Computational modeling-based discovery of novel classes of anti-inflammatory drugs that target lanthionine synthetase C-like protein 2

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Lu, Pinyi ^a,b   Hontecillas, Raquel ^a,b   Horne, William T ^a,b   Carbo, Adria ^a,b   Viladomiu, Monica ^a,b   Pedragosa, Mireia ^a,b   Bevan, David R ^a   Lewis, Stephanie N ^a,b   Bassaganya Riera, Josep ^a,b  

^a VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^b VIRGINIA BIOINFORMATICS INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; ANTIINFLAMMATORY AGENT; CD11B ANTIGEN; CYCLIC AMP; DEXTRAN SULFATE; INTERLEUKIN 10; LANTHIONINE SYNTHETASE C LIKE PROTEIN 2; LUCIFERASE; MEMBRANE ENZYME; NSC 61610; NUTRACEUTICAL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; UNCLASSIFIED DRUG; CELL SURFACE RECEPTOR; LANCL2 PROTEIN, MOUSE;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; COLITIS; COLON; CONTROLLED STUDY; CRYSTAL STRUCTURE; DATA BASE; DISEASE ACTIVITY; DOSE RESPONSE; DOWN REGULATION; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG SCREENING; DRUG TARGETING; GENE EXPRESSION; IN VIVO STUDY; INFLAMMATORY INFILTRATE; LAMINA PROPRIA; LYMPHOCYTIC INFILTRATION; MACROPHAGE; MESENTERY LYMPH NODE; MODEL; MOLECULAR DOCKING; MOUSE; NONHUMAN; REGULATORY T LYMPHOCYTE; REPORTER GENE; SIGNAL TRANSDUCTION; SPLEEN; SUBMUCOSA; ANIMAL; C57BL MOUSE; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER INTERFACE; COMPUTER SIMULATION; DRUG EFFECT; ENTERITIS; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; PHENOTYPE; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY;

EUKARYOTA;

ADENYLATE CYCLASE; ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; COLON; COMPUTER SIMULATION; CYCLIC AMP; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; HUMANS; INFLAMMATORY BOWEL DISEASES; MICE; MICE, INBRED C57BL; MODELS, MOLECULAR; PHENOTYPE; PPAR GAMMA; PROTEIN CONFORMATION; RECEPTORS, CELL SURFACE; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; USER-COMPUTER INTERFACE;

EID: 84859609283     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0034643     Document Type: Article

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