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Volumn 42, Issue 1, 2012, Pages 58-65

Drug treatments in development for Alzheimer's disease

Author keywords

[No Author keywords available]

Indexed keywords

AF 267B; ALPHA SECRETASE INHIBITOR; AMPA RECEPTOR AGONIST; AMYLOID; ANTIOXIDANT; ASP 1702; BETA SECRETASE INHIBITOR; CEREBROLYSIN; COLOSTRININ; CTS 21166; CURCUMIN; DIMEBON; ETANERCEPT; GAMMA SECRETASE INHIBITOR; GANTENERUMAB; GRL 8234; HISTAMINE H3 RECEPTOR ANTAGONIST; HOMOTAURINE; KMI 429; LY 2811376; METHYLENE BLUE; MK 0752; MUSCARINIC AGENT; NERVE GROWTH FACTOR; NEW DRUG; NICOTINIC AGENT; POLYCLONAL ANTIBODY; SELENIUM; SEMAGACESTAT; SEROTONIN 6 ANTAGONIST; TARENFLURBIL; TAU PROTEIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 84859652393     PISSN: 1445937X     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.2055-2335.2012.tb00133.x     Document Type: Review
Times cited : (9)

References (64)
  • 1
    • 0022899577 scopus 로고
    • Oral tetrahydroaminoacridine in long-term treatment of senile dementia, Alzheimer type
    • Summers WK, Majovski LV, Marsh GM, Tachiki K, Kling A. Oral tetrahydroaminoacridine in long-term treatment of senile dementia, Alzheimer type. N Engl J Med 1986; 315: 241-5.
    • (1986) N Engl J Med , vol.315 , pp. 241-245
    • Summers, W.K.1    Majovski, L.V.2    Marsh, G.M.3    Tachiki, K.4    Kling, A.5
  • 2
    • 85038462939 scopus 로고    scopus 로고
    • Behavioural and psychological symptoms of dementia
    • In: Caplan G, editor, Sydney: IP Communications. In press
    • Woodward M. Behavioural and psychological symptoms of dementia. In: Caplan G, editor. Dementia. Sydney: IP Communications. In press.
    • Dementia
    • Woodward, M.1
  • 3
    • 47549107705 scopus 로고    scopus 로고
    • Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): Results of a randomized, controlled trial of naproxen and celecoxib
    • Martin BK, Szekely C, Brandt J, Piantadosi S, Breitner JC, Craft S, et al. Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib. Arch Neurol 2008; 65: 896-905.
    • (2008) Arch Neurol , vol.65 , pp. 896-905
    • Martin, B.K.1    Szekely, C.2    Brandt, J.3    Piantadosi, S.4    Breitner, J.C.5    Craft, S.6
  • 4
    • 84859643862 scopus 로고    scopus 로고
    • Anti-inflammatory drugs
    • In: Ritchie CW, Ames D, Masters CL, Cummings J, editors, Oxford: Atlas Medical Publishing
    • Woodward M. Anti-inflammatory drugs. In: Ritchie CW, Ames D, Masters CL, Cummings J, editors. Therapeutic strategies in dementia. Oxford: Atlas Medical Publishing; 2007. pp. 111-19.
    • (2007) Therapeutic strategies in dementia , pp. 111-119
    • Woodward, M.1
  • 5
    • 0033536163 scopus 로고    scopus 로고
    • Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in PDAPP mouse
    • Schenk D, Barbour R, Dunn W, Gordon G, Grajeda H, Guido T, et al. Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in PDAPP mouse. Nature 1999; 400: 173-7.
    • (1999) Nature , vol.400 , pp. 173-177
    • Schenk, D.1    Barbour, R.2    Dunn, W.3    Gordon, G.4    Grajeda, H.5    Guido, T.6
  • 6
    • 84984755327 scopus 로고    scopus 로고
    • A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
    • Morgan D, Diamond DM, Gottschall PE, Ugen KE, Dickey C, Hardy J, et al. A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature 2000; 408: 982-5.
    • (2000) Nature , vol.408 , pp. 982-985
    • Morgan, D.1    Diamond, D.M.2    Gottschall, P.E.3    Ugen, K.E.4    Dickey, C.5    Hardy, J.6
  • 7
    • 11444267243 scopus 로고    scopus 로고
    • Evaluation of the safety and immunogenicity of synthetic AE42 (AN1792) in patients with AD
    • Bayer AJ, Bullock R, Jones RW, Wilkinson D, Paterson KR, Jenkins L, et al. Evaluation of the safety and immunogenicity of synthetic AE42 (AN1792) in patients with AD. Neurology 2005; 64: 94-101.
    • (2005) Neurology , vol.64 , pp. 94-101
    • Bayer, A.J.1    Bullock, R.2    Jones, R.W.3    Wilkinson, D.4    Paterson, K.R.5    Jenkins, L.6
  • 8
    • 10744230547 scopus 로고    scopus 로고
    • Subacute meningo-encephalitis in a subset of patients with AD after AS42 immunization
    • Orgogozo JM, Gilman S, Dartigues JF, Laurent B, Puel M, Kirby LC, et al. Subacute meningo-encephalitis in a subset of patients with AD after AS42 immunization. Neurology 2003; 61: 46-54.
    • (2003) Neurology , vol.61 , pp. 46-54
    • Orgogozo, J.M.1    Gilman, S.2    Dartigues, J.F.3    Laurent, B.4    Puel, M.5    Kirby, L.C.6
  • 10
    • 47149112621 scopus 로고    scopus 로고
    • Long-term effects of AL42 immunisation in Alzheimer's disease: Follow-up of a randomised, placebo-controlled phase I trial
    • Holmes C, Boche D, Wilkinson D, Yadegarfar G, Hopkins V, Bayer A, et al. Long-term effects of AL42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial. Lancet 2008; 372: 216-23.
    • (2008) Lancet , vol.372 , pp. 216-223
    • Holmes, C.1    Boche, D.2    Wilkinson, D.3    Yadegarfar, G.4    Hopkins, V.5    Bayer, A.6
  • 11
    • 49149124343 scopus 로고    scopus 로고
    • Amyloid-beta protein dimers isolated directly from Alzheimer brains impair synaptic plasticity and memory
    • Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, et al. Amyloid-beta protein dimers isolated directly from Alzheimer brains impair synaptic plasticity and memory. Nat Med 2008; 14: 837-42.
    • (2008) Nat Med , vol.14 , pp. 837-842
    • Shankar, G.M.1    Li, S.2    Mehta, T.H.3    Garcia-Munoz, A.4    Shepardson, N.E.5    Smith, I.6
  • 12
    • 73349091534 scopus 로고    scopus 로고
    • A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease
    • Salloway S, Sperling R, Gilman S, Fox NC, Blennow K, Raskind M, et al. A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease. Neurology 2009; 73: 2061-70.
    • (2009) Neurology , vol.73 , pp. 2061-2070
    • Salloway, S.1    Sperling, R.2    Gilman, S.3    Fox, N.C.4    Blennow, K.5    Raskind, M.6
  • 13
    • 77949300796 scopus 로고    scopus 로고
    • 11C PiB-PET assessment of change in fibrillar amyloid-beta load in patients with Alzheimer's disease treated with bapineuzumab: A phase 2, double-blind, placebo-controlled, ascending-dose study
    • Rinne JO, Brooks DJ, Rossor MN, Fox NC, Bullock R, Klunk WE, et al. 11C PiB-PET assessment of change in fibrillar amyloid-beta load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study. Lancet Neurol 2010; 9: 363-72.
    • (2010) Lancet Neurol , vol.9 , pp. 363-372
    • Rinne, J.O.1    Brooks, D.J.2    Rossor, M.N.3    Fox, N.C.4    Bullock, R.5    Klunk, W.E.6
  • 15
  • 16
    • 79960817113 scopus 로고    scopus 로고
    • Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: Recommendations from the Alzheimer's Association Research Roundtable Workgroup
    • Sperling RA, Jack CR Jr, Black SE, Frosch MP, Greenberg SM, Hyman BT, et al. Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: recommendations from the Alzheimer's Association Research Roundtable Workgroup. Alzheimers Dement 2011; 7: 367-85.
    • (2011) Alzheimers Dement , vol.7 , pp. 367-385
    • Sperling, R.A.1    Jack Jr., C.R.2    Black, S.E.3    Frosch, M.P.4    Greenberg, S.M.5    Hyman, B.T.6
  • 17
    • 68949169046 scopus 로고    scopus 로고
    • IV immunoglobulin is associated with a reduced risk of Alzheimer disease and related disorders
    • Fillit H, Hess G, Hill J, Bonnet P, Toso C. IV immunoglobulin is associated with a reduced risk of Alzheimer disease and related disorders. Neurology 2009; 73: 180-5.
    • (2009) Neurology , vol.73 , pp. 180-185
    • Fillit, H.1    Hess, G.2    Hill, J.3    Bonnet, P.4    Toso, C.5
  • 18
    • 70349093083 scopus 로고    scopus 로고
    • Disease-modifying approach to the treatment of Alzheimer's disease: From alpha-secretase activators to gamma-secretase inhibitors and modulators
    • Panza F, Solfrizzi V, Frisardi V, Capurso C, D'Introno A, Colacicco AM, et al. Disease-modifying approach to the treatment of Alzheimer's disease: from alpha-secretase activators to gamma-secretase inhibitors and modulators. Drugs Aging 2009; 26: 537-55.
    • (2009) Drugs Aging , vol.26 , pp. 537-555
    • Panza, F.1    Solfrizzi, V.2    Frisardi, V.3    Capurso, C.4    D'Introno, A.5    Colacicco, A.M.6
  • 19
    • 49449101906 scopus 로고    scopus 로고
    • Phase 2 safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer disease
    • Fleisher AS, Raman R, Siemers ER, Becerra L, Clark CM, Dean RA, et al. Phase 2 safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer disease. Arch Neurol 2008; 65: 1031-8.
    • (2008) Arch Neurol , vol.65 , pp. 1031-1038
    • Fleisher, A.S.1    Raman, R.2    Siemers, E.R.3    Becerra, L.4    Clark, C.M.5    Dean, R.A.6
  • 22
    • 33847719509 scopus 로고    scopus 로고
    • The gammasecretase inhibitor MK-0752 acutely and significantly reduces CSF Ai concentrations in humans [abstract]
    • Rosen LB, Stone JA, Plump A, Yaun J, Harrison T, Flynn M, et al. The gammasecretase inhibitor MK-0752 acutely and significantly reduces CSF Ai concentrations in humans [abstract]. Alzheimers Dement 2006; 2 (suppl): S79.
    • (2006) Alzheimers Dement , vol.2 , Issue.SUPPL.
    • Rosen, L.B.1    Stone, J.A.2    Plump, A.3    Yaun, J.4    Harrison, T.5    Flynn, M.6
  • 24
    • 84855691982 scopus 로고    scopus 로고
    • The K-secretase enzyme BACE1 as a therapeutic target for Alzheimer's disease
    • Vassar R, Kandalepas PC. The K-secretase enzyme BACE1 as a therapeutic target for Alzheimer's disease. Alzheimers Res Ther 2011; 3: 20.
    • (2011) Alzheimers Res Ther , vol.3 , pp. 20
    • Vassar, R.1    Kandalepas, P.C.2
  • 25
    • 33845388059 scopus 로고    scopus 로고
    • A phase I study targeting amyloid-beta with 3APS in mild-to-moderate Alzheimer disease
    • Aisan PS, Saumier D, Briand R, Laurin J, Gervais F, Tremblay P, et al. A phase I study targeting amyloid-beta with 3APS in mild-to-moderate Alzheimer disease. Neurology 2006; 67: 1757-63.
    • (2006) Neurology , vol.67 , pp. 1757-1763
    • Aisan, P.S.1    Saumier, D.2    Briand, R.3    Laurin, J.4    Gervais, F.5    Tremblay, P.6
  • 26
    • 34547451145 scopus 로고    scopus 로고
    • Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores neuritis in an Alzheimer mouse model
    • Garcia-Alloza M, Borrelli LA, Rozkaine A, Hyman BT, Bacskai BJ. Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores neuritis in an Alzheimer mouse model. J Neurochem 2007; 102: 1095-104.
    • (2007) J Neurochem , vol.102 , pp. 1095-1104
    • Garcia-Alloza, M.1    Borrelli, L.A.2    Rozkaine, A.3    Hyman, B.T.4    Bacskai, B.J.5
  • 27
    • 0034964390 scopus 로고    scopus 로고
    • Treatment with a copper-zinc chelator markedly and rapidly inhibits betaamyloid accumulation in Alzheimer's disease transgenic mice
    • Cheney RA, Atwood CS, Xilinas E, Gray DN, Jones WD, McLean CA, et al. Treatment with a copper-zinc chelator markedly and rapidly inhibits betaamyloid accumulation in Alzheimer's disease transgenic mice. Neuron 2001; 30: 665-76.
    • (2001) Neuron , vol.30 , pp. 665-676
    • Cheney, R.A.1    Atwood, C.S.2    Xilinas, E.3    Gray, D.N.4    Jones, W.D.5    McLean, C.A.6
  • 28
    • 48949098573 scopus 로고    scopus 로고
    • Safety, efficacy, and biomarker findings of PBT2 in targeting ASSas a modifying therapy for Alzheimer's disease: A phase IIa, double-blind, randomised, placebocontrolled trial
    • Lannfelt L, Blennow K, Zetterberg H, Batsman S, Ames D, Harrison J, et al. Safety, efficacy, and biomarker findings of PBT2 in targeting ASSas a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebocontrolled trial. Lancet Neurol 2008; 7: 779-86.
    • (2008) Lancet Neurol , vol.7 , pp. 779-786
    • Lannfelt, L.1    Blennow, K.2    Zetterberg, H.3    Batsman, S.4    Ames, D.5    Harrison, J.6
  • 29
    • 0036774346 scopus 로고    scopus 로고
    • Colostrinin proline-rich polypeptide complex from ovine colostrum-a long-term study of its efficacy in Alzheimer's disease
    • Leszek J, Inglot AD, Janusz M, Byczkiewicz F, Kiejna A, Georgiades J, et al. Colostrinin proline-rich polypeptide complex from ovine colostrum-a long-term study of its efficacy in Alzheimer's disease. Med Sci Monit 2002; 8: 193-6.
    • (2002) Med Sci Monit , vol.8 , pp. 193-196
    • Leszek, J.1    Inglot, A.D.2    Janusz, M.3    Byczkiewicz, F.4    Kiejna, A.5    Georgiades, J.6
  • 30
    • 0042904882 scopus 로고    scopus 로고
    • AW42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signalling through the APP intracellular domain
    • Weggen S, Eriksen JL, Sagi SA, Pietrzik CU, Golde TE, Koo EH. AW42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signalling through the APP intracellular domain. J Biol Chem 2003; 278: 30748-54.
    • (2003) J Biol Chem , vol.278 , pp. 30748-30754
    • Weggen, S.1    Eriksen, J.L.2    Sagi, S.A.3    Pietrzik, C.U.4    Golde, T.E.5    Koo, E.H.6
  • 31
    • 85047691727 scopus 로고    scopus 로고
    • NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower AN42 in vivo
    • Eriksen JL, Sagi SA, Smith TE, Weggen S, Das P, McLendon DC, et al. NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower AN42 in vivo. J Clin Invest 2003; 112: 440-9.
    • (2003) J Clin Invest , vol.112 , pp. 440-449
    • Eriksen, J.L.1    Sagi, S.A.2    Smith, T.E.3    Weggen, S.4    Das, P.5    McLendon, D.C.6
  • 32
    • 37349104196 scopus 로고    scopus 로고
    • Safety, tolerability, pharmacokinetics, and A beta levels after short-term administration of R-flurbiprofen in healthy elderly individuals
    • Galasko DR, Graff-Radford N, May S, Hendrix S, Cottrell BA, Sagi SA, et al. Safety, tolerability, pharmacokinetics, and A beta levels after short-term administration of R-flurbiprofen in healthy elderly individuals. Alzheimers Dis Assoc Disord 2007; 21: 292-9.
    • (2007) Alzheimers Dis Assoc Disord , vol.21 , pp. 292-299
    • Galasko, D.R.1    Graff-Radford, N.2    May, S.3    Hendrix, S.4    Cottrell, B.A.5    Sagi, S.A.6
  • 33
    • 43249122280 scopus 로고    scopus 로고
    • Efficacy and safety of tarenflurbil in mild to moderate Alzheimer's disease: A randomised phase II trial
    • Wilcock GK, Black SE, Hendrix SB, Zavitz KH, Swabb EA, Laughlin MA, et al. Efficacy and safety of tarenflurbil in mild to moderate Alzheimer's disease: a randomised phase II trial. Lancet Neurol 2008; 7: 483-93.
    • (2008) Lancet Neurol , vol.7 , pp. 483-493
    • Wilcock, G.K.1    Black, S.E.2    Hendrix, S.B.3    Zavitz, K.H.4    Swabb, E.A.5    Laughlin, M.A.6
  • 34
    • 72549105935 scopus 로고    scopus 로고
    • Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer Disease
    • Green RC, Schneider LS, Amato DA, Beelen AP, Wilcock G, Swabb EA, et al. Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer Disease. JAMA 2009; 302: 2557-64.
    • (2009) JAMA , vol.302 , pp. 2557-2564
    • Green, R.C.1    Schneider, L.S.2    Amato, D.A.3    Beelen, A.P.4    Wilcock, G.5    Swabb, E.A.6
  • 35
    • 43949141594 scopus 로고    scopus 로고
    • A nasal proteosome adjuvant activates microglia and prevents amyloid deposition
    • Frenkel D, Puckett L, Petrovic S, Xia W, Chen G, Vega J, et al. A nasal proteosome adjuvant activates microglia and prevents amyloid deposition. Ann Neurol 2008; 63: 591-601.
    • (2008) Ann Neurol , vol.63 , pp. 591-601
    • Frenkel, D.1    Puckett, L.2    Petrovic, S.3    Xia, W.4    Chen, G.5    Vega, J.6
  • 36
    • 77952117808 scopus 로고    scopus 로고
    • Targeting tau protein in Alzheimer's disease
    • Gong CX, Grundke-Iqbal I, Iqbal K. Targeting tau protein in Alzheimer's disease. Drugs Aging 2010; 27: 351-65.
    • (2010) Drugs Aging , vol.27 , pp. 351-365
    • Gong, C.X.1    Grundke-Iqbal, I.2    Iqbal, K.3
  • 37
    • 67349200953 scopus 로고    scopus 로고
    • Tau aggregation inhibitor (TAI) therapy with rember™ arrests disease progression in mild and moderate Alzheimer's disease over 50 weeks [abstract]
    • Wischik CM, Bentham P, Wischik DJ, Seng KM. Tau aggregation inhibitor (TAI) therapy with rember™ arrests disease progression in mild and moderate Alzheimer's disease over 50 weeks [abstract]. Alzheimers Dement 2008; 4 (suppl): T167.
    • (2008) Alzheimers Dement , vol.4 , Issue.SUPPL.
    • Wischik, C.M.1    Bentham, P.2    Wischik, D.J.3    Seng, K.M.4
  • 38
    • 77956385203 scopus 로고    scopus 로고
    • Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models
    • van Eersel J, Ke YD, Liu X, Delerue F, Kril JJ, Götz J, et al. Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models. Proc Natl Acad Sci USA 2010; 107: 13888-93.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 13888-13893
    • van Eersel, J.1    Ke, Y.D.2    Liu, X.3    Delerue, F.4    Kril, J.J.5    Götz, J.6
  • 39
    • 21044458854 scopus 로고    scopus 로고
    • A phase I clinical trial of nerve growth factor gene therapy for Alzheimer disease
    • Tuszynski MH, Thal L, Pay M, Salmon DP, U HS, Bakay R, et al. A phase I clinical trial of nerve growth factor gene therapy for Alzheimer disease. Nat Med 2005; 11: 551-5.
    • (2005) Nat Med , vol.11 , pp. 551-555
    • Tuszynski, M.H.1    Thal, L.2    Pay, M.3    Salmon, D.P.U.H.S.4    Bakay, R.5
  • 40
    • 33645239847 scopus 로고    scopus 로고
    • A 24-week, double-blind, placebo-controlled study of three doses of Cerebrolysin in patients with mild to moderate Alzheimer's disease
    • Alvarez XA, Cacabelos R, Laredo M, Couceiro V, Sampedro C, Varela M, et al. A 24-week, double-blind, placebo-controlled study of three doses of Cerebrolysin in patients with mild to moderate Alzheimer's disease. Eur J Neurol 2006; 13: 43-54.
    • (2006) Eur J Neurol , vol.13 , pp. 43-54
    • Alvarez, X.A.1    Cacabelos, R.2    Laredo, M.3    Couceiro, V.4    Sampedro, C.5    Varela, M.6
  • 41
    • 38049027779 scopus 로고    scopus 로고
    • We should not distinguish between symptomatic and diseasemodifying treatments in Alzheimer's disease drug development
    • Doody RS. We should not distinguish between symptomatic and diseasemodifying treatments in Alzheimer's disease drug development. Alzheimers Dement 2008a; 4 (suppl 1): S21-S25.
    • (2008) Alzheimers Dement , vol.4 , Issue.SUPPL. 1
    • Doody, R.S.1
  • 42
    • 34248562939 scopus 로고    scopus 로고
    • GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models
    • Medhurst AD, Atkins AR, Beresford IJ, Brackenborough K, Briggs MA, Calver AR, et al. GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models. J Pharmacol Exp Ther 2007; 321: 1032-45.
    • (2007) J Pharmacol Exp Ther , vol.321 , pp. 1032-1045
    • Medhurst, A.D.1    Atkins, A.R.2    Beresford, I.J.3    Brackenborough, K.4    Briggs, M.A.5    Calver, A.R.6
  • 43
    • 46749118971 scopus 로고    scopus 로고
    • 5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer's disease
    • Upton N, Chuang TT, Hunter AJ, Virley DJ. 5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer's disease. Neurotherapeutics 2008; 5: 458-69.
    • (2008) Neurotherapeutics , vol.5 , pp. 458-469
    • Upton, N.1    Chuang, T.T.2    Hunter, A.J.3    Virley, D.J.4
  • 44
    • 0036451888 scopus 로고    scopus 로고
    • Non-cholinergic strategies for treating and preventing Alzheimer's disease
    • Doraiswamy PM. Non-cholinergic strategies for treating and preventing Alzheimer's disease. CNS Drugs 2002; 16: 811-24.
    • (2002) CNS Drugs , vol.16 , pp. 811-824
    • Doraiswamy, P.M.1
  • 46
    • 38549178015 scopus 로고    scopus 로고
    • Rapid cognitive improvement in Alzheimer's disease following perispinal etanercept administration
    • Tobinick EL, Gross H. Rapid cognitive improvement in Alzheimer's disease following perispinal etanercept administration. J Neuroinflammation 2008; 5: 2.
    • (2008) J Neuroinflammation , vol.5 , pp. 2
    • Tobinick, E.L.1    Gross, H.2
  • 47
    • 47149108940 scopus 로고    scopus 로고
    • Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: A randomised, double-blind, placebo-controlled study
    • Doody RS, Gavrilova SI, Sano M, Thomas RG, Aisen PS, Bachurin SO, et al. Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: a randomised, double-blind, placebo-controlled study. Lancet 2008; 372: 207-15.
    • (2008) Lancet , vol.372 , pp. 207-215
    • Doody, R.S.1    Gavrilova, S.I.2    Sano, M.3    Thomas, R.G.4    Aisen, P.S.5    Bachurin, S.O.6
  • 48
    • 77956666900 scopus 로고    scopus 로고
    • Dimebon disappointment
    • Jones RW. Dimebon disappointment. Alzheimers Res Ther 2010; 2: 25.
    • (2010) Alzheimers Res Ther , vol.2 , pp. 25
    • Jones, R.W.1
  • 49
    • 0030967165 scopus 로고    scopus 로고
    • A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease
    • Sano M, Ernesto C, Thomas RG, Klauber MR, Schafer K, Grundman M, et al. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. N Engl J Med 1997; 336: 1216-22.
    • (1997) N Engl J Med , vol.336 , pp. 1216-1222
    • Sano, M.1    Ernesto, C.2    Thomas, R.G.3    Klauber, M.R.4    Schafer, K.5    Grundman, M.6
  • 51
    • 28844462038 scopus 로고    scopus 로고
    • A review of antioxidants and Alzheimer's disease
    • Frank B, Gupta S. A review of antioxidants and Alzheimer's disease. Ann Clin Psychiatry 2005; 17: 269-86.
    • (2005) Ann Clin Psychiatry , vol.17 , pp. 269-286
    • Frank, B.1    Gupta, S.2
  • 52
    • 20844440894 scopus 로고    scopus 로고
    • Atorvastatin for the treatment of mild to moderate Alzheimer's disease: Preliminary results
    • Sparks DL, Sabbagh MN, Connor DJ, Lopez J, Launer LJ, Browne P, et al. Atorvastatin for the treatment of mild to moderate Alzheimer's disease: preliminary results. Arch Neurol 2005; 62: 753-7.
    • (2005) Arch Neurol , vol.62 , pp. 753-757
    • Sparks, D.L.1    Sabbagh, M.N.2    Connor, D.J.3    Lopez, J.4    Launer, L.J.5    Browne, P.6
  • 54
    • 80053336026 scopus 로고    scopus 로고
    • A randomised, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease
    • Sano M, Bell KL, Galasko D, Galvin JE, Thomas RG, van Dyck CH, et al. A randomised, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease. Neurology 2011; 77: 556-63.
    • (2011) Neurology , vol.77 , pp. 556-563
    • Sano, M.1    Bell, K.L.2    Galasko, D.3    Galvin, J.E.4    Thomas, R.G.5    van Dyck, C.H.6
  • 55
    • 28444459842 scopus 로고    scopus 로고
    • Insulin resistance syndrome and Alzheimer's disease: Age and obesityrelated effects on memory, amyloid and inflammation
    • Craft S. Insulin resistance syndrome and Alzheimer's disease: age and obesityrelated effects on memory, amyloid and inflammation. Neurobiol Aging 2005; 26 (suppl 1): S65-S69.
    • (2005) Neurobiol Aging , vol.26 , Issue.SUPPL. 1
    • Craft, S.1
  • 56
    • 33644592598 scopus 로고    scopus 로고
    • Preserved cognition in patients with early Alzheimer's disease and amnestic mild cognitive impairment after treatment with rosiglitazone; a preliminary study
    • Watson GS, Cholerton BA, Reger MA, Baker LD, Plymate SR, Asthana S, et al. Preserved cognition in patients with early Alzheimer's disease and amnestic mild cognitive impairment after treatment with rosiglitazone; a preliminary study. Am J Geriatr Psychiatry 2005; 13: 950-8.
    • (2005) Am J Geriatr Psychiatry , vol.13 , pp. 950-958
    • Watson, G.S.1    Cholerton, B.A.2    Reger, M.A.3    Baker, L.D.4    Plymate, S.R.5    Asthana, S.6
  • 57
    • 79959974461 scopus 로고    scopus 로고
    • Rosiglitazone does not improve cognition or global function when used as an adjunctive therapy to AChE inhibitors in mild-to-moderate Alzheimer's disease: Two phase 3 studies
    • Harrington C, Sawchak S, Chiang C, Davies J, Donovan C, Saunders AM, et al. Rosiglitazone does not improve cognition or global function when used as an adjunctive therapy to AChE inhibitors in mild-to-moderate Alzheimer's disease: two phase 3 studies. Curr Alzheimer Res 2011; 8: 592-606.
    • (2011) Curr Alzheimer Res , vol.8 , pp. 592-606
    • Harrington, C.1    Sawchak, S.2    Chiang, C.3    Davies, J.4    Donovan, C.5    Saunders, A.M.6
  • 59
    • 31844434789 scopus 로고    scopus 로고
    • Effects of intranasal insulin on cognition in memory-impaired older adults: Modulation by APOE genotype
    • Reger MA, Watson GS, Frey WH 2nd, Baker LD, Cholerton B, Keeling ML, et al. Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype. Neurobiol Aging 2006; 27: 451-8.
    • (2006) Neurobiol Aging , vol.27 , pp. 451-458
    • Reger, M.A.1    Watson, G.S.2    Frey II, W.H.3    Baker, L.D.4    Cholerton, B.5    Keeling, M.L.6
  • 61
    • 33645808672 scopus 로고    scopus 로고
    • Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer's disease
    • Mahley RW, Weisgraber KH, Huang Y. Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease. Proc Natl Acad Sci USA 2006; 103: 5644-51.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 5644-5651
    • Mahley, R.W.1    Weisgraber, K.H.2    Huang, Y.3
  • 62
    • 79958248678 scopus 로고    scopus 로고
    • Medical foods for Alzheimer's disease
    • Shah RC. Medical foods for Alzheimer's disease. Drugs Aging 2011; 28: 421-8.
    • (2011) Drugs Aging , vol.28 , pp. 421-428
    • Shah, R.C.1
  • 63
    • 57549093318 scopus 로고    scopus 로고
    • Examining the nootropic effects of a special extract of Bacopa monniera on human cognitive functioning: 90 day double-blind placebo-controlled randomized trial
    • Stough C, Downey LA, Lloyd J, Silber B, Redman S, Hutchison C, et al. Examining the nootropic effects of a special extract of Bacopa monniera on human cognitive functioning: 90 day double-blind placebo-controlled randomized trial. Psychother Res 2008; 22: 1629-34.
    • (2008) Psychother Res , vol.22 , pp. 1629-1634
    • Stough, C.1    Downey, L.A.2    Lloyd, J.3    Silber, B.4    Redman, S.5    Hutchison, C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.