Molecular mechanism underlying persistent induction of LCN2 by lipopolysaccharide in kidney fibroblasts

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Glaros, Trevor ^a   Fu, Yan ^a   Xing, Jianhua ^a   Li, Liwu ^a  

^a VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN DELTA; CYCLOHEXIMIDE; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; MESSENGER RNA; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA; ACUTE PHASE PROTEIN; CCAAT ENHANCER BINDING PROTEIN; LCN2 PROTEIN, MOUSE; LIPOCALIN; LIPOPOLYSACCHARIDE; ONCOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL STIMULATION; CHROMATIN IMMUNOPRECIPITATION; CONNECTIVE TISSUE CELL; CONTROLLED STUDY; FEMALE; IMMUNOPRECIPITATION; IN VIVO STUDY; INTRACELLULAR SIGNALING; KIDNEY CELL; KIDNEY FIBROBLAST; KIDNEY PARENCHYMA; MATHEMATICAL MODEL; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN SYNTHESIS INHIBITION; TISSUE LEVEL; WILD TYPE; ANIMAL; BIOLOGY; CELL CULTURE; CYTOLOGY; DRUG EFFECT; FIBROBLAST; GENETICS; KIDNEY; METABOLISM; METHODOLOGY; MOUSE MUTANT; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

AMINO ACID SEQUENCE; ARCHAEAL PROTEINS; BINDING SITES; DNA, ARCHAEAL; DNA-BINDING PROTEINS; METHANOBACTERIUM; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; ACUTE-PHASE PROTEINS; ANIMALS; BLOTTING, WESTERN; CCAAT-ENHANCER-BINDING PROTEINS; CELLS, CULTURED; CHROMATIN IMMUNOPRECIPITATION; COMPUTATIONAL BIOLOGY; FEMALE; FIBROBLASTS; KIDNEY; LIPOCALINS; LIPOPOLYSACCHARIDES; MICE; MICE, MUTANT STRAINS; ONCOGENE PROTEINS; PROTEIN BINDING; REAL-TIME POLYMERASE CHAIN REACTION; TUMOR NECROSIS FACTOR-ALPHA;

BACTERIA (MICROORGANISMS); MUS;

EID: 84859715394     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0034633     Document Type: Article

References (27)

1. Kjeldsen L, Johnsen AH, Sengelov H, Borregaard N, (1993) Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase. J Biol Chem 268: 10425-10432.
2. Flo TH, Smith KD, Sato S, Rodriguez DJ, Holmes MA, et al. (2004) Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature 432: 917-921.
3. Cowland JB, Borregaard N, (1997) Molecular characterization and pattern of tissue expression of the gene for neutrophil gelatinase-associated lipocalin from humans. Genomics 45: 17-23.
4. Lu YC, Kim I, Lye E, Shen F, Suzuki N, et al. (2009) Differential role for c-Rel and C/EBPbeta/delta in TLR-mediated induction of proinflammatory cytokines. J Immunol 182: 7212-7221.
5. Ding L, Hanawa H, Ota Y, Hasegawa G, Hao K, et al. (2010) Lipocalin-2/neutrophil gelatinase-B associated lipocalin is strongly induced in hearts of rats with autoimmune myocarditis and in human myocarditis. Circ J 74: 523-530.
6. Viau A, El Karoui K, Laouari D, Burtin M, Nguyen C, et al. (2010) Lipocalin 2 is essential for chronic kidney disease progression in mice and humans. J Clin Invest 120: 4065-4076.
7. Bolignano D, Coppolino G, Lacquaniti A, Buemi M, (2010) From kidney to cardiovascular diseases: NGAL as a biomarker beyond the confines of nephrology. Eur J Clin Invest 40: 273-276.
8. Bonomini F, Foglio E, Rodella LF, Rezzani R, (2010) Clinical biomarkers in kidney diseases. Front Biosci (Schol Ed) 2: 591-615.
9. Cowland JB, Sorensen OE, Sehested M, Borregaard N, (2003) Neutrophil gelatinase-associated lipocalin is up-regulated in human epithelial cells by IL-1 beta, but not by TNF-alpha. J Immunol 171: 6630-6639.
10. Sunil VR, Patel KJ, Nilsen-Hamilton M, Heck DE, Laskin JD, et al. (2007) Acute endotoxemia is associated with upregulation of lipocalin 24p3/Lcn2 in lung and liver. Exp Mol Pathol 83: 177-187.
11. Moreno-Navarrete JM, Manco M, Ibanez J, Garcia-Fuentes E, Ortega F, et al. (2010) Metabolic endotoxemia and saturated fat contribute to circulating NGAL concentrations in subjects with insulin resistance. Int J Obes (Lond) 34: 240-249.
12. Smolens P, Stein JH, (1981) Pathophysiology of acute renal failure. Am J Med 70: 479-482.
13. Mehta NN, McGillicuddy FC, Anderson PD, Hinkle CC, Shah R, et al. (2010) Experimental endotoxemia induces adipose inflammation and insulin resistance in humans. Diabetes 59: 172-181.
14. Cani PD, Bibiloni R, Knauf C, Waget A, Neyrinck AM, et al. (2008) Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 57: 1470-1481.
15. Shen F, Hu Z, Goswami J, Gaffen SL, (2006) Identification of common transcriptional regulatory elements in interleukin-17 target genes. J Biol Chem 281: 24138-24148.
16. Su JZT, Tyson J, Li L, (2009) The Interleukin-1 Receptor-Associated Kinase M (IRAK-M) selectively inhibits the alternative, instead of the classical NFkB pathway. Journal of Innate Immunity 1: 164-174.
17. Litvak V, Ramsey SA, Rust AG, Zak DE, Kennedy KA, et al. (2009) Function of C/EBPdelta in a regulatory circuit that discriminates between transient and persistent TLR4-induced signals. Nat Immunol 10: 437-443.
18. Peairs A, Dai R, Gan L, Shimp S, Rylander MN, et al. (2010) Epigallocatechin-3-gallate (EGCG) attenuates inflammation in MRL/lpr mouse mesangial cells. Cell Mol Immunol 7: 123-132.
19. Maitra U, Parks JS, Li L, (2009) An innate immunity signaling process suppresses macrophage ABCA1 expression through IRAK-1-mediated downregulation of retinoic acid receptor alpha and NFATc2. Mol Cell Biol 29: 5989-5997.
20. Tyson JJ, Novak B, (2010) Functional motifs in biochemical reaction networks. Annu Rev Phys Chem 61: 219-240.
21. Kravchenko VV, Mathison JC, Schwamborn K, Mercurio F, Ulevitch RJ, (2003) IKKi/IKKepsilon plays a key role in integrating signals induced by pro-inflammatory stimuli. J Biol Chem 278: 26612-26619.
22. Nakagawa R, Naka T, Tsutsui H, Fujimoto M, Kimura A, et al. (2002) SOCS-1 participates in negative regulation of LPS responses. Immunity 17: 677-687.
23. Gilchrist M, Thorsson V, Li B, Rust AG, Korb M, et al. (2006) Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4. Nature 441: 173-178.
24. Li X, Qin J, (2005) Modulation of Toll-interleukin 1 receptor mediated signaling. J Mol Med 83: 258-266.
25. Yamamoto M, Akira S, (2009) Lipid A receptor TLR4-mediated signaling pathways. Adv Exp Med Biol 667: 59-68.
26. Maitra U, Gan L, Chang S, Li L, (2011) Low-Dose Endotoxin Induces Inflammation by Selectively Removing Nuclear Receptors and Activating CCAAT/Enhancer-Binding Protein {delta}. J Immunol 186: 4467-4473.
27. Li L, Cousart S, Hu J, McCall CE, (2000) Characterization of interleukin-1 receptor-associated kinase in normal and endotoxin-tolerant cells. J Biol Chem 275: 23340-23345.