Neurobiology of substance P and the NK1 receptor

Journal of Clinical Psychiatry

Volumn 63, Issue SUPPL. 11, 2002, Pages 6-10

  Mantyh, Patrick W ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMIC ACID; NEUROKININ 1 RECEPTOR; NEUROTRANSMITTER; SUBSTANCE P;

AFFECT; ANXIETY NEUROSIS; BEHAVIOR; BINDING AFFINITY; BRAIN; CELL MEMBRANE; CENTRAL NERVOUS SYSTEM; DENDRITE; DEPRESSION; DIFFUSION; NERVE CELL; NEUROBIOLOGY; NOCICEPTION; PERIKARYON; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; RECEPTOR BINDING; RECYCLING; REVIEW; SPINAL CORD; STRESS; VOMITING;

AFFECT; ANIMALS; ANTIDEPRESSIVE AGENTS; ANXIETY DISORDERS; BRAIN; CELL DEATH; CELLS, CULTURED; DEPRESSIVE DISORDER; HUMANS; IMMUNOTOXINS; KILLER CELLS, NATURAL; MICE; MODELS, ANIMAL; RATS; RECEPTORS, IMMUNOLOGIC; RECEPTORS, NEUROKININ-1; SPINAL CORD; SUBSTANCE P;

EID: 0036448830     PISSN: 01606689     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (47)

1. Von Euler US, Gaddum JH. An unidentified depressor substance in certain tissue extracts. J Physiol 1931;72:74-87
2. Pernow B. Studies on substance P purification, occurrence, and biological actions. Acta Physiol Scand 1953;29:1-90
3. Hokfelt T, Pernow B, Wahren J. Substance P: A pioneer amongst neuropeptides. J Intern Med 2001;249:27-40
4. Chang MM, Leeman SE, Niall HD. Amino-acid sequence of substance P. Nat New Biol 1971;232:86-87
5. Tregear GW, Niall HD, Potts JT Jr, et al. Synthesis of substance P. Nat New Biol 1971;232:87-89
6. Saria A. The tachykinin NK1 receptor in the brain: Pharmacology and putative functions. Eur J Pharmacol 1999;375:51-60
7. Cao YQ, Mantyh PW, Carlson EJ, et al. Primary afferent tachykinins are required to experience moderate to intense pain. Nature 1998;392:390-394
8. De Felipe C, Herrero JF, O'Brien JA, et al. Altered nociception, analgesia and aggression in mice lacking the receptor for substance P. Nature 1998;392:394-397
9. King TE, Heath MJ, Debs P, et al. The development of the nociceptive responses in neurokinin-1 receptor knockout mice. Neuroreport 2000;11:587-591
10. Armstrong DM, Pickel VM, Joh TH, et al. Immunocytochemical localization of catecholamine synthesizing enzymes and neuropeptides in area postrema and medial nucleus tractus solitarius of rat brain. J Comp Neurol 1981;196:505-517
11. Campos D, Pereira JR, Reinhardt RR, et al. Prevention of cisplatin-induced emesis by the oral neurokinin-1 antagonist, MK-869, in combination with granisetron and dexamethasone or with dexamethasone alone. J Clin Oncol 2001;19:1759-1767
12. Van Belle S, Lichinitser MR, Navari RM, et al. Prevention of cisplatin-induced acute and delayed emesis by the selective neurokinin-1 antagonists, L-758,298 and MK-869. Cancer 2002;94:3032-3041
13. Quartara L, Maggi CA. The tachykinin NK1 receptor, pt 2: Distribution and pathophysiological roles. Neuropeptides 1998;32:1-49
14. Mantyh PW, Hunt SP, Maggio JE. Substance P receptors: Localization by light microscopic autoradiography in rat brain using [3H]SP as the radioligand. Brain Res 1984;307:147-165
15. Kramer MS, Cutler N, Feighner J, et al. Distinct mechanism for anti-depressant activity by blockade of central substance P receptors. Science 1998;281:1640-1645
16. Rupniak NM, Carlson EC, Harrison T, et al. Pharmacological blockade or genetic deletion of substance P (NK(1)) receptors attenuates neonatal vocalisation in guinea-pigs and mice. Neuropharmacology 2000;39:1413-1421
17. Santarelli L, Gobbi G, Debs PC, et al. Genetic and pharmacological disruption of neurokinin-1 receptor function decreases anxiety-related behaviors and increases serotonergic function. Proc Natl Acad Sci U S A 2001;98:1912-1917
18. Brownstein MJ, Mroz EA, Kizer JS, et al. Regional distribution of substance P in the brain of the rat. Brain Res 1976;116:299-305
19. Ljungdahl A, Hokfelt T, Nilsson G. Distribution of substance P-like immunoreactivity in the central nervous system of the rat, 1: Cell bodies and nerve terminals. Neuroscience 1978;3:861-943
20. Nicoll RA, Schenker C, Leeman SE. Substance P as a transmitter candidate. Annu Rev Neurosci 1980;3:227-268
21. Nakaya Y, Kaneko T, Shigemoto R, et al. Immunohistochemical localization of substance P receptor in the central nervous system of the adult rat. J Comp Neurol 1994;347:249-274
22. Pickel VM, Joh TH, Reis DJ, et al. Electron microscopic localization of substance P and enkephalin in axon terminals related to dendrites of catecholaminergic neurons. Brain Res 1979;160:387-400
23. Iversen LL, Jessell T, Kanazawa I. Release and metabolism of substance P in rat hypothalamus. Nature 1976;264:81-83
24. Otsuka M, Konishi S. Release of substance P-like immunoreactivity from isolated spinal cord of newborn rat. Nature 1976;264:83-84
25. Cheeseman HJ, Pinnock RD, Henderson G. Substance P excitation of rat locus coeruleus neurones. Eur J Pharmacol 1983;94:93-99
26. Ogata N. Effects of substance P on neurons of various brain regions in vitro. Brain Res 1979;176:395-400
27. Ogata N, Abe H. Substance P decreases membrane conductance in neurons of the guinea pig hypothalamus in vitro. Neuropharmacology 1982;21:187-189
28. Murase K, Nedeljkov V, Randic M. The actions of neuropeptides on dorsal horn neurons in the rat spinal cord slice preparation: An intracellular study. Brain Res 1982;234:170-176
29. Maeno H, Kiyama H, Tohyama M. Distribution of the substance P receptor (NK-1 receptor) in the central nervous system. Brain Res Mol Brain Res 1993;18:43-58
30. Mantyh PW, DeMaster E, Malhotra A, et al. Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation. Science 1995;268:1629-1632
31. Mantyh PW, Hunt SP. Changes in 3H-substance P receptor binding in the rat brain after kainic acid lesion of the corpus striatum. J Neurosci 1986;6:1537-1544
32. Mantyh PW, Gates T, Mantyh CR, et al. Autoradiographic localization and characterization of tachykinin receptor binding sites in the rat brain and peripheral tissues. J Neurosci 1989;9:258-279
33. Mantyh PW, Pinnock RD, Downes CP, et al. Correlation between inositol phospholipid hydrolysis and substance P receptors in rat CNS. Nature 1984;309:795-797
34. Mantyh PW, Allen CJ, Ghilardi JR, et al. Rapid endocytosis of a G protein-coupled receptor: Substance P evoked internalization of its receptor in the rat striatum in vivo. Proc Natl Acad Sci U S A 1995;92:2622-2626
35. Allen BJ, Rogers SD, Ghilardi JR, et al. Noxious cutaneous thermal stimuli induce a graded release of endogenous substance P in the spinal cord: Imaging peptide action in vivo. J Neurosci 1997;17:5921-5927
36. Stucky CL, Galeazza MT, Seybold VS. Time-dependent changes in Bolton-Hunter-labeled 1251-substance P binding in rat spinal cord following unilateral adjuvant-induced peripheral inflammation. Neuroscience 1993;57:397-409
37. Abbadie C, Trafton J, Liu H, et al. Inflammation increases the distribution of dorsal horn neurons that internalize the neurokinin-1 receptor in response to noxious and non-noxious stimulation. J Neurosci 1997;17:8049-8060
38. Elliott PJ. Place aversion induced by the substance P analogue, dimethyl-C7, is not state dependent: Implication of substance P in aversion. Exp Brain Res 1988;73:354-356
39. Aguiar MS, Brandao ML. Effects of microinjections of the neuropeptide substance P in the dorsal periaqueductal gray on the behaviour of rats in the plus-maze test. Physiol Behav 1996;60:1183-1186
40. Krase W, Koch M, Schnitzler HU. Substance P is involved in the sensitization of the acoustic startle response by footshocks in rats. Behav Brain Res 1994;63:81-88
41. Rupniak NM, Kramer MS. Discovery of the antidepressant and anti-emetic efficacy of substance P receptor (NK1) antagonists. Trends Pharmacol Sci 1999;20:485-490
42. Boyce S, Smith D, Carlson E, et al. Intra-amygdala injection of the substance P [NK(1) receptor] antagonist L-760735 inhibits neonatal vocalisations in guinea-pigs. Neuropharmacology 2001;41:130-137
43. Hofer MA. Multiple regulators of ultrasonic vocalization in the infant rat. Psychoneuroendocrinology 1996;21:203-217
44. 1). J Clin Psychiatry 2002;63(suppl 11):11-17
45. Mantyh PW, Rogers SD, Honore P, et al. Inhibition of hyperalgesia by ablation of lamina 1 spinal neurons expressing the substance P receptor. Science 1997;278:275-279
46. Wiley RG, Lappi DA. Destruction of neurokinin-1 receptor expressing cells in vitro and in vivo using substance P-saporin in rats. Neurosci Lett 1997;230:97-100
47. Nichols ML, Allen BJ, Rogers SD, et al. Transmission of chronic nociception by spinal neurons expressing the substance P receptor. Science 1999;286:1558-1561