Nigericin-induced Na+/H+ and K+/H+ exchange in synaptosomes: Effect on [3H]GABA release

Neurochemical Research

Volumn 21, Issue 8, 1996, Pages 889-895

  Rodríguez, Ricardo ^a   Sitges, María ^a  

^a INSTITUTO DE INVESTIGACIONES BIOMÉDICAS   (Mexico)

Author keywords

cytosolic Ca2+; cytosolic Na+; cytosolic pH; GABA release; K+ H+ ionophore; Na+ H+ ionophore; Nigericin; synaptosomes

Indexed keywords

4 AMINOBUTYRIC ACID; POTASSIUM ION; PROTON; SODIUM ION;

4 AMINOBUTYRIC ACID RELEASE; ANIMAL TISSUE; ARTICLE; BRAIN SYNAPTOSOME; CONTROLLED STUDY; MOUSE; NONHUMAN; PH; POTASSIUM TRANSPORT; PRIORITY JOURNAL; PROTON SODIUM EXCHANGE; TRANSPORT KINETICS;

ANIMALS; ANTIPORTERS; BENZOFURANS; BRAIN; FLUORESCEINS; FLUORESCENT DYES; FURA-2; GAMMA-AMINOBUTYRIC ACID; HYDROGEN-ION CONCENTRATION; KINETICS; MICE; NIGERICIN; PHTHALIC ACIDS; POTASSIUM; POTASSIUM-HYDROGEN ANTIPORTERS; SODIUM; SODIUM-HYDROGEN ANTIPORTER; SYNAPTOSOMES;

ANIMALIA;

EID: 84864889207     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02532337     Document Type: Article

References (28)

1. Pressman, B. C. 1976. Biological applications of ionophores. Ann. Rev. Biochem. 45:501-530.
2. + permeability. J. Neurosci. 6:1570-1574.
3. Sitges, M. 1989. Characterization of the effect of monensin on σ-amino-n-butyric acid release from isolated nerve terminals. J. Neurochem. 53:442-447.
4. 2+ levels in cerebrocortical synaptosomes of rats. J. Neurochem. 57:1270-1275.
5. Moulian, N., Gaudry-Talarmain, Y.M., and Israel, M. 1994. Spontaneous release of acetylcholine from Torpedo synaptosomes: Effect of cetiedil and its analogue MR16728. J. Neurochem. 62:113-118.
6. Bode, H. P., Eder, B., and Trautmann, M. 1994. An investigation on the role of vacuolar-type proton pumps and luminal acidity in calcium sequestration by nonmitochondrial and inositol-1,4,5-triphosphate-sensitive intracellular calcium stores in clonal insulin-secreting cells. Eur. J. Biochem. 222:869-877.
7. + ionophores inhibit nerve growth factor-induced neuronal differentiation in rat adrenal pheochromocytoma PC12 cells. Biochim. Biophys. Acta 1220:310-314.
8. Vääräniemi, J., Huotari, V., Lehto, V. P., and Eskelinen, S. 1994. The effects of PMA and TFP and alterations in intracellular pH and calcium concentration on the membrane associations of phospholipid-binding proteins fodrin, protein kinase C and annexin II in cultured MDCK. cells. Biochim. Biophys. Acta 1189:21-30.
9. Perregaux, D., and Gabel, C. A. 1994. Interleukin-1β maturation and release in response to ATP and nigericin. J. Biol. Chem. 269: 15195-15203.
10. Erecinska, M., Nelson, D., Dagani, F., Deas, J., and Silver, I. A. 1993. Relations between intracellular ions and energy metabolism under acidotic conditions: A study with nigericin in synaptosomes, neurons and C6 glioma cells. J. Neurochem. 61:1356-1368.
11. Levi, G. 1984. Release of putative transmitter aminoacids. Pages 463-509, in Lajtha, A. (ed.), Handbook of Neurochemistry. Plenum Press, New York.
12. Sihra, T. S., and Nicholls, D. G. 1987. 4-Aminobutyrate can be released exocytotically from guinea-pig cerebral cortical synaptosomes. J. Neurochem. 49:261-267.
13. Sitges, M. 1989. Effect of organic and inorganic calcium channel blockers on σ-amino-n-butyric acid release induced by monensin and veratrine in the absence of external calcium. J. Neurochem. 53:436-441.
14. Nicholls, D. G. 1989. Release of glutamate, aspartate, and gamma-aminobutyric acid from isolated nerve terminals. J. Neurochem. 52:331-341.
15. Bernath, S. 1992. Calcium-independent release of amino acid neurotransmitters: fact or artifact? Progress in Neurobiology 38:57-91.
16. Meyer, D. K. 1991. Nonexocytotic release of gamma-aminobutyric acid: Implications for volume transmission. Pages 433-440, in Fuxe, K. and Agnati, L. F. (eds.), Volume transmission in the brain. Raven Press, New York.
17. 3H-GABA: Inhibition by verapamil and amiloride. Neurochem. Res. 18:1081-1087.
18. Reed, P. W. 1979. Ionophores. Methods Enzymol. 55:435-454.
19. Erecinska, M., Dagani, F., Nelson, D., Deas, J., and Silver, I. A. 1991. Relations between intracellular ions and energy metabolism: A study with monensin in synaptosomes, neurons and C6 glioma cells. J. Neurosci. 11:2410-2421.
20. Hajós, F. 1975. An improved method for the preparation of synaptosomal fractions in high purity. Brain Res. 136:387-392.
21. 3H]GABA from synaptosomes. Neurochem. Res. 20:1065-1071.
22. Minta, A., and Tsien, R. Y. 1989. Fluorescent indicators for cytosolic sodium. J. Biol. Chem. 264:19449-19457.
23. + in individual fibroblasts and lymphocytes. J. Biol. Chem. 264:19458-19467.
24. Sánchez-Armass, S., Martínez-Zaguillán, R., Martínez, G. M., and Gillies, R. 1994. Regulation of pH in rat brain synaptosomes. I. Role of sodium, bicarbonate, and potassium. J. Neurophysiol. 71: 2236-2248.
25. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260:3440-3450.
26. +-binding benzofuran isophthalate: The effect of veratridine, ouabain, and α-latrotoxin. J. Neurochem. 61:818-825.
27. Nachshen, D. A., and Drapeau, P. 1989. The regulation of cytosolic pH in isolated presynaptic nerve terminals from rat brain. J. Gen. Physiol. 91:289-303.
28. + exchange system in rat brain synaptosomes. J. Biol. Chem. 260:9678-9684.