Low activation of Insulin-like Growth Factor 1-Receptor (IGF1R) is associated with local recurrence in early breast carcinoma

Breast Cancer Research and Treatment

Volumn 117, Issue 2, 2009, Pages 433-441

  Peiró, Gloria ^a   Benlloch, Susana ^a   Sánchez Tejada, Laura ^a   Adrover, Encarna ^a   Lerma, Enrique ^b   Peiró, Francisca M ^a   Sánchez Payá, José ^a   Aranda, F Ignacio ^a  

^a HOSPITAL GENERAL UNIVERSITARIO DE ALICANTE   (Spain)

^b HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

Author keywords

Early breast carcinoma; IGF1R; mRNA; Mutation

Indexed keywords

ESTROGEN RECEPTOR; MESSENGER RNA; PROGESTERONE RECEPTOR; SOMATOMEDIN C RECEPTOR; TUMOR MARKER;

ADULT; AGED; ARTICLE; BREAST CARCINOMA; CANCER GRADING; CANCER PATIENT; CANCER RECURRENCE; CANCER RELAPSE; CONTROLLED STUDY; DISTANT METASTASIS; DNA SEQUENCE; EARLY CANCER; EXON; FEMALE; GENE ACTIVATION; GENE MUTATION; HUMAN; HUMAN TISSUE; IGF1R GENE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; PARTIAL MASTECTOMY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; RECEPTOR GENE; RECURRENCE RISK; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RISK FACTOR;

ADULT; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BREAST NEOPLASMS; COMBINED MODALITY THERAPY; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MASTECTOMY, SEGMENTAL; MIDDLE AGED; MUTATION; NEOPLASM RECURRENCE, LOCAL; RADIOTHERAPY; RECEPTOR, IGF TYPE 1; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RISK FACTORS; RNA, MESSENGER; TISSUE ARRAY ANALYSIS;

EID: 68949083287     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-008-0139-6     Document Type: Article

References (43)

1. M Clarke R Collins S Darby 2005 Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials Lancet 366 2087 2106
2. Early Breast Cancer trialists' Collaborative Group (EBCTCG) (2005) Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 365:1687-1717. doi: 10.1016/S0140-6736(05)66544-0
3. L Livi F Paiar C Saieva 2007 Survival and breast relapse in 3834 patients with T1-T2 breast cancer after conserving surgery and adjuvant treatment Radiother Oncol 82 287 293 10.1016/j.radonc.2006.11.009
4. JL Connolly J Boyages AJ Nixon 1998 Predictors of breast recurrence after conservative surgery and radiation therapy for invasive breast cancer Mod Pathol 11 134 139
5. G Peiro BA Bornstein JL Connolly 2000 The influence of infiltrating lobular carcinoma on the outcome of patients treated with breast-conserving surgery and radiation therapy Breast Cancer Res Treat 59 49 54 10.1023/A:1006384407690
6. A Neri D Marrelli S Rossi 2007 Breast cancer local recurrence: risk factors and prognostic relevance of early time to recurrence World J Surg 31 36 45 10.1007/s00268-006-0097-2
7. S Yakar D Leroith P Brodt 2005 The role of the growth hormone/insulin-like growth factor axis in tumor growth and progression: lessons from animal models Cytokine Growth Factor Rev 16 407 420 10.1016/j.cytogfr. 2005.01.010
8. TE Adams VC Epa TP Garrett CW Ward 2000 Structure and function of the type 1 insulin-like growth factor receptor Cell Mol Life Sci 57 1050 1093 10.1007/PL00000744
9. H Werner S Maor 2006 The insulin-like growth factor-I receptor gene: a downstream target for oncogene and tumor suppressor action Trends Endocrinol Metab 17 236 242 10.1016/j.tem.2006.06.007
10. H Kato TN Faria B Stannard 1994 Essential role of tyrosine residues 1131, 1135, and 1136 of the insulin-like growth factor-I (IGF-I) receptor in IGF-I action Mol Endocrinol 8 40 50 10.1210/me.8.1.40
11. VA Blakesley T Kalebic LJ Helman 1996 Tumorigenic, mitogenic capacities are reduced in transfected fibroblasts expressing mutant insulin-like growth factor (IGF)-I receptors. The role of tyrosine residues 1250 1251, and 1316 in the carboxy-terminus of the IGF-I receptor Endocrinology 137 410 417 10.1210/en.137.2.410
12. A Hongo G Yumet M Resnicoff 1998 Inhibition of tumorigenesis and induction of apoptosis in human tumor cells by the stable expression of a myristylated COOH terminus of the insulin-like growth factor I receptor Cancer Res 58 2477 2484
13. P Brodt L Fallavollita AM Khatib 2001 Cooperative regulation of the invasive and metastatic phenotypes by different domains of the type I insulin-like growth factor receptor beta subunit J Biol Chem 276 33608 33615 10.1074/jbc.M102754200
14. BC Turner BG Haffty L Narayanan 1997 Insulin-like growth factor-I receptor overexpression mediates cellular radioresistance and local breast cancer recurrence after lumpectomy and radiation Cancer Res 57 3079 3083
15. A Ouban P Muraca T Yeatman D Coppola 2003 Expression and distribution of insulin-like growth factor-1 receptor in human carcinomas Hum Pathol 34 803 808 10.1016/S0046-8177(03)00291-0
16. G Peiro P Lohse D Mayr J Diebold 2003 Insulin-like growth factor-I receptor and PTEN protein expression in endometrial carcinoma. Correlation with bax and bcl-2 expression, microsatellite instability status, and outcome Am J Clin Pathol 120 78 85 10.1309/C1KAH1PRL1UBW798
17. V Papa B Gliozzo GM Clark 1993 Insulin-like growth factor-I receptors are overexpressed and predict a low risk in human breast cancer Cancer Res 53 3736 3740
18. LC Happerfield DW Miles DM Barnes 1997 The localization of the insulin-like growth factor receptor 1 (IGFR-1) in benign and malignant breast tissue J Pathol 183 412 417 10.1002/(SICI)1096-9896(199712)183:4<412::AID- PATH944>3.0.CO;2-4
19. JL Resnik DB Reichart K Huey 1998 Elevated insulin-like growth factor I receptor autophosphorylation and kinase activity in human breast cancer Cancer Res 58 1159 1164
20. B Schnarr K Strunz J Ohsam 2000 Down-regulation of insulin-like growth factor-I receptor and insulin receptor substrate-1 expression in advanced human breast cancer Int J Cancer 89 506 513 10.1002/1097-0215(20001120)89:6<506:: AID-IJC7>3.0.CO;2-F
21. C Shimizu T Hasegawa Y Tani 2004 Expression of insulin-like growth factor 1 receptor in primary breast cancer: immunohistochemical analysis Hum Pathol 35 1537 1542 10.1016/j.humpath.2004.09.005
22. W Al Sarakbi Y Chong S Williams 2006 The mRNA expression of IGF-1 and IGF-1R in human breast cancer: association with clinico-pathological parameters J Carcinog 5 16 10.1186/1477-3163-5-16
23. YM Chong K Colston WG Jiang 2006 The relationship between the insulin-like growth factor-1 system and the oestrogen metabolising enzymes in breast cancer tissue and its adjacent non-cancerous tissue Breast Cancer Res Treat 99 275 288 10.1007/s10549-006-9215-y
24. J Dupont D Le Roith 2001 Insulin-like growth factor 1 and oestradiol promote cell proliferation of MCF-7 breast cancer cells: new insights into their synergistic effects Mol Pathol 54 149 154 10.1136/mp. 54.3.149
25. TW Chan M Pollak H Huynh 2001 Inhibition of insulin-like growth factor signaling pathways in mammary gland by pure antiestrogen ICI 182, 780 Clin Cancer Res 7 2545 2554
26. E Surmacz M Bartucci 2004 Role of estrogen receptor alpha in modulating IGF-I receptor signaling and function in breast cancer J Exp Clin Cancer Res 23 385 394
27. S Ueda H Tsuda K Sato 2006 Alternative tyrosine phosphorylation of signaling kinases according to hormone receptor status in breast cancer overexpressing the insulin-like growth factor receptor type 1 Cancer Sci 97 597 604 10.1111/j.1349-7006.2006.00228.x
28. JM Gee JF Robertson E Gutteridge 2005 Epidermal growth factor receptor/HER2/insulin-like growth factor receptor signalling and oestrogen receptor activity in clinical breast cancer Endocr Relat Cancer 12 Suppl 1 S99 S111 10.1677/erc.1.01005
29. J Bonneterre JP Peyrat R Beuscart A Demaille 1990 Prognostic significance of insulin-like growth factor 1 receptors in human breast cancer Cancer Res 50 6931 6935
30. MJ Railo K von Smitten F Pekonen 1994 The prognostic value of insulin-like growth factor-I in breast cancer patients. Results of a follow-up study on 126 patients Eur J Cancer 30A 307 311 10.1016/0959-8049(94)90247-X
31. LM McShane DG Altman W Sauerbrei 2006 REporting recommendations for tumor MARKer prognostic studies (REMARK) Breast Cancer Res Treat 100 229 235 10.1007/s10549-006-9242-8
32. CW Elston IO Ellis 1991 Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up Histopathology 19 403 410 10.1111/j.1365-2559. 1991.tb00229.x
33. G Peiro E Adrover FI Aranda 2007 Prognostic implications of HER-2 status in steroid receptor-positive, lymph node-negative breast carcinoma Am J Clin Pathol 127 780 786 10.1309/FWHEQX6HB9190LVY
34. G Arpino H Weiss AV Lee 2005 Estrogen receptor-positive, progesterone receptor-negative breast cancer: association with growth factor receptor expression and tamoxifen resistance J Natl Cancer Inst 97 1254 1261
35. RS Punglia M Morrow EP Winer JR Harris 2007 Local therapy and survival in breast cancer N Engl J Med 356 2399 2405 10.1056/NEJMra065241
36. E Lerma G Peiro T Ramon 2007 Immunohistochemical heterogeneity of breast carcinomas negative for estrogen receptors, progesterone receptors and Her2/neu (basal-like breast carcinomas) Mod Pathol 20 1200 1207 10.1038/modpathol.3800961
37. MA Guvakova E Surmacz 1997 Tamoxifen interferes with the insulin-like growth factor I receptor (IGF-IR) signaling pathway in breast cancer cells Cancer Res 57 2606 2610
38. DW Voskuil A Bosma A Vrieling 2004 Insulin-like growth factor (IGF)-system mRNA quantities in normal and tumor breast tissue of women with sporadic and familial breast cancer risk Breast Cancer Res Treat 84 225 233 10.1023/B:BREA.0000019954.59130.d3
39. R O'Connor A Kauffmann-Zeh Y Liu 1997 Identification of domains of the insulin-like growth factor I receptor that are required for protection from apoptosis Mol Cell Biol 17 427 435
40. T Petley K Graff W Jiang 1999 Variation among cell types in the signaling pathways by which IGF-I stimulates specific cellular responses Horm Metab Res 31 70 76
41. DS Nuyten B Kreike AA Hart 2006 Predicting a local recurrence after breast-conserving therapy by gene expression profiling Breast Cancer Res 8 R62 10.1186/bcr1614
42. Y Wang JG Klijn Y Zhang 2005 Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer Lancet 365 671 679
43. S Paik S Shak G Tang 2004 A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer N Engl J Med 351 2817 2826 10.1056/NEJMoa041588