Imbalance of regulatory T cells to Th17 cells in IgA nephropathy

Scandinavian Journal of Clinical and Laboratory Investigation

Volumn 72, Issue 3, 2012, Pages 221-229

  Lin, Fu Jun ^a   Jiang, Geng Ru ^a   Shan, Jian Ping ^a   Zhu, Chun ^a   Zou, Jun ^a   Wu, Xiang Ru ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Homeostasis; IGA nephropathy; regulatory T cells; Interleukin 17; Th17 cells

Indexed keywords

CD45RA ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 21; INTERLEUKIN 23; INTERLEUKIN 6; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; ARTICLE; ATROPHY; CELL INFILTRATION; DISEASE SEVERITY; FEMALE; FIBROSIS; HOMEOSTASIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOGLOBULIN A NEPHROPATHY; IMMUNOHISTOCHEMISTRY; KIDNEY FUNCTION; KIDNEY INJURY; MAJOR CLINICAL STUDY; MALE; MONONUCLEAR CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEINURIA; REGULATORY T LYMPHOCYTE; TH17 CELL;

ADULT; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GLOMERULONEPHRITIS, IGA; HUMANS; INTERLEUKIN-17; INTERLEUKINS; MALE; MIDDLE AGED; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; T-LYMPHOCYTES, REGULATORY; TH17 CELLS;

EID: 84859593037     PISSN: 00365513     EISSN: 15027686     Source Type: Journal    
DOI: 10.3109/00365513.2011.652158     Document Type: Article

References (30)

1. Glassock RJ. The pathogenesis of IgA nephropathy. Curr Opin Nephrol Hypertens 2011;20:153-60.
2. Donadio JV, Grande JP. IgA nephropathy. N Engl J Med 2002;347:738-48. (Pubitemid 35203906)
3. Yamada K, Kobayashi N, Ikeda T, Suzuki Y, Tsuge T, Horikoshi S, Emancipator SN, Tomino Y. Down-regulation of core 1 beta 1, 3- galactosylatransferase and Cosmc by Th2 cytokine alters O-glycosylation of IgA1. Nephrol Dial Transplant 2010;25:3890-7.
4. Suzuki H, Suzuki Y, Aizawa M, Yamanaka T, Kihara M, Pang H, Horikoshi S, Tomino Y. Th1 polarization in murine IgA nephropathy directed by bone marrow-derived cells. Kidney Int 2007;72:319-27. (Pubitemid 47172373)
5. Sakaguchi S, Ono M, Setoguchi R, Yagi H, Hori S, Fehervari A, Shimizu J, Takahashi T, Nomura T. FoxP3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol Rev 2006;212:8-27. (Pubitemid 44116697)
6. Korn T, Bettelli E, Oukka M, Kuchroo VK. IL-17 and Th17 cells. Annu Rev Immunol 2009;27:485-517.
7. Huang H, Peng Y, Liu H, Yang X, Liu F. Decreased CD4+ CD25+ cells and increased dimeric IgA-producing cells in tonsils in IgA nephropathy. J Nephrol 2010;23: 202-9.
8. Matsumoto K, Kanmatsuse K. Increased urinary excretion of interleukin-17 in nephritic patients. Nephron 2002;91: 243-49. (Pubitemid 34621690)
9. Matsumoto K, Kanmatsuse K. Interleukin-17 stimulates the release of pro-inflammatory cytokines by blood monocytes in patients with IgA nephropathy. Scand J Urol Nephrol 2003;37:164-71. (Pubitemid 36535237)
10. Ma YC, Zuo L, Chen JH, Luo Q, Yu XQ, Li Y, Xu JS, Huang SM, Wang LN, Huang W, Wang M, Xu GB, Wang HY. Modified glomerular filtration rate estimating equation for Chinese patients with chronic kidney disease. J Am Soc Nephrol 2006;17:2937-44. (Pubitemid 44484685)
11. Allan SE, Crome SQ, Crellin NK, Passerini L, Steiner TS, Bacchetta R, Roncarolo MG, Levings MK. Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production. Int Immunol 2007;19:345-54. (Pubitemid 46523383)
12. Wang J, Ioan-Facsinav A, van der Vooort EI, Huizinqa TW, Toes RE. Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells. Eur J Immunol 2007;37: 129-38. (Pubitemid 46128793)
13. Miyara M, Yoshioka Y, Kitoh A, Shima T, Wing K, Niwa A, Parizot C, Taflin C, Heiki T, Valeyre D, Mathian A, NakahataT, Yamaguchi T, Nomura T, Ono M, Amoura Z, Gorochov G, Sakaguchi S. Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. Immunity 2009;30:899-911.
14. Working Group of the International IgA Nephropathy Network and the Renal Pathology Society, Cattran DC, Coppo R, Cook HT, Feehally J, Roberts IS, Troyanov S, Alpers CE, Amore A, Barratt J, Berthoux F, Bonsib S, Bruijn JA, D'Agati V, D'Amico G, Emancipator S, Emma F, Ferrario F, Fervenza FC, Florquin S, Fogo A, Geddes CC, Groene HJ, Haas M, Herzenberg AM, Hill PA, Hogg RJ, Hsu SI, Jennette JC, Joh K, Julian BA, Kawamura T, Lai FM, Leung CB, Li LS, Li PK, Liu ZH, Mackinnon B, Mezzano S, Schena FP, Tomino Y, Walker PD, Wang H, Weening JJ, Yoshikawa N, Zhang H. The Oxford classification of IgA nephropathy: rationale, clinicopathological correlations, and classification. Kidney Int 2009;76:534-45.
15. Weaver CT, Hatton RD. Interplay between the TH17 and TReg cell lineages: a (co)evolutionary perspective. Nat Rev Immunol 2009;9:883-9.
16. Taflin C, Miyara M, Nochy D, Valeyre D, Nacache JM, Altare F, Salek-Peyron P, Badoual C, Bruneval P, Haroche J, Mathian A, Amoura Z, Hill G, Gorochov G. FoxP3+ regulatory T cells suppress early stages of granuloma formation but have little impact on sarcoidosis lesions. Am J Pathol 2009;174:497-508.
17. Marwaha AK, Sarah QC, Panagiotopoulos C, Berg KB, Qin HL, Ouyang Q, Xu L, Priatel JJ, Levings MK, Tan R. Cutting edge: increased IL-17-secreting T cells in children with new-onset type 1 diabetes. J Immunol 2010;185: 3814-8.
18. Fujii H, Arakawa A, Kitoh A, Miyara M, Kato M, Kore-eda S, Sakaguchi S, Miyachi Y, Tanioka M, Ono M. Perturbations of both nonregulatory and regulatory FOXP3+ T cells in patients with malignant melanoma. Br J Dermatol 2011:164: 1052-60.
19. Lee YK, Mukasa R, Hatton RD, Weaver CT. Developmental plasticity of Th17 and Treg cells. Curr Opin Immunol 2009;21:274-80.
20. Veronese F, Rotman S, Smith RN, Pelle TD, Farrell ML, Kawai T, Benedict Cosimi A, Colvin RB. Pathological and clinical correlates of FOXP3+ cells in renal allografts during acute rejection. Am J Transplant 2007;7:914-22. (Pubitemid 46481190)
21. Yoshimura J, Fukami K, Koike K, Nagano M, Matsumoto T, Iwatani R, Kusumoto T, Hazama T, Ueda S, Adachi H, Hirai Y, Takasu K, Ohshima K, Yamaqishi S, Okuda S. Interstitial FoxP3-positive T cells may predict renal survival in patients with myeroperoxidase anti-neutrophil cytoplasmic antibody-associated glomerulonephritis. Clin Exp Pharmacol Physiol 2010;37:879-83.
22. Loverre A, Divella C, Castellano G, Tataranni T, Zaza G, Rossini M, Ditonno P, Battaglia M, Palazzo S, Gigante M, Ranieri E, Schena FP, Grandaliano G. T helper 1, 2 and 17 cell subsets in renal transplant patients with delayed graft function. Transpl Int 2011;24:233-42.
23. Paust HJ, Turner JE, Steinmetz OM, Peters A, Heymann F, Holscher C, Wolf G, Kurts C, Mittrucker HW, Stahl RA, Panzer U. The IL-23/Th17 axis contributes to renal injury in experimental glomerulonephritis. J Am Soc Nephrol 2009;20:969-79.
24. Shah K, Lee WW, Lee SH, Kim SH, Kang SW, Craft J, Kang I. Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus. Arthritis Res Ther 2010;12:R53.
25. Eller P, Eller K, Wolf AM, Reinstadler SJ, Tagwerker A, Patsch JR, Mayer G, Rosenkranz AR. Atorvastatin attenuates murine anti-glomerular basement membrane glomerulonephritis. Kidney Int 2010;77:428-35.
26. Gan PY, Steinmetz OZ, Tan DS, O 'S ullivan KM, Iwakura Y, Kitching AR, Holdsworth SR. Th17 cells promote autoimmune anti-myeloperoxidase glomerulonephritis. J Am Soc Nephrol 2010;21:925-31.
27. Dudas PL, Sague SL, Elloso MM, Farrell FX. Proinflammatory/ profibrotic effects of interleukin-17A on human proximal tubule epithelium. Nephron Exp Nephrol 2010;117: e114-23.
28. Iyoda M, Shibata T, Kawaguchi M, Hizawa N, Yamaoka T, Kokubu F, Akizawa T. IL-17A and IL-17F stimulate chemokines via MAPK pathways (ERK1/2 and p38 but not JNK) in mouse cultured mesangial cells: synergy with TNF-alpha and IL-1beta. Am J Physiol Renal Physiol 2010;298:779-87.
29. Loverre A, Tataranni T, Castellano G, Divella C, Battaglia M, Ditonno P , Corcelli M, Manqino M, Gesualdo L, Schena FP, Grandaliano G. IL-17 expression by tubular epithelial cells in renal transplant recipients with acute antibody-mediated rejection. Am J Transplant 2011;11:1248-59.
30. Wang Y, Ito S, Chino Y, Goto D, Matsumoto I, Murata H, Tsutsumi A, Hayashi T, Uchida K, Usui J, Yamagata K, Sumida T. Laser microdissection-based analysis of cytokine balance in the kidneys of patients with lupus nephritis. Clin Exp Immunol 2009;159:1-10.