Veratridine induced absence like-seizure in the freely moving rats: A study correlating the behavioural findings with the electrophysiological activities

Neuroendocrinology Letters

Volumn 32, Issue 4, 2011, Pages 487-490

  Otoom, Sameer ^a   Sequeira, Reginald P ^b  

^a UNIVERSITY OF BAHRAIN   (Bahrain)

^b ARABIAN GULF UNIVERSITY   (Bahrain)

Author keywords

Behaviour, electroencephalogram; Ethosuximide; Rats; Seizure; Veratridine

Indexed keywords

ETHOSUXIMIDE; VERATRIDINE;

ABSENCE; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; AUTOMATISM; BRAIN ELECTROPHYSIOLOGY; CONTROLLED STUDY; ELECTROENCEPHALOGRAM; GROOMING; MALE; MASTICATION; NONHUMAN; RAT; SEIZURE; WET DOG SHAKES;

EID: 80053480534     PISSN: 0172780X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Ates N, Sahin D, Ilbay G (2004) Theophylline, a methylxanthine derivative, suppress absence epileptic seizures in WAG/Rij rats. Epilepsy Behav. 5: 645-648. (Pubitemid 40392579)
2. Bouwman BM, van Rijn CM (2004) Effects of leviracetam on spike and wave discharge in WAG/Rij rats. Seziure. 13: 591-594. (Pubitemid 39549833)
3. Brandt C, Gastens AM, Sun M, Hausnecht M, Loscher W (2006) Treatment with valproate after status epilepticus: effect on neuronal damage, epileptogenesis, and behavioral alterations in rats. Neuropharmacology. 51: 789-804. (Pubitemid 44286933)
4. Chuang YC, Lin JW, Chen SD, Lin TK, Liou CW, Lu CH, Chang WN (2009) Preservation of mitochondrial integrity and energy metabolism during experimental status epilepticus leads to neuronal apoptotic cell death in the hippocampus of rat. Seizure. 18: 420-428
5. Cunningham J, Neal MJ (1981) On the mechanism by which veratridine cause a calcium independent release of gamma-aminobutyric acid from brain slices. Br J Pharmacol. 73: 655-667. (Pubitemid 11067903)
6. Gilman S (2007) Neurobiology of Disease. Elsevier Press, Amsterdam.
7. Kumaresan S, David J, Joseph T (2000) Comparative profiles of sodium valproate and ethosuximide on electro-behavioural correlates in gamma- hydroxybutyrate and pentylenetetrazol induced absence seizures in rats. Indian J Physiol Pharmacol. 44: 411-418.
8. Lingamaneni R, Hemmings HC Jr (1999) Effects of Anticonvulsants on veratridine- and cortical synaptosomes. Neurosci Lett. 276: 127-130.
9. Otoom S, Tian LM, Alkadhi KA (1998) Veratridine-treated brain slices: a cellular model for epileptiform activity. Brain Res. 789: 150-156. (Pubitemid 28206855)
10. Otoom SA, Alkadhi KA (1999) Valproic acid intensifies epileptiform activity in the hippocampal pyramidal neurons. Neurosci. Res. 35: 299-230.
11. Otoom SA, Alkadhi KA (2000A) Action of carbamazepine on epileptiform activity of the verartidine model in CA1 neurons. Brain Res. 885: 289-294.
12. Otoom SA, Alkadhi KA (2000B) Epileptiform activity of veratridine model in rat brain slices: effects of antiepileptic drugs. Epilepsy Res. 38: 161-170.
13. Otoom SA, Handu SS, Wazir JF, James H, Sharma PR, Hasan ZA, Sequeira RP (2006) Veratridine-induced wet dog shake behaviour and apoptosis in rat hippocampus. Basic Clin Pharmacol Toxicol. 98: 423-6.
14. Otoom SA, Hasan Z (2004) Propofol exhibits antiepileptic activity in hippocampal pyramidal neurons. Pharmacol. Biochem. Behav. 77: 595-599. (Pubitemid 38296820)
15. Otoom SA, Nusier MK (2001) Effect of lamotrigine on a novel model of epilepsy. Cytobios 106(Suppl. 1): 75-83. (Pubitemid 33681315)
16. 2+ - mediated neuronal death in rat brain neuronal cultures by veratridine: protection by flunarizine. MoI Pharmacol. 36: 525-531.
17. Peterson SL, Albertson TE (1998) Neuropharmacology Methods in Epilepsy Research. CRC Press, Boca Raton.
18. Pitkanen A, Schwartzkroin PA, Moshe SL (2006) Models of Seizures and Epilepsy. Elsevier Academic Press, Amsterdam.
19. +-stimulated release of glutamate from mouse cortex. Eur J Pharmacol. 315: 285-288.
20. Subrmanyan K, David J, Jospeh T (2001) Interaction of flunarizine with sodium valproate or ethosuximide in gamma-hydroxybutyrate induced absence seizures in rats. Indian J Expt Biol. 39: 998-1001. (Pubitemid 32961647)
21. Tapia R (1985) Effects of drugs on neurotransmitter release: experiments in vivo and in vitro. Neurosci Biobehav Rev. 9: 391-397.
22. Terzioglu B, Aypak C, Onat FY, Kucukibrahimoglu E, Ozkaynakci AE, Goren MZ (2006) The effects of ethosuximide on amino acids in genetic absence epilepsy rat model. J Pharmacol Sci. 100: 227-233.
23. Tian LM, Otoom S, Alkadhi KA (1995) Endogenous bursting due to altered sodium channel function in rat hippocampal CA1 neurons. Brain Res. 680: 164-72.
24. 2+]i increase in rat hippocampal CAI pyramidal cells. Neurochem Res. 26: 1095-1100.