Sertraline inhibits pre-synaptic Na + channel-mediated responses in hippocampus-isolated nerve endings

Journal of Neurochemistry

Volumn 121, Issue 2, 2012, Pages 197-205

  Aldana, Blanca I ^a   Sitges, María ^a  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

5 HT; GABA; Glu; Neurotransmitter release; Sodium channels; Veratridine

Indexed keywords

4 AMINOBUTYRIC ACID; 5 HYDROXYINDOLEACETIC ACID; CALCIUM ION; GLUTAMINE; SEROTONIN; SEROTONIN TRANSPORTER; SERTRALINE; SODIUM CHANNEL; VERATRIDINE;

ANIMAL TISSUE; ARTICLE; BRAIN FUNCTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; ELECTROENCEPHALOGRAM; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; MALE; NERVE ENDING; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; RAT; SYNAPTOSOME;

ANIMALS; CALCIUM; GAMMA-AMINOBUTYRIC ACID; GLUTAMIC ACID; HIPPOCAMPUS; HYDROXYINDOLEACETIC ACID; MALE; NERVE ENDINGS; NEUROTRANSMITTER AGENTS; PRESYNAPTIC TERMINALS; RATS; RATS, WISTAR; SEROTONIN; SERTRALINE; SODIUM; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; TETRODOTOXIN; VERATRIDINE;

EID: 84859642225     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2012.07674.x     Document Type: Article

References (30)

1. Bell G. S. and Sander J. W. (2009) Suicide and epilepsy. Curr. Opin. Neurol. 22, 174-178.
2. Boeijinga P. H. and Boddeke H. W. (1996) Activation of 5-HT1B receptors suppresses low but not high frequency synaptic transmission in the rat subicular cortex in vitro. Brain Res. 721, 59-65.
3. Bolden-Watson C. and Richelson E. (1993) Blockade by newly-developed antidepressants of biogenic amine uptake into rat brain synaptosomes. Life Sci. 52, 1023-1029.
4. Doran A., Obach R. S., Smith B. J. et al. (2005) The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model. Drug Metab. Dispos. 33, 165-174. (Pubitemid 40023528)
5. Engel D. and Jonas P. (2005) Presynaptic action potential amplification by voltage-gated Na+ channels in hippocampal mossy fiber boutons. Neuron 45, 405-417. (Pubitemid 40188208)
6. Fekete A., Franklin L., Ikemoto T., Rózsa B., Lendvai B., Vizi E. S. and Zelles T. (2009) Mechanism of the persistent sodium current activator veratridine-evoked Ca elevation: implication for epilepsy. J. Neurochem. 111, 745-756.
7. Galindo C. and Sitges M. (2004) Dihydropiridines mechanism of action in striatal isolated nerve endings. Comparison with -agatoxin IVA. Neurochem. Res. 29, 659-669. (Pubitemid 38429183)
8. Gershon E., Weigi L., Lotan I., Schreibmayer W. and Dascal N. (1992) Protein kinase A reduces voltage-dependent Na+ current in Xenopus oocytes. J. Neurosci. 12, 3743-3752.
9. Huang C. J., Harootunian A., Maher M. P., Quan C., Raj C. D., Mc- Cormack K., Numann R., Negulescu P. A. and González J. E. (2006) Characterization of voltage-gated sodium-channel blockers by electrical stimulation and fluorescence detection of membrane potential. Nat. Biotechnol. 24, 439-446.
10. Kanner A. M. (2008) Depression in epilepsy: a complex relation with unexpected consequences. Curr. Opin. Neurol. 21, 190-194.
11. Kanner A. M., Trimble M. and Schmitz B. (2010) Postictal affective episodes. Epilepsy Behav. 19, 156-158.
12. Koe B. K., Weissman A., Welch W. M. and Browne R. G. (1983) Sertraline, 1S,4S-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro- 1-naphthylamine, a new uptake inhibitor with selectivity for serotonin. J. Pharmacol. Exp. Ther. 226, 686-700. (Pubitemid 13007714)
13. Kuhn D. M., Vogel R. L. and Lovenberg W. (1978) Calcium-dependent activation of tryptophan hydroxylase by ATP and magnesium. Biochem. Biophys. Res. Commun. 82, 759-766. (Pubitemid 8348793)
14. Otoom S. and Sequeira R. P. (2011) Veratridine induced absence like-seizure in the freely moving rats: a study correlating the behavioral findings with the electrophysiological activities. Neuro Endocrinol. Lett. 32, 487-490.
15. + exchange in synaptosomes: effect on [3H]GABA release. Neurochem. Res. 21, 889-895.
16. Seethalakshmi R. and Krishnamoorthy E. S. (2007) Depression in epilepsy: phenomenology, diagnosis and management. Epileptic Disord. 9, 1-10. (Pubitemid 46396670)
17. Sheehan D. V. and Kamijima K. (2009) An evidence-based review of the clinical use of sertraline in mood and anxiety disorders. Int. Clin. Psychopharmacol. 24, 43-60.
18. Sitges M. (1989) Effect of organic and inorganic calcium channel blockers on r-amino-n-butyric acid release induced by monensin and veratrine in the absence of external calcium. J. Neurochem. 53, 436-441.
19. 3H]GABA from synaptosomes. Neurochem. Res. 20, 1065-1071.
20. 2+ and glutamate release in depolarised brain nerve terminals. Neurochem. Int. 46, 53-60.
21. Sitges M., Chiu L. M. and Gonzalez L. (1993) Vesicular and carriermediated depolarization-induced release of [3H]GABA: inhibition by amiloride and verapamil. Neurochem. Res. 18, 1081-1087. (Pubitemid 23309273)
22. Sitges M., Reyes A. and Chiu L. M. (1994) Dopamine transporter mediated release of dopamine: role of chloride. J. Neurosci. Res. 39, 11-22. (Pubitemid 24286530)
23. Sitges M., Peña F., Chiu L. M. and Guarneros A. (1998) Study on the possible involvement of protein kinases in the modulation of brain presynaptic sodium channels; comparison with calcium channels. Neurochem. Int. 32, 177-190. (Pubitemid 28105304)
24. Sitges M., Chiu L. M. and Nekrassov V. (2006) Single and combined effects of carbamazepine and vinpocetine on depolarization-induced changes in Na(+), Ca(2+) and glutamate release in hippocampal isolated nerve endings. Neurochem. Int. 49, 55-61. (Pubitemid 44275195)
25. Sitges M., Chiu L. M. and Nekrassov V. (2007) Effects of carbamazepine, phenytoin, lamotrigine, oxcarbazepine, topiramate and vinpocetine on Na+ channel-mediated release of [3H]glutamate in hippocampal nerve endings. Neuropharmacology 52, 598-605. (Pubitemid 46151686)
26. Sitges M., Aldana B. I., Chiu L. M. and Nekrassov V. (2009) Characterization of phenytoin, carbamazepine, vinpocetine and clorgyline simultaneous effects on sodium channels and catecholamine metabolism in rat striatal nerve endings. Neurochem. Res. 34, 470-479.
27. Smith R. D. and Goldin A. L. (1992) Protein kinase A phosphorylation enhances sodium channel currents in Xenopus oocytes. Am. J. Physiol. 263, C660-C666.
28. Stevanovic D., Jancic J. and Lakic A. (2011) The impact of depression and anxiety disorder symptoms on the health-related quality of life of children and adolescents with epilepsy. Epilepsia 52, e75-e78.
29. Tatsumi M., Groshan K., Blakely R. D. and Richelson E. (1997) Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur. J. Pharmacol. 340, 249-258. (Pubitemid 28022649)
30. Wang G. K., Mitchell J. and Wang S. Y. (2008) Block of persistent late Na+ currents by antidepressant sertraline and paroxetine. J. Membr. Biol. 222, 79-90.