메뉴 건너뛰기




Volumn 51, Issue 1, 2012, Pages 91-100

Adenovirus type 35, but not type 5, stimulates NK cell activation via plasmacytoid dendritic cells and TLR9 signaling

Author keywords

Adenovirus; Interferon ; NK cells; Plasmacytoid dendritic cells; TLR9

Indexed keywords

ALPHA INTERFERON; CD56 ANTIGEN; CD69 ANTIGEN; INTERLEUKIN 2; TOLL LIKE RECEPTOR 9;

EID: 84859581254     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2012.02.119     Document Type: Article
Times cited : (17)

References (67)
  • 4
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • Banchereau J., Steinman R.M. Dendritic cells and the control of immunity. Nature 1998, 392:245-252.
    • (1998) Nature , vol.392 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 6
    • 33751225361 scopus 로고    scopus 로고
    • Adenovirus efficiently transduces plasmacytoid dendritic cells resulting in TLR9-dependent maturation and IFN-alpha production
    • Basner-Tschakarjan E., Gaffal E., O'Keeffe M., Tormo D., Limmer A., Wagner H., Hochrein H., Tuting T. Adenovirus efficiently transduces plasmacytoid dendritic cells resulting in TLR9-dependent maturation and IFN-alpha production. J. Gene Med. 2006, 8:1300-1306.
    • (2006) J. Gene Med. , vol.8 , pp. 1300-1306
    • Basner-Tschakarjan, E.1    Gaffal, E.2    O'Keeffe, M.3    Tormo, D.4    Limmer, A.5    Wagner, H.6    Hochrein, H.7    Tuting, T.8
  • 8
    • 0036720393 scopus 로고    scopus 로고
    • Adenovirus infections following allogeneic stem cell transplantation: incidence and outcome in relation to graft manipulation, immunosuppression, and immune recovery
    • Chakrabarti S., Mautner V., Osman H., Collingham K.E., Fegan C.D., Klapper P.E., Moss P.A., Milligan D.W. Adenovirus infections following allogeneic stem cell transplantation: incidence and outcome in relation to graft manipulation, immunosuppression, and immune recovery. Blood 2002, 100:1619-1627.
    • (2002) Blood , vol.100 , pp. 1619-1627
    • Chakrabarti, S.1    Mautner, V.2    Osman, H.3    Collingham, K.E.4    Fegan, C.D.5    Klapper, P.E.6    Moss, P.A.7    Milligan, D.W.8
  • 9
    • 15244349785 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells in immunity
    • Colonna M., Trinchieri G., Liu Y.J. Plasmacytoid dendritic cells in immunity. Nat. Immunol. 2004, 5:1219-1226.
    • (2004) Nat. Immunol. , vol.5 , pp. 1219-1226
    • Colonna, M.1    Trinchieri, G.2    Liu, Y.J.3
  • 10
    • 33847360348 scopus 로고    scopus 로고
    • NKp46 and NKG2D recognition of infected dendritic cells is necessary for NK cell activation in the human response to influenza infection
    • Draghi M., Pashine A., Sanjanwala B., Gendzekhadze K., Cantoni C., Cosman D., Moretta A., Valiante N.M., Parham P. NKp46 and NKG2D recognition of infected dendritic cells is necessary for NK cell activation in the human response to influenza infection. J. Immunol. 2007, 178:2688-2698.
    • (2007) J. Immunol. , vol.178 , pp. 2688-2698
    • Draghi, M.1    Pashine, A.2    Sanjanwala, B.3    Gendzekhadze, K.4    Cantoni, C.5    Cosman, D.6    Moretta, A.7    Valiante, N.M.8    Parham, P.9
  • 12
    • 54249125346 scopus 로고    scopus 로고
    • Adenoviruses in immunocompromised hosts
    • Echavarria M. Adenoviruses in immunocompromised hosts. Clin. Microbiol. Rev. 2008, 21:704-715.
    • (2008) Clin. Microbiol. Rev. , vol.21 , pp. 704-715
    • Echavarria, M.1
  • 14
    • 0022658185 scopus 로고
    • Molecular biology of adenovirus type 2 semipermissive infections. I. Viral growth and expression of viral replicative functions during restricted adenovirus infection
    • Eggerding F.A., Pierce W.C. Molecular biology of adenovirus type 2 semipermissive infections. I. Viral growth and expression of viral replicative functions during restricted adenovirus infection. Virology 1986, 148:97-113.
    • (1986) Virology , vol.148 , pp. 97-113
    • Eggerding, F.A.1    Pierce, W.C.2
  • 16
    • 10744220237 scopus 로고    scopus 로고
    • A prospective comparison of immune reconstitution in pediatric recipients of positively selected CD34+ peripheral blood stem cells from unrelated donors vs recipients of unmanipulated bone marrow from related donors
    • Eyrich M., Leiler C., Lang P., Schilbach K., Schumm M., Bader P., Greil J., Klingebiel T., Handgretinger R., Niethammer D., Schlegel P.G. A prospective comparison of immune reconstitution in pediatric recipients of positively selected CD34+ peripheral blood stem cells from unrelated donors vs recipients of unmanipulated bone marrow from related donors. Bone Marrow Transplant. 2003, 32:379-390.
    • (2003) Bone Marrow Transplant. , vol.32 , pp. 379-390
    • Eyrich, M.1    Leiler, C.2    Lang, P.3    Schilbach, K.4    Schumm, M.5    Bader, P.6    Greil, J.7    Klingebiel, T.8    Handgretinger, R.9    Niethammer, D.10    Schlegel, P.G.11
  • 17
    • 0037606040 scopus 로고    scopus 로고
    • CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunity
    • Fehniger T.A., Cooper M.A., Nuovo G.J., Cella M., Facchetti F., Colonna M., Caligiuri M.A. CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunity. Blood 2003, 101:3052-3057.
    • (2003) Blood , vol.101 , pp. 3052-3057
    • Fehniger, T.A.1    Cooper, M.A.2    Nuovo, G.J.3    Cella, M.4    Facchetti, F.5    Colonna, M.6    Caligiuri, M.A.7
  • 20
    • 0028897676 scopus 로고
    • Characterization of human proliferative T cell responses to adenovirus
    • Flomenberg P., Piaskowski V., Truitt R.L., Casper J.T. Characterization of human proliferative T cell responses to adenovirus. J. Infect. Dis. 1995, 171:1090-1096.
    • (1995) J. Infect. Dis. , vol.171 , pp. 1090-1096
    • Flomenberg, P.1    Piaskowski, V.2    Truitt, R.L.3    Casper, J.T.4
  • 21
    • 0033993462 scopus 로고    scopus 로고
    • Productive replication of human adenoviruses in mouse epidermal cells
    • Ganly I., Mautner V., Balmain A. Productive replication of human adenoviruses in mouse epidermal cells. J. Virol. 2000, 74:2895-2899.
    • (2000) J. Virol. , vol.74 , pp. 2895-2899
    • Ganly, I.1    Mautner, V.2    Balmain, A.3
  • 22
    • 11844268647 scopus 로고    scopus 로고
    • The reciprocal interaction of NK cells with plasmacytoid or myeloid dendritic cells profoundly affects innate resistance functions
    • Gerosa F., Gobbi A., Zorzi P., Burg S., Briere F., Carra G., Trinchieri G. The reciprocal interaction of NK cells with plasmacytoid or myeloid dendritic cells profoundly affects innate resistance functions. J. Immunol. 2005, 174:727-734.
    • (2005) J. Immunol. , vol.174 , pp. 727-734
    • Gerosa, F.1    Gobbi, A.2    Zorzi, P.3    Burg, S.4    Briere, F.5    Carra, G.6    Trinchieri, G.7
  • 23
    • 48749085127 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases
    • Gilliet M., Cao W., Liu Y.J. Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases. Nat. Rev. Immunol. 2008, 8:594-606.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 594-606
    • Gilliet, M.1    Cao, W.2    Liu, Y.J.3
  • 25
    • 0019951384 scopus 로고
    • Lymphokine-activated killer cell phenomenon. Lysis of natural killer-resistant fresh solid tumor cells by interleukin 2-activated autologous human peripheral blood lymphocytes
    • Grimm E.A., Mazumder A., Zhang H.Z., Rosenberg S.A. Lymphokine-activated killer cell phenomenon. Lysis of natural killer-resistant fresh solid tumor cells by interleukin 2-activated autologous human peripheral blood lymphocytes. J. Exp. Med. 1982, 155:1823-1841.
    • (1982) J. Exp. Med. , vol.155 , pp. 1823-1841
    • Grimm, E.A.1    Mazumder, A.2    Zhang, H.Z.3    Rosenberg, S.A.4
  • 26
    • 57449095648 scopus 로고    scopus 로고
    • Signalling pathways leading to IFN-alpha production in human plasmacytoid dendritic cell and the possible use of agonists or antagonists of TLR7 and TLR9 in clinical indications
    • Guiducci C., Coffman R.L., Barrat F.J. Signalling pathways leading to IFN-alpha production in human plasmacytoid dendritic cell and the possible use of agonists or antagonists of TLR7 and TLR9 in clinical indications. J. Intern. Med. 2009, 265:43-57.
    • (2009) J. Intern. Med. , vol.265 , pp. 43-57
    • Guiducci, C.1    Coffman, R.L.2    Barrat, F.J.3
  • 27
    • 0042346153 scopus 로고    scopus 로고
    • Repetitive elements in mammalian telomeres suppress bacterial DNA-induced immune activation
    • Gursel I., Gursel M., Yamada H., Ishii K.J., Takeshita F., Klinman D.M. Repetitive elements in mammalian telomeres suppress bacterial DNA-induced immune activation. J. Immunol. 2003, 171:1393-1400.
    • (2003) J. Immunol. , vol.171 , pp. 1393-1400
    • Gursel, I.1    Gursel, M.2    Yamada, H.3    Ishii, K.J.4    Takeshita, F.5    Klinman, D.M.6
  • 33
    • 0026771406 scopus 로고
    • Adenoviruses in the immunocompromised host
    • Hierholzer J.C. Adenoviruses in the immunocompromised host. Clin. Microbiol. Rev. 1992, 5:262-274.
    • (1992) Clin. Microbiol. Rev. , vol.5 , pp. 262-274
    • Hierholzer, J.C.1
  • 35
    • 0026381749 scopus 로고
    • Natural human interferon-alpha augments interleukin-2 production by a direct action on the activated IL-2-producing T cells
    • Holan V., Kohno K., Minowada J. Natural human interferon-alpha augments interleukin-2 production by a direct action on the activated IL-2-producing T cells. J. Interferon Res. 1991, 11:319-325.
    • (1991) J. Interferon Res. , vol.11 , pp. 319-325
    • Holan, V.1    Kohno, K.2    Minowada, J.3
  • 36
    • 78049382659 scopus 로고    scopus 로고
    • NK cells as effectors of acquired immune responses: effector CD4+ T cell-dependent activation of NK cells following vaccination
    • Horowitz A., Behrens R.H., Okell L., Fooks A.R., Riley E.M. NK cells as effectors of acquired immune responses: effector CD4+ T cell-dependent activation of NK cells following vaccination. J. Immunol. 2010, 185:2808-2818.
    • (2010) J. Immunol. , vol.185 , pp. 2808-2818
    • Horowitz, A.1    Behrens, R.H.2    Okell, L.3    Fooks, A.R.4    Riley, E.M.5
  • 37
    • 33846532947 scopus 로고    scopus 로고
    • Preferential activation of Toll-like receptor nine by CD46-utilizing adenoviruses
    • Iacobelli-Martinez M., Nemerow G.R. Preferential activation of Toll-like receptor nine by CD46-utilizing adenoviruses. J. Virol. 2007, 81:1305-1312.
    • (2007) J. Virol. , vol.81 , pp. 1305-1312
    • Iacobelli-Martinez, M.1    Nemerow, G.R.2
  • 38
    • 0035179882 scopus 로고    scopus 로고
    • Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells
    • Jarrossay D., Napolitani G., Colonna M., Sallusto F., Lanzavecchia A. Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells. Eur. J. Immunol. 2001, 31:3388-3393.
    • (2001) Eur. J. Immunol. , vol.31 , pp. 3388-3393
    • Jarrossay, D.1    Napolitani, G.2    Colonna, M.3    Sallusto, F.4    Lanzavecchia, A.5
  • 39
    • 0035903288 scopus 로고    scopus 로고
    • Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens
    • Kadowaki N., Ho S., Antonenko S., Malefyt R.W., Kastelein R.A., Bazan F., Liu Y.J. Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J. Exp. Med. 2001, 194:863-869.
    • (2001) J. Exp. Med. , vol.194 , pp. 863-869
    • Kadowaki, N.1    Ho, S.2    Antonenko, S.3    Malefyt, R.W.4    Kastelein, R.A.5    Bazan, F.6    Liu, Y.J.7
  • 40
    • 0038029587 scopus 로고    scopus 로고
    • The impact of adenovirus infection on the immunocompromised host
    • Kojaoghlanian T., Flomenberg P., Horwitz M.S. The impact of adenovirus infection on the immunocompromised host. Rev. Med. Virol. 2003, 13:155-171.
    • (2003) Rev. Med. Virol. , vol.13 , pp. 155-171
    • Kojaoghlanian, T.1    Flomenberg, P.2    Horwitz, M.S.3
  • 42
    • 0842328805 scopus 로고    scopus 로고
    • Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9
    • Krug A., Luker G.D., Barchet W., Leib D.A., Akira S., Colonna M. Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9. Blood 2004, 103:1433-1437.
    • (2004) Blood , vol.103 , pp. 1433-1437
    • Krug, A.1    Luker, G.D.2    Barchet, W.3    Leib, D.A.4    Akira, S.5    Colonna, M.6
  • 43
    • 41349106548 scopus 로고    scopus 로고
    • TLR9 as a key receptor for the recognition of DNA
    • Kumagai Y., Takeuchi O., Akira S. TLR9 as a key receptor for the recognition of DNA. Adv. Drug Deliv. Rev. 2008, 60:795-804.
    • (2008) Adv. Drug Deliv. Rev. , vol.60 , pp. 795-804
    • Kumagai, Y.1    Takeuchi, O.2    Akira, S.3
  • 44
    • 1342323794 scopus 로고    scopus 로고
    • Fiber-modified adenoviruses generate subgroup cross-reactive, adenovirus-specific cytotoxic T lymphocytes for therapeutic applications
    • Leen A.M., Sili U., Savoldo B., Jewell A.M., Piedra P.A., Brenner M.K., Rooney C.M. Fiber-modified adenoviruses generate subgroup cross-reactive, adenovirus-specific cytotoxic T lymphocytes for therapeutic applications. Blood 2004, 103:1011-1019.
    • (2004) Blood , vol.103 , pp. 1011-1019
    • Leen, A.M.1    Sili, U.2    Savoldo, B.3    Jewell, A.M.4    Piedra, P.A.5    Brenner, M.K.6    Rooney, C.M.7
  • 45
    • 57049146779 scopus 로고    scopus 로고
    • Clinical features and treatment of adenovirus infections
    • Lenaerts L., De Clercq E., Naesens L. Clinical features and treatment of adenovirus infections. Rev. Med. Virol. 2008, 18:357-374.
    • (2008) Rev. Med. Virol. , vol.18 , pp. 357-374
    • Lenaerts, L.1    De Clercq, E.2    Naesens, L.3
  • 46
    • 0025847781 scopus 로고
    • Membrane cofactor protein (MCP or CD46): newest member of the regulators of complement activation gene cluster
    • Liszewski M.K., Post T.W., Atkinson J.P. Membrane cofactor protein (MCP or CD46): newest member of the regulators of complement activation gene cluster. Annu. Rev. Immunol. 1991, 9:431-455.
    • (1991) Annu. Rev. Immunol. , vol.9 , pp. 431-455
    • Liszewski, M.K.1    Post, T.W.2    Atkinson, J.P.3
  • 47
    • 34548606400 scopus 로고    scopus 로고
    • Myeloid and plasmacytoid dendritic cells are susceptible to recombinant adenovirus vectors and stimulate polyfunctional memory T cell responses
    • Lore K., Adams W.C., Havenga M.J., Precopio M.L., Holterman L., Goudsmit J., Koup R.A. Myeloid and plasmacytoid dendritic cells are susceptible to recombinant adenovirus vectors and stimulate polyfunctional memory T cell responses. J. Immunol. 2007, 179:1721-1729.
    • (2007) J. Immunol. , vol.179 , pp. 1721-1729
    • Lore, K.1    Adams, W.C.2    Havenga, M.J.3    Precopio, M.L.4    Holterman, L.5    Goudsmit, J.6    Koup, R.A.7
  • 48
    • 0042123694 scopus 로고    scopus 로고
    • Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells
    • Lund J., Sato A., Akira S., Medzhitov R., Iwasaki A. Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J. Exp. Med. 2003, 198:513-520.
    • (2003) J. Exp. Med. , vol.198 , pp. 513-520
    • Lund, J.1    Sato, A.2    Akira, S.3    Medzhitov, R.4    Iwasaki, A.5
  • 49
    • 0024391085 scopus 로고
    • Comparative studies of human FcRIII-positive and negative natural killer cells
    • Nagler A., Lanier L.L., Cwirla S., Phillips J.H. Comparative studies of human FcRIII-positive and negative natural killer cells. J. Immunol. 1989, 143:3183-3191.
    • (1989) J. Immunol. , vol.143 , pp. 3183-3191
    • Nagler, A.1    Lanier, L.L.2    Cwirla, S.3    Phillips, J.H.4
  • 51
    • 1642264887 scopus 로고    scopus 로고
    • Prevalence of neutralizing antibodies to adenoviral serotypes 5 and 35 in the adult populations of The Gambia, South Africa, and the United States
    • Nwanegbo E., Vardas E., Gao W., Whittle H., Sun H., Rowe D., Robbins P.D., Gambotto A. Prevalence of neutralizing antibodies to adenoviral serotypes 5 and 35 in the adult populations of The Gambia, South Africa, and the United States. Clin. Diagn. Lab. Immunol. 2004, 11:351-357.
    • (2004) Clin. Diagn. Lab. Immunol. , vol.11 , pp. 351-357
    • Nwanegbo, E.1    Vardas, E.2    Gao, W.3    Whittle, H.4    Sun, H.5    Rowe, D.6    Robbins, P.D.7    Gambotto, A.8
  • 53
    • 36849067467 scopus 로고    scopus 로고
    • Inhibitory oligodeoxynucleotides downregulate herpes simplex virus-induced plasmacytoid dendritic cell type I interferon production and modulate cell function
    • Peng W.M., Yu C.F., Allam J.P., Oldenburg J., Bieber T., Hoch J., Eis-Hubinger A.M., Novak N. Inhibitory oligodeoxynucleotides downregulate herpes simplex virus-induced plasmacytoid dendritic cell type I interferon production and modulate cell function. Hum. Immunol 2007, 68:879-887.
    • (2007) Hum. Immunol , vol.68 , pp. 879-887
    • Peng, W.M.1    Yu, C.F.2    Allam, J.P.3    Oldenburg, J.4    Bieber, T.5    Hoch, J.6    Eis-Hubinger, A.M.7    Novak, N.8
  • 54
    • 0022530989 scopus 로고
    • Dissection of the lymphokine-activated killer phenomenon. Relative contribution of peripheral blood natural killer cells and T lymphocytes to cytolysis
    • Phillips J.H., Lanier L.L. Dissection of the lymphokine-activated killer phenomenon. Relative contribution of peripheral blood natural killer cells and T lymphocytes to cytolysis. J. Exp. Med. 1986, 164:814-825.
    • (1986) J. Exp. Med. , vol.164 , pp. 814-825
    • Phillips, J.H.1    Lanier, L.L.2
  • 55
    • 0035871784 scopus 로고    scopus 로고
    • Highly efficient transduction of human monocyte-derived dendritic cells with subgroup B fiber-modified adenovirus vectors enhances transgene-encoded antigen presentation to cytotoxic T cells
    • Rea D., Havenga M.J., van Den A.M., Sutmuller R.P., Lemckert A., Hoeben R.C., Bout A., Melief C.J., Offringa R. Highly efficient transduction of human monocyte-derived dendritic cells with subgroup B fiber-modified adenovirus vectors enhances transgene-encoded antigen presentation to cytotoxic T cells. J. Immunol. 2001, 166:5236-5244.
    • (2001) J. Immunol. , vol.166 , pp. 5236-5244
    • Rea, D.1    Havenga, M.J.2    van Den, A.M.3    Sutmuller, R.P.4    Lemckert, A.5    Hoeben, R.C.6    Bout, A.7    Melief, C.J.8    Offringa, R.9
  • 56
    • 59849102099 scopus 로고    scopus 로고
    • Adenoviruses: update on structure and function
    • Russell W.C. Adenoviruses: update on structure and function. J. Gen. Virol. 2009, 90:1-20.
    • (2009) J. Gen. Virol. , vol.90 , pp. 1-20
    • Russell, W.C.1
  • 58
    • 41149180540 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 vaccine development: recent advances in the cytotoxic T-lymphocyte platform spotty business
    • Schoenly K.A., Weiner D.B. Human immunodeficiency virus type 1 vaccine development: recent advances in the cytotoxic T-lymphocyte platform spotty business. J. Virol. 2008, 82:3166-3180.
    • (2008) J. Virol. , vol.82 , pp. 3166-3180
    • Schoenly, K.A.1    Weiner, D.B.2
  • 59
    • 0342632772 scopus 로고    scopus 로고
    • Adenovirus types 11p and 35p show high binding efficiencies for committed hematopoietic cell lines and are infective to these cell lines
    • Segerman A., Mei Y.F., Wadell G. Adenovirus types 11p and 35p show high binding efficiencies for committed hematopoietic cell lines and are infective to these cell lines. J. Virol. 2000, 74:1457-1467.
    • (2000) J. Virol. , vol.74 , pp. 1457-1467
    • Segerman, A.1    Mei, Y.F.2    Wadell, G.3
  • 60
    • 0032127610 scopus 로고    scopus 로고
    • Extensive cross-reactivity of adenovirus-specific cytotoxic T cells
    • Smith C.A., Woodruff L.S., Rooney C., Kitchingman G.R. Extensive cross-reactivity of adenovirus-specific cytotoxic T cells. Hum. Gene Ther. 1998, 9:1419-1427.
    • (1998) Hum. Gene Ther. , vol.9 , pp. 1419-1427
    • Smith, C.A.1    Woodruff, L.S.2    Rooney, C.3    Kitchingman, G.R.4
  • 66
    • 45749110171 scopus 로고    scopus 로고
    • A critical role for type I IFN-dependent NK cell activation in innate immune elimination of adenoviral vectors in vivo
    • Zhu J., Huang X., Yang Y. A critical role for type I IFN-dependent NK cell activation in innate immune elimination of adenoviral vectors in vivo. Mol. Ther. 2008, 16:1300-1307.
    • (2008) Mol. Ther. , vol.16 , pp. 1300-1307
    • Zhu, J.1    Huang, X.2    Yang, Y.3
  • 67
    • 78650675402 scopus 로고    scopus 로고
    • NKG2D is required for NK cell activation and function in response to E1-deleted adenovirus
    • Zhu J., Huang X., Yang Y. NKG2D is required for NK cell activation and function in response to E1-deleted adenovirus. J. Immunol. 2010, 185:7480-7486.
    • (2010) J. Immunol. , vol.185 , pp. 7480-7486
    • Zhu, J.1    Huang, X.2    Yang, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.