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Volumn , Issue , 2006, Pages 529-545

Empirical Pharmacokinetic/Pharmacodynamic Models

Author keywords

Chronopharmacokinetics; Direct empirical models; Drug tolerance; Emax model; Linear pharmacodynamic model; Pharmacokinetic pharmacodynamic modeling; Sigmoidal Emax model; Splines; The link model; Time invariant systems; Time variant systems

Indexed keywords


EID: 60349097109     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470087978.ch20     Document Type: Chapter
Times cited : (8)

References (71)
  • 1
    • 0001146538 scopus 로고
    • Kinetics of distribution of substances administered to the body. I. The extravascular modes of administration
    • T. Teorell, Kinetics of distribution of substances administered to the body. I. The extravascular modes of administration. Arch Int Pharmacodyn 57:205-225 (1937).
    • (1937) Arch Int Pharmacodyn , vol.57 , pp. 205-225
    • Teorell, T.1
  • 2
    • 0001146538 scopus 로고
    • Kinetics of distribution of substances administered to the body. II. The intravascular modes of administration
    • T. Teorell, Kinetics of distribution of substances administered to the body. II. The intravascular modes of administration. Arch Int Pharmacodyn 57:226-240 (1937).
    • (1937) Arch Int Pharmacodyn , vol.57 , pp. 226-240
    • Teorell, T.1
  • 3
    • 0003426746 scopus 로고
    • Empirical Model-Building and Response Surfaces
    • Wiley, Hoboken, NJ, 15-33
    • G. E. P. Box and N. R. Draper, Empirical Model-Building and Response Surfaces. Wiley, Hoboken, NJ, 1987, pp. 1-3, 15-33.
    • (1987) , pp. 1-3
    • Box, G.E.P.1    Draper, N.R.2
  • 4
    • 33751397601 scopus 로고    scopus 로고
    • Simulation in Drug Development: Good Practices
    • Version 1.0. Draft Publication of the Center for Drug Development Science (CDDS)
    • P. Bonate, W. R. Gillespie, T. Ludden, D. B. Rubin, and D. Stanski, Simulation in Drug Development: Good Practices, Version 1.0. Draft Publication of the Center for Drug Development Science (CDDS), 1999, pp. 1-19.
    • (1999) , pp. 1-19
    • Bonate, P.1    Gillespie, W.R.2    Ludden, T.3    Rubin, D.B.4    Stanski, D.5
  • 5
    • 0000137448 scopus 로고
    • The pharmacology of vascular smooth muscle
    • R. F. Furchgott, The pharmacology of vascular smooth muscle. Pharmacol Rev 7:183-265 (1955).
    • (1955) Pharmacol Rev , vol.7 , pp. 183-265
    • Furchgott, R.F.1
  • 6
    • 0018394195 scopus 로고
    • Simultaneous modeling of pharmacokinetics and pharmacodynamics: application to d-tubocurarine
    • L. B. Sheiner, D. R. Stanski, S. Vozeh, R. D. Miller, and J. Ham, Simultaneous modeling of pharmacokinetics and pharmacodynamics: application to d-tubocurarine. Clin Pharmacol Ther 25:358-371 (1979).
    • (1979) Clin Pharmacol Ther , vol.25 , pp. 358-371
    • Sheiner, L.B.1    Stanski, D.R.2    Vozeh, S.3    Miller, R.D.4    Ham, J.5
  • 7
    • 0014341045 scopus 로고
    • Kinetics of interaction between drugs and biological systems
    • G. Segre, Kinetics of interaction between drugs and biological systems. Farmaco (Sci) 23:907-918 (1968).
    • (1968) Farmaco (Sci) , vol.23 , pp. 907-918
    • Segre, G.1
  • 8
    • 0019825066 scopus 로고
    • Simultaneous pharmacokinetic and pharmacodynamic modeling
    • W. A. Colburn, Simultaneous pharmacokinetic and pharmacodynamic modeling. J Pharmacokinet Biopharm 9:367-388 (1981).
    • (1981) J Pharmacokinet Biopharm , vol.9 , pp. 367-388
    • Colburn, W.A.1
  • 9
    • 0024239867 scopus 로고
    • Combined pharmacokinetic/pharmacodynamic (PK/PD) modeling
    • W. A. Colburn, Combined pharmacokinetic/pharmacodynamic (PK/PD) modeling. J Clin Pharmacol 28:769-771 (1988).
    • (1988) J Clin Pharmacol , vol.28 , pp. 769-771
    • Colburn, W.A.1
  • 10
    • 33745792813 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic modelling: history and perspectives
    • C. Csajka and D. Verotta, Pharmacokinetic-pharmacodynamic modelling: history and perspectives. J Pharmacokinet Pharmacodyn 1-53 (2006).
    • (2006) J Pharmacokinet Pharmacodyn , pp. 1-53
    • Csajka, C.1    Verotta, D.2
  • 11
    • 0029749999 scopus 로고    scopus 로고
    • Applications of pharmacokinetic/pharmacodynamic research in rational drug development
    • M. Danhof, Applications of pharmacokinetic/pharmacodynamic research in rational drug development. Methods Find Exp Clin Pharmacol 18 (Suppl C):53-54 (1996).
    • (1996) Methods Find Exp Clin Pharmacol , vol.18 , Issue.SUPPL C , pp. 53-54
    • Danhof, M.1
  • 12
    • 0027263323 scopus 로고
    • Pharmacokinetic- pharmacodynamic modelling in pre-clinical investigations: principles and perspectives
    • M. Danhof, J. W. Mandema, A. Hoogerkamp, and R. A. Mathot, Pharmacokinetic- pharmacodynamic modelling in pre-clinical investigations: principles and perspectives. Eur J Drug Metab Pharmacokinet 18:41-47 (1993).
    • (1993) Eur J Drug Metab Pharmacokinet , vol.18 , pp. 41-47
    • Danhof, M.1    Mandema, J.W.2    Hoogerkamp, A.3    Mathot, R.A.4
  • 14
    • 0019785890 scopus 로고
    • Understanding the dose-effect relationship: clinical application of pharmacokinetic-pharmacodynamic models
    • N. H. G. Holford and L. B. Sheiner, Understanding the dose-effect relationship: clinical application of pharmacokinetic-pharmacodynamic models. Clin Pharmacokinet 6:429-453 (1981).
    • (1981) Clin Pharmacokinet , vol.6 , pp. 429-453
    • Holford, N.H.G.1    Sheiner, L.B.2
  • 15
    • 0022503230 scopus 로고
    • Simultaneous modeling of pharmacokinetics and pharmacodynamics with nonparametric kinetic and dynamic models
    • J. D. Unadkat, F. Bartha, and L. B. Sheiner, Simultaneous modeling of pharmacokinetics and pharmacodynamics with nonparametric kinetic and dynamic models. Clin Pharmacol Ther 40:86-93 (1986).
    • (1986) Clin Pharmacol Ther , vol.40 , pp. 86-93
    • Unadkat, J.D.1    Bartha, F.2    Sheiner, L.B.3
  • 16
    • 0014318562 scopus 로고
    • Kinetics of pharmacologic response. I. Proposed relationships between response and drug concentration in the intact animal and man
    • J. G. Wagner, Kinetics of pharmacologic response. I. Proposed relationships between response and drug concentration in the intact animal and man. J Theor Biol 20:173-201 (1968).
    • (1968) J Theor Biol , vol.20 , pp. 173-201
    • Wagner, J.G.1
  • 17
    • 0017188890 scopus 로고
    • Relationship between the pharmacokinetics and pharmacodynamics of procainamide
    • R. L. Galeazzi, L. Z. Benet, and L. B. Sheiner, Relationship between the pharmacokinetics and pharmacodynamics of procainamide. Clin Pharmacol Ther 20:278-289 (1976).
    • (1976) Clin Pharmacol Ther , vol.20 , pp. 278-289
    • Galeazzi, R.L.1    Benet, L.Z.2    Sheiner, L.B.3
  • 18
    • 53149144677 scopus 로고    scopus 로고
    • Empirical versus mechanistic modelling: comparison of an artificial neural network to a mechanistically based model for quantitative structure pharmacokinetic relationships of a homologous series of barbiturates
    • I. S. Nestorov, S. T. Hadjitodorov, I. Petrov, and M. Rowland, Empirical versus mechanistic modelling: comparison of an artificial neural network to a mechanistically based model for quantitative structure pharmacokinetic relationships of a homologous series of barbiturates. AAPS Pharm Sci 1:E17 (1999).
    • (1999) AAPS Pharm Sci , vol.1
    • Nestorov, I.S.1    Hadjitodorov, S.T.2    Petrov, I.3    Rowland, M.4
  • 19
    • 0028800137 scopus 로고
    • Convergence of direct and indirect pharmacodynamic response models
    • discussion 9-10
    • W. J. Jusko, H. C. Ko, and W. F. Ebling, Convergence of direct and indirect pharmacodynamic response models. J Pharmacokinet Biopharm 23:5-8; discussion 9-10 (1995).
    • (1995) J Pharmacokinet Biopharm , vol.23 , pp. 5-8
    • Jusko, W.J.1    Ko, H.C.2    Ebling, W.F.3
  • 20
    • 0001293911 scopus 로고
    • Pharmacokinetics
    • 2nd ed. Drugs and the Pharmaceutical Sciences, Marcel Dekker, New York
    • M. Gibaldi and D. Perrier, Pharmacokinetics, 2nd ed. Drugs and the Pharmaceutical Sciences, Vol. 15. Marcel Dekker, New York, 1982, pp. 45-144.
    • (1982) , vol.15 , pp. 45-144
    • Gibaldi, M.1    Perrier, D.2
  • 21
    • 84914659402 scopus 로고
    • in Pharmacokinetics
    • A Modern View, L. Z. Benet, G. Levy, and B. L. Ferraiolo (Eds). Plenum Press, New York
    • M. Rowland, in Pharmacokinetics, A Modern View, L. Z. Benet, G. Levy, and B. L. Ferraiolo (Eds). Plenum Press, New York, 1984, pp. 133-146.
    • (1984) , pp. 133-146
    • Rowland, M.1
  • 22
    • 0003403775 scopus 로고
    • Clinical Pharmacokinetics: Concepts and Applications
    • 3rd ed. Williams & Wilkins, Baltimore
    • M. Rowland and T. N. Tozer, Clinical Pharmacokinetics: Concepts and Applications, 3rd ed. Williams & Wilkins, Baltimore, 1995, pp. 137-152.
    • (1995) , pp. 137-152
    • Rowland, M.1    Tozer, T.N.2
  • 23
    • 0026725364 scopus 로고
    • Modeling of the effect site equilibration kinetics and pharmacodynamics of racemic baclofen and its enantiomers using quantitative EEG effect measures
    • J. W. Mandema, C. D. Heijligers-Feijen, E. Tukker, A. G. De Boer, and M. Danhof, Modeling of the effect site equilibration kinetics and pharmacodynamics of racemic baclofen and its enantiomers using quantitative EEG effect measures. J Pharmacol Exp Ther 261:88-95 (1992).
    • (1992) J Pharmacol Exp Ther , vol.261 , pp. 88-95
    • Mandema, J.W.1    Heijligers-Feijen, C.D.2    Tukker, E.3    De Boer, A.G.4    Danhof, M.5
  • 25
    • 0027098056 scopus 로고
    • Pharmacodynamic system analysis of the biophase level predictor and the transduction function
    • P. Veng-Pedersen and N. B. Modi, Pharmacodynamic system analysis of the biophase level predictor and the transduction function. J Pharm Sci 81:925-934 (1992).
    • (1992) J Pharm Sci , vol.81 , pp. 925-934
    • Veng-Pedersen, P.1    Modi, N.B.2
  • 27
    • 0022970370 scopus 로고
    • Receptor-mediated pharmacodynamics of prednisolone in the rat
    • F. D. Boudinot, R. D'Ambrosio, and W. J. Jusko, Receptor-mediated pharmacodynamics of prednisolone in the rat. J Pharmacokinet Biopharm 14:469-493 (1986).
    • (1986) J Pharmacokinet Biopharm , vol.14 , pp. 469-493
    • Boudinot, F.D.1    D'Ambrosio, R.2    Jusko, W.J.3
  • 28
    • 0021051414 scopus 로고
    • A pharmacokinetic/pharmacodynamic/receptor binding model to predict the onset and duration of pharmacological activity of the benzodiazepines
    • M. L. Jack, W. A. Colburn, N. M. Spirt, G. Bautz, M. Zanko, W. D. Horst, and R. A. O'Brien, A pharmacokinetic/pharmacodynamic/receptor binding model to predict the onset and duration of pharmacological activity of the benzodiazepines. Prog Neuropsychopharmacol Biol Psychiatry 7:629-635 (1983).
    • (1983) Prog Neuropsychopharmacol Biol Psychiatry , vol.7 , pp. 629-635
    • Jack, M.L.1    Colburn, W.A.2    Spirt, N.M.3    Bautz, G.4    Zanko, M.5    Horst, W.D.6    O'Brien, R.A.7
  • 29
    • 0003654388 scopus 로고    scopus 로고
    • Pharmacologic Analysis of Drug-Receptor Interaction
    • 3rd ed. Lippincott-Raven Publishers, Philadelphia
    • T. P. Kenakin, Pharmacologic Analysis of Drug-Receptor Interaction, 3rd ed. Lippincott-Raven Publishers, Philadelphia, 1997, pp. 11-26.
    • (1997) , pp. 11-26
    • Kenakin, T.P.1
  • 30
    • 0003519552 scopus 로고
    • Receptors: Models for Binding, Trafficking, and Signaling
    • Oxford University Press, New York
    • D. A. Lauffenburger and J. J. Linderman, Receptors: Models for Binding, Trafficking, and Signaling. Oxford University Press, New York, 1993, pp. 135-281.
    • (1993) , pp. 135-281
    • Lauffenburger, D.A.1    Linderman, J.J.2
  • 31
    • 0003777368 scopus 로고    scopus 로고
    • Cell Surface Receptors: A Short Course on Theory and Methods
    • 2nd ed. Kluwer Academic Publishers, Boston
    • L. D. Limbird, Cell Surface Receptors: A Short Course on Theory and Methods, 2nd ed. Kluwer Academic Publishers, Boston, 1996, pp. 27-60.
    • (1996) , pp. 27-60
    • Limbird, L.D.1
  • 32
    • 0027769745 scopus 로고
    • Comparison of four basic models of indirect pharmacodynamic responses
    • N. L. Dayneka, V. Garg, and W. J. Jusko, Comparison of four basic models of indirect pharmacodynamic responses. J Pharmacokinet Biopharm 21:457-478 (1993).
    • (1993) J Pharmacokinet Biopharm , vol.21 , pp. 457-478
    • Dayneka, N.L.1    Garg, V.2    Jusko, W.J.3
  • 33
    • 24044497597 scopus 로고    scopus 로고
    • Mechanism-based pharmacokinetic-pharmacodynamic modeling-a new classification of biomarkers
    • M. Danhof, G. Alvan, S. G. Dahl, J. Kuhlmann, and G. Paintaud, Mechanism-based pharmacokinetic-pharmacodynamic modeling-a new classification of biomarkers. Pharm Res 22:1432-1437 (2005).
    • (2005) Pharm Res , vol.22 , pp. 1432-1437
    • Danhof, M.1    Alvan, G.2    Dahl, S.G.3    Kuhlmann, J.4    Paintaud, G.5
  • 34
    • 0034832459 scopus 로고    scopus 로고
    • Pharmacodynamic modeling of time-dependent transduction systems
    • D. E. Mager and W. J. Jusko, Pharmacodynamic modeling of time-dependent transduction systems. Clin Pharmacol Ther 70:210-216 (2001).
    • (2001) Clin Pharmacol Ther , vol.70 , pp. 210-216
    • Mager, D.E.1    Jusko, W.J.2
  • 35
    • 0031835741 scopus 로고    scopus 로고
    • Transit compartments versus gamma distribution function to model signal transduction processes in pharmacodynamics
    • Y. N. Sun and W. J. Jusko, Transit compartments versus gamma distribution function to model signal transduction processes in pharmacodynamics. J Pharm Sci 87:732-737 (1998).
    • (1998) J Pharm Sci , vol.87 , pp. 732-737
    • Sun, Y.N.1    Jusko, W.J.2
  • 36
    • 78651145136 scopus 로고
    • Relationship between elimination rate of drugs and rate of decline of their pharmacologic effects
    • G. Levy, Relationship between elimination rate of drugs and rate of decline of their pharmacologic effects. J Pharm Sci 53:342-343 (1964).
    • (1964) J Pharm Sci , vol.53 , pp. 342-343
    • Levy, G.1
  • 37
    • 0013909219 scopus 로고
    • Kinetics of pharmacologic effects
    • G. Levy, Kinetics of pharmacologic effects. Clin Pharmacol Ther 7:362-372 (1966).
    • (1966) Clin Pharmacol Ther , vol.7 , pp. 362-372
    • Levy, G.1
  • 38
    • 0004061532 scopus 로고
    • Molecular Pharmacology: The Mode of Action of Biologically Active Compounds
    • Academic Press, New York
    • E. J. Arièens, Molecular Pharmacology: The Mode of Action of Biologically Active Compounds. Academic Press, New York, 1964, pp. 29-42.
    • (1964) , pp. 29-42
    • Arièens, E.J.1
  • 39
    • 0030021932 scopus 로고    scopus 로고
    • Is it possible to estimate the parameters of the sigmoid Emax model with truncated data typical of clinical studies?
    • S. Dutta, Y. Matsumoto, and W. F. Ebling, Is it possible to estimate the parameters of the sigmoid Emax model with truncated data typical of clinical studies? J Pharm Sci 85:232-239 (1996).
    • (1996) J Pharm Sci , vol.85 , pp. 232-239
    • Dutta, S.1    Matsumoto, Y.2    Ebling, W.F.3
  • 42
    • 0032730943 scopus 로고    scopus 로고
    • Analysis of asymmetry of agonist concentration-effect curves
    • P. H. Van der Graaf and R. C. Schoemaker, Analysis of asymmetry of agonist concentration-effect curves. J Pharmacol Toxicol Methods 41:107-115 (1999).
    • (1999) J Pharmacol Toxicol Methods , vol.41 , pp. 107-115
    • Van Der Graaf, P.H.1    Schoemaker, R.C.2
  • 43
    • 4043127524 scopus 로고    scopus 로고
    • Pharmacodynamics of controlled release verapamil in patients with hypertension: an analysis using spline functions
    • L. Aarons, C. Baxter, and S. Gupta, Pharmacodynamics of controlled release verapamil in patients with hypertension: an analysis using spline functions. Biopharm Drug Dispos 25:219-225 (2004).
    • (2004) Biopharm Drug Dispos , vol.25 , pp. 219-225
    • Aarons, L.1    Baxter, C.2    Gupta, S.3
  • 44
    • 0036714377 scopus 로고    scopus 로고
    • Estimation and inference for a splineenhanced population pharmacokinetic model
    • L. Li, M. B. Brown, K. H. Lee, and S. Gupta, Estimation and inference for a splineenhanced population pharmacokinetic model. Biometrics 58:601-611 (2002).
    • (2002) Biometrics , vol.58 , pp. 601-611
    • Li, L.1    Brown, M.B.2    Lee, K.H.3    Gupta, S.4
  • 45
    • 0031403082 scopus 로고    scopus 로고
    • A semiparametric method for describing noisy population pharmacokinetic data
    • K. Park, D. Verotta, T. F. Blaschke, and L. B. Sheiner, A semiparametric method for describing noisy population pharmacokinetic data. J Pharmacokinet Biopharm 25:615-642 (1997).
    • (1997) J Pharmacokinet Biopharm , vol.25 , pp. 615-642
    • Park, K.1    Verotta, D.2    Blaschke, T.F.3    Sheiner, L.B.4
  • 46
    • 0346040525 scopus 로고    scopus 로고
    • Volterra series in pharmacokinetics and pharmacodynamics
    • D. Verotta, Volterra series in pharmacokinetics and pharmacodynamics. J Pharmacokinet Pharmacodyn 30:337-362 (2003).
    • (2003) J Pharmacokinet Pharmacodyn , vol.30 , pp. 337-362
    • Verotta, D.1
  • 47
    • 0003494616 scopus 로고
    • An Introduction to Splines for Use in Computer Graphics and Geometric Modeling
    • Morgan Kaufmann Publishers, Los Altos, CA
    • R. H. Bartels, J. C. Beatty, and B. A. Barsky, An Introduction to Splines for Use in Computer Graphics and Geometric Modeling. Morgan Kaufmann Publishers, Los Altos, CA, 1987, pp. 9-17.
    • (1987) , pp. 9-17
    • Bartels, R.H.1    Beatty, J.C.2    Barsky, B.A.3
  • 48
    • 0004045887 scopus 로고    scopus 로고
    • Numerical Analysis
    • 8th ed. Brooks/Cole, Belmont, CA
    • R. L. Burden, Numerical Analysis, 8th ed. Brooks/Cole, Belmont, CA, 2005, pp. 137-156.
    • (2005) , pp. 137-156
    • Burden, R.L.1
  • 49
    • 0003474751 scopus 로고
    • Numerical Recipes in C: The Art of Scientific Computing
    • 2nd ed. Cambridge University Press, New York
    • W. H. Press, S. A. Teukolsky, W. T. Vetterling, and B. P. Flannery, Numerical Recipes in C: The Art of Scientific Computing, 2nd ed. Cambridge University Press, New York, 1992, pp. 113-116.
    • (1992) , pp. 113-116
    • Press, W.H.1    Teukolsky, S.A.2    Vetterling, W.T.3    Flannery, B.P.4
  • 50
    • 0026400983 scopus 로고
    • Semiparametric analysis of non-steady-state pharmacodynamic data
    • D. Verotta and L. B. Sheiner, Semiparametric analysis of non-steady-state pharmacodynamic data. J Pharmacokinet Biopharm 19:691-712 (1991).
    • (1991) J Pharmacokinet Biopharm , vol.19 , pp. 691-712
    • Verotta, D.1    Sheiner, L.B.2
  • 52
    • 0035353082 scopus 로고    scopus 로고
    • Circadian chronotherapy for human cancers
    • F. Levi, Circadian chronotherapy for human cancers. Lancet Oncol 2:307-315 (2001).
    • (2001) Lancet Oncol , vol.2 , pp. 307-315
    • Levi, F.1
  • 55
    • 0025058867 scopus 로고
    • Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infusion
    • B. E. Harris, R. Song, S. J. Soong, and R. B. Diasio, Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infusion. Cancer Res 50:197-201 (1990).
    • (1990) Cancer Res , vol.50 , pp. 197-201
    • Harris, B.E.1    Song, R.2    Soong, S.J.3    Diasio, R.B.4
  • 56
    • 0027932318 scopus 로고
    • Spontaneous or imposed circadian changes in plasma concentrations of 5-fluorouracil coadministered with folinic acid and oxaliplatin: relationship with mucosal toxicity in patients with cancer
    • G. Metzger, C. Massari, M. C. Etienne, M. Comisso, S. Brienza, Y. Touitou, G. Milano, G. Bastian, J. L. Misset, and F. Levi, Spontaneous or imposed circadian changes in plasma concentrations of 5-fluorouracil coadministered with folinic acid and oxaliplatin: relationship with mucosal toxicity in patients with cancer. Clin Pharmacol Ther 56:190-201 (1994).
    • (1994) Clin Pharmacol Ther , vol.56 , pp. 190-201
    • Metzger, G.1    Massari, C.2    Etienne, M.C.3    Comisso, M.4    Brienza, S.5    Touitou, Y.6    Milano, G.7    Bastian, G.8    Misset, J.L.9    Levi, F.10
  • 57
    • 0023876379 scopus 로고
    • Circadian rhythmvarying plasma concentration of 5-fluorouracil during a five-day continuous venous infusion at a constant rate in cancer patients
    • E. Petit, G. Milano, F. Levi, A. Thyss, F. Bailleul, and M. Schneider, Circadian rhythmvarying plasma concentration of 5-fluorouracil during a five-day continuous venous infusion at a constant rate in cancer patients. Cancer Res 48:1676-1679 (1988).
    • (1988) Cancer Res , vol.48 , pp. 1676-1679
    • Petit, E.1    Milano, G.2    Levi, F.3    Thyss, A.4    Bailleul, F.5    Schneider, M.6
  • 58
    • 0041055512 scopus 로고    scopus 로고
    • Randomised multicentre trial of chronotherapy with oxaliplatin, fluorouracil, and folinic acid in metastatic colorectal cancer. International Organization for Cancer Chronotherapy.
    • F. Levi, R. Zidani, and J. L. Misset, Randomised multicentre trial of chronotherapy with oxaliplatin, fluorouracil, and folinic acid in metastatic colorectal cancer. International Organization for Cancer Chronotherapy. Lancet 350:681-686 (1997).
    • (1997) Lancet , vol.350 , pp. 681-686
    • Levi, F.1    Zidani, R.2    Misset, J.L.3
  • 59
    • 0036223408 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of 5-fluorouracil with consideration of chronopharmacokinetics
    • G. Milano and A. L. Chamorey, Clinical pharmacokinetics of 5-fluorouracil with consideration of chronopharmacokinetics. Chronobiol Int 19:177-189 (2002).
    • (2002) Chronobiol Int , vol.19 , pp. 177-189
    • Milano, G.1    Chamorey, A.L.2
  • 61
    • 0023931469 scopus 로고
    • Pharmacodynamic model of tolerance: application to nicotine
    • H. C. Porchet, N. L. Benowitz, and L. B. Sheiner, Pharmacodynamic model of tolerance: application to nicotine. J Pharmacol Exp Ther 244:231-236 (1988).
    • (1988) J Pharmacol Exp Ther , vol.244 , pp. 231-236
    • Porchet, H.C.1    Benowitz, N.L.2    Sheiner, L.B.3
  • 62
    • 0024811607 scopus 로고
    • Clinical pharmacology and the choice between theory and empiricism
    • L. B. Sheiner, Clinical pharmacology and the choice between theory and empiricism. Clin Pharmacol Ther 46:605-615 (1989).
    • (1989) Clin Pharmacol Ther , vol.46 , pp. 605-615
    • Sheiner, L.B.1
  • 63
    • 0027441595 scopus 로고
    • Pharmacokinetic- pharmacodynamic modeling of caffeine: tolerance to pressor effects
    • J. Shi, N. L. Benowitz, C. P. Denaro, and L. B. Sheiner, Pharmacokinetic- pharmacodynamic modeling of caffeine: tolerance to pressor effects. Clin Pharmacol Ther 53:6-14 (1993).
    • (1993) Clin Pharmacol Ther , vol.53 , pp. 6-14
    • Shi, J.1    Benowitz, N.L.2    Denaro, C.P.3    Sheiner, L.B.4
  • 64
    • 0030924745 scopus 로고    scopus 로고
    • Pharmacodynamics and tolerance development during multiple intravenous bolus morphine administration in rats
    • D. M.-C. Ouellet and G. M. Pollack, Pharmacodynamics and tolerance development during multiple intravenous bolus morphine administration in rats. J Pharmacol Exp Ther 281:713-720 (1997).
    • (1997) J Pharmacol Exp Ther , vol.281 , pp. 713-720
    • Ouellet, D.M.-C.1    Pollack, G.M.2
  • 65
    • 0014824340 scopus 로고
    • On the mechanism of desensitization at cholinergic receptors
    • H. P. Rang and J. M. Ritter, On the mechanism of desensitization at cholinergic receptors. Mol Pharmacol 6:357-382 (1970).
    • (1970) Mol Pharmacol , vol.6 , pp. 357-382
    • Rang, H.P.1    Ritter, J.M.2
  • 66
    • 84965075853 scopus 로고
    • A study of the "Desensitization" produced by acetylcholine at motor end-plate
    • B. Katz and S. Thesleff, A study of the "Desensitization" produced by acetylcholine at motor end-plate. J Physiol 138:63-80 (1957).
    • (1957) J Physiol , vol.138 , pp. 63-80
    • Katz, B.1    Thesleff, S.2
  • 67
    • 0017717088 scopus 로고
    • Kinetics of agonistmediated transitions in state of the cholinergic receptor
    • G. Weiland, B. Georgia, S. Lappi, C. F. Chignell, and P. Taylor, Kinetics of agonistmediated transitions in state of the cholinergic receptor. J Biol Chem 252:7648-7656 (1977).
    • (1977) J Biol Chem , vol.252 , pp. 7648-7656
    • Weiland, G.1    Georgia, B.2    Lappi, S.3    Chignell, C.F.4    Taylor, P.5
  • 68
    • 0023054484 scopus 로고
    • A mechanism for exact sensory adaptation based on receptor modification
    • L. A. Segel, A. Goldbeter, P. N. Devreotes, and B. E. Knox, A mechanism for exact sensory adaptation based on receptor modification. J Theor Biol 120:151-179 (1986).
    • (1986) J Theor Biol , vol.120 , pp. 151-179
    • Segel, L.A.1    Goldbeter, A.2    Devreotes, P.N.3    Knox, B.E.4
  • 69
    • 84889387160 scopus 로고
    • Drugs, receptors and tolerance
    • in Pharmacokinetics and Pharmacodynamics of Psychoactive Drugs, G. Barnett and C. N. Chary (Ed.). Biomedical Publications, Foster City
    • V. Licko, Drugs, receptors and tolerance, in Pharmacokinetics and Pharmacodynamics of Psychoactive Drugs, G. Barnett and C. N. Chary (Ed.). Biomedical Publications, Foster City, 1985, pp. 311-322.
    • (1985) , pp. 311-322
    • Licko, V.1
  • 70
    • 0031742890 scopus 로고    scopus 로고
    • Precursor-dependent indirect pharmacodynamic response model for tolerance and rebound phenomena
    • A. Sharma, W. F. Ebling, and W. J. Jusko, Precursor-dependent indirect pharmacodynamic response model for tolerance and rebound phenomena. J Pharm Sci 87:1577-1584 (1998).
    • (1998) J Pharm Sci , vol.87 , pp. 1577-1584
    • Sharma, A.1    Ebling, W.F.2    Jusko, W.J.3


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