NPY suppressed development of experimental autoimmune encephalomyelitis in Dark Agouti rats by disrupting costimulatory molecule interactions

Journal of Neuroimmunology

Volumn 245, Issue 1-2, 2012, Pages 23-31

  Dimitrijević, Mirjana ^a   Mitić, Katarina ^a   Kuštrimović, Nataša ^a   Vujić, Vesna ^b   Stanojević, Stanislava ^a  

^a Immunology Research Center Belgrade   (Yugoslavia)

^b UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

Dipeptidyl peptidase 4; EAE; Neuropeptide Y; Rat

Indexed keywords

B7 ANTIGEN; CD11B ANTIGEN; CD28 ANTIGEN; CD86 ANTIGEN; CELL PROTEIN; DIPEPTIDYL PEPTIDASE IV; ISOLEUCINE THIAZOLIDIDE; NEUROPEPTIDE Y; NEUROPEPTIDE Y1 RECEPTOR; NEUROPEPTIDE Y2 RECEPTOR; NEUROPEPTIDE Y5 RECEPTOR; PROTEIN ED1; PROTEIN OX62; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; CELL INFILTRATION; CONTROLLED STUDY; DARK AGOUTI RAT; DENDRITIC CELL; DISEASE COURSE; DRUG MECHANISM; ENCEPHALOMYELITIS; IMMUNOSTIMULATION; LYMPHATIC DRAINAGE; MACROPHAGE; MALE; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SPINAL CORD;

ANIMALS; ANTIGENS, CD11B; ANTIGENS, CD28; ANTIGENS, CD80; CELL COUNT; CELL MOVEMENT; COSTIMULATORY AND INHIBITORY T-CELL RECEPTORS; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; HUMANS; INFLAMMATION MEDIATORS; MALE; NEUROPEPTIDE Y; PRIMARY CELL CULTURE; PROTEIN INTERACTION MAPPING; RATS; RATS, INBRED STRAINS; SPINAL CORD;

EID: 84859644108     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2012.01.013     Document Type: Article

References (46)

1. Agostini C., Trentin L., Perin A., Facco M., Siviero M., Piazza F., Basso U., Adami F., Zambello R., Semenzato G. Regulation of alveolar macrophage-T cell interactions during Th1-type sarcoid inflammatory process. Am. J. Physiol. 1999, 277:L240-L250.
2. Bedoui S., Kuhlmann S., Nave H., Drube J., Pabst R., von Horsten S. Differential effects of neuropeptide Y (NPY) on leukocyte subsets in the blood: mobilization of B-1-like B-lymphocytes and activated monocytes. J. Neuroimmunol. 2001, 117:125-132.
3. Bedoui S., Lechner S., Gebhardt T., Nave H., Beck-Sickinger A.G., Straub R.H., Pabst R., von Horsten S. NPY modulates epinephrine-induced leukocytosis via Y-1 and Y-5 receptor activation in vivo: sympathetic co-transmission during leukocyte mobilization. J. Neuroimmunol. 2002, 132:25-33.
4. Bedoui S., Miyake S., Lin Y., Miyamoto K., Oki S., Kawamura N., Beck-Sickinger A., von Horsten S., Yamamura T. Neuropeptide Y (NPY) suppresses experimental autoimmune encephalomyelitis: NPY1 receptor-specific inhibition of autoreactive Th1 responses in vivo. J. Immunol. 2003, 171:3451-3458.
5. Carson M.J., Doose J.M., Melchior B., Schmid C.D., Ploix C.C. CNS immune privilege: hiding in plain sight. Immunol. Rev. 2006, 213:48-65.
6. Damoiseaux J.G., Yagita H., Okumura K., van Breda Vriesman P.J. Costimulatory molecules CD80 and CD86 in the rat; tissue distribution and expression by antigen-presenting cells. J. Leukoc. Biol. 1998, 64:803-809.
7. De la Fuente M., Bernaez I., Del Rio M., Hernanz A. Stimulation of murine peritoneal macrophage functions by neuropeptide Y and peptide YY. Involvement of protein kinase C. Immunology 1993, 80:259-265.
8. Dimitrijevic M., Laban O., Djuric V.J., Stanojevic S., Miletic T., Kovacevic-Jovanovic V., Todorovic C., Radulovic J. Behavior and severity of adjuvant arthritis in four rat strains. Brain Behav. Immun. 2001, 15:255-265.
9. Dimitrijevic M., Stanojevic S., Mitic K., Kustrimovic N., Vujic V., Miletic T., Kovacevic-Jovanovic V. The anti-inflammatory effect of neuropeptide Y (NPY) in rats is dependent on dipeptidyl peptidase 4 (DP4) activity and age. Peptides 2008, 29:2179-2187.
10. Dimitrijevic M., Stanojevic S., Vujic V., Kovacevic-Jovanovic V., Beck-Sickinger A., Demuth H., von Horsten S. Effect of neuropeptide Y on inflammatory paw edema in the rat: involvement of peripheral NPY Y1 and Y5 receptors and interaction with dipeptidyl-peptidase IV (CD26). J. Neuroimmunol. 2002, 129:35-42.
11. Gicquiaux H., Lecat S., Gaire M., Dieterlen A., Mely Y., Takeda K., Bucher B., Galzi J.L. Rapid internalization and recycling of the human neuropeptide Y Y(1) receptor. J. Biol. Chem. 2002, 277:6645-6655.
12. Gorrell M.D. Dipeptidyl peptidase IV and related enzymes in cell biology and liver disorders. Clin. Sci. (Lond.) 2005, 108:277-292.
13. Griffiths M.M., Eichwald E.J., Martin J.H., Smith C.B., DeWitt C.W. Immunogenetic control of experimental type II collagen-induced arthritis. I. Susceptibility and resistance among inbred strains of rats. Arthritis Rheum. 1981, 24:781-789.
14. Hart D.N. Dendritic cells: unique leukocyte populations which control the primary immune response. Blood 1997, 90:3245-3287.
15. Imrich H., Harzer K. On the role of peripheral macrophages during active experimental allergic encephalomyelitis (EAE). J. Neural Transm. 2001, 108:379-395.
16. Karl T., Chwalisz W.T., Wedekind D., Hedrich H.J., Hoffmann T., Jacobs R., Pabst R., von Horsten S. Localization, transmission, spontaneous mutations, and variation of function of the Dpp 4 (Dipeptidyl-peptidase IV; CD26) gene in rats. Regul. Pept. 2003, 115:81-90.
17. Kawamura N., Tamura H., Obana S., Wenner M., Ishikawa T., Nakata A., Yamamoto H. Differential effects of neuropeptides on cytokine production by mouse helper T cell subsets. Neuroimmunomodulation 1998, 5:9-15.
18. Khoury S.J., Guttmann C.R., Orav E.J., Kikinis R., Jolesz F.A., Weiner H.L. Changes in activated T cells in the blood correlate with disease activity in multiple sclerosis. Arch. Neurol. 2000, 57:1183-1189.
19. Kitlinska J. Neuropeptide Y in neural crest-derived tumors: effect on growth and vascularization. Cancer Lett. 2007, 245:293-302.
20. Levite M., Cahalon L., Hershkoviz R., Steinman L., Lider O. Neuropeptides, via specific receptors, regulate T cell adhesion to fibronectin. J. Immunol. 1998, 160:993-1000.
21. Lorentzen J.C., Issazadeh S., Storch M., Mustafa M.I., Lassman H., Linington C., Klareskog L., Olsson T. Protracted, relapsing and demyelinating experimental autoimmune encephalomyelitis in DA rats immunized with syngeneic spinal cord and incomplete Freund's adjuvant. J. Neuroimmunol. 1995, 63:193-205.
22. Medina S., Del Rio M., Hernanz A., De la Fuente M. The NPY effects on murine leukocyte adherence and chemotaxis change with age. Adherent cell implication. Regul. Pept. 2000, 95:35-45.
23. Medina S., Del Rio M., Manuel Victor V., Hernanz A., De la Fuente M. Changes with ageing in the modulation of murine lymphocyte chemotaxis by CCK-8S, GRP and NPY. Mech. Ageing Dev. 1998, 102:249-261.
24. Mentlein R. Dipeptidyl-peptidase IV (CD26) - role in the inactivation of regulatory peptides. Regul. Pept. 1999, 85:9-24.
25. Michel M.C., Beck-Sickinger A., Cox H., Doods H.N., Herzog H., Larhammar D., Quirion R., Schwartz T., Westfall T. XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors. Pharmacol. Rev. 1998, 50:143-150.
26. Mikita J., Dubourdieu-Cassagno N., Deloire M.S., Vekris A., Biran M., Raffard G., Brochet B., Canron M.H., Franconi J.M., Boiziau C., Petry K.G. Altered M1/M2 activation patterns of monocytes in severe relapsing experimental rat model of multiple sclerosis. Amelioration of clinical status by M2 activated monocyte administration. Mult. Scler. 2011, 17:2-15.
27. Miljkovic D., Stosic-Grujicic S., Markovic M., Momcilovic M., Ramic Z., Maksimovic-Ivanic D., Mijatovic S., Popadic D., Cvetkovic I., Mostarica-Stojkovic M. Strain difference in susceptibility to experimental autoimmune encephalomyelitis between Albino Oxford and Dark Agouti rats correlates with disparity in production of IL-17, but not nitric oxide. J. Neurosci. Res. 2006, 84:379-388.
28. Murphy A.C., Lalor S.J., Lynch M.A., Mills K.H. Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis. Brain Behav. Immun. 2010, 24:641-651.
29. Nave H., Bedoui S., Moenter F., Steffens J., Felies M., Gebhardt T., Straub R.H., Pabst R., Dimitrijevic M., Stanojevic S., von Horsten S. Reduced tissue immigration of monocytes by neuropeptide Y during endotoxemia is associated with Y2 receptor activation. J. Neuroimmunol. 2004, 155:1-12.
30. Ohnuma K., Yamochi T., Uchiyama M., Nishibashi K., Iwata S., Hosono O., Kawasaki H., Tanaka H., Dang N.H., Morimoto C. CD26 mediates dissociation of Tollip and IRAK-1 from caveolin-1 and induces upregulation of CD86 on antigen-presenting cells. Mol. Cell. Biol. 2005, 25:7743-7757.
31. Petitto J.M., Huang Z., McCarthy D.B. Molecular cloning of NPY-Y1 receptor cDNA from rat splenic lymphocytes: evidence of low levels of mRNA expression and [125I]NPY binding sites. J. Neuroimmunol. 1994, 54:81-86.
32. Preller V., Gerber A., Wrenger S., Togni M., Marguet D., Tadje J., Lendeckel U., Rocken C., Faust J., Neubert K., Schraven B., Martin R., Ansorge S., Brocke S., Reinhold D. TGF-beta1-mediated control of central nervous system inflammation and autoimmunity through the inhibitory receptor CD26. J. Immunol. 2007, 178:4632-4640.
33. Puerto M., Guayerbas N., Alvarez P., De la Fuente M. Modulation of neuropeptide Y and norepinephrine on several leucocyte functions in adult, old and very old mice. J. Neuroimmunol. 2005, 165:33-40.
34. Rabinovitch P.S., Torres R.M., Engel D. Simultaneous cell cycle analysis and two-color surface immunofluorescence using 7-amino-actinomycin D and single laser excitation: applications to study of cell activation and the cell cycle of murine Ly-1 B cells. J Immunol 1986, 136:2769-2775.
35. Reinhold D., Bank U., Buhling F., Kahne T., Kunt D., Faust J., Neubert K., Ansorge S. Inhibitors of dipeptidyl peptidase IV (DP IV, CD26) specifically suppress proliferation and modulate cytokine production of strongly CD26 expressing U937 cells. Immunobiology 1994, 192:121-136.
36. Reinhold D., Bank U., Buhling F., Lendeckel U., Faust J., Neubert K., Ansorge S. Inhibitors of dipeptidyl peptidase IV induce secretion of transforming growth factor-beta 1 in PWM-stimulated PBMC and T cells. Immunology 1997, 91:354-360.
37. Reinhold D., Biton A., Pieper S., Lendeckel U., Faust J., Neubert K., Bank U., Tager M., Ansorge S., Brocke S. Dipeptidyl peptidase IV (DP IV, CD26) and aminopeptidase N (APN, CD13) as regulators of T cell function and targets of immunotherapy in CNS inflammation. Int. Immunopharmacol. 2006, 6:1935-1942.
38. Reinhold D., Hemmer B., Gran B., Born I., Faust J., Neubert K., McFarland H.F., Martin R., Ansorge S. Inhibitors of dipeptidyl peptidase IV/CD26 suppress activation of human MBP-specific CD4+ T cell clones. J. Neuroimmunol. 1998, 87:203-209.
39. Saurer T.B., Ijames S.G., Lysle D.T. Neuropeptide Y Y1 receptors mediate morphine-induced reductions of natural killer cell activity. J. Neuroimmunol. 2006, 177:18-26.
40. Shrikant P., Benveniste E.N. The central nervous system as an immunocompetent organ: role of glial cells in antigen presentation. J. Immunol. 1996, 157:1819-1822.
41. Steinbrecher A., Reinhold D., Quigley L., Gado A., Tresser N., Izikson L., Born I., Faust J., Neubert K., Martin R., Ansorge S., Brocke S. Targeting dipeptidyl peptidase IV (CD26) suppresses autoimmune encephalomyelitis and up-regulates TGF-beta 1 secretion in vivo. J. Immunol. 2001, 166:2041-2048.
42. Tanaka S., Murakami T., Horikawa H., Sugiura M., Kawashima K., Sugita T. Suppression of arthritis by the inhibitors of dipeptidyl peptidase IV. Int. J. Immunopharmacol. 1997, 19:15-24.
43. Tanaka S., Murakami T., Nonaka N., Ohnuki T., Yamada M., Sugita T. Anti-arthritic effects of the novel dipeptidyl peptidase IV inhibitors TMC-2A and TSL-225. Immunopharmacology 1998, 40:21-26.
44. Wheway J., Herzog H., Mackay F. The Y1 receptor for NPY: a key modulator of the adaptive immune system. Peptides 2007, 28:453-458.
45. Wheway J., Mackay C.R., Newton R.A., Sainsbury A., Boey D., Herzog H., Mackay F. A fundamental bimodal role for neuropeptide Y1 receptor in the immune system. J. Exp. Med. 2005, 202:1527-1538.
46. Zhou J.R., Xu Z., Jiang C.L. Neuropeptide Y promotes TGF-beta1 production in RAW264.7 cells by activating PI3K pathway via Y1 receptor. Neurosci. Bull. 2008, 24:155-159.