Interstitial Foxp3-positive T cells may predict renal survival in patients with myeroperoxidase anti-neutrophil cytoplasmic antibody-associated glomerulonephritis

Clinical and Experimental Pharmacology and Physiology

Volumn 37, Issue 9, 2010, Pages 879-883

  Yoshimura, Junko ^a   Fukami, Kei ^a   Koike, Kiyomi ^a   Nagano, Makio ^a   Matsumoto, Takafumi ^a   Iwatani, Ryuji ^a   Kusumoto, Takuo ^a   Hazama, Takuma ^a   Ueda, Seiji ^a   Adachi, Hisashi ^a   Hirai, Yuji ^a   Takasu, Konomi ^a   Ohshima, Koichi ^a   Yamagishi, Sho Ichi ^a   Okuda, Seiya ^a  

^a KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

anti neutrophil cytoplasmic antibodies; forkhead box P3; prognosis; regulatory T cells; T cell intracytoplasmic antigen 1

Indexed keywords

CYCLOPHOSPHAMIDE; CYCLOSPORIN; MIZORIBINE; MYELOPEROXIDASE; NEUTROPHIL CYTOPLASMIC ANTIBODY; PREDNISOLONE; T CELL INTRACYTOPLASMIC ANTIGEN 1; T LYMPHOCYTE ANTIGEN; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG;

AGED; ARTICLE; BLOOD CHEMISTRY; CYTOTOXIC T LYMPHOCYTE; DISEASE MARKER; FEMALE; GLOMERULONEPHRITIS; GLOMERULUS; HEMODIALYSIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY BIOPSY; KIDNEY FAILURE; KIDNEY INTERSTITIUM; MAINTENANCE THERAPY; MAJOR CLINICAL STUDY; MALE; MINIMAL CHANGE NEPHROTIC SYNDROME; NEPHROTIC SYNDROME; PHYSICAL EXAMINATION; PROGNOSIS; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SURVIVAL RATE; T LYMPHOCYTE;

ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; FORKHEAD TRANSCRIPTION FACTORS; GLOMERULONEPHRITIS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY; NEPHROSIS, LIPOID; PEROXIDASE; PROGNOSIS; RENAL DIALYSIS; RENAL INSUFFICIENCY; RNA-BINDING PROTEINS; T-LYMPHOCYTES, CYTOTOXIC; T-LYMPHOCYTES, REGULATORY;

EID: 77956022652     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2010.05412.x     Document Type: Article

References (16)

1. Jennette JC, Xiao H, Falk RJ. Pathogenesis of vascular inflammation by anti-neutrophil cytoplasmic antibodies. J. Am. Soc. Nephrol. 2006 17 : 1235 1242.
2. Koyama A, Yamagata K, Makino H et al. A nationwide survey of rapidly progressive glomerulonephritis in Japan: etiology, prognosis and treatment diversity. Clin. Exp. Nephrol. 2009 13 : 633 650.
3. Tsuchiya N, Kobayashi S, Hashimoto H, Ozaki S, Tokunaga K. Association of HLA-DRB1*0901-DQB1*0303 haplotype with microscopic polyangiitis in Japanese. Genes Immun. 2006 7 : 81 4.
4. Okano K, Yumura W, Nitta K, Honda K, Uchida K, Nihei H. Evaluation of prognostic factors for myeloperoxidase anti-neutrophic cytoplasmic antibody-(MPO-ANCA) associated glomerulonephritis. Clin. Nephrol. 2001 55 : 275 281.
5. Hogan SL, Nachman PH, Wilkman AS, Jennette JC, Falk RJ. Prognostic markers in patients with antineutrophil cytoplasmic antibody-associated microscopic polyangitis and glomerulonephritis. J. Am. Soc. Nephrol. 1996 7 : 23 32.
6. Marinaki S, Kälsch AI, Grimminger P et al. Persistent T-cell activation and clinical correlations in patients with ANCA-associated vasculitis. Nephrol. Dial. Transplant. 2006 2 : 1825 1832.
7. + T cells with the phenotypic and functional characteristics of regulatory T cells are enriched in the synovial fluid of patients with rheumatoid arthritis. Clin. Exp. Immunol. 2005 140 : 360 367.
8. + regulatory T Cells predicts outcome of suclinical rejection of renal allografts. J. Am. Soc. Nephrol. 2008 19 : 2020 2026.
9. + regulatory T cells. Nat. Immunol. 2003 4 : 330 336.
10. Wan YY, Flavell RA. Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature 2007 445 : 766 770.
11. Shigematsu H, Yamaguchi N, Koyama A. Glomerulointerstitial events in rapidly progressive nephritic syndrome, with special reference to histologic grade and stage on the renal lesion. Clin. Exp. Nephrol. 1998 2 : 330 338.
12. Hirayama K, Yamagata K, Kobayashi M, Koyama A. Anti-glomerular basement membrane antibody disease in Japan: part of the nationwide rapidly progressive glomerulonephritis survey in Japan. Clin. Exp. Nephrol. 2008 12 : 339 347.
13. Karube K, Aoki R, Sugita Y et al. The relationship of FOXP3 expression and clinicopathological characteristics in adult T-cell leukemia/lymphoma. Mod. Pathol. 2008 21 : 617 625.
14. + T cell subpopulations in ANCA-associated vasculitis. Clin. Exp. Immunol. 2005 140 : 181 191.
15. Yorioka N, Taniguchi Y, Amimoto D et al. Clinicopathological study of myeloperoxidase anti-neutrophil cytoplasmic antibody-associated glomerulonephritis. Clin. Neprol. 1999 52 : 293 296.
16. van Es LA, de Heer E, Vleming LJ et al. GMP-17-positive T-lymphocytes in renal tubules predict progression in early stages of IgA nephropathy. Kidney Int. 2008 73 : 1426 1443.