Inhibition of Aurora kinases enhances chemosensitivity to temozolomide and causes radiosensitization in glioblastoma cells

Journal of Cancer Research and Clinical Oncology

Volumn 138, Issue 3, 2012, Pages 405-414

  Borges, Kleiton Silva ^a   Castro Gamero, Angel Maurício ^a   Moreno, Daniel Antunes ^a   Da Silva Silveira, Vanessa ^a   Brassesco, Maria Sol ^a   De Paula Queiroz, Rosane Gomes ^a   De Oliveira, Harley Francisco ^a   Carlotti Jr , Carlos Gilberto ^a   Scrideli, Carlos Alberto ^a   Tone, Luiz Gonzaga ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Aurora A; Aurora B; Glioblastoma; Radiation; Temozolomide; ZM447439

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; AURORA A KINASE; AURORA B KINASE; AURORA KINASE INHIBITOR; MESSENGER RNA; N [4 [6 METHOXY 7 (3 MORPHOLINOPROPOXY) 4 QUINAZOLINYLAMINO]PHENYL]BENZAMIDE; TEMOZOLOMIDE; 4 (4 (N BENZOYLAMINO)ANILINO) 6 METHOXY 7 (3 (1 MORPHOLINO)PROPOXY)QUINAZOLINE; 4-(4-(N-BENZOYLAMINO)ANILINO)-6-METHOXY-7-(3-(1-MORPHOLINO)PROPOXY)QUINAZOLINE; ALKYLATING AGENT; AURORA KINASE; BENZAMIDE DERIVATIVE; DACARBAZINE; DRUG DERIVATIVE; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE; QUINAZOLINE DERIVATIVE; RADIOSENSITIZING AGENT; RNA;

ARTICLE; CANCER CELL CULTURE; CELL ASSAY; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DRUG POTENTIATION; FLOW CYTOMETRY; GAMMA RADIATION; GLIOBLASTOMA; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RADIOSENSITIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; APOPTOSIS; BRAIN TUMOR; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; ISOLATION AND PURIFICATION; METABOLISM; TIME; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, ALKYLATING; APOPTOSIS; BENZAMIDES; BLOTTING, WESTERN; BRAIN NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; DACARBAZINE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOBLASTOMA; HUMANS; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; QUINAZOLINES; RADIATION-SENSITIZING AGENTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, NEOPLASM; TIME FACTORS;

EID: 84859725892     PISSN: 01715216     EISSN: 14321335     Source Type: Journal    
DOI: 10.1007/s00432-011-1111-0     Document Type: Article

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