Peptide YY (PYY) gene polymorphisms in the 3′-untranslated and proximal promoter regions regulate cellular gene expression and PYY secretion and metabolic syndrome traits in vivo

Journal of Clinical Endocrinology and Metabolism

Volumn 94, Issue 11, 2009, Pages 4557-4566

  Shih, Pei An Betty ^b   Wang, Lei ^b   Chiron, Stephane ^b   Wen, Gen ^b   Nievergelt, Caroline ^b   Mahata, Manjula ^b   Khandrika, Srikrishna ^b   Rao, Fangwen ^b   Fung, Maple M ^b   Mahata, Sushil K ^b   Hamilton, Bruce A ^b   O'Connor, Daniel T ^a  

^a VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA; LUCIFERASE; PEPTIDE YY;

3' UNTRANSLATED REGION; ADULT; ARTICLE; BIOINFORMATICS; BLOOD SAMPLING; BODY MASS; DNA POLYMORPHISM; ETHNICITY; FEMALE; GENE CONTROL; GENE EXPRESSION; GENE LOCUS; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC TRANSFECTION; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HETEROZYGOTE; HUMAN; IN VIVO STUDY; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; METABOLIC SYNDROME X; MOLECULAR GENETICS; OBESITY; PLEIOTROPY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN SECRETION; SINGLE NUCLEOTIDE POLYMORPHISM; ZYGOSITY;

EID: 70449107605     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2009-0465     Document Type: Article

References (51)

1. Hedley AA, Ogden CL, Johnson CL, Carroll MD, Curtin LR, Flegal KM 2004 Prevalence of overweight and obesity among US children, adolescents, and adults, 1999-2002. JAMA 291:2847-2850 (Pubitemid 38747805)
2. Batterham RL, Cowley MA, Small CJ, Herzog H, Cohen MA, Dakin CL, Wren AM, Brynes AE, Low MJ, Ghatei MA, Cone RD, Bloom SR 2002 Gut hormone PYY(3-36) physiologically inhibits food intake. Nature 418:650-654 (Pubitemid 34886868)
3. Batterham RL, Bloom SR 2003 The gut hormone peptide YY regulates appetite. Ann N Y Acad Sci 994:162-168
4. Doucet E, Laviolette M, Imbeault P, Strychar I, Rabasa-Lhoret R, Prud'homme D 2008 Total peptide YY is a correlate of postprandial energy expenditure but not of appetite or energy intake in healthy women. Metabolism 57:1458-1464
5. Vincent RP, le Roux CW 2008 The satiety hormone peptide YY as a regulator of appetite. J Clin Pathol 61:548-552
6. Sloth B, Davidsen L, Holst JJ, Flint A, Astrup A 2007 Effect of subcutaneous injections of PYY1-36 and PYY3-36 on appetite, ad libitum energy intake, and plasma free fatty acid concentration in obese males. Am J Physiol Endocrinol Metab 293:E604-E609 (Pubitemid 47205105)
7. Hagan MM 2002 Peptide YY: a key mediator of orexigenic behavior. Peptides 23:377-382
8. Batterham RL, Cohen MA, Ellis SM, Le Roux CW, Withers DJ, Frost GS, Ghatei MA, Bloom SR 2003 Inhibition of food intake in obese subjects by peptide YY3-36. N Engl J Med 349:941-948 (Pubitemid 37064767)
9. Cai G, Cole SA, Butte NF, Voruganti VS, Comuzzie AG 2008 Genome- wide scan revealed genetic loci for energy metabolism in Hispanic children and adolescents. Int J Obes (Lond) 32:579-585
10. Perusse L, Rice T, Chagnon YC, Despres JP, Lemieux S, Roy S, Lacaille M, Ho-Kim MA, Chagnon M, Province MA, Rao DC, Bouchard C 2001 A genome-wide scan for abdominal fat assessed by computed tomography in the Quebec Family Study. Diabetes 50:614-621 (Pubitemid 32195227)
11. Torekov SS, Larsen LH, Glumer C, Borch-Johnsen K, Jorgensen T, Holst JJ, Madsen OD, Hansen T, Pedersen O 2005 Evidence of an association between the Arg72 allele of the peptide YY and increased risk of type 2 diabetes. Diabetes 54:2261-2265 (Pubitemid 40911293)
12. O'Connor DT, Kailasam MT, Kennedy BP, Ziegler MG, Yanaihara N, Parmer RJ 2002 Early decline in the catecholamine release-inhibitory peptide catestatin in humans at genetic risk of hypertension. J Hypertens 20:1335-1345 (Pubitemid 34925678)
13. Cockburn M, Hamilton A, Zadnick J, Cozen W, Mack TM 2002 The occurrence of chronic disease and other conditions in a large population-based cohort of native Californian twins. Twin Res 5:460-467 (Pubitemid 35315503)
14. Nievergelt CM, Schork NJ 2005 Admixture mapping as a gene discovery approach for complex human traits and diseases. Curr Hypertens Rep 7:31-37
15. Corander J, Marttinen P 2006 Bayesian identification of admixture events using multilocus molecular markers. Mol Ecol 15:2833-2843 (Pubitemid 44215457)
16. Halperin E, Eskin E 2004 Haplotype reconstruction from genotype data using Imperfect Phylogeny. Bioinformatics 20:1842-1849 (Pubitemid 39199048)
17. Lewontin RC The Interaction of Selection and Linkage. Ii. Optimum Models. Genetics 50:757-782, 1964 Oct
18. Barrett JC, Fry B, Maller J, Daly MJ 2005 Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21:263-265 (Pubitemid 40202029)
19. Almasy L, Blangero J 1998 Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 62:1198-1211 (Pubitemid 28199022)
20. Abecasis GR, Cardon LR, Cookson WO 2000 A general test of association for quantitative traits in nuclear families. Am J Hum Genet 66:279-292
21. Thompson JD, Gibson TJ, Higgins DG 2002 Multiple sequence alignment using ClustalW and ClustalX. Curr Protoc Bioinformatics Chapter 2:Unit 2 3
22. Huang HY, Chien CH, Jen KH, Huang HD 2006 RegRNA: an integrated web server for identifying regulatory RNA motifs and elements. Nucleic Acids Res 34:W429-W434
23. Brodskii LI, Ivanov VV, Kalaidzidis Ia L, Leontovich AM, Nikolaev VK, Feranchuk SI, Drachev VA 1995 [GeneBee-NET: An Internet based server for biopolymer structure analysis]. Biokhimiia 60: 1221-1230
24. Hung CC, Pirie F, Luan J, Lank E, Motala A, Yeo GS, Keogh JM, Wareham NJ, O'Rahilly S, Farooqi IS 2004 Studies of the peptide YY and neuropeptide Y2 receptor genes in relation to human obesity and obesity-related traits. Diabetes 53:2461-2466 (Pubitemid 39145604)
25. Ahituv N, Kavaslar N, Schackwitz W, Ustaszewska A, Collier JM, Hebert S, Doelle H, Dent R, Pennacchio LA, McPherson R 2006 A PYY Q62P variant linked to human obesity. Hum Mol Genet 15:387-391 (Pubitemid 43159891)
26. Santoro N, Del Giudice EM, Grandone A, Marzuillo P, Cozzolino D, Di Salvo G, Pacileo G, Calabro R, Perrone L 2008 Y2 receptor gene variants reduce the risk of hypertension in obese children and adolescents. J Hypertens 26:1590-1594
27. Lavebratt C, Alpman A, Persson B, Arner P, Hoffstedt J 2006 Common neuropeptide Y2 receptor gene variant is protective against obesity among Swedish men. Int J Obes (Lond) 30:453-459 (Pubitemid 43315809)
28. Ma L, Tataranni PA, Hanson RL, Infante AM, Kobes S, Bogardus C, Baier LJ 2005 Variations in peptide YY and Y2 receptor genes are associated with severe obesity in Pima Indian men. Diabetes 54:1598-1602 (Pubitemid 40586696)
29. Siddiq A, Gueorguiev M, Samson C, Hercberg S, Heude B, Levy-Marchal C, Jouret B, Weill J, Meyre D, Walley A, Froguel P 2007 Single nucleotide polymorphisms in the neuropeptide Y2 receptor (NPY2R) gene and association with severe obesity in French white subjects. Diabetologia 50:574-584 (Pubitemid 46215501)
30. Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, Heid IM, Berndt SI, Elliott AL, Jackson AU, Lamina C, Lettre G, Lim N, Lyon HN, McCarroll SA, Papadakis K, Qi L, Randall JC, Roccasecca RM, Sanna S, Scheet P, Weedon MN, Wheeler E, Zhao JH, Jacobs LC, Prokopenko I, et al. 2009 Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 41:25-34
31. Bodmer W, Bonilla C 2008 Common and rare variants in multifactorial susceptibility to common diseases. Nat Genet 40:695-701 (Pubitemid 351748875)
32. Hort Y, Baker E, Sutherland GR, Shine J, Herzog H 1995 Gene duplication of the human peptide YY gene (PYY) generated the pancreatic polypeptide gene (PPY) on chromosome 17q21.1. Genomics 26:77-83
33. Mazumder B, Seshadri V, Fox PL 2003 Translational control by the 3′-UTR: the ends specify the means. Trends Biochem Sci 28:91-98 (Pubitemid 36165138)
34. Standart N, Jackson RJ 2007 MicroRNAs repress translation of m7Gppp-capped target mRNAs in vitro by inhibiting initiation and promoting deadenylation. Genes Dev 21:1975-1982 (Pubitemid 47267282)
35. Bosma PJ, Chowdhury JR, Bakker C, Gantla S, de Boer A, Oostra BA, Lindhout D, Tytgat GN, Jansen PL, Oude Elferink RP, et al. 1995 The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome. N Engl J Med 333:1171-1175
36. Ekman R, Wahlestedt C, Bottcher G, Sundler F, Hakanson R, Panula P 1986 Peptide YY-like immunoreactivity in the central nervous system of the rat. Regul Pept 16:157-168 (Pubitemid 17213872)
37. Lundberg JM, Terenius L, Hokfelt T, Tatemoto K 1984 Comparative immunohistochemical and biochemical analysis of pancreatic polypeptide-like peptides with special reference to presence of neuropeptide Y in central and peripheral neurons. J Neurosci 4:2376-2386 (Pubitemid 14010934)
38. Happola O, Wahlestedt C, Ekman R, Soinila S, Panula P, Hakanson R1990 Peptide YY-like immunoreactivity in sympatheticneurons of the rat. Neuroscience 39:225-230
39. Yang H 2002 Central and peripheral regulation of gastric acid secretion by peptide YY. Peptides 23:349-358 (Pubitemid 34127972)
40. Grudell AB, Camilleri M 2007 The role of peptide YY in integrative gut physiology and potential role in obesity. Curr Opin Endocrinol Diabetes Obes 14:52-57 (Pubitemid 46375389)
41. Clark JT, Sahu A, Kalra PS, Balasubramaniam A, Kalra SP 1987 Neuropeptide Y (NPY)-induced feeding behavior in female rats: comparison with human NPY ([Met17]NPY), NPY analog ([norLeu4]NPY) and peptide YY. Regul Pept 17:31-39 (Pubitemid 17029339)
42. Stanley BG, Daniel DR, Chin AS, Leibowitz SF 1985 Paraventricular nucleus injections of peptide YY and neuropeptide Y preferentially enhance carbohydrate ingestion. Peptides 6:1205-1211
43. Morley JE, Levine AS, Grace M, Kneip J 1985 Peptide YY (PYY), a potent orexigenic agent. Brain Res 341:200-203 (Pubitemid 15246340)
44. Rahardjo GL, Huang XF, Tan YY, Deng C 2007 Decreased plasma peptide YY accompanied by elevated peptide YY and Y2 receptor binding densities in the medulla oblongata of diet-induced obese mice. Endocrinology 148:4704-4710 (Pubitemid 47481511)
45. Korner J, Leibel RL 2003 To eat or not to eat - how the gut talks to the brain. N Engl J Med 349:926-928 (Pubitemid 37064764)
46. Pappas TN, Debas HT, Goto Y, Taylor IL 1985 Peptide YY inhibits meal-stimulated pancreatic and gastric secretion. Am J Physiol 248: G118-123 (Pubitemid 15127414)
47. le Roux CW, Batterham RL, Aylwin SJ, Patterson M, Borg CM, Wynne KJ, Kent A, Vincent RP, Gardiner J, Ghatei MA, Bloom SR 2006 Attenuated peptide YY release in obese subjects is associated with reduced satiety. Endocrinology 147:3-8 (Pubitemid 43004254)
48. Scheid JL, Williams NI, West SL, VanHeest JL, De Souza MJ 2009 Elevated PYY is associated with energy deficiency and indices of subclinical disordered eating in exercising women with hypothalamic amenorrhea. Appetite 52:184-192
49. Xiao Q, Han X, Arany E, Hill D, Challis JR, McDonald TJ 1998 Human placenta and fetal membranes contain peptide YY1-36 and peptide YY3-36. J Endocrinol 156:485-492
50. Brakch N, Rholam M, Simonetti M, Cohen P 2000 Favourable side-chain orientation of cleavage site dibasic residues of prohormone in proteolytic processing by prohormone convertase 1/3. Eur J Biochem 267:1626-1633 (Pubitemid 30165514)
51. Mayor C, Brudno M, Schwartz JR, Poliakov A, Rubin EM, Frazer KA, Pachter LS, Dubchak I 2000 VISTA: visualizing global DNA sequence alignments of arbitrary length. Bioinformatics 16: 1046-1047 (Pubitemid 32051021)