5 , pp. 259-264
    • Hong, S.J.1    Dawson, T.M.2    Dawson, V.L.3
  • 21
    • 0033991685 scopus 로고    scopus 로고
    • International trends and patterns of prostate cancer incidence and mortality
    • Hsing AW, Tsao L and Devesa SS 2000 International trends and patterns of prostate cancer incidence and mortality. Int. J. Cancer 85 60-67
    • (2000) Int. J. Cancer , vol.85 , pp. 60-67
    • Hsing, A.W.1    Tsao, L.2    Devesa, S.S.3
  • 23
    • 0037854571 scopus 로고    scopus 로고
    • Phenoxodiol - An isoflavone analog - Induces apoptosis in chemoresistant ovarian cancer cells
    • DOI 10.1038/sj.onc.1206422
    • Kamsteeg M, Rutherford T, Sapi E, Hanczaruk B, Shahabi S, Flick M, Brown D and Mor G 2003 Phenoxodiol - an isoflavone analog - induces apoptosis in chemoresistant ovarian cancer cells. Oncogene 22 2611-2620 (Pubitemid 36605609)
    • (2003) Oncogene , vol.22 , Issue.17 , pp. 2611-2620
    • Kamsteeg, M.1    Rutherford, T.2    Sapi, E.3    Hanczaruk, B.4    Shahabi, S.5    Flick, M.6    Brown, D.7    Mor, G.8
  • 24
    • 0034523818 scopus 로고    scopus 로고
    • Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c
    • DOI 10.1038/sj.cdd.4400783
    • Korsmeyer SJ, Wei MC, Saito M, Weiler S, Oh KJ and Schlesinger PH 2000 Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c. Cell Death Differ. 7 1166-1173 (Pubitemid 32042223)
    • (2000) Cell Death and Differentiation , vol.7 , Issue.12 , pp. 1166-1173
    • Korsmeyer, S.J.1    Wei, M.C.2    Saito, M.3    Weiler, S.4    Oh, K.J.5    Schlesinger, P.H.6
  • 25
    • 60349110340 scopus 로고    scopus 로고
    • Enhancement of the activity of phenoxodiol by cisplatin in prostate cancer cells
    • McPherson RA, Galettis PT and de Souza PL 2009 Enhancement of the activity of phenoxodiol by cisplatin in prostate cancer cells. Br. J. Cancer 100 649-655
    • (2009) Br. J. Cancer , vol.100 , pp. 649-655
    • McPherson, R.A.1    Galettis, P.T.2    De Souza, P.L.3
  • 26
    • 0033637140 scopus 로고    scopus 로고
    • The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer
    • Middleton E Jr, Kandaswami C and Theoharides TC 2000 The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev. 52 673-751
    • (2000) Pharmacol Rev. , vol.52 , pp. 673-751
    • Middleton Jr., E.1    Kandaswami, C.2    Theoharides, T.C.3
  • 28
    • 0036097786 scopus 로고    scopus 로고
    • Keeping killers on a tight leash: Transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins
    • DOI 10.1038/sj/cdd/4400998
    • Puthalakath H and Strasser A 2002 Keeping killers on a tight leash: transcriptional and post-translational control of the proapoptotic activity of BH3-only proteins. Cell Death Differ. 9 505-512 (Pubitemid 34521178)
    • (2002) Cell Death and Differentiation , vol.9 , Issue.5 , pp. 505-512
    • Puthalakath, H.1    Strasser, A.2
  • 29
    • 0034657818 scopus 로고    scopus 로고
    • Effects of the multidrug transporter P-glycoprotein on cellular responses to ionizing radiation
    • Ruth AC and Roninson IB 2000 Effects of the multidrug transporter P-glycoprotein on cellular responses to ionizing radiation. Cancer Res. 60 2576-2578 (Pubitemid 30318226)
    • (2000) Cancer Research , vol.60 , Issue.10 , pp. 2576-2578
    • Ruth, A.C.1    Roninson, I.B.2
  • 31
    • 0032828118 scopus 로고    scopus 로고
    • BCL-2 and p53 expression in clinically localized prostate cancer predicts response to external beam radiotherapy
    • discussion 16-17
    • Scherr DS, Vaughan ED Jr, Wei J, Chung M, Felsen D, Allbright R and Knudsen BS 1999 BCL-2 and p53 expression in clinically localized prostate cancer predicts response to external beam radiotherapy. J. Urol. 162 12-16; discussion 16-17
    • (1999) J. Urol. , vol.162 , pp. 12-16
    • Scherr, D.S.1    Vaughan Jr., E.D.2    Wei, J.3    Chung, M.4    Felsen, D.5    Allbright, R.6    Knudsen, B.S.7
  • 32
    • 67649619170 scopus 로고    scopus 로고
    • Phenoxodiol: Pharmacology and clinical experience in cancer monotherapy and in combination with chemotherapeutic drugs
    • Silasi DA, Alvero AB, Rutherford TJ, Brown D and Mor G 2009 Phenoxodiol: pharmacology and clinical experience in cancer monotherapy and in combination with chemotherapeutic drugs. Expert Opin. Pharmacother. 10 1059-1067
    • (2009) Expert Opin. Pharmacother. , vol.10 , pp. 1059-1067
    • Silasi, D.A.1    Alvero, A.B.2    Rutherford, T.J.3    Brown, D.4    Mor, G.5
  • 33
    • 31544477200 scopus 로고    scopus 로고
    • Docetaxel followed by castration improves outcomes in LNCaP prostate cancer - Bearing severe combined immunodeficient mice
    • DOI 10.1158/1078-0432.CCR-05-1388
    • Tang Y, Khan MA, Goloubeva O, Lee DI, Jelovac D, Brodie AM and Hussain A 2006 Docetaxel followed by castration improves outcomes in LNCaP prostate cancer-bearing severe combined immunodeficient mice. Clin. Cancer Res. 12 169-174 (Pubitemid 43166191)
    • (2006) Clinical Cancer Research , vol.12 , Issue.1 , pp. 169-174
    • Tang, Y.1    Khan, M.A.2    Goloubeva, O.3    Lee, D.I.4    Jelovac, D.5    Brodie, A.M.6    Hussain, A.7
  • 34
    • 0035135693 scopus 로고    scopus 로고
    • Evidence against apoptosis as a major mechanism for reproductive cell death following treatment of cell lines with anti-cancer drugs
    • DOI 10.1054/bjoc.2000.1538
    • Tannock IF and Lee C 2001 Evidence against apoptosis as a major mechanism for reproductive cell death following treatment of cell lines with anti-cancer drugs. Br. J. Cancer 84 100-105 (Pubitemid 32102512)
    • (2001) British Journal of Cancer , vol.84 , Issue.1 , pp. 100-105
    • Tannock, I.F.1    Lee, C.2


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