Structure of geranyl diphosphate C -methyltransferase from Streptomyces coelicolor and implications for the mechanism of isoprenoid modification

Biochemistry

Volumn 51, Issue 14, 2012, Pages 3003-3010

  Köksal, Mustafa ^a   Chou, Wayne K W ^b   Cane, David E ^b   Christianson, David W ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; CARBOCATIONS; COFACTOR BINDING; COFACTORS; CYCLASES; CYCLIZATION REACTIONS; DEMETHYLATION; DIPHOSPHATES; DOUBLE BONDS; IN-SITU; ISOPRENOIDS; METHYLISOBORNEOL; METHYLTRANSFERASES; MOLECULAR MECHANISM; S ADENOSYL L METHIONINES; STREPTOMYCES COELICOLOR; STREPTOMYCES COELICOLOR A3(2); SYNTHASES; TERPENOIDS;

ALKYLATION; AMINO ACIDS; BACTERIA; CYCLIZATION; REACTION INTERMEDIATES;

LIPIDS;

2 METHYLISOBORNEOL; GERANYL DIPHOSPHATE METHYLTRANSFERASE; ISOPRENOID; METHYLISOBORNEOL SYNTHASE; METHYLTRANSFERASE; PYROPHOSPHATE; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE; SYNTHETASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CHEMICAL BOND; CHEMICAL MODIFICATION; CHEMICAL REACTION KINETICS; CRYSTAL STRUCTURE; CRYSTALLIZATION; CYCLIZATION; DEMETHYLATION; DISSOCIATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; METHYLATION; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; STREPTOMYCES COELICOLOR;

BACTERIAL PROTEINS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DIPHOSPHATES; DITERPENES; METHYLATION; METHYLTRANSFERASES; PROTEIN CONFORMATION; S-ADENOSYLMETHIONINE; STREPTOMYCES COELICOLOR;

STREPTOMYCES COELICOLOR;

EID: 84859595838     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi300109c     Document Type: Article

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