Absence of diffuse cervical cord tissue damage in early, non-disabling relapsing-remitting MS: A preliminary study

Multiple Sclerosis

Volumn 14, Issue 6, 2008, Pages 853-856

  Rovaris, M ^a   Judica, E ^a   Ceccarelli, A ^a   Ghezzi, A ^b   Martinelli, V ^a   Comi, G ^a   Filippi, Massimo ^a  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b S ANTONIO HOSPITAL   (Italy)

Author keywords

Cervical cord; Magnetization transfer magnetic resonance imaging; Relapsing remitting multiple sclerosis

Indexed keywords

ADULT; ARTICLE; CERVICAL SPINAL CORD INJURY; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC VALUE; DISEASE COURSE; DISEASE DURATION; DISEASE SEVERITY; FEMALE; HISTOGRAM; HUMAN; INJURY SCALE; MALE; MULTIPLE SCLEROSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; TISSUE INJURY;

ADULT; CERVICAL VERTEBRAE; DISABILITY EVALUATION; EARLY DIAGNOSIS; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS, RELAPSING-REMITTING; PILOT PROJECTS; SPINAL CORD;

EID: 48349111947     PISSN: 13524585     EISSN: None     Source Type: Journal    
DOI: 10.1177/1352458507088103     Document Type: Article

References (23)

1. Lycklama à Nijeholt, GJ, Thompson, AJ, Filippi, M, Miller, D, Polman, C, Fazekas, F, et al. Spinal-cord MRI in multiple sclerosis. Lancet Neurol 2003; 2: 555-562.
2. Brex, PA, Leary, SM, O'Riordan, JI, Miszkiel, KA, Plant, GT, Thompson, AJ, et al. Measurement of spinal cord area in clinically isolated syndromes suggestive of multiple sclerosis. J Neurol Neurosurg Psychiatry 2001; 70: 544-547.
3. Rashid, W, Davies, GR, Chard, DT, Griffin, CM, Altmann, DR, Gordon, R, et al. Increasing cord atrophy in early relapsing-remitting multiple sclerosis: a 3 year study. J Neurol Neurosurg Psychiatry 2006; 77: 51-55.
4. Schmierer, K, Scaravilli, F, Altmann, DR, Barker, GJ, Miller, DH. Magnetization transfer ratio and myelin in post mortem multiple sclerosis brain. Ann Neurol 2004; 56: 407-415.
5. Bozzali, M, Rocca, MA, Iannucci, G, Pereira, C, Comi, G, Filippi, M. Magnetization transfer histogram analysis of the cervical cord in patients wth multiple sclerosis. Am J Neuroradiol 1999; 20: 1803-1808.
6. Filippi, M, Bozzali, M, Horsfield, MA, Rocca, MA, Sormani, MP, Iannucci, G, et al. A conventional and magnetization transfer MRI study of the cervical cord in patients with multiple sclerosis. Neurology 2000; 54: 207-213.
7. Lycklamà Nijeholt, GJ, Castelijns, JA, Lazeron, RH, van Waesberghe, JH, Polman, CH, Uitdehaag, BM, et al. Magnetization transfer ratio of the spinal cordin multiple sclerosis: relationship to atrophy and neurologic disability. J Neuroimaging 2000; 10: 67-72.
8. Rovaris, M, Bozzali, M, Santuccio, G, Iannucci, G, Sormani, MP, Colombo, B, et al. Relative contributions of brain and cervical cord pathology to MS disability: a study with MTR histogram analysis. J Neurol Neurosurg Psychiatry 2000; 69: 723-727.
9. Rovaris, M, Bozzali, M, Santuccio, G, Ghezzi, A, Caputo, D, Montanari, E, et al. In vivo assessment of the brain and cervical cord pathology of patients with primary progressive multiple sclerosis. Brain 2001; 124: 2540-2549.
10. Agosta, F, Pagani, E, Caputo, D, Filippi, M. Cervical cord gray, matter damage is associated with disability in patients with MS. Arch Neurol 2007; 64: 1302-1305.
11. van Buchem, MA, McGowan, JC, Kolson, DL, Polansky, M, Grossman, RI. Quantitative volumetric magnetization transfer analysis in multiple sclerosis: estimation of macroscopic and microscopic disease burden. Magnetic Resonance in Medicine 1996; 36: 632-636.
12. Polman, CH, Reingold, SC, Edan, G, Filippi, M, Hartung, HP, Kappos, L, et al. Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald Criteria". Ann Neurol 2005; 58: 840-846.
13. Kurtzke, JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 1983; 33: 1444-1452.
14. Rovaris, M, Filippi, M, Calori, G, Rodegher, M, Campi, A, Colombo, B, et al. Intra-observet reproducibility in measuring new putative MR markers of demyelination and axonal loss in multiple sclerosis: a comparison with conventional T2-weighted images. J Neurol 1997; 244: 266-270.
15. Chard, DT, Griffin, CM, McLean, MA, Kapeller, P, Kapoor, R, Thompson, AJ, et al. Brain metabolite changes in cortical grey and normal-appearing white matter in clinically early relapsing-remitting multiple sclerosis. Brain 2002; 125: 2342-2352.
16. Davies, GR, Altmann, DR, Hadjiprocopis, A, Rashid, W, Chard, DT, Griffin, CM, et al. Increasing normal-appearing grey and white matter magnetization transfer ratio abnormality in early relapsing-remitting multiple sclerosis. J Neurol 2005; 252: 1037-1044.
17. Tiberio, M, Chard, DT, Altmann, DR, Davies, G, Griffin, CM, Rashid, W, et al. Gray and White matter volume changes in early RRMS. A 2-year longitudinal study. Neurology 2005; 64: 1001-1007.
18. Bieniek, M, Altmann, DR, Davies, GR, Ingle, GT, Rashid, W, Sastre-Garriga, J, et al. Cord atrophy separates early primary progressive and relapsing remitting MS. J Neurol Neurosurg Psychiatry 2006; 77: 1036-1039.
19. Rovaris, M,, Gallo, A, Riva, R, Ghezzi, A, Bozzali, M, Benedetti, B, et al. An MT MRI study of the cervical cord in clinically isolated syndromes suggestive of MS. Neurology 2004; 63: 584-585.
20. Miller, DH, Barkhof, F, Frank, JA, Parker, GJ, Thompson, AJ. Measurement of atrophy in multiple sclerosis: pathological basis, methodological aspests and clinical relevance. Brain 2002; 125: 1676-1695.
21. Dousset, V, Grossman, RI, Rames, KN, Schnall, MD, Young, LH, Gonzalez-Scarano, F, et al. Experimental allergic encephalomyelitis and multiple sclerosis: lesion characterization with magnetization transfer imaging. Radiology 1992; 182: 483-491.
22. Bot, JCJ, Barkhof, F, Polman, CH, Lycklama à Nijeholt, GJ, de Groot, V, Bergers, E, et al. Spinal cord abnormalities in recently diagnosed MS patients. Added value of spinal MRI examination. Neurology 2004; 62: 226-233.
23. De Stefano, N, Battaglini, M, Stronillio, ML, Zipoli, V, Bartolozzi, ML, Guidi, L, et al. Brain damage as detected by magnetization transfer imaging is less pronounced in benign than in early relapsing multiple sclerosis. Brain 2006; 129: 2008-2016.