Suppression of arthritis by the inhibitors of dipeptidyl peptidase IV

International Journal of Immunopharmacology

Volumn 19, Issue 1, 1997, Pages 15-24

  Tanaka, Sumiko ^a   Murakami, Takanori ^a   Horikawa, Hiroshi ^a   Sugiura, Masaki ^a   Kawashima, Keisuke ^a   Sugita, Takahisa ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

Arthritis; CD26; Dipeptyl peptidase IV; Protease inhibitor

Indexed keywords

ADJUVANT; ALANYLPROLYLNITROBENZOYLHYDROXYLAMINE; ALANYLPYRROLIDINE BORONIC ACID; ANTIGEN; BORONIC ACID DERIVATIVE; COLLAGEN TYPE 2; DIPEPTIDYL PEPTIDASE IV; DIPEPTIDYL PEPTIDASE IV INHIBITOR; MITOGENIC AGENT; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ARTHRITIS; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME DEFICIENCY; FEMALE; IMMUNE RESPONSE; LYMPHOCYTE PROLIFERATION; NONHUMAN; ORAL DRUG ADMINISTRATION; PAW EDEMA; PRIORITY JOURNAL; RAT; RHEUMATOID ARTHRITIS; SPLEEN CELL; SUBCUTANEOUS DRUG ADMINISTRATION; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD26; ARTHRITIS, RHEUMATOID; BORONIC ACIDS; CELLS, CULTURED; COLLAGEN; DIAMINES; DIPEPTIDES; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; FEMALE; HYDROXYLAMINES; IMMUNOSUPPRESSIVE AGENTS; LYMPHOCYTE ACTIVATION; LYSINE; MODELS, IMMUNOLOGICAL; RATS; RATS, INBRED F344; RATS, INBRED LEW; SERINE PROTEINASE INHIBITORS; T-LYMPHOCYTES; THIAZOLES;

EID: 0030924956     PISSN: 01920561     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0192-0561(97)00004-0     Document Type: Article

References (52)

1. Bachovchin, W. W., Plaut, A. G., Flentke, G. R., Lynch, M. & Kettner, C. A. (1990) Inhibition of IgA1 proteinases from Neisseria gonorrhoeae and Hemophilus influenzae by peptide prolyl boronic acids. J. Biol. Chem., 265, 3738-3743.
2. Barton, R. W., Prendergast, J. & Kennedy, C. A. (1990) Binding of the T cell activation monoclonal antibody Ta1 to dipeptidyl peptidase IV. J. Leukoc. Biol., 48, 291-296.
3. Bednarczyk, J. L., Carroll, S. M., Marin, C. & McIntyre, B. W. (1991) Triggering of the proteinase dipeptidyl peptidase IV (CD26) amplifies human T lymphocyte proliferation. J. Cell Biochem., 46, 206-218.
4. Bone, R., Shenvi, A. B., Kettner, C. A. & Agard, D. A. (1987) Serine protease mechanism: structure of an inhibitory complex of alpha-lytic protease and a tightly bound peptide boronic acid. Biochem., 26, 7609-7614.
5. Bristol, L. A., Sakaguchi, K., Appella, E., Doyle, D. & Takacs, L. (1992) Thymocyte costimulating antigen is CD26 (dipeptidyl-peptidase IV). Costimulation of granulocyte, macrophage, and T lineage cell proliferation via CD26. J. Immunol., 149, 367-372.
6. Buhling, F., Kunz, D., Reinhold, D., Ulmer, A. J., Ernst, M., Flad, H. D. & Ansorge, S. (1994) Expression and functional role of dipeptidyl peptidase IV (CD26) on human natural killer cells. Nat. Immun., 13, 270-279.
7. Buhling, F., Junker, U., Reinhold, D., Neubert, K., Jager, L. & Ansorge, S. (1995) Functional role of CD26 on human B lymphocytes. Immunol. Lett., 45, 47-51.
8. Dang, N. H., Torimoto, Y., Deusch, K., Schlossman, S. F. & Morimoto, C. (1990) Comitogenic effect of solid-phase immobilized anti-1F7 on human CD4 T cell activation via CD3 and CD2 pathways. J. Immunol., 144, 4092-4100.
9. Dang, N. H., Torimoto, Y., Sugita, K., Daley, J. F., Schow, P., Prado, C., Schlossman, S. F. & Morimoto, C. (1990) Cell surface modulation of CD26 by anti-1F7 monoclonal antibody. Analysis of surface expression and human T cell activation. J. Immunol., 145, 3963-3971.
10. Dang, N. H., Torimoto, Y., Schlossman, S. F. & Morimoto, C. (1990) Human CD4 helper T cell activation: functional involvement of two distinct collagen receptors, 1F7 and VLA integrin family. J. Exp. Med., 172, 649-652.
11. De-Meester, L., Vanham, G., Kestens, L., Vanhoof, G., Bosmans, E., Gigase, P. & Scharpe, S. (1994) Binding of adenosine deaminase to the lymphocyte surface via CD26. Eur. J. Immunol., 24, 566-570.
12. Demuth, H. U., Baumgrass, R., Schaper, C., Fischer, G. & Barth, A. (1988) Dipeptidylpeptidase IV-inactivation with N-peptidyl-O-aroyl hydroxylamines. J. Enzym. Inhib., 2, 129-142.
13. Demuth, H. U. (1990) Recent developments in inhibiting cysteine and serine proteases. J. Enzym. Inhib., 3, 249-278.
14. Dixon, M. (1953) The determination of enzyme inhibitor constants. Biochem. J., 55, 170-171.
15. Dong, R. P., Kameoka, J., Hegen, M., Tanaka, T., Xu, Y., Schlossman, S. F. & Morimoto, C. (1996) Characterization of adenosine deaminase binding to human CD26 on T cells and its biologic role in immune response. J. Immunol., 156, 1349-1355.
16. Eguchi, K., Ueki, Y., Shimomura, C., Otsubo, T., Nakao, H., Migita, K., Kawakami, A., Matsunaga, M., Tezuka, H., Ishikawa, N. & Ito, K. (1989) Increment in the Ta1 + cells in the peripheral blood and thyroid tissue of patients with Graves' disease. J. Immunol., 142, 4233-4240.
17. Flentke, G. R., Munoz, E., Huber, B. T., Plaut, A. G., Kettner, C. A. & Bachovchin, W. W. (1991) Inhibition of dipeptidyl aminopeptidase IV (DP-IV) by Xaa-boroPro dipeptides and use of these inhibitors to examine the role of DP-IV in T-cell function. Proc. Natl. Acad. Sci. USA, 88, 1556-1559.
18. Gorrell, M. D., Wickson, J. & McCaughan, G. W. (1991) Expression of the rat CD26 antigen (dipeptidyl peptidase IV) on subpopulations of rat lymphocytes. Cell. Immunol., 134, 205-215.
19. Hafler, D. A., Fox, D. A., Manning, M. E., Schlossman, S. F., Reinherts, E. L. & Weiner, W. L. (1985) In vitro activation T lymphocytes in the peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. N. Engl. J. Med., 312, 1405.
20. Hagihara, M., Ohhashi, M., Nagatsu, T. (1987) Activities of dipeptidyl peptidase II and dipeptidyl peptidase IV in mice with lupus erythematosus-like syndrome and in patients with lupus erythematosus and rheumatoid arthritis. Clin. Chem., 33, 1463-1465.
21. Hartel, S., Gossrau, R., Hanski, C. & Reutter, W. (1988) Dipeptidyl peptidase (DPP) IV in rat organs. Comparison of immunohistochemistry and activity histochemistry.. Histochem., 89, 151-161.
22. Hino, M., Nagatsu, T., Kakumu, S., Okuyama, S., Yoshii, Y. & Nagatsu, I. (1975) Glycylprolyl beta-naphtylamidase activity in human serum. Clin. Chim. Acta, 50, 799.
23. Hopsu-Havu VK, G. G. (1966) A new dipeptide naphtylamidease hydrolysing glycyl-prolyl-beta-naphthylamide. Histochem., 7, 197-201.
24. Ishiyama, M. S., Sasamoto, K., Mizoguchi, M. & He, P. -G. (1993) A new sulfonated tetrazolium salt that produces a highly water-soluble formazon dye. Chem. Pharm. Bull., 41, 1118.
25. Kameoka, J., Tanaka, T., Nojima, Y., Schlossman, S. F. & Morimoto, C. (1993) Direct association of adenosine deaminase with a T cell activation antigen, CD26. Science, 261, 466-469.
26. Kubota, T., Flentke, G. R., Bachovchin, W. W. & Stollar, B. D. (1992) Involvement of dipeptidyl peptidase IV in an in vivo immune response. Clin. Exp. Immunol., 89, 192-197.
27. Kubota, T., Iizuka, H., Bachovchin, W. W. & Stollar, B. D. (1994) Dipeptidyl peptidase IV (DP IV) activity in serum and on lymphocytes of MRL/Mp-1pr/1pr mice correlates with disease onset. Clin. Exp. Immunol., 96, 292-296.
28. Masuyama, J., Berman, J. S., Cruikshank, W. W., Morimoto, C. & Center, D. M. (1992) Evidence for recent as well as long term activation of T cells migrating through endothelial cell monolayers in vitro. J. Immunol., 148, 1367-1374.
29. Mattern, T., Scholz, W., Feller, A. C., Flad, H. D. & Ulmer, A. J. (1991) Expression of CD26 (dipeptidyl peptidase IV) on resting and activated human T-lymphocytes. Scand. J. Immunol., 33, 737-748.
30. Morrison, M. E., Vijayasaradhi, S., Engelstein, D., Albino, A. P. & Houghton, A. N. (1993) A marker for neoplastic progression of human melanocytes is a cell surface ectopeptidase. J. Exp. Med., 177, 1135-1143.
31. Muscat, C., Bertotto, A., Agea, E., Bistoni, O., Ercolani, R., Tognellini, R., Spinozzi, F., Cesarotti, M. & Gerli, R. (1994) Expression and functional role of 1F7 (CD26) antigen on peripheral blood and synovial fluid T cells in rheumatoid arthritis patients. Clin. Exp. Immunol., 98, 252-256.
32. Nakao, H., Eguchi, K., Kawakami, A., Migita, K., Otsubo, T., Ueki, Y., Shimomura, C., Tezuka, H., Matsunaga, M., Maeda, K. & Nagataki, S. (1989) Increment of Ta1 positive cells in peripheral blood from patients with rheumatoid arthritis. J. Rheumatol., 16, 904-910.
33. Piazza, G. A., Callanan, H. M., Mowery, J. & Hixson, D. C. (1989) Evidence for a role of dipeptidyl peptidase IV in fibronectin-mediated interactions of hepatocytes with extracellular matrix. Biochem. J., 262, 327-334.
34. Reinhold, D., Bank, U., Buhling, F., Neubert, K., Mattern, T., Ulmer, A. J., Flad, H. D., Ansorge, S. (1993) Dipeptidyl peptidase IV (CD26) on human lymphocytes. Synthetic inhibitors of and antibodies against dipeptidyl peptidase IV suppress the proliferation of pokeweed mitogen-stimulated peripheral blood mononuclear cells, and IL-2 and IL-6 production. Immunobiol., 188, 403-414.
35. Reinhold, D., Bank, U., Buhling, F., Kahne, T., Kunt, D., Faust, J., Neubert, K. & Ansorge, S. (1994) Inhibitors of dipeptidyl peptidase IV (DP IV, CD26) specifically suppress proliferation and modulate cytokine production of strongly CD26 expressing U937 cells. Immunobiol., 192, 121-136.
36. Sarimo, V.K.H.-H.a.S.R. (1967) Purification and characterization of an aminopeptidase hydrolyzing glycyl-proline-naphthylamide. Hoppe-Seyler's Z. Physiol. Chem, 348, 1540-1550.
37. Schon, E. E., Grunow, R., Jahn, S., Kiessig, S. T., Volk, H. D. & Ansorge, S. (1986) Dipeptidyl peptidase IV in human T lymphocytes. An approach to the role of a membrane peptidase in the immune system. Biomed. Biochim. Acta, 45, 1523-1528.
38. Schon, E., Jahn, S., Kiessig, S. T., Demuth, H. U., Neubert, K., Barth, A., Von Baehr, R., Ansorge, S. (1987) The role of dipeptidyl peptidase IV in human T lymphocyte activation. Inhibitors and antibodies against dipeptidyl peptidase IV suppress lymphocyte proliferation and immunoglobulin synthesis in vitro. Eur. J. Immunol., 17, 1821-1826.
39. Schon, E., Born, L., Demuth, H. U., Faust, J., Neubert, K., Steinmetzer, T., Barth, A. & Ansorge, S. (1991) Dipeptidyl peptidase IV in the immune system. Effects of specific enzyme inhibitors on activity of dipeptidyl peptidase IV and proliferation of human lymphocytes. Biol. Chem. Hoppe. Seyler., 372, 305-311.
40. Seidl, R. & Schaefer, W. (1991) Preparative purification of dipeptidyl peptidase IV. Prep. Biochem., 210, 141-150.
41. Snow, R. J., Bachovchin, W. W., Barton, R. W., Campbell, S. J., Coutts, S. J., Freeman, D. M., Gutheil, W. G., Kelly, T. A., Kennedy, C. A., Krolikowsky, D. A., Leonard, S. F., Pargellis, C. A., Tong, L. & Adams, J. (1994) Studies on proline boronic acid dipeptide inhibitors of dipeptide peptidase IV: identification of a cyclic species containing a B-N bond. J. Am. Chem. Soc., 116, 10860-10869.
42. Steeg, C., Hartwig, U. & Fleischer, B. (1995) Unchanged signaling capacity of mutant CD26/dipeptidylpeptidase IV molecules devoid of enzymatic activity. Cell. Immunol., 164, 311-315.
43. Sudmeier, J. L., Gunther, U. L., Gutheil, W. G., Coutts, S. J., Snow, R. J., Barton, R. W. & Bachovchin, W. W. (1994) Solution structures of active and inactive forms of the DP IV (CD26) inhibitor Pro-boroPro determined by NMR spectroscopy. Biochem., 33, 12427-12438.
44. Tanaka, T., Kameoka, J., Yaron, A., Schlossman, S. F. & Morimoto, C. (1993) The costimulatory activity of the CD26 antigen requires dipeptidyl peptidase IV enzymatic activity. Proc. Natl Acad. Sci. USA, 90, 4586-4590.
45. Torimoto, Y., Dang, N. H., Vivier, E., Tanaka, T., Schlossman, S. F. & Morimoto, C. (1991) Coassociation of CD26 (dipeptidyl peptidase IV) with CD45 on the surface of human T lymphocytes. J. Immunol., 147, 2514-2517.
46. Tsuji, E., Misumi, Y., Fujiwara, T., Takami, N., Ogata, S. & Ikehara, Y. (1992) An active-site mutation (Gly633-> Arg) of dipeptidyl peptidase IV causes its retention and rapid degradation in the endoplasmic reticulum. Biochem., 31, 11921-11927.
47. Ulmer, A. J., Mattern, T., Feller, A. C., Heymann, E. & Flad, H. D. (1990) CD26 antigen is a surface dipeptidyl peptidase IV (DPPIV) as characterized by monoclonal antibodies clone TII-19-4-7 and 4EL1C7. Scand. J. Immunol., 31, 429-435.
48. Vivier, L., Marguet, D., Naquet, P., Bonicel, J., Black, D., Li, C. X., Bernard, A. M., Gorvel, J. P. & Pierres, M. (1991) Evidence that thymocyte-activating molecule is mouse CD26 (dipeptidyl peptidase IV). J. Immunol., 147, 441-454.
49. Walter, R., Simmons, W. H. & Yoshimoto, T. (1980) Mol. Cell. Biochem., 30, 112-127.
50. Watanabe, Y., Kojima, T. & Fujimoto, Y. (1987) Deficiency of membrane-bound dipeptidyl aminopeptidase IV in a certain rat strain. Experientia, 43, 400-401.
51. William, G., Gutheil, William, W. B. (1993) Separation of L-Pro-DL-boroPro into its component diastereomers and kinetic analysis of their inhibition of dipeptidyl peptidase IV. A new method for the analysis of slow tight-binding inhibition. Biochem., 32, 8723-8731.
52. Yi-Han Chang, C. M. P. & Chiyuki, A. (1980) Adjuvant polyarthritis IV. Induction by synthetic adjuvant: immunologic histopathologic, and other studies. Arthrit. Rheumat., 23, 62-71.