Single particle detection of Aβ aggregates associated with Alzheimer's disease

Biochemical and Biophysical Research Communications

Volumn 364, Issue 4, 2007, Pages 902-907

  Funke, Susanne Aileen ^a   Birkmann, Eva ^a,b   Henke, Franziska ^b   Görtz, Philipp ^b   Lange Asschenfeldt, Christian ^b   Riesner, Detlev ^b   Willbold, Dieter ^a,b  

^a FORSCHUNGSZENTRUM JÜLICH   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Alzheimer's disease; Amyloid aggregates; Early diagnosis; Fluorescence correlation spectroscopy (FCS); Protein misfolding diseases

Indexed keywords

AMYLOID BETA PROTEIN;

ALZHEIMER DISEASE; ARTICLE; BODY FLUID; CEREBROSPINAL FLUID ANALYSIS; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; FLUORESCENCE; FLUORESCENCE CORRELATION SPECTROSCOPY; HUMAN; NEUROFIBRILLARY TANGLE; PRIORITY JOURNAL; PROTEIN ANALYSIS;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; CEREBROSPINAL FLUID; HUMANS; IMAGE ENHANCEMENT; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; PARTICLE SIZE;

EID: 36048986456     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.10.085     Document Type: Article

References (22)

1. Soto C. Plaque busters: strategies to inhibit amyloid formation in Alzheimer's disease. Mol. Med. Today 5 (1999) 343-350
2. Mattson M.P. Pathways towards and away from Alzheimer's disease. Nature 430 (2004) 631-639
3. Haass C., and Selkoe D.J. Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide. Cell 75 (1993) 1039-1042
4. Kang J., Lemaire H.G., Unterbeck A., Salbaum J.M., Masters C.L., Grzeschik K.H., Multhaup G., Beyreuther K., and Muller-Hill B. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325 (1987) 733-736
5. Weidemann A., Konig G., Bunke D., Fischer P., Salbaum J.M., Masters C.L., and Beyreuther K. Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein. Cell 57 (1989) 115-126
6. Hardy J.A., and Higgins G.A. Alzheimer's disease: the amyloid cascade hypothesis. Science 256 (1992) 184-185
7. Nilsberth C., Westlind-Danielsson A., Eckman C.B., Condron M.M., Axelman K., Forsell C., Stenh C., Luthman J., Teplow D.B., Youngkin S.G., Naslund J., and Lannfelt L. The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation. Nat. Neurosci. 4 (2001) 859-860
8. Selkoe D.J., and Podlisny M.P. Deciphering the genetic basis of Alzheimer's disease. Annu. Rev. Genomics Hum. Genet. 3 (2002) 67-99
9. Flirski M., and Sobow T. Biochemical markers and risk factors of Alzheimer's disease. Curr. Alzheimer Res. 2 (2005) 47-64
10. Andreasen N., and Blennow K. CSF biomarkers for mild cognitive impairment and early Alzheimer's disease. Clin. Neurol. Neurosurg. 107 (2005) 165-173
11. Pitschke M., Prior R., Haupt M., and Riesner D. Detection of single amyloid-β-protein aggregates in the cerebrospinal fluid of Alzheimer's patients by fluorescence correlation spectroscopy. Nat. Med. 4 (1998) 832-834
12. Georganopoulou D.G., Chang L., Nam J.M., Thaxton S., Mufson E.J., Klein W.L., and Mirkin C.A. From the cover: nanoparticle based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease. Proc. Natl. Acad. Sci. USA 102 (2005) 2273-2276
13. Haes A.J., Chang L., Klein W.L., and Van Dyne R. Detection of a biomarker for Alzheimer's disease from synthetic and clinical samples using a nanoscale optical biosensor. J. Am. Chem. Soc. 127 (2005) 2264-2271
14. Haass C., Koo E.H., Mellon A., and Selkoe D.J. Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments. Nature 359 (1992) 322-325
15. Seubert P., Vigo-Pelfrey C., Esch F., Lee M., Dovey H., Davis D., Sinha S., Schlossmacher M., Whaley J., Swindlehurst C., McCormack R., Wolfert R., Selkoe D.J., Lieberburg I., and Schenk D. Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids. Nature 359 (1992) 325-327
16. Eigen M., and Rigler R. Sorting single molecules-application to diagnosis and evolutionary biotechnology. Proc. Natl. Acad. Sci. USA 91 (1994) 5740-5747
17. Birkmann E., Schäfer O., Weinmann N., Dumpitak C., Beekes M., Jackman R., Thorne L., and Riesner D. Detection of prion particles in samples of BSE and scrapie by fluorescence correlation spectroscopy without proteinase K digestion. Biol. Chem. 387 (2006) 95-102
18. Birkmann E., Henke F., Weinmann N., Dumpitak C., Groschup M., Funke A., Willbold D., and Riesner D. Counting of single prion particles bound to a capture-antibody surface (surface-FIDA). Vet. Microbiol. 123 (2007) 294-304
19. McKhann G., Drachman D., Folstein M., Katzman R., Price D., and Stadlan E.M. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 7 (1984) 939-944
20. Kask P., Palo K., Ullmann D., and Gall K. Fluorescence-intensity distribution analysis and its application in biomolecular detection technology. Proc. Natl. Acad. Sci. USA 96 (1999) 13756-13760
21. Santos A.N., Torkler S., Nowak D., Schlittig C., Goerdes M., Lauber T., Trischmann L., Schaupp M., Penz M., Tiller F.W., and Böhm G. Detection of amyloid-beta oligomers in human cerebrospinal fluid by flow cytometry and fluorescence resonance energy transfer. J. Alzheimers Dis. 11 (2007) 117-125
22. Englund H., Seehlin D., Johansson A.S., Nilsson L.N.G., Gellerfors P., Paulie S., Lannfelt L., and Ekholm Pettersson F. Sensitive ELISA detection of amyloid-β protofibrils in biological samples. J. Neurochem. 103 (2007) 334-545